Detailed information for compound 1292985

Basic information

Technical information
  • TDR Targets ID: 1292985
  • Name: 3-(naphthalen-1-yloxymethyl)benzoic acid
  • MW: 278.302 | Formula: C18H14O3
  • H donors: 1 H acceptors: 2 LogP: 4.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cccc(c1)COc1cccc2c1cccc2
  • InChi: 1S/C18H14O3/c19-18(20)15-8-3-5-13(11-15)12-21-17-10-4-7-14-6-1-2-9-16(14)17/h1-11H,12H2,(H,19,20)
  • InChiKey: DNEWINHTWSXKJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(1-naphthyloxymethyl)benzoic acid
  • Oprea1_384835
  • 3-[(1-naphthyloxy)methyl]benzoic acid
  • MLS001180399
  • SMR000476753
  • STK298505

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.003 0.0154 0.0145
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Onchocerca volvulus 0.002 0.0026 0.0089
Mycobacterium tuberculosis Conserved protein 0.0038 0.0271 0.084
Mycobacterium tuberculosis Probable dehydrogenase 0.0126 0.149 0.4798
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Brugia malayi RNA, U transporter 1 0.0093 0.1033 0.1024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0187 0.0177
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0019 0.0015 0.0005
Echinococcus granulosus RUN 0.002 0.0026 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0097 0.0291
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0303 0.1806
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0012 0.001
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0136 0.1625 0.5389
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0019 0.001 0.0017
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0044 0.0359 0.2151
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Onchocerca volvulus 0.0019 0.0015 0.0027
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0731 0.0722
Schistosoma mansoni hypothetical protein 0.0051 0.0451 0.075
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0044 0.0359 0.2151
Plasmodium falciparum importin beta, putative 0.0033 0.0199 0.3774
Onchocerca volvulus 0.0019 0.0015 0.0027
Echinococcus multilocularis hypothetical protein 0.0019 0.0015 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0044 0.0359 0.2151
Echinococcus granulosus ubiquitin specific protease 41 0.0236 0.3007 0.3
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0303 0.0977
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0012 0.0005
Trypanosoma brucei unspecified product 0.0034 0.0214 0.0679
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0236 0.3007 1
Leishmania major hypothetical protein, conserved 0.003 0.0154 0.0481
Onchocerca volvulus 0.0019 0.0015 0.0027
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0097 0.0291
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0731 0.0722
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0012 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0012 0.0032
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0097 0.0291
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0187 0.0177
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0214 0.0679
Brugia malayi polk-prov protein 0.003 0.0168 0.0158
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0015 0.0005
Brugia malayi PAS domain containing protein 0.0098 0.1095 0.1087
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.008 0.0232
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0303 0.0977
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0019 0.0015 0.0017
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0019 0.001 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0303 0.0977
Echinococcus multilocularis peregrin 0.0032 0.0187 0.0177
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0019 0.0015 0.0005
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0015 0.0025
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0114 0.0346
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0015 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0271 0.0261
Onchocerca volvulus 0.0038 0.0271 0.1425
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0012 0.0032
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0012 0.0005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0451 0.0441
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0042 0.0634
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0044 0.0359 0.1126
Brugia malayi hypothetical protein 0.0328 0.4271 0.4265
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0393 0.5172 0.5167
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0042 0.0106
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0154 0.2877
Trypanosoma brucei cytochrome P450, putative 0.0082 0.0878 0.2898
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0012 0.0005
Schistosoma mansoni ap endonuclease 0.0021 0.0042 0.007
Onchocerca volvulus 0.0019 0.0015 0.0027
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0126 0.149 0.4798
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0451 0.0441
Echinococcus multilocularis dna polymerase kappa 0.004 0.0303 0.0293
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Schistosoma mansoni hypothetical protein 0.0193 0.2405 0.3999
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0019 0.001 0.0017
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.008 0.139
Echinococcus multilocularis snurportin 1 0.035 0.4576 0.4571
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0044 0.0359 0.1126
Plasmodium falciparum thioredoxin reductase 0.0019 0.0012 0.0032
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0064 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0393 0.5172 0.86
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0126 0.149 0.88
Leishmania major protein kinase, putative 0.0025 0.0097 0.0291
Schistosoma mansoni protein tyrosine phosphatase 0.0019 0.0015 0.0025
