Detailed information for compound 1293244

Basic information

Technical information
  • TDR Targets ID: 1293244
  • Name: (7S)-8-(2-methyl-3,5-dinitrobenzoyl)-3-[3-(2- methylprop-2-enoylamino)phenyl]-1-oxa-2,8-dia zaspiro[4.4]non-2-ene-7-carboxamide
  • MW: 536.493 | Formula: C25H24N6O8
  • H donors: 2 H acceptors: 7 LogP: 2.1 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=O)[C@@H]1CC2(CN1C(=O)c1cc(cc(c1C)[N+](=O)[O-])[N+](=O)[O-])ON=C(C2)c1cccc(c1)NC(=O)C(=C)C
  • InChi: 1S/C25H24N6O8/c1-13(2)23(33)27-16-6-4-5-15(7-16)19-10-25(39-28-19)11-21(22(26)32)29(12-25)24(34)18-8-17(30(35)36)9-20(14(18)3)31(37)38/h4-9,21H,1,10-12H2,2-3H3,(H2,26,32)(H,27,33)/t21-,25?/m0/s1
  • InChiKey: VRZLMSMBSGRBMV-BWDMCYIDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (7S)-8-(2-methyl-3,5-dinitro-benzoyl)-3-[3-(2-methylprop-2-enoylamino)phenyl]-1-oxa-2,8-diazaspiro[4.4]non-2-ene-7-carboxamide
  • (7S)-8-[(2-methyl-3,5-dinitrophenyl)-oxomethyl]-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl]-1-oxa-2,8-diazaspiro[4.4]non-2-ene-7-carboxamide
  • (7S)-3-(3-methacrylamidophenyl)-8-(2-methyl-3,5-dinitro-benzoyl)-1-oxa-2,8-diazaspiro[4.4]non-2-ene-7-carboxamide
  • (7S)-8-(2-methyl-3,5-dinitro-phenyl)carbonyl-3-[3-(2-methylprop-2-enoylamino)phenyl]-1-oxa-2,8-diazaspiro[4.4]non-2-ene-7-carboxamide
  • MLS000561947
  • SMR000390650

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens myeloid cell leukemia 1 Starlite/ChEMBL No references
Homo sapiens apoptotic peptidase activating factor 1 Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens small ubiquitin-like modifier 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania major small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) SMO-1 protein Get druggable targets OG5_127053 All targets in OG5_127053
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva ubiquitin, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Small ubiquitin-related modifier 2 precursor, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Ubiquitin-like protein SMT3 Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania donovani small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Entamoeba histolytica ubiquitin like protein Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Sentrin Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis ubiquitin-like protein Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Babesia bovis ubiquitin-like protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Toxoplasma gondii small ubiquitin family modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Plasmodium falciparum 6-cysteine protein small ubiquitin-like modifier 1 101 aa 92 aa 28.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Small ubiquitin modifier 2 0.0037 0.0402 0.0754
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0373 0.0699
Mycobacterium ulcerans hypothetical protein 0.0192 0.4944 0.9264
Echinococcus multilocularis muscleblind protein 0.018 0.4601 0.8621
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0566 0.106
Onchocerca volvulus 0.005 0.0777 0.0583
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.5337 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.043 0.043
Onchocerca volvulus 0.0286 0.7696 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0699 0.0477
Brugia malayi Muscleblind-like protein 0.018 0.4601 0.6889
Treponema pallidum phosphoglycerate kinase 0.0206 0.5337 0.5
Schistosoma mansoni hypothetical protein 0.0037 0.0411 0.0769
Brugia malayi jmjC domain containing protein 0.0043 0.0566 0.0847
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.2246 0.3364
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0819 0.0819
Brugia malayi chromobox protein homolog 3 0.0047 0.0699 0.1046
Echinococcus multilocularis caspase 2 0.0037 0.041 0.0769
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0699 0.0908
Onchocerca volvulus 0.0182 0.4662 0.5871
Schistosoma mansoni hypothetical protein 0.0035 0.0349 0.0653
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1527 0.1527
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0935 0.14
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.5337 0.5337
Echinococcus granulosus dna polymerase eta 0.0054 0.0901 0.1688
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0037 0.0402 0.0754
Onchocerca volvulus 0.0037 0.04 0.007
Onchocerca volvulus 0.0037 0.041 0.0084
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1782 0.2315
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1527 0.1527
Echinococcus multilocularis chromobox protein 1 0.0084 0.1782 0.3338
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0752 0.141
Echinococcus multilocularis peregrin 0.0035 0.0349 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0699 0.0908
Loa Loa (eye worm) SMO-1 protein 0.0037 0.0402 0.0603
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.1148 0.1148
Echinococcus multilocularis chromobox protein 1 0.0084 0.1782 0.3338
Loa Loa (eye worm) hypothetical protein 0.006 0.1085 0.1625
Toxoplasma gondii small ubiquitin family modifier, putative 0.0037 0.0402 0.0108
