Detailed information for compound 1292962

Basic information

Technical information
  • TDR Targets ID: 1292962
  • Name: [1-[(3-nitrophenyl)-(propanoylamino)methyl]na phthalen-2-yl] acetate
  • MW: 392.405 | Formula: C22H20N2O5
  • H donors: 1 H acceptors: 4 LogP: 4.03 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)NC(c1c(ccc2c1cccc2)OC(=O)C)c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C22H20N2O5/c1-3-20(26)23-22(16-8-6-9-17(13-16)24(27)28)21-18-10-5-4-7-15(18)11-12-19(21)29-14(2)25/h4-13,22H,3H2,1-2H3,(H,23,26)
  • InChiKey: LNDABDSJXOLGCB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-[(3-nitrophenyl)-(propanoylamino)methyl]-2-naphthyl] acetate
  • acetic acid [1-[(3-nitrophenyl)-(1-oxopropylamino)methyl]-2-naphthyl] ester
  • acetic acid [1-[(3-nitrophenyl)-propionamido-methyl]-2-naphthyl] ester
  • [1-[(3-nitrophenyl)-(propanoylamino)methyl]naphthalen-2-yl] ethanoate
  • Oprea1_108340
  • MLS000527141
  • SMR000117615
  • Oprea1_047605
  • Acetic acid 1-[(3-nitro-phenyl)-propionylamino-methyl]-naphthalen-2-yl ester
  • BAS 01277994

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0265 0.2002
Brugia malayi hypothetical protein 0.0034 0.0024 0.0069
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.013 0.037 0.1606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Brugia malayi Calcitonin receptor-like protein seb-1 0.03 0.0981 0.283
Schistosoma mansoni synaptic glycoprotein sc2 related 0.013 0.037 0.036
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.003 0.0173
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.003 0.002
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0079 0.0186 0.0176
Echinococcus multilocularis protein dispatched 1 0.0049 0.0079 0.0069
Echinococcus granulosus neuropeptide s receptor 0.1396 0.493 0.4925
Loa Loa (eye worm) hypothetical protein 0.0101 0.0264 0.0762
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0064 0.0134 0.0386
Loa Loa (eye worm) integrin alpha pat-2 0.0234 0.0745 0.2149
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.007 0.006
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0079 0.0186 0.0828
Brugia malayi Carboxylesterase family protein 0.0047 0.007 0.0201
Loa Loa (eye worm) hypothetical protein 0.0064 0.0134 0.0386
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.003 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0022 0.0115
Schistosoma mansoni alpha-glucosidase 0.0138 0.04 0.039
Schistosoma mansoni hypothetical protein 0.0686 0.2373 0.2365
Loa Loa (eye worm) hypothetical protein 0.0205 0.0639 0.1845
Mycobacterium tuberculosis Carboxylesterase LipT 0.0047 0.007 0.0115
Trypanosoma cruzi protein farnesyltransferase, putative 0.0039 0.0042 0.0139
Giardia lamblia Kinase, PLK 0.01 0.0261 0.6954
Echinococcus granulosus fatty acid amide hydrolase 1 0.0101 0.0264 0.0254
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0047 0.007 0.006
Leishmania major phosphatidylinositol 3-kinase, putative 0.0079 0.0186 0.0828
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0314 0.1033 0.1024
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0481 0.0471
Onchocerca volvulus 0.0033 0.0019 0.0054
Echinococcus multilocularis integrin alpha ps 0.0068 0.0147 0.0137
Onchocerca volvulus 0.0033 0.0019 0.0054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0024 0.0069
Trypanosoma cruzi phospholipase A1, putative 0.0651 0.2246 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0265 0.0255
Echinococcus multilocularis peregrin 0.0037 0.0035 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.0064 0.0134 0.0124
Toxoplasma gondii exonuclease III APE 0.0041 0.0051 0.0303
Echinococcus multilocularis acetylcholinesterase 0.0277 0.0899 0.0889
Entamoeba histolytica hypothetical protein 0.0117 0.0324 0.245
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0039 0.0042 0.0121
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0154 0.0144
Schistosoma mansoni integrin alpha-ps 0.0035 0.0029 0.0019
Loa Loa (eye worm) hypothetical protein 0.0277 0.0899 0.2594
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0039 0.0042 0.0265
Brugia malayi Synaptic glycoprotein SC2 0.013 0.037 0.1067
Loa Loa (eye worm) hypothetical protein 0.0064 0.0134 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.005 0.008 0.0556
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0261 0.0251
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.003 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.0771 0.2226
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0265 0.0764
Loa Loa (eye worm) hypothetical protein 0.0033 0.0019 0.0054
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0079 0.0186 0.0786
Echinococcus granulosus carboxylesterase 5A 0.0277 0.0899 0.0889
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0032
Chlamydia trachomatis replicative DNA helicase 0.0384 0.1286 0.5
Schistosoma mansoni thyroid hormone receptor 0.0064 0.0134 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.0924 0.6975
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.0733 0.2117
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0079 0.0186 0.0537
Brugia malayi jmjC domain containing protein 0.0048 0.0073 0.021
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0039 0.0042 0.0317
Schistosoma mansoni jumonji domain containing protein 0.008 0.019 0.018
Brugia malayi CHE-14 protein 0.0043 0.0057 0.0165
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.003 0.002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.003 0.0086
Schistosoma mansoni cpg binding protein 0.0158 0.0472 0.0462
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0167 0.0483
Brugia malayi ecdysteroid receptor 0.0064 0.0134 0.0386
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0167 0.0157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0064 0.0134 0.0124
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0079 0.0186 0.0828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0416