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0097 0.0291
Mycobacterium leprae Probable lipase LipE 0.0038 0.0271 0.1277
Schistosoma mansoni pcd6 interacting protein-related 0.0019 0.0015 0.0025
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0042 0.0032
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0261
Echinococcus granulosus cytochrome P450 2K1 0.0044 0.0359 0.0349
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Echinococcus multilocularis RUN 0.002 0.0026 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0044 0.0359 0.1126
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Echinococcus granulosus tar DNA binding protein 0.0071 0.0731 0.0722
Schistosoma mansoni single-minded 0.0098 0.1095 0.1821
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0042 0.0106
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0271 0.084
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0019 0.001 0.0017
Echinococcus multilocularis 0.0044 0.0359 0.0349
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0873 0.0864
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0015 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0731 0.1215
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0012 0.0005
Entamoeba histolytica hypothetical protein 0.0043 0.0347 0.1123
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0019 0.0015 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0044 0.0359 0.1126
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.014 0.1685 0.543
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0271 0.084
Onchocerca volvulus 0.0019 0.0015 0.0027
Schistosoma mansoni lipoxygenase 0.0121 0.1419 0.2359
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0042 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0656 0.0646
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0467 0.6192 0.6188
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0892 0.1483
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0044 0.0359 0.1126
Onchocerca volvulus 4.1 G protein, putative homolog 0.0019 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0012 0.0005
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.008 0.007
Loa Loa (eye worm) doublecortin family protein 0.002 0.0026 0.0016
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0097 0.0087
Onchocerca volvulus 0.0019 0.0015 0.0027
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0042 0.0106
Leishmania major DNA polymerase kappa, putative 0.0021 0.0032 0.0074
Loa Loa (eye worm) hypothetical protein 0.0328 0.4271 0.4265
Leishmania major protein kinase, putative 0.0025 0.0097 0.0291
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0154 0.0144
Loa Loa (eye worm) hypothetical protein 0.011 0.1268 0.1259
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.1972 0.1964
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0097 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0136 0.1625 0.5236
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0019 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0019 0.0015 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Schistosoma mansoni protein tyrosine phosphatase 0.0019 0.0015 0.0025
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.008 0.0232
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.008 0.0431
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0305 0.0295
Schistosoma mansoni cpg binding protein 0.0034 0.0212 0.0352
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0012 0.0005
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0012 0.0002
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.008 0.0232
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0019 0.0015 0.0025
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0019 0.0015 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0168 0.0526
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0126 0.149 0.4798
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0271 0.0261
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0064 0.0178
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0019 0.001 0.0017
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0236 0.3007 0.3
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0731 0.1215
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0019 0.0015 0.0005
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0044 0.0359 0.2151
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0012 0.001
Loa Loa (eye worm) protein tyrosine phosphatase 0.0019 0.0015 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0731 0.1215
Schistosoma mansoni hypothetical protein 0.002 0.0026 0.0044
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0236 0.3007 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0044 0.0359 0.1126
Entamoeba histolytica hypothetical protein 0.0043 0.0347 0.1123
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0271 0.0869
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0236 0.3007 0.4999
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0097 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0261
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0044 0.0359 0.2151
Brugia malayi Thioredoxin reductase 0.0055 0.0511 0.0502
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0097 0.0291
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0126 0.149 0.4798
Onchocerca volvulus 0.0025 0.0097 0.0477
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0012 0.0005
Echinococcus granulosus single minded 2 0.0072 0.0745 0.0736
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0042 0.0106
Echinococcus granulosus dna polymerase kappa 0.004 0.0303 0.0293
Trichomonas vaginalis pten, drome, putative 0.0019 0.0015 0.0017
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0187 0.0311
