TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 255.272 | Formula: C14H13N3O2
H donors: 1 H acceptors: 2 LogP: 1.51 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(=NNC(=O)c1cccnc1)/C=C/c1ccco1
InChi: 1S/C14H13N3O2/c1-11(6-7-13-5-3-9-19-13)16-17-14(18)12-4-2-8-15-10-12/h2-10H,1H3,(H,17,18)/b7-6+,16-11?
InChiKey: XBWPZJMPCZZRSM-YERMKXDQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calcium channel, voltage-dependent, N type, alpha 1B subunit	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	Get druggable targets OG5_126791	All targets in OG5_126791
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent calcium channel type D subunit alpha-1, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Muscle calcium channel subunit alpha-1, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma mansoni	high voltage-activated calcium channel Cav1	Get druggable targets OG5_126791	All targets in OG5_126791
Toxoplasma gondii	transporter, cation channel family protein	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126791	All targets in OG5_126791
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	voltage-dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent calcium channel type A subunit alpha-1, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent calcium channel type A subunit alpha-1, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma mansoni	voltage-gated cation channel	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus granulosus	voltage dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	Get druggable targets OG5_126791	All targets in OG5_126791
Trypanosoma congolense	Voltage-dependent calcium channel subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus granulosus	voltage dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent N-type calcium channel subunit alpha-1B, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent calcium channel type D subunit alpha-1, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Trypanosoma brucei gambiense	calcium channel protein, putative	Get druggable targets OG5_126791	All targets in OG5_126791

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.1046
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0215	0.1046
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0155	0.0139
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.013	0.3419	0.7238
Toxoplasma gondii	thioredoxin reductase	0.0057	0.1258	0.7017
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0058	0.1271	0.6352
Toxoplasma gondii	transporter, cation channel family protein	0.0024	0.0289	0.0985
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0116	0.3	0.6006
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.013	0.3419	0.7238
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1271	0.1133
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.002	0.0155	0.0139
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0019	0.013	0.0221
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.1669	0.3283
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.1669	0.5466
Loa Loa (eye worm)	hypothetical protein	0.008	0.1926	0.5724
Loa Loa (eye worm)	hypothetical protein	0.0116	0.3	0.9029
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0116	0.3	0.9048
Echinococcus granulosus	dna polymerase eta	0.0022	0.0215	0.0509
Schistosoma mansoni	jumonji domain containing protein	0.0019	0.013	0.0133
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.008	0.1926	0.6341
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0639	0.1929
Echinococcus granulosus	lysine specific demethylase 6a	0.0019	0.013	0.0221
Brugia malayi	jmjC domain containing protein	0.0019	0.013	0.0393
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.1737	0.5698
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0065	0.0197
Schistosoma mansoni	DNA polymerase eta	0.0022	0.0215	0.0305
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0215	0.006
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0057	0.1258	0.4064
Loa Loa (eye worm)	MH2 domain-containing protein	0.0127	0.3315	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.002	0.0155	0.0139
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.1046
Loa Loa (eye worm)	hypothetical protein	0.0019	0.013	0.02
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.002	0.0155	0.0306
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.1669	0.4935
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0215	0.0647
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.008	0.1926	1
Giardia lamblia	Kinase, CMGC MAPK	0.0058	0.1271	0.1133
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0058	0.1271	0.6572
Echinococcus granulosus	JmjC domain containing protein 4	0.0019	0.013	0.0221
Toxoplasma gondii	hypothetical protein	0.0021	0.0202	0.0446
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0116	0.3	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0145	0.3849	0.819
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0116	0.3	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.1737	0.3508
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.1046
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0215	0.047
Brugia malayi	abnormal cell lineage protein 10 (Protein lin-10), putative	0.0074	0.1763	0.5317
Trypanosoma brucei	protein kinase, putative	0.0058	0.1271	0.6572
Echinococcus multilocularis	lysine specific demethylase 6a	0.0019	0.013	0.0221
Echinococcus multilocularis	jumonji domain containing 1A	0.0019	0.013	0.0221
Brugia malayi	jmjC domain containing protein	0.0019	0.013	0.0393
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.1737	0.3508
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.4665	1
Brugia malayi	jmjC domain containing protein	0.0019	0.013	0.0393
Echinococcus granulosus	amyloid beta A4 protein	0.0083	0.2021	0.6666
Trypanosoma cruzi	trypanothione reductase, putative	0.0057	0.1258	0.6279
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.1271	0.2467