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.2246 0.4209
Plasmodium falciparum small ubiquitin-related modifier 0.0037 0.0402 0.0108
Echinococcus granulosus apoptotic protease activating factor 1 0.0037 0.0411 0.0769
Loa Loa (eye worm) hypothetical protein 0.0037 0.04 0.0599
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0566 0.106
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.5337 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0777 0.1455
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.5337 1
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.5337 1
Echinococcus granulosus muscleblind protein 0.018 0.4601 0.8621
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0373 0.0699
Leishmania major DNA polymerase eta, putative 0.0038 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0182 0.4662 0.6981
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.4373 0.4373
Brugia malayi Phosphoglycerate kinase 0.0206 0.5337 0.7991
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1447 0.2166
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0819 0.0819
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0901 0.1349
Schistosoma mansoni hypothetical protein 0.01 0.2246 0.4209
Schistosoma mansoni chromobox protein 0.0084 0.1782 0.3338
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.6679 1
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0402 0.0402
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0349 0.0653
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0349 0.0653
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1782 0.2668
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0373 0.0699
Echinococcus granulosus peregrin 0.0035 0.0349 0.0653
Loa Loa (eye worm) hypothetical protein 0.018 0.4601 0.6889
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.5337 0.6935
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0334 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0295 0.0384
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0373 0.0699
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0295 0.0384
Entamoeba histolytica ubiquitin like protein 0.0037 0.0402 0.0754
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.5337 1
Loa Loa (eye worm) hypothetical protein 0.01 0.2246 0.3364
Schistosoma mansoni hypothetical protein 0.01 0.2246 0.4209
Loa Loa (eye worm) hypothetical protein 0.0206 0.5337 0.7991
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.1527 0.1527
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0935 0.1752
Trypanosoma brucei small ubiquitin-related modifier 0.0037 0.0402 0.0402
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.5337 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0373 0.0559
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.5337 0.5337
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.5337 1
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.5337 0.5
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0804 0.1044
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0373 0.0049
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.1527 0.1527
Plasmodium vivax SET domain protein, putative 0.0036 0.0373 0.0049
Echinococcus granulosus caspase 2 0.0037 0.041 0.0769
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.4944 0.9264
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0901 0.0901
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0935 0.1752
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0752 0.141
Giardia lamblia PHD finger protein 15 0.0035 0.0349 0.0653
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0373 0.0699
Loa Loa (eye worm) hypothetical protein 0.0047 0.0699 0.1046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0935 0.1752
Loa Loa (eye worm) hypothetical protein 0.0035 0.0349 0.0522
Schistosoma mansoni chromobox protein 0.0084 0.1782 0.3338
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0804 0.0619
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0349 0.0522
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0566 0.106
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1527 0.1527
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0819 0.0819
Echinococcus granulosus Small ubiquitin modifier 2 0.0037 0.0402 0.0754
Schistosoma mansoni caspase-7 (C14 family) 0.0037 0.041 0.0769
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0935 0.14
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0804 0.1044
Loa Loa (eye worm) hypothetical protein 0.0037 0.041 0.0614
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.2246 0.4209
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0349 0.0653
Schistosoma mansoni apoptosis regulator bax 0.01 0.2246 0.4209
Brugia malayi Phosphoglycerate kinase 0.0075 0.1527 0.2287
Leishmania major small ubiquitin protein, putative 0.0037 0.0402 0.0402
Plasmodium vivax small ubiquitin-related modifier, putative 0.0037 0.0402 0.0108
Loa Loa (eye worm) hypothetical protein 0.018 0.4601 0.6889
Brugia malayi hypothetical protein 0.0182 0.4662 0.6981