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0236 0.3007 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0032 0.0074
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0731 0.0722
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Echinococcus multilocularis transfer RNA-Lys 0.0072 0.0745 0.0736
Plasmodium falciparum glutathione reductase 0.0019 0.0012 0.0032
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0271 0.0261
Schistosoma mansoni ran 0.0024 0.008 0.0133
Brugia malayi CXXC zinc finger family protein 0.0032 0.0187 0.0177
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0303 0.0977
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0467 0.6192 0.6188
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0044 0.0359 0.1126
Loa Loa (eye worm) RNA binding protein 0.0071 0.0731 0.0722
Brugia malayi jmjC domain containing protein 0.004 0.0305 0.0295
Loa Loa (eye worm) hypothetical protein 0.0033 0.0199 0.0189
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.0017
Toxoplasma gondii ABC1 family protein 0.0038 0.0271 0.1613
Echinococcus granulosus importin subunit beta 1 0.0033 0.0199 0.0189
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0044 0.0359 0.2151
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0271 0.084
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0303 0.0977
Leishmania major trypanothione reductase 0.0055 0.0511 0.1672
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0044 0.0359 0.2151
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.035 0.4576 0.4571
Schistosoma mansoni survival motor neuron protein 0.0152 0.1838 0.3056
Mycobacterium tuberculosis Probable reductase 0.0126 0.149 0.4798
Loa Loa (eye worm) hypothetical protein 0.0422 0.5566 0.5561
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0044 0.0359 0.1164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Toxoplasma gondii cytochrome p450 superfamily protein 0.0044 0.0359 0.2159
Onchocerca volvulus 0.0019 0.0015 0.0027
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0236 0.3007 1
Brugia malayi hypothetical protein 0.002 0.0026 0.0016
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0393 0.5172 0.5167
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0019 0.0015 0.0025
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0044 0.0359 0.1126
Brugia malayi Cytochrome P450 family protein 0.0124 0.1457 0.1448
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0044 0.0359 0.1126
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0025 0.0015
Giardia lamblia Protein tyrosine phosphatase 0.0019 0.0015 0.0017
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0873 0.1451
Schistosoma mansoni ap endonuclease 0.0021 0.0042 0.007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0271 0.045
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.1625 0.2702
Schistosoma mansoni hypothetical protein 0.011 0.1268 0.2108
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.1188 0.1179
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0581 0.3532
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0347 0.0576
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0064 0.0321
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0012 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.0082 0.0878 0.2898
Brugia malayi hypothetical protein 0.0019 0.0015 0.0005
Leishmania major GTP-binding protein, putative 0.0024 0.008 0.0232
Onchocerca volvulus 0.0019 0.0015 0.0027
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0187 0.1095
Mycobacterium leprae Conserved hypothetical protein 0.0044 0.0359 0.1821
Echinococcus granulosus dnaJ subfamily B 0.0454 0.6014 0.601
Onchocerca volvulus 0.0019 0.0015 0.0027
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0044 0.0359 0.1126
Onchocerca volvulus 0.0019 0.0015 0.0027
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.008 0.139
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0271 0.1605
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0044 0.0359 0.1164
Onchocerca volvulus 0.0019 0.0015 0.0027
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.0178
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0032 0.0067
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0305 0.0507
Echinococcus granulosus cpg binding protein 0.0034 0.0212 0.0202
Schistosoma mansoni lipoxygenase 0.0085 0.0916 0.1523
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0044 0.0359 0.2151
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0019 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0261
Brugia malayi jmjC domain containing protein 0.0104 0.1188 0.118
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0097 0.0291
Echinococcus granulosus geminin 0.0193 0.2405 0.2398
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0136 0.1625 0.1617
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0873 0.0864
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0271 0.0869
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0074
Loa Loa (eye worm) beta-lactamase 0.0038 0.0271 0.0261
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0012 0.0005
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Brugia malayi hypothetical protein 0.0019 0.0015 0.0005
Brugia malayi hypothetical protein 0.0019 0.0015 0.0005
Brugia malayi TAR-binding protein 0.0071 0.0731 0.0722
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0187 0.1095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0087
Onchocerca volvulus Alhambra homolog 0.0032 0.0187 0.0967
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.008 0.007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0261
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Giardia lamblia PHD finger protein 15 0.0032 0.0187 0.059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.1625 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.1419 0.141