Loa Loa (eye worm) RNA binding protein 0.0074 0.0167 0.0483
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.0924 0.6975
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0277 0.0899 0.0889
Echinococcus multilocularis FTZ F1 alpha 0.0064 0.0134 0.0124
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0039 0.0042 0.0265
Loa Loa (eye worm) hypothetical protein 0.0034 0.0024 0.0069
Brugia malayi Carboxylesterase family protein 0.0277 0.0899 0.2594
Giardia lamblia Synaptic glycoprotein SC2 0.013 0.037 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0109 0.0292 0.1259
Trypanosoma brucei glucosidase, putative 0.0036 0.003 0.0085
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0057 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0064 0.0134 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0261 0.193
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0079 0.0186 0.0176
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.0736 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0416
Loa Loa (eye worm) hypothetical protein 0.0115 0.0315 0.0909
Echinococcus granulosus geminin 0.0686 0.2373 0.2365
Brugia malayi hypothetical protein 0.003 0.0011 0.0031
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0298 0.0976 0.432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.0925 0.0916
Echinococcus multilocularis neuropeptide receptor A26 0.1396 0.493 0.4925
Toxoplasma gondii FATC domain-containing protein 0.0109 0.0292 0.2145
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.0011 0.0001
Onchocerca volvulus 0.0047 0.007 0.0201
Loa Loa (eye worm) hypothetical protein 0.013 0.037 0.1067
Onchocerca volvulus 0.0651 0.2246 0.6483
Loa Loa (eye worm) hypothetical protein 0.0045 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0047 0.007 0.0201
Echinococcus granulosus integrin alpha ps 0.0033 0.0019 0.0009
Loa Loa (eye worm) hypothetical protein 0.0989 0.3464 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0011 0.0031
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.013 0.037 0.2796
Echinococcus granulosus acetylcholinesterase 0.0277 0.0899 0.0889
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0022 0.0115
Loa Loa (eye worm) hypothetical protein 0.0047 0.007 0.0201
Plasmodium falciparum polyprenol reductase, putative 0.013 0.037 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0011 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0025 0.0139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0011 0.0001
Brugia malayi follicle stimulating hormone receptor 0.0231 0.0733 0.2117
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0012 0.0002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0078 0.0542
Loa Loa (eye worm) carboxylesterase 0.0277 0.0899 0.2594
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0284 0.0925 0.2671
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0079 0.0186 0.0783
Echinococcus granulosus acetylcholinesterase 0.0277 0.0899 0.0889
Echinococcus multilocularis zinc finger protein 0.0031 0.0014 0.0004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.0459 0.045
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.0261 0.1162
Brugia malayi F/Y-rich N-terminus family protein 0.0057 0.0107 0.0309
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0121
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0034 0.0024
Brugia malayi hypothetical protein 0.0232 0.0736 0.2125
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.003 0.0173
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0064 0.0134 0.0124
Entamoeba histolytica protein kinase rad3, putative 0.0045 0.0062 0.0467
Brugia malayi TAR-binding protein 0.0074 0.0167 0.0483
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0329 0.2485
Echinococcus granulosus dnaJ subfamily B 0.1703 0.6036 0.6032
Echinococcus granulosus neuroligin 0.0047 0.007 0.006
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.0329 0.0542
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0046 0.0066 0.0056
Loa Loa (eye worm) hypothetical protein 0.0064 0.0134 0.0386
Schistosoma mansoni hypothetical protein 0.0117 0.0324 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0051 0.0383
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Brugia malayi Bromodomain containing protein 0.0041 0.0049 0.014
Loa Loa (eye worm) acetyltransferase 0.0162 0.0484 0.1396
Brugia malayi hypothetical protein 0.0034 0.0024 0.0069
Echinococcus granulosus para nitrobenzyl esterase 0.0047 0.007 0.006
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0394 0.1322 0.5868
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.0329 0.0319
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0261 0.193
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0079 0.0186 0.0828
Schistosoma mansoni acetylcholinesterase 0.0047 0.007 0.006
Brugia malayi hypothetical protein 0.0047 0.007 0.0201
Mycobacterium leprae Conserved hypothetical protein 0.0504 0.1716 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0064 0.0134 0.0386
Loa Loa (eye worm) hypothetical protein 0.0084 0.0203 0.0586
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0117 0.0324 0.0314
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.0421 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0022 0.0115
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0064 0.0134 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.0925 0.0916
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0064 0.0134 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0042 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0573 0.43
Loa Loa (eye worm) hypothetical protein 0.0047 0.007 0.0201
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0243 0.0233
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0024 0.0014
Schistosoma mansoni integrin alpha-ps 0.0068 0.0147 0.0137
Mycobacterium ulcerans hypothetical protein 0.0394 0.1322 1
Echinococcus granulosus lysine specific demethylase 5A 0.0048 0.0073 0.0063
