Detailed information for compound 1293704

Basic information

Technical information
  • TDR Targets ID: 1293704
  • Name: N-[2-(4-chlorophenyl)ethyl]-4-[5-methyl-4-[(4 -methylphenyl)sulfanylmethyl]-1,3-oxazol-2-yl ]benzamide
  • MW: 477.018 | Formula: C27H25ClN2O2S
  • H donors: 1 H acceptors: 2 LogP: 6.67 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)SCc1nc(oc1C)c1ccc(cc1)C(=O)NCCc1ccc(cc1)Cl
  • InChi: 1S/C27H25ClN2O2S/c1-18-3-13-24(14-4-18)33-17-25-19(2)32-27(30-25)22-9-7-21(8-10-22)26(31)29-16-15-20-5-11-23(28)12-6-20/h3-14H,15-17H2,1-2H3,(H,29,31)
  • InChiKey: DWZPSPPQHJJZEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-chlorophenyl)ethyl]-4-[5-methyl-4-[(4-methylphenyl)sulfanylmethyl]oxazol-2-yl]benzamide
  • N-[2-(4-chlorophenyl)ethyl]-4-[5-methyl-4-[[(4-methylphenyl)thio]methyl]-2-oxazolyl]benzamide
  • N-[2-(4-chlorophenyl)ethyl]-4-[5-methyl-4-[[(4-methylphenyl)thio]methyl]oxazol-2-yl]benzamide
  • E776-0035
  • NCGC00125273-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0379 0.0426
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0112
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2253 0.2192
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0429 0.0524
Mycobacterium ulcerans hypothetical protein 0.0176 0.3699 1
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0593 0.0549
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0089 0.0012
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.075 0.072
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0379 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0163 0.0002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.059 0.0296
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0593 0.0804
Schistosoma mansoni hypothetical protein 0.0168 0.3491 0.5425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0572 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0763 0.118
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0138 0.2769 0.4273
Onchocerca volvulus 0.006 0.0894 0.0812
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0578 0.0493
Schistosoma mansoni hypothetical protein 0.0287 0.6359 1
Onchocerca volvulus 0.0038 0.0379 0.0292
Loa Loa (eye worm) runx1 0.0055 0.078 0.0708
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0138 0.2769 0.2703
Brugia malayi beta-lactamase 0.0038 0.0379 0.0292
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.075 0.0667
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0189 0.0159
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0138 0.2769 0.2712
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0593 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0238 0.0149
Loa Loa (eye worm) hypothetical protein 0.0038 0.0379 0.0303
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0335 0.751 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0578 0.0532
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0863 0.0842
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0429 0.0524
Loa Loa (eye worm) hypothetical protein 0.006 0.0894 0.0823
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0189 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0496 0.0656
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0379 0.0315
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0863 0.1234
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0497 0.0166
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0593 0.0804
Loa Loa (eye worm) beta-lactamase 0.0038 0.0379 0.0303
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0763 0.0539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0578 0.078
Echinococcus multilocularis Protein lozenge 0.0055 0.078 0.0753
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0075 0.01
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0138 0.2769 0.2918
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0593 0.0549
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.059 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0763 0.118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0305 0.0282
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.2769 0.3687
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0578 0.078
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0379 0.0426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0578 0.078
Onchocerca volvulus 0.0038 0.0379 0.0292
Brugia malayi beta-lactamase family protein 0.0038 0.0379 0.0292
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0593 0.052
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0863 0.0679
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0894 0.1284
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.3932 0.4184
Trichomonas vaginalis esterase, putative 0.0038 0.0379 0.0426
Toxoplasma gondii ABC1 family protein 0.0038 0.0379 0.3343
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0838 0.0644
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0497 0.0166
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0379 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0158 0.3269 0.4352
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0138 0.2769 0.2918
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0162 0.0079
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0763 0.0539
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0763 0.0539
Echinococcus granulosus transcription factor Dp 1 0.008 0.1374 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.023 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0333 0.0337
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.5341 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.023 0.0134
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.075 0.1054
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0763 0.0539
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0335 0.751 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0863 0.1458
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0189 0.0159
Giardia lamblia GTOR 0.0054 0.0763 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0863 0.0975
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0763 0.118