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0097 0.0291
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0019 0.0015 0.0025
Schistosoma mansoni aryl hydrocarbon receptor 0.0098 0.1095 0.1821
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0451 0.0441
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0044 0.0359 0.2151
Brugia malayi Protein-tyrosine phosphatase 1 0.0019 0.0015 0.0005
Onchocerca volvulus 0.0019 0.0015 0.0027
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0347 0.0337
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0064 0.0331
Loa Loa (eye worm) CYP4Cod1 0.0082 0.0878 0.0869
Onchocerca volvulus 0.0019 0.0015 0.0027
Onchocerca volvulus 0.0038 0.0271 0.1425
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0044 0.0359 0.1126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0044 0.0359 0.1126
Leishmania major hypothetical protein, conserved 0.0038 0.0271 0.0869
Schistosoma mansoni hypothetical protein 0.0152 0.1838 0.3056
Schistosoma mansoni hypothetical protein 0.0051 0.0451 0.075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0271 0.0869
Loa Loa (eye worm) hypothetical protein 0.0422 0.5566 0.5561
Toxoplasma gondii exonuclease III APE 0.0021 0.0042 0.0197
Brugia malayi Cytochrome P450 family protein 0.0044 0.0359 0.0349
Brugia malayi Cytochrome P450 family protein 0.0082 0.0878 0.0869
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0064 0.1066
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0042 0.5824
Mycobacterium ulcerans beta-lactamase 0.0038 0.0271 0.1605
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0019 0.0015 0.0005
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0097 0.0087
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0012 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Toxoplasma gondii thioredoxin reductase 0.0055 0.0511 0.3103
Schistosoma mansoni hypothetical protein 0.035 0.4576 0.7609
Schistosoma mansoni polycystin 1-related 0.002 0.0026 0.0044
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0873 0.0864
Entamoeba histolytica hypothetical protein 0.0043 0.0347 0.1123
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0019 0.001 0.0017
Brugia malayi cytochrome P450 0.0044 0.0359 0.0349
Schistosoma mansoni rab6-interacting 0.002 0.0026 0.0044
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0271 0.084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.1972 0.1964
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0731 0.1215
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0154 0.0481
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0015 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0236 0.3007 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0044 0.0359 0.2151
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0012 0.0005
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0097 0.0087
Loa Loa (eye worm) cytochrome P450 family protein 0.0124 0.1457 0.1448
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0044 0.0359 0.2151
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0019 0.0015 0.0005
Plasmodium falciparum phd finger protein, putative 0.0032 0.0187 0.353
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.1188 0.1179
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0019 0.0015 0.0005
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0019 0.0015 0.0025
Echinococcus multilocularis GPCR, family 2 0.0051 0.0451 0.0441
Loa Loa (eye worm) hypothetical protein 0.0032 0.0187 0.0177
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0199 0.0631
Onchocerca volvulus 0.0038 0.0271 0.1425
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0012 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0082 0.0878 0.0869
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0303 0.0977
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0019 0.0015 0.0017
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0511 0.1621
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0511 0.0502
Giardia lamblia DINP protein human, muc B family 0.0021 0.0032 0.0074
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0114 0.0346
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0303 0.1806
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0097 0.0291
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0012 0.0005
Brugia malayi Importin beta-1 subunit 0.0033 0.0199 0.019
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0019 0.0015 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Brugia malayi beta-lactamase family protein 0.0038 0.0271 0.0261
Brugia malayi hypothetical protein 0.0019 0.0015 0.0005
Schistosoma mansoni hypothetical protein 0.0051 0.0451 0.075
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0019 0.001 0.0017
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0199 0.1171
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0019 0.0015 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0012 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0731 0.1215
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0303 0.0977
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.1972 0.1964
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0305 0.0295
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0731 0.0722
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0064 0.0321
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0451 0.0441
Brugia malayi Protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Schistosoma mansoni protein tyrosine phosphatase 0.0019 0.0015 0.0025
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0359 0.035
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0019 0.001 0.0017
Mycobacterium tuberculosis Probable oxidoreductase 0.014 0.1685 0.543