Brugia malayi Carboxylesterase family protein 0.0047 0.007 0.0201
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0481 0.1388
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0026 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0573 0.43
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0022 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0134 0.0124
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0243 0.0701
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0039 0.0042 0.0236
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0167 0.0483
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1711 0.6068 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.0484 0.0474
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0265 0.0255
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.0011 0.0001
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0079 0.0186 0.0783
Schistosoma mansoni hypothetical protein 0.0095 0.0243 0.0233
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0039 0.0042 0.0265
Brugia malayi nuclear receptor RXR 0.003 0.0011 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0079 0.0186 0.0537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Entamoeba histolytica hypothetical protein 0.0117 0.0324 0.245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Leishmania major hypothetical protein, conserved 0.003 0.0011 0.0049
Schistosoma mansoni hypothetical protein 0.0095 0.0243 0.0233
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.013 0.037 1
Echinococcus multilocularis dnaJ subfamily B 0.1703 0.6036 0.6032
Loa Loa (eye worm) hypothetical protein 0.0101 0.0265 0.0764
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.0771 0.2226
Onchocerca volvulus 0.0047 0.0072 0.0207
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0064 0.0134 0.0386
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0051 0.0146
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0036 0.0025
Echinococcus granulosus BC026374 protein S09 family 0.0047 0.007 0.006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0134 0.0124
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0051 0.0178
Loa Loa (eye worm) hypothetical protein 0.005 0.008 0.0231
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.0011 0.0031
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0078 0.0514
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.013 0.0376
Schistosoma mansoni hypothetical protein 0.0686 0.2373 0.2365
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0022 0.0115
Onchocerca volvulus Protein ultraspiracle homolog 0.0064 0.0134 0.0386
Loa Loa (eye worm) hypothetical protein 0.0277 0.0899 0.2594
Loa Loa (eye worm) pigment dispersing factor receptor c 0.03 0.0981 0.283
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0064 0.0134 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.0924 0.6975
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0039 0.0042 0.0121
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0022 0.0115
Schistosoma mansoni ap endonuclease 0.0041 0.0051 0.0041
Schistosoma mansoni zinc finger protein 0.0031 0.0014 0.0004
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0034 0.0025 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0064 0.0134 0.0386
Brugia malayi steroid hormone receptor 0.0064 0.0134 0.0386
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.0261 0.0753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0039 0.0042 0.0139
Schistosoma mansoni nuclear receptor 0.003 0.0011 0.0001
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0039 0.0042 0.0265
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Onchocerca volvulus 0.0064 0.0134 0.0386
Plasmodium falciparum geranylgeranyltransferase, putative 0.0039 0.0042 0.0863
Schistosoma mansoni hypothetical protein 0.0042 0.0052 0.0042
Schistosoma mansoni retinoic acid receptor RXR 0.0064 0.0134 0.0124
Onchocerca volvulus 0.003 0.0011 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.0924 0.6975
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0134 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0051 0.0041
Onchocerca volvulus 0.0651 0.2246 0.6483
Schistosoma mansoni lamin 0.0033 0.0019 0.0008
Brugia malayi intermediate filament protein 0.0033 0.0019 0.0054
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0481 0.1388
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0109 0.0292 0.1259
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0011 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0064 0.0134 0.0386
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0039 0.0042 0.0265
Onchocerca volvulus Phospholipase A2 homolog 0.0989 0.3464 1
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.0924 0.6975
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0064 0.0134 0.0386
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0039 0.0042 0.0139
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0134 0.0124
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0011 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0079 0.0186 0.0176
Schistosoma mansoni hypothetical protein 0.0034 0.0025 0.0015
Brugia malayi conserved hypotetical protein 0.003 0.0011 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0073 0.0063
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.0011 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0115 0.0315 0.0909
Loa Loa (eye worm) hypothetical protein 0.0034 0.0025 0.0073
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0072 0.0207
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0265 0.0255
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.0484 0.0474
Onchocerca volvulus Alhambra homolog 0.0031 0.0012 0.0035
Leishmania major lanosterol synthase, putative 0.0246 0.0788 0.351
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.0011 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0079 0.0549