Loa Loa (eye worm) hypothetical protein 0.0054 0.0901 0.1349
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0935 0.1752
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.5337 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2695 0.5049
Brugia malayi Pre-SET motif family protein 0.0251 0.6679 1
Echinococcus granulosus chromobox protein 1 0.0084 0.1782 0.3338
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.4373 0.4373
Leishmania major DNA polymerase eta, putative 0.0054 0.0901 0.0901
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0935 0.1752
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.1527 0.1527
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.4373 0.4373
Echinococcus granulosus chromobox protein 1 0.0084 0.1782 0.3338
Echinococcus multilocularis dna polymerase eta 0.0054 0.0901 0.1688
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0402 0.0402
Brugia malayi hypothetical protein 0.0037 0.041 0.0614
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.043 0.0164
Giardia lamblia Sentrin 0.0037 0.0402 0.0754
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.5337 0.5337
Schistosoma mansoni DNA polymerase eta 0.0054 0.0901 0.1688
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.5337 0.5337
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.2246 0.4209
Brugia malayi Cell death protein 3 precursor 0.0037 0.041 0.0614
Schistosoma mansoni hypothetical protein 0.01 0.2246 0.4209
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2695 0.5049
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0566 0.0847
Brugia malayi PHD-finger family protein 0.0035 0.0349 0.0522
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.5337 0.5
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.5337 0.5337
Brugia malayi Heterochromatin protein 1 0.0084 0.1782 0.2668
Echinococcus multilocularis muscleblind protein 1 0.018 0.4601 0.8621
Schistosoma mansoni jumonji domain containing protein 0.0092 0.2001 0.3748
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.1527 0.1527
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.5337 0.5
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0819 0.0819
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.5337 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0566 0.106
Toxoplasma gondii hypothetical protein 0.0059 0.104 0.1387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0373 0.0699
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.5337 0.6935
Onchocerca volvulus Cell death protein 3 homolog 0.0037 0.041 0.0084
Trichomonas vaginalis set domain proteins, putative 0.0286 0.7696 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.2246 0.3364
Loa Loa (eye worm) hypothetical protein 0.0036 0.0373 0.0559
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.2246 0.4209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0935 0.1752
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0402 0.0523
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.2246 0.4209
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.5337 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.5337 0.5337
Giardia lamblia Phosphoglycerate kinase 0.0206 0.5337 1
Brugia malayi Bromodomain containing protein 0.0035 0.0349 0.0522
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.1527 0.1527
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0935 0.1752
Loa Loa (eye worm) hypothetical protein 0.0037 0.041 0.0614
Brugia malayi jmjC domain containing protein 0.0115 0.2695 0.4035
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1782 0.2315
Brugia malayi Ubiquitin-like protein SMT3 0.0037 0.0402 0.0603
Echinococcus multilocularis apoptotic protease activating factor 1 0.0037 0.0411 0.0769
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0901 0.0901
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.5337 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 10.8 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS Activators of the Apaf-1 Pathway in Fluorescent format. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489031, AID492946] ChEMBL. No reference
EC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Dose Response validation of Activators of Apaf-1 using a Fluorescent Interference Counterscreen assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489031, AID492946] ChEMBL. No reference
IC50 (functional) = 4.084774462 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] ChEMBL. No reference
IC50 (functional) = 4.589 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
IC50 (functional) 8.54 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 14 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493012, AID493028] ChEMBL. No reference
IC50 (functional) 66.6 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493012, AID493028] ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2609 uM PubChem BioAssay. qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 19.0115 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.193 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.