Leishmania major importin beta-1 subunit, putative 0.0027 0.0114 0.0346
Loa Loa (eye worm) hypothetical protein 0.0236 0.3007 0.3
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0044 0.0359 0.1164
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0042 0.0106
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0154 0.2877
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Onchocerca volvulus 0.0082 0.0873 0.472
Leishmania major cytochrome p450-like protein 0.0044 0.0359 0.1164
Leishmania major cytochrome p450-like protein 0.0044 0.0359 0.1164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0236 0.3007 0.4999
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0154 0.2877
Brugia malayi beta-lactamase 0.0038 0.0271 0.0261
Schistosoma mansoni loxhd1 0.002 0.0026 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0044 0.0359 0.1126
Mycobacterium ulcerans lipase LipD 0.0038 0.0271 0.1605
Toxoplasma gondii aldehyde dehydrogenase 0.0136 0.1625 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0501 0.0492
Echinococcus multilocularis 0.0019 0.0015 0.0005
Leishmania major tyrosine specific protein phosphatase, putative 0.0019 0.0015 0.0017
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0019 0.0015 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0454 0.6014 0.601
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0019 0.0015 0.0017
Schistosoma mansoni cytochrome P450 0.0044 0.0359 0.0597
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0044 0.0359 0.1126
Echinococcus multilocularis geminin 0.0193 0.2405 0.2398
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0097 0.0291
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0044 0.0359 0.2151
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0261
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.014 0.1685 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0114 0.0346
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0271 0.045
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0019 0.001 0.0017
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0019 0.001 0.0017
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0267 0.0257
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0012 0.0032
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0271 0.084
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0271 0.1605
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0271 0.0869
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0161 0.1972 0.1964
Brugia malayi hypothetical protein 0.0043 0.0347 0.0337
Schistosoma mansoni hypothetical protein 0.0193 0.2405 0.3999
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0097 0.0087
Brugia malayi Cytochrome P450 family protein 0.0082 0.0878 0.0869
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.1419 0.141
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0303 0.0977
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0303 0.0977
Schistosoma mansoni cpg binding protein 0.0034 0.0212 0.0352
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0044 0.0359 0.2151
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0064 1
Plasmodium falciparum thioredoxin reductase 0.0055 0.0511 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0451 0.0441
Schistosoma mansoni hypothetical protein 0.0051 0.0451 0.075
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0187 0.353
Loa Loa (eye worm) cytochrome P450 family protein 0.0082 0.0878 0.0869
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0154 0.0893
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0393 0.5172 0.5167
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0199 0.0189
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0026 0.0016
Onchocerca volvulus 0.0019 0.0015 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0303 0.0977
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0042 0.0098
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0012 0.0005
Entamoeba histolytica hypothetical protein 0.0027 0.0114 0.0346
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.001 0.0017
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0097 0.0291
Onchocerca volvulus 0.0032 0.0187 0.0967
Loa Loa (eye worm) hypothetical protein 0.0082 0.0873 0.0864
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0511 0.1672
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0019 0.0015 0.0017
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0019 0.0015 0.0005
Onchocerca volvulus 0.0019 0.0015 0.0027
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0019 0.0015 0.0005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0136 0.1625 0.1617
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0042 0.5824
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0042 0.0032
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0019 0.001 0.0017
Schistosoma mansoni hypothetical protein 0.0043 0.0347 0.0576
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.1625 0.2702
Schistosoma mansoni peptidase 0.0019 0.001 0.0017
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0097 0.0291
Onchocerca volvulus 0.002 0.0026 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0303 0.0977
Echinococcus multilocularis cpg binding protein 0.0034 0.0212 0.0202
Brugia malayi Protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0044 0.0359 0.2151
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0019 0.001 0.0017
Loa Loa (eye worm) glutathione reductase 0.0055 0.0511 0.0502
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0044 0.0359 0.1126
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0064 0.0178
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0271 0.084
Echinococcus granulosus GPCR family 2 0.0051 0.0451 0.0441
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0271 0.0869
Schistosoma mansoni cpg binding protein 0.0032 0.0187 0.0311