Schistosoma mansoni intermediate filament proteins 0.0033 0.0019 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0101 0.0264 0.0254
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0039 0.0042 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0573 0.43
Echinococcus granulosus cpg binding protein 0.0158 0.0472 0.0462
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.003 0.0173
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0261 0.1118
Leishmania major geranylgeranyltransferase, putative 0.0039 0.0042 0.0187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0329 0.2485
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0022 0.0115
Toxoplasma gondii histone lysine methyltransferase SET1 0.0287 0.0935 0.7043
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0079 0.0186 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0057 0.0382
Loa Loa (eye worm) acetylcholinesterase 1 0.0277 0.0899 0.2594
Onchocerca volvulus 0.0047 0.007 0.0201
Loa Loa (eye worm) hypothetical protein 0.0043 0.0057 0.0165
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0158 0.047 0.0775
Toxoplasma gondii target of rapamycin (TOR), putative 0.0079 0.0186 0.1335
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0019 0.0054
Loa Loa (eye worm) hypothetical protein 0.0064 0.0134 0.0386
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0022 0.0115
Schistosoma mansoni hypothetical protein 0.0095 0.0243 0.0233
Echinococcus multilocularis acetylcholinesterase 0.0277 0.0899 0.0889
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0064 0.0134 0.0124
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0034 0.0025 0.0015
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0019 0.0054
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.0261 0.0251
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0167 0.0157
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0051 0.1106
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0039 0.0042 0.0032
Brugia malayi nuclear hormone receptor 0.0064 0.0134 0.0386
Brugia malayi PHD-finger family protein 0.0031 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0093 0.0238 0.0686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0039 0.0042 0.0236
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.0011 0.0031
Trichomonas vaginalis helicase, putative 0.0034 0.0022 0.0115
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.013 0.037 0.036
Trichomonas vaginalis spcc417.12 protein, putative 0.0047 0.007 0.0477
Echinococcus granulosus fatty acid amide hydrolase 1 0.0101 0.0264 0.0254
Onchocerca volvulus 0.0651 0.2246 0.6483
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0051 0.0178
Brugia malayi Phospholipase A2 family protein 0.0989 0.3464 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0073 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0064 0.0134 0.0386
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.0573 0.1653
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0037 0.0034 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.008 0.0556
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0034 0.0024 0.0069
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0284 0.0925 0.2671
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.013 0.037 0.2758
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0243 0.0233
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.003 0.0144
Treponema pallidum replicative DNA helicase (dnaB) 0.0384 0.1286 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0039 0.0042 0.0032
Loa Loa (eye worm) hypothetical protein 0.0064 0.0134 0.0386
Echinococcus multilocularis geminin 0.0686 0.2373 0.2365
Brugia malayi nuclear receptor NHR-88 0.003 0.0011 0.0031
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.0329 0.0319
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0022 0.0115
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0035
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.007 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0064 0.0134 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0057 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.0925 0.0916
Brugia malayi MH2 domain containing protein 0.0241 0.0771 0.2226
Echinococcus granulosus integrin alpha ps 0.0068 0.0147 0.0137
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0056 0.1258
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0011 0.0001
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0047 0.007 0.0477
Echinococcus multilocularis ecdysone induced protein 78C 0.0064 0.0134 0.0124
Echinococcus granulosus expressed conserved protein 0.0095 0.0243 0.0233
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.0925 0.0916
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0051 0.0331
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0039 0.0042 0.0863
Schistosoma mansoni amidase 0.0101 0.0264 0.0254
Brugia malayi FAT domain containing protein 0.0034 0.0025 0.0073
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0056 0.1225
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.0484 0.1396
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.0011 0.0031
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.013 0.037 0.2758
Echinococcus multilocularis serine protein kinase ATM 0.0109 0.0292 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Brugia malayi PHD-finger family protein 0.0036 0.0032 0.0094
Schistosoma mansoni neuroligin 3 (S09 family) 0.0047 0.007 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0416
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0117 0.0324 0.0314
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0394 0.1322 0.5868
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.0261 0.0753
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0121
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0079 0.0186 0.1406
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0394 0.1322 0.5868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0416