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.008	0.1926	0.5725
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0215	0.0305
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0215	0.0132
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.002	0.0155	0.0222
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.1737	0.3422
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.1737	0.8949
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.002	0.0155	0.5
Loa Loa (eye worm)	thioredoxin reductase	0.0057	0.1258	0.3669
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0058	0.1271	0.371
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0215	0.047
Loa Loa (eye worm)	hypothetical protein	0.0019	0.013	0.02
Brugia malayi	Thioredoxin reductase	0.0057	0.1258	0.3794
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1271	0.1133
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0215	0.0305
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.1046
Loa Loa (eye worm)	glutathione reductase	0.0057	0.1258	0.3669
Echinococcus granulosus	jumonji domain containing 1A	0.0019	0.013	0.0221
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.002	0.0155	0.0735
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0024	0.0289	0.0687
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.002	0.0155	0.0139
Brugia malayi	MAP kinase sur-1	0.0058	0.1271	0.3833
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0071	0.1657	0.8499
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0215	0.047
Echinococcus multilocularis	sodium channel protein	0.0049	0.1025	0.3271
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.1737	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0019	0.013	0.0221
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0116	0.3	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.1046
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.1046
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0459
Mycobacterium tuberculosis	Probable reductase	0.013	0.3419	0.7238
Plasmodium falciparum	thioredoxin reductase	0.0057	0.1258	1
Toxoplasma gondii	NADPH-glutathione reductase	0.002	0.0155	0.0156
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.1046
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.002	0.0155	0.0306
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0071	0.1669	0.5466
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0065	0.0197
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.1926	1
Trypanosoma brucei	trypanothione reductase	0.0057	0.1258	0.6504
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0071	0.1669	0.5466
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0019	0.013	0.0133
Brugia malayi	hypothetical protein	0.008	0.1926	0.5808
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1271	0.1133
Echinococcus granulosus	mitogen activated protein kinase 3	0.0058	0.1271	0.4109
Plasmodium vivax	glutathione reductase, putative	0.0057	0.1258	1
Echinococcus multilocularis	mitogen activated protein kinase	0.0058	0.1271	0.4109
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0145	0.3849	0.819
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.008	0.1926	0.6341
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.013	0.3419	0.7238
Echinococcus multilocularis	phd:f box containing protein	0.0019	0.013	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0202	0.042
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.002	0.0155	0.0735
Loa Loa (eye worm)	transcription factor SMAD2	0.0127	0.3315	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0215	0.1046
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.002	0.0155	0.0735
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.008	0.1926	0.5809
Plasmodium falciparum	thioredoxin reductase	0.002	0.0155	0.0222
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0215	0.0132
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.4665	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0155	0.0139
Brugia malayi	jmjC domain containing protein	0.0071	0.1669	0.5035
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0155	0.0139
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.1669	0.3283
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0215	0.0509
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.002	0.0155	0.0222
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.1737	0.3508
Echinococcus granulosus	thioredoxin glutathione reductase	0.0057	0.1258	0.4064
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0057	0.1258	0.2445
Brugia malayi	jmjC domain containing protein	0.0019	0.013	0.0393
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0058	0.1271	0.6352
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0019	0.013	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1134	0.3289
Echinococcus multilocularis	JmjC domain containing protein 4	0.0019	0.013	0.0221
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0215	0.0509
Schistosoma mansoni	amyloid beta A4 protein related	0.0083	0.2021	0.4004
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.002	0.0155	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0215	0.1046
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.013	0.3419	0.7238
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.1926	1
Echinococcus multilocularis	amyloid beta A4 protein	0.0083	0.2021	0.6666
Schistosoma mansoni	voltage-gated cation channel	0.0116	0.3	0.6006
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0145	0.3849	0.819
Echinococcus multilocularis	dna polymerase eta	0.0022	0.0215	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0289	0.0687
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0215	0.047
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.1046
Echinococcus multilocularis	voltage dependent calcium channel	0.0116	0.3	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0058	0.1271	0.6352
Schistosoma mansoni	jumonji domain containing protein	0.0071	0.1669	0.3283