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0044 0.0359 0.2151
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0187 0.0177
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0097 0.0291
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0236 0.3007 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0303 0.0977
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0187 0.0177
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0026 0.0016
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0236 0.3007 0.3
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0019 0.001 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0012 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0261
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0082 0.0878 0.5372
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0016
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0015 0.0025
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0271 0.1277
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Echinococcus granulosus snurportin 1 0.035 0.4576 0.4571
Plasmodium vivax glutathione reductase, putative 0.0055 0.0511 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0064 0.0331
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.0015 0.0005
Plasmodium vivax importin-beta 2, putative 0.0033 0.0199 0.3774
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0044 0.0359 0.1164
Brugia malayi hypothetical protein 0.002 0.0026 0.0016
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.0015 0.0005
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0019 0.001 0.0017
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0271 0.084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.1625 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.028 0.027
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0042 0.0106
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0044 0.0359 0.1126
Onchocerca volvulus 0.0019 0.0015 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0271 0.0869
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0042 0.0634
Schistosoma mansoni hypothetical protein 0.0044 0.0359 0.0597
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0271 0.0869
Trypanosoma brucei trypanothione reductase 0.0055 0.0511 0.1672
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0019 0.001 0.0017
Brugia malayi hypothetical protein 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Echinococcus granulosus protein tyrosine phosphatase n9 0.0019 0.0015 0.0005
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0019 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Brugia malayi hypoxia-induced factor 1 0.0302 0.3921 0.3915
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0044 0.0359 0.2151
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0026 0.0016
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.008 0.007
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0026 0.0016
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0012 0.0005
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0064 0.0168
Mycobacterium leprae Possible regulatory protein 0.0025 0.0097 0.0208
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0303 0.0977
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0015 0.0025
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypoxia-induced factor 1 0.0302 0.3921 0.3914
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Schistosoma mansoni rab6-interacting 0.002 0.0026 0.0044
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0511 0.0502
Brugia malayi bHLH-PAS transcription factor 0.0072 0.0745 0.0736
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0026 0.0324
Onchocerca volvulus 0.0019 0.0015 0.0027
Schistosoma mansoni importin beta-1 0.0033 0.0199 0.0331
Trichomonas vaginalis ran, putative 0.0024 0.008 0.0232
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0199 0.0631
Trypanosoma brucei protein tyrosine phosphatase 1 0.0019 0.0015 0.0017
Loa Loa (eye worm) cytochrome P450 0.0044 0.0359 0.0349
Entamoeba histolytica hypothetical protein 0.0043 0.0347 0.1123
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0511 0.0502
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.008 0.007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0347 0.0337
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0042 0.0032
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0236 0.3007 0.3
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0012 0.0005
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0044 0.0359 0.2151
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0451 0.0441
Trichomonas vaginalis esterase, putative 0.0038 0.0271 0.0869
Echinococcus granulosus peregrin 0.0032 0.0187 0.0177
Trypanosoma cruzi cytochrome P450, putative 0.0082 0.0878 0.2898
Onchocerca volvulus 0.0072 0.0745 0.402
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0271 0.0869
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0042 0.0106
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0026 0.0016
Mycobacterium ulcerans hypothetical protein 0.0038 0.0271 0.1605
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0511 1
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0019 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Brugia malayi RNA binding protein 0.0071 0.0731 0.0722
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0154 0.0481
Brugia malayi beta-lactamase family protein 0.0038 0.0271 0.0261
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0236 0.3007 1
Mycobacterium ulcerans putative regulatory protein 0.0072 0.0745 0.4544
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0305 0.0507
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0236 0.3007 0.3
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.068 0.1131