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0134 0.0124
Loa Loa (eye worm) hypothetical protein 0.0064 0.0134 0.0386
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0481 0.0471
Giardia lamblia Rab geranylgeranyltransferase 0.0039 0.0042 0.0829
Echinococcus granulosus zinc finger protein 0.0031 0.0014 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0064 0.0134 0.0386
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.0011 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0167 0.0157
Schistosoma mansoni bromodomain containing protein 0.0073 0.0166 0.0156
Trypanosoma cruzi lanosterol synthase, putative 0.0285 0.0929 0.4107
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0039 0.0042 0.0236
Loa Loa (eye worm) histone methyltransferase 0.0046 0.0066 0.0192
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.007 0.006
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0057 0.0165
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0051 0.1106
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0064 0.0134 0.0124
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0651 0.2246 0.6483
Schistosoma mansoni gliotactin 0.0047 0.007 0.006
Loa Loa (eye worm) steroid hormone receptor 0.0064 0.0134 0.0386
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.0329 0.2422
Plasmodium vivax geranylgeranyltransferase, putative 0.0039 0.0042 0.0863
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0051 0.0225
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0056 0.0046
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0064 0.0134 0.0124
Echinococcus multilocularis GPCR, family 2 0.0095 0.0243 0.0233
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.013 0.037 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0022 0.0115
Schistosoma mansoni lamin 0.0033 0.0019 0.0008
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.003 0.0133
Entamoeba histolytica hypothetical protein 0.0117 0.0324 0.245
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.003 0.0085
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Leishmania major farnesyltransferase beta subunit 0.0039 0.0042 0.0187
Echinococcus granulosus FTZ F1 alpha 0.0064 0.0134 0.0124
Brugia malayi hypothetical protein 0.003 0.0011 0.0031
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0298 0.0976 0.432
Plasmodium falciparum phd finger protein, putative 0.0031 0.0012 0.0037
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0064 0.0134 0.0124
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0039 0.0042 0.0032
Schistosoma mansoni hypothetical protein 0.0042 0.0052 0.0042
Schistosoma mansoni hypothetical protein 0.0042 0.0052 0.0042
Onchocerca volvulus 0.013 0.037 0.1067
Echinococcus multilocularis lamin 0.0033 0.0019 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Brugia malayi Steroid receptor seven-up type 2 0.0064 0.0134 0.0386
Loa Loa (eye worm) hypothetical protein 0.0053 0.0092 0.0264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.0925 0.0916
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1327 0.4683 0.7718
Loa Loa (eye worm) hypothetical protein 0.0033 0.0019 0.0054
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Echinococcus granulosus GPCR family 2 0.0095 0.0243 0.0233
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0012 0.0037
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0045 0.0062 0.0467
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0134 0.0386
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.003 0.0226
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0012 0.0002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0051 0.0041
Schistosoma mansoni RAR-like nuclear receptor 0.0064 0.0134 0.0124
Schistosoma mansoni hypothetical protein 0.1703 0.6036 0.6032
Echinococcus granulosus peregrin 0.0037 0.0035 0.0024
Schistosoma mansoni patched 1 0.0043 0.0057 0.0047
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0026 0.0016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0024 0.0014
Schistosoma mansoni hypothetical protein 0.0042 0.0052 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0064 0.0134 0.0124
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0394 0.1322 0.5888
Onchocerca volvulus 0.0047 0.007 0.0201
Echinococcus granulosus lamin 0.0033 0.0019 0.0008
Loa Loa (eye worm) hypothetical protein 0.03 0.0981 0.283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Brugia malayi nuclear hormone receptor 0.003 0.0011 0.0031
Onchocerca volvulus 0.0093 0.0236 0.0682
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0024 0.0069
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0064 0.0134 0.0124
Echinococcus granulosus synaptic glycoprotein sc2 0.013 0.037 0.036
Onchocerca volvulus 0.0047 0.007 0.0201
Loa Loa (eye worm) hypothetical protein 0.0034 0.0024 0.0069
Loa Loa (eye worm) hypothetical protein 0.0047 0.007 0.0201
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0011 0.0031
Schistosoma mansoni BC026374 protein (S09 family) 0.0047 0.007 0.006
Loa Loa (eye worm) hypothetical protein 0.0119 0.0331 0.0955
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0329 0.2485
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0022 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0416
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.0011 0.0001
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.013 0.037 0.2736
Brugia malayi RNA binding protein 0.0074 0.0167 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0416
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0024 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0609 0.4575
Loa Loa (eye worm) hypothetical protein 0.0054 0.0094 0.0272
Echinococcus multilocularis neuroligin 0.0047 0.007 0.006
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0078 0.0542
Echinococcus multilocularis expressed conserved protein 0.0095 0.0243 0.0233
Schistosoma mansoni nuclear receptor 0.003 0.0011 0.0001
