Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.4838 | 0.6372 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1088 | 0.1434 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.1834 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.1834 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.1088 | 0.1191 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.1088 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1088 | 0.1334 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0652 | 0.0859 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.4838 | 0.6372 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8972 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1088 | 0.1434 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0652 | 0.0704 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.1088 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.7592 | 0.8342 |
Echinococcus granulosus | geminin | 0.0205 | 0.8972 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.063 | 0.083 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.1088 | 0.5 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0652 | 0.0704 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.1088 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0652 | 0.0859 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.1088 | 0.1434 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.1088 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.1834 | 0.2024 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1088 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1088 | 0.1334 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1088 | 0.1434 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.1088 | 0.1191 |
Onchocerca volvulus | 0.0035 | 0.1088 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.1088 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0652 | 0.0704 |
Onchocerca volvulus | 0.0035 | 0.1088 | 1 | |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0652 | 0.0704 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.1634 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.1088 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.1088 | 0.1434 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1088 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1088 | 0.1434 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0652 | 0.0753 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0087 | 0.0114 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.1834 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.1088 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.4838 | 0.633 |
Onchocerca volvulus | 0.0035 | 0.1088 | 1 | |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0652 | 0.0704 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0652 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1088 | 0.1434 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.1634 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0652 | 0.0753 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8972 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.7592 | 0.8459 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.7592 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.7592 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.7363 | 0.8203 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1088 | 0.5 |
Brugia malayi | beta-lactamase | 0.0035 | 0.1088 | 0.1334 |
Echinococcus granulosus | lamin | 0.0026 | 0.0652 | 0.0704 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.1834 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0022 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1088 | 0.1434 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.1834 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.1088 | 0.1334 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1088 | 0.0524 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.1634 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.1088 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8972 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.6109 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.