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0763 0.0734
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0379 0.5
Brugia malayi Pre-SET motif family protein 0.0212 0.4555 0.4506
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0379 0.0426
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2253 0.2192
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0189 0.0109
Onchocerca volvulus 0.0047 0.0593 0.0509
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0379 0.0504
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0138 0.2769 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.2769 0.3351
Loa Loa (eye worm) hypothetical protein 0.0038 0.0379 0.0303
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0863 0.0842
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.4555 0.4513
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0497 0.0662
Brugia malayi beta-lactamase family protein 0.0038 0.0379 0.0292
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.075 0.072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0163 0.0002
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0593 0.0549
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0189 0.0159
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.3269 0.4052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0379 0.0462
Mycobacterium leprae Probable lipase LipE 0.0038 0.0379 0.5
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0593 0.0509
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0578 0.0504
Loa Loa (eye worm) hypothetical protein 0.0038 0.0379 0.0303
Loa Loa (eye worm) hypothetical protein 0.0026 0.0089 0.0012
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.3269 0.4052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0496 0.0656
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0578 0.0532
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.075 0.072
Echinococcus granulosus tumor protein p63 0.0408 0.9272 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0763 0.0734
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0335 0.751 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0429 0.0524
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0578 0.0532
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0379 0.0292
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0379 0.0426
Echinococcus multilocularis tumor protein p63 0.0408 0.9272 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0163 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0578 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0429 0.0524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0496 0.0656
Echinococcus multilocularis geminin 0.0168 0.3491 0.3704
Loa Loa (eye worm) hypothetical protein 0.0038 0.0379 0.0303
Loa Loa (eye worm) hypothetical protein 0.0038 0.0379 0.0303
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.075 0.072
Onchocerca volvulus 0.0038 0.0379 0.0292
Brugia malayi mbt repeat family protein 0.0047 0.0593 0.0509
Loa Loa (eye worm) hypothetical protein 0.0054 0.075 0.0678
Onchocerca volvulus 0.003 0.0189 0.0101
Loa Loa (eye worm) hypothetical protein 0.0047 0.0593 0.052
Echinococcus multilocularis transcription factor Dp 1 0.008 0.1374 0.1399
Trichomonas vaginalis set domain proteins, putative 0.0241 0.526 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0176 0.3699 0.6691
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0429 0.4223
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0863 0.0781
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0429 0.0524
Brugia malayi mbt repeat family protein 0.0047 0.0593 0.0509
Schistosoma mansoni lozenge 0.0055 0.078 0.1102
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.3932 0.4184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0163 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0429 0.0524
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0089 0.0012
Leishmania major mitochondrial DNA polymerase beta 0.0335 0.751 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0238 0.0149
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.2769 0.3351
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.059 0.0786
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0763 0.1016
Brugia malayi Pre-SET motif family protein 0.003 0.0189 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0379 0.0462
Loa Loa (eye worm) MBCTL1 0.0054 0.075 0.0678
Brugia malayi MH2 domain containing protein 0.0116 0.2253 0.2183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0238 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0429 0.0524
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.059 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0496 0.0656
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0763 0.1075
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0379 0.0315
Loa Loa (eye worm) hypothetical protein 0.0038 0.0379 0.0303
Echinococcus granulosus geminin 0.0168 0.3491 0.3704
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0189 0.0109
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0763 0.1016
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0768 0.0696
Schistosoma mansoni hypothetical protein 0.0168 0.3491 0.5425
Toxoplasma gondii hypothetical protein 0.0054 0.0757 1
Onchocerca volvulus 0.0241 0.526 0.5217
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0189 0.0109
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0379 0.0303
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0863 0.1458
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0763 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0496 0.0656
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0763 0.068
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0593 0.0804
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0138 0.2769 0.3351

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0355 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6898 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 4.14 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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