Onchocerca volvulus Bile acid receptor homolog 0.0064 0.0134 0.0386
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0243 0.0233
Echinococcus multilocularis synaptic glycoprotein sc2 0.013 0.037 0.036
Schistosoma mansoni Replicative DNA helicase 0.0384 0.1286 0.1277
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0394 0.1322 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0079 0.0186 0.0783
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0064 0.0134 0.0386
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0039 0.0042 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.027 0.026
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.0261 0.1973
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.013 0.037 0.036
Brugia malayi tailless protein 0.003 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0064 0.0134 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0261 0.193
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.005 0.008 0.031
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.0011 0.0001
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0394 0.1322 1
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0039 0.0042 0.0863
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.003 0.0086
Entamoeba histolytica hypothetical protein 0.0109 0.0292 0.221
Loa Loa (eye worm) DR-78 0.003 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.013 0.037 0.1067
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0079 0.0186 0.0176
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.0011 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0167 0.0483
Loa Loa (eye worm) hypothetical protein 0.0232 0.0736 0.2125
Onchocerca volvulus Phospholipase A2 homolog 0.018 0.055 0.1588
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0078 0.1879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Loa Loa (eye worm) hypothetical protein 0.0047 0.007 0.0201
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.003 0.0173
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0079 0.0186 0.0783
Brugia malayi Integrin alpha pat-2 precursor 0.0152 0.0448 0.1294
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0481 0.0471
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0039 0.0042 0.0121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0022 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0064 0.0134 0.0386
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0079 0.0186 0.1406
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0394 0.1322 1
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0573 0.43
Loa Loa (eye worm) hypothetical protein 0.0095 0.0243 0.0701
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0394 0.1322 1
Loa Loa (eye worm) hypothetical protein 0.0394 0.1322 0.3817
Schistosoma mansoni cpg binding protein 0.0158 0.0472 0.0462
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0079 0.0186 0.0828
Brugia malayi photoreceptor-specific nuclear receptor 0.0064 0.0134 0.0386
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0154 0.0144
Echinococcus multilocularis carboxylesterase 5A 0.0277 0.0899 0.0889
Loa Loa (eye worm) hypothetical protein 0.0047 0.007 0.0201
Loa Loa (eye worm) hypothetical protein 0.0032 0.0016 0.0047
Loa Loa (eye worm) carboxylesterase 0.0047 0.007 0.0201
Brugia malayi CXXC zinc finger family protein 0.0148 0.0435 0.1255
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.0329 0.1463
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.0011 0.0031
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0284 0.0924 0.2668
Echinococcus multilocularis thyroid hormone receptor alpha 0.0064 0.0134 0.0124
Echinococcus granulosus integrin alpha 3 0.0116 0.0321 0.0311
Schistosoma mansoni transcription factor LCR-F1 0.0117 0.0324 0.0314
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.013 0.037 0.1606
Schistosoma mansoni zinc finger protein 0.003 0.0011 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0416
Entamoeba histolytica hypothetical protein 0.0117 0.0324 0.245
Brugia malayi Carboxylesterase family protein 0.0047 0.007 0.0201
Echinococcus multilocularis protein patched 0.0043 0.0057 0.0047
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0051 0.0083
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0012 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0011 0.0001
Schistosoma mansoni hypothetical protein 0.0033 0.0019 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.0925 0.0916
Echinococcus multilocularis para nitrobenzyl esterase 0.0047 0.007 0.006
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0093 0.0238 0.1014
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.0011 0.0001
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0057 0.0047
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0329 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.007 0.0115
Brugia malayi Nuclear hormone receptor E75 0.003 0.0011 0.0031
Brugia malayi amidase 0.0101 0.0264 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Schistosoma mansoni cpg binding protein 0.0148 0.0435 0.0425
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0039 0.0042 0.0032
Brugia malayi ecdysone receptor 0.003 0.0011 0.0031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0051 0.0178
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0012 0.001
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0045 0.0062 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.003 0.0085
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0024 0.0014
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0109 0.0292 0.0282
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0651 0.2246 0.6483
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0039 0.0042 0.0032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0064 0.0134 0.0386
Mycobacterium ulcerans carboxylesterase, LipT 0.0047 0.007 0.0528
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0064 0.0134 0.0386