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0058	0.1271	0.6352
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0215	0.0132
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.1737	0.3508
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0202	0.042
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.1134	0.3421
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0058	0.1271	0.4109
Leishmania major	trypanothione reductase	0.0057	0.1258	0.6279
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0116	0.3	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.002	0.0155	0.0156
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.002	0.0155	0.5
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0215	0.0132
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0215	0.0647
Mycobacterium tuberculosis	Probable dehydrogenase	0.013	0.3419	0.7238
Loa Loa (eye worm)	calcium channel	0.0116	0.3	0.9029
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1271	0.1133
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.002	0.0155	0.0139
Plasmodium vivax	thioredoxin reductase, putative	0.0057	0.1258	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0215	0.047
Echinococcus granulosus	voltage dependent calcium channel	0.0116	0.3	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0155	0.0139
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.1046
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.013	0.02
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0116	0.3	1
Trypanosoma cruzi	trypanothione reductase, putative	0.002	0.0155	0.0139
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.1737	0.3422
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.1737	0.5698
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.013	0.02
Leishmania major	DNA polymerase eta, putative	0.0022	0.0215	0.047
Plasmodium falciparum	glutathione reductase	0.002	0.0155	0.0222
Echinococcus granulosus	phd:f box containing protein	0.0019	0.013	0.0221
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0058	0.1271	0.7098
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0145	0.3849	0.3447
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0058	0.1271	0.6352
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.002	0.0155	0.0222
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0215	0.047
Brugia malayi	MH2 domain containing protein	0.0127	0.3315	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0049	0.1025	0.3271
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.1046
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0639	0.1767
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0215	0.0509
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.002	0.0155	0.0184
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.008	0.1926	0.1749
Brugia malayi	glutathione reductase	0.0057	0.1258	0.3794
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.008	0.1926	0.3808
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0116	0.3	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.4665	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0215	0.006
Schistosoma mansoni	phd/f-box containing protein	0.0019	0.013	0.0133
Schistosoma mansoni	hypothetical protein	0.0036	0.0639	0.1175
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0116	0.3	0.6006
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.002	0.0155	0.0468
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.002	0.0155	0.0139
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.1926	1
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0215	0.006
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0116	0.3	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0215	0.1046
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.1134	0.3289
Loa Loa (eye worm)	hypothetical protein	0.0019	0.013	0.02
Echinococcus granulosus	voltage dependent calcium channel	0.0024	0.0289	0.0761
Schistosoma mansoni	phosphatidylserine receptor	0.0019	0.013	0.0133
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0215	0.047
Echinococcus multilocularis	transcription factor Dp 1	0.0046	0.0934	0.296
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0155	0.0139
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0155	0.0139
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.1134	0.3421
Echinococcus granulosus	mitogen activated protein kinase	0.0058	0.1271	0.4109
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0071	0.1657	0.859
Echinococcus granulosus	lysine specific demethylase 5A	0.0071	0.1669	0.5466
Schistosoma mansoni	protein phosphatase 2C	0.0019	0.013	0.0133
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0215	0.0509
Trypanosoma brucei	unspecified product	0.0022	0.0215	0.1046
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0215	0.0459
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.002	0.0155	0.0222
Echinococcus multilocularis	voltage dependent calcium channel	0.0116	0.3	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.002	0.0155	0.0735
Plasmodium falciparum	glutathione reductase	0.0057	0.1258	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0058	0.1271	0.6352
Brugia malayi	jmjC domain containing protein	0.0071	0.1669	0.5035
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.013	0.02
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.002	0.0155	0.0139
Loa Loa (eye worm)	X11 protein	0.0083	0.2021	0.6019
Echinococcus granulosus	transcription factor Dp 1	0.0046	0.0934	0.296

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 6.99 uM	PUBCHEM_BIOASSAY: SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2073, AID2091, AID2093, AID2489]	ChEMBL.	No reference
IC50 (functional)	= 21.4 uM	PUBCHEM_BIOASSAY: SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2073, AID2091, AID2093, AID434980]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1399577

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1293347