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0236 0.3007 0.3
Mycobacterium tuberculosis Conserved protein 0.0038 0.0271 0.084
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0154 0.0481
Schistosoma mansoni hypothetical protein 0.0032 0.0187 0.0311
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.1268 0.1259
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0042 0.0187
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0016
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0015 0.0005
Brugia malayi glutathione reductase 0.0055 0.0511 0.0502
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0126 0.149 0.4798
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0044 0.0359 0.2151
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0097 0.0291
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0044 0.0359 0.1164
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0044 0.0359 0.2151
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0044 0.0359 0.1126
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.0015 0.0005
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0097 0.0291
Schistosoma mansoni hypothetical protein 0.0454 0.6014 1
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0019 0.0015 0.0017
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.0015 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0012 0.0019
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0012 0.0002
Entamoeba histolytica Ran family GTPase 0.0024 0.008 0.0232
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0236 0.3007 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0026 0.0016
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0019 0.0015 0.0005
Onchocerca volvulus 0.0152 0.1838 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0271 0.5199
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0271 0.0261
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0044 0.0359 0.1126
Onchocerca volvulus 0.0019 0.0015 0.0027
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0019 0.001 0.0017
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0097 0.0291
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0019 0.0015 0.0025
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0026 0.0324
Brugia malayi Doublecortin family protein 0.002 0.0026 0.0016
Mycobacterium leprae putative cytochrome p450 0.0044 0.0359 0.1821
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0044 0.0359 0.2151
Onchocerca volvulus 0.0019 0.0015 0.0027
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0451 0.0441
Brugia malayi PHD-finger family protein 0.0032 0.0187 0.0177
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0019 0.0015 0.0025
Leishmania major cytochrome p450-like protein 0.0082 0.0878 0.2898
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0019 0.0015 0.0005
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0064 0.1066
Onchocerca volvulus 0.0019 0.0015 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0042 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0303 0.0977
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0097 0.0291
Plasmodium falciparum glutathione reductase 0.0055 0.0511 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0303 0.0977
Echinococcus multilocularis ubiquitin specific protease 41 0.0236 0.3007 0.3
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0236 0.3007 1
Brugia malayi Bromodomain containing protein 0.0032 0.0187 0.0177
Onchocerca volvulus 0.0019 0.0015 0.0027
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.014 0.1685 0.543
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Onchocerca volvulus 0.0019 0.0015 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0097 0.0291
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.3093 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0019 0.0015 0.0005
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.008 0.0232
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0044 0.0359 0.1126
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0015 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0015 0.0005
Onchocerca volvulus 0.0019 0.0015 0.0027
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0097 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0303 0.0977
Loa Loa (eye worm) hypothetical protein 0.0051 0.0451 0.0441
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0019 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0012 0.0005
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0359 0.035
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0019 0.0015 0.0005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0114 0.0346
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0012 0.0005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0152 0.1838 0.183
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0158
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0012 0.0032
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0019 0.0015 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0015 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0044 0.0359 0.1126
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0019 0.001 0.0017
Mycobacterium tuberculosis Conserved protein 0.0038 0.0271 0.084
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0168 0.0526
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0064 0.6057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.1625 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0393 0.5172 0.5167
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0303 0.0977
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0019 0.0015 0.0005
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0015 0.0005
Schistosoma mansoni ran 0.0024 0.008 0.0133

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.