Onchocerca volvulus 0.0047 0.007 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0064 0.0134 0.0386
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0039 0.0042 0.0139
Schistosoma mansoni hypothetical protein 0.0095 0.0243 0.0233
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.0011 0.0031
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.003 0.0226
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0019 0.0054
Trypanosoma brucei phospholipase A1, putative 0.0651 0.2246 1
Onchocerca volvulus 0.0148 0.0435 0.1255
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.007 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0573 0.43
Loa Loa (eye worm) hypothetical protein 0.0047 0.007 0.0201
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0046 0.0066 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.0925 0.0916
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.0261 0.0251
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0039 0.0042 0.0863
Schistosoma mansoni steroid hormone receptor ad4bp 0.0064 0.0134 0.0124
Schistosoma mansoni survival motor neuron protein 0.0047 0.0072 0.0061
Schistosoma mansoni nuclear hormone receptor 0.003 0.0011 0.0001
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.0011 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0243 0.0233
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0079 0.0186 0.0783
Giardia lamblia Prenyltransferase 0.0039 0.0042 0.0829
Echinococcus multilocularis integrin alpha 3 0.0116 0.0321 0.0311
Echinococcus granulosus lamin dm0 0.0033 0.0019 0.0008
Plasmodium vivax polyprenol reductase, putative 0.013 0.037 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0101 0.0264 0.0254
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0045 0.0062 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0134 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.013 0.037 0.2758
Brugia malayi Bromodomain containing protein 0.0085 0.0207 0.0597
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0167 0.0157
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0101 0.0264 0.0254
Loa Loa (eye worm) hypothetical protein 0.0068 0.0147 0.0426
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0064 0.0134 0.0386
Leishmania major phospholipase A1, putative 0.0651 0.2246 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0045 0.0062 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0261 0.193
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0024 0.0014
Echinococcus granulosus tar DNA binding protein 0.0074 0.0167 0.0157
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0394 0.1322 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.007 0.006
Echinococcus multilocularis musashi 0.0033 0.0019 0.0008
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0039 0.0042 0.0032
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.0011 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.0079 0.0186 0.0537
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0573 0.43
Echinococcus multilocularis BC026374 protein (S09 family) 0.0047 0.007 0.006
Loa Loa (eye worm) carboxylesterase 0.0047 0.007 0.0201
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0039 0.0042 0.0032
Schistosoma mansoni alpha glucosidase 0.0036 0.003 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0024 0.0069
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.343 0.3423
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.0421 0.0411
Loa Loa (eye worm) hypothetical protein 0.0053 0.0092 0.0266
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0079 0.0186 0.0783
Leishmania major phosphatidylinositol kinase related protein, putative 0.0079 0.0186 0.083
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0022 0.0115
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0384 0.1286 0.9725
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0261 0.193
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0384 0.1286 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0064 0.0134 0.0386
Schistosoma mansoni hypothetical protein 0.0205 0.0639 0.063
Brugia malayi Carboxylesterase family protein 0.0277 0.0899 0.2594
Trypanosoma brucei polo-like protein kinase 0.01 0.0261 0.1118
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0243 0.0701
Schistosoma mansoni nuclear hormone receptor 0.003 0.0011 0.0001
Brugia malayi hypothetical protein 0.0117 0.0324 0.0935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Schistosoma mansoni kinase 0.0051 0.0084 0.0074
Schistosoma mansoni synaptic glycoprotein sc2 related 0.013 0.037 0.036
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.013 0.037 0.2758
Trichomonas vaginalis conserved hypothetical protein 0.013 0.037 0.2758
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0167 0.0157
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0022 0.0115
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.0736 0.0727
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0064 0.0134 0.0124
Echinococcus granulosus neuropeptide receptor A26 0.1396 0.493 0.4925
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0051 0.0146
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0079 0.0186 0.0176
Schistosoma mansoni hypothetical protein 0.0047 0.0072 0.0061
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0056 0.0424
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0243 0.0701
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0079 0.0549
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.01
Schistosoma mansoni thyroid hormone receptor 0.0064 0.0134 0.0124
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0039 0.0042 0.0265
Loa Loa (eye worm) hypothetical protein 0.0064 0.0134 0.0386
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0167 0.0157
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0609 0.4575
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.013 0.037 0.2736
Loa Loa (eye worm) hypothetical protein 0.0034 0.0024 0.0069
Loa Loa (eye worm) hypothetical protein 0.0043 0.0057 0.0165
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0047 0.007 0.006
Schistosoma mansoni ap endonuclease 0.0041 0.0051 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.0924 0.6975
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0078 0.0068
Toxoplasma gondii non-specific serine/threonine protein kinase 0.005 0.008 0.0528
Echinococcus multilocularis lamin dm0 0.0033 0.0019 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0022 0.0115
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.013 0.037 0.2796
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0039 0.0042 0.0265
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0265 0.0255
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0051 0.0383
Echinococcus multilocularis integrin alpha ps 0.0033 0.0019 0.0009
Trypanosoma brucei lanosterol synthase 0.0285 0.0929 0.4107
Schistosoma mansoni coup transcription factor 0.0064 0.0134 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0292 0.2169
Trypanosoma cruzi phospholipase A1, putative 0.0651 0.2246 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0078 0.0514
Brugia malayi nuclear receptor NHR-88 0.0064 0.0134 0.0386
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0039 0.0042 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0573 0.43
Loa Loa (eye worm) twinkle helicase 0.011 0.0297 0.0857
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0109 0.0292 0.0844
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0394 0.1322 0.3817
Brugia malayi Bromodomain containing protein 0.0037 0.0035 0.01
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0064 0.0134 0.0386
Trypanosoma cruzi target of rapamycin kinase 3 0.0079 0.0186 0.0783
Brugia malayi Carboxylesterase family protein 0.0047 0.007 0.0201
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0329 0.0319
Brugia malayi Nuclear hormone receptor E75 0.003 0.0011 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0284 0.0924 0.2668
Schistosoma mansoni integrin alpha 0.0152 0.0448 0.0439
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0045 0.0062 0.0052
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0039 0.0042 0.0317
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0056 0.0046
Echinococcus multilocularis neuropeptide s receptor 0.1396 0.493 0.4925
Entamoeba histolytica hypothetical protein 0.013 0.037 0.2796
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0384 0.1286 0.7495
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.003 0.0173
Echinococcus granulosus serine protein kinase ATM 0.0109 0.0292 0.0282
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0064 0.0134 0.0124
Brugia malayi jmjC domain containing protein 0.0101 0.0265 0.0764
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0039 0.0042 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0064 0.0134 0.0386
Trypanosoma cruzi lanosterol synthase, putative 0.0285 0.0929 0.4107
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0002
Onchocerca volvulus 0.003 0.0011 0.0031
Brugia malayi nuclear receptor RXR 0.0034 0.0024 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Echinococcus granulosus intermediate filament protein 0.0033 0.0019 0.0008
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0039 0.0042 0.0032
Trypanosoma cruzi protein farnesyltransferase, putative 0.0039 0.0042 0.0139
Loa Loa (eye worm) phosphatidylinositol 3 0.0079 0.0186 0.0537
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.003 0.0173
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0039 0.0042 0.0121
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0079 0.0186 0.0783
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0051 0.1074
Echinococcus multilocularis integrin alpha ps 0.0068 0.0147 0.0137
Giardia lamblia GTOR 0.0079 0.0186 0.4858
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0079 0.0186 0.0783
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0012 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0022 0.0115
Brugia malayi latrophilin 2 splice variant baaae 0.0205 0.0639 0.1845
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0261 0.1118
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.003 0.0173
Schistosoma mansoni alpha-glucosidase 0.0138 0.04 0.039
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0073 0.021
Loa Loa (eye worm) CXXC zinc finger family protein 0.0148 0.0435 0.1255
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0064 0.0134 0.0124
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0261 0.193
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0064 0.0134 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0039 0.0042 0.0265
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0022 0.0115
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0051 0.0331
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0079 0.0186 0.0176
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0034 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.013 0.037 0.2758
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0012 0.0002
Brugia malayi hypothetical protein 0.003 0.0011 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0186 0.136
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0042 0.0139
Brugia malayi nuclear receptor NHR-67 0.003 0.0011 0.0031
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0039 0.0042 0.0317
Echinococcus multilocularis cpg binding protein 0.0158 0.0472 0.0462
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.0261 0.0753
Echinococcus granulosus mixed lineage leukemia protein mll 0.0037 0.0034 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.03 0.0981 0.283
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0261 0.193
Loa Loa (eye worm) hypothetical protein 0.018 0.055 0.1588
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0064 0.0134 0.0386

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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