Detailed information for compound 1293765

Basic information

Technical information
  • TDR Targets ID: 1293765
  • Name: ethyl 3-[[2-(3-oxo-5,6,7,8-tetrahydrocinnolin -2-yl)acetyl]amino]benzoate
  • MW: 355.388 | Formula: C19H21N3O4
  • H donors: 1 H acceptors: 3 LogP: 1.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cccc(c1)NC(=O)Cn1nc2CCCCc2cc1=O
  • InChi: 1S/C19H21N3O4/c1-2-26-19(25)14-7-5-8-15(10-14)20-17(23)12-22-18(24)11-13-6-3-4-9-16(13)21-22/h5,7-8,10-11H,2-4,6,9,12H2,1H3,(H,20,23)
  • InChiKey: FZFLCDWKGGXLCM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[1-oxo-2-(3-oxo-5,6,7,8-tetrahydrocinnolin-2-yl)ethyl]amino]benzoic acid ethyl ester
  • 3-[[2-(3-keto-5,6,7,8-tetrahydrocinnolin-2-yl)acetyl]amino]benzoic acid ethyl ester
  • ethyl 3-[2-(3-oxo-5,6,7,8-tetrahydrocinnolin-2-yl)ethanoylamino]benzoate
  • G835-0046
  • NCGC00134925-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0227 0.1465
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.059 0.059
Echinococcus multilocularis calpain 0.0019 0.002 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0227 0.1683
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0445 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.025 0.025
Onchocerca volvulus 0.0033 0.0123 0.5198
Brugia malayi Stress-activated protein kinase jnk-1 0.0463 0.3323 0.6282
Loa Loa (eye worm) hypothetical protein 0.0302 0.2123 0.4
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0227 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0728 0.5291 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0142 0.6269
Brugia malayi MH2 domain containing protein 0.005 0.025 0.0472
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0227 0.5107
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0149 0.0149
Schistosoma mansoni smad1 5 8 and 0.005 0.025 0.025
Brugia malayi MH1 domain containing protein 0.005 0.025 0.0472
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.022 0.0396
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0142 0.0918
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0142 0.0142
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0142 0.0918
Trypanosoma brucei trypanothione reductase 0.0046 0.0224 0.5042
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0149 0.6566
Brugia malayi MH1 domain containing protein 0.0027 0.0085 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0261 0.1819 0.1819
Loa Loa (eye worm) hypothetical protein 0.0047 0.0227 0.041
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.025 0.025
Brugia malayi MH2 domain containing protein 0.0728 0.5291 1
Loa Loa (eye worm) RNA binding protein 0.0261 0.1819 0.3425
Echinococcus granulosus neuropeptide s receptor 0.0451 0.3237 0.3237
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0244
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0249
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0142 0.0142
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.014 0.0901
Leishmania major trypanothione reductase 0.0046 0.0224 0.5042
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.2123 0.4
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0142 0.3202
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0142 0.0918
Echinococcus granulosus calpain A 0.0066 0.0372 0.0372
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.014 0.314
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0123 0.0213
Mycobacterium tuberculosis Conserved protein 0.0035 0.0142 0.0918
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.3237 0.3237
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.002 0.0454
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0149 0.3354
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0227 0.0429
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0142 0.0249
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0227 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0227 0.0429
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0227 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0142 0.0918
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.002 0.0454
Schistosoma mansoni smad 0.0022 0.0046 0.0046
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0224 0.1446
Trypanosoma cruzi kinesin, putative 0.0019 0.002 0.0454
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0149 0.6231
Echinococcus multilocularis GPCR, family 2 0.0095 0.059 0.059
Echinococcus multilocularis musashi 0.0033 0.0123 0.0123
Entamoeba histolytica protein kinase, putative 0.002 0.0027 0.0333
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0142 0.6269
Loa Loa (eye worm) hypothetical protein 0.0044 0.0209 0.0376
Loa Loa (eye worm) Smad1 0.005 0.025 0.0452
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.155 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0142 0.3202
Trichomonas vaginalis esterase, putative 0.0035 0.0142 0.9547
Echinococcus granulosus lamin 0.0033 0.0123 0.0123
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.002 0.0454
Loa Loa (eye worm) hypothetical protein 0.0044 0.0209 0.0376
Loa Loa (eye worm) nuclear factor I 0.0027 0.0085 0.014
Echinococcus granulosus GPCR family 2 0.0095 0.059 0.059
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.025 0.025
Trypanosoma cruzi kinesin, putative 0.0019 0.002 0.0454
Entamoeba histolytica hypothetical protein 0.0035 0.0142 0.5895
Leishmania major kinesin, putative 0.0019 0.002 0.0454
Echinococcus multilocularis calpain 5 0.0019 0.002 0.002
Mycobacterium tuberculosis Conserved protein 0.0035 0.0142 0.0918
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0142 0.0918
Schistosoma mansoni inositol monophosphatase 0.0036 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0047 0.0227 0.041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0149 0.3354
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0463 0.3323 0.3323
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0142 0.0142
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0142 0.0142
Echinococcus multilocularis smad 0.005 0.025 0.025
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0664 0.4282
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0149 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0244
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0227 0.1465
Trypanosoma brucei antigen, putative 0.0019 0.002 0.0454
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.022 0.022
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0227 1
Schistosoma mansoni smad 0.005 0.025 0.025
Onchocerca volvulus 0.0035 0.0142 0.6084
Onchocerca volvulus 0.0035 0.0142 0.6084
Echinococcus multilocularis tar DNA binding protein 0.0261 0.1819 0.1819
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0126 0.081
Echinococcus multilocularis lamin dm0 0.0033 0.0123 0.0123
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0224 0.0404
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0664 0.4282
Brugia malayi Latrophilin receptor protein 2 0.0095 0.059 0.1116
Brugia malayi TAR-binding protein 0.0261 0.1819 0.3439
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0227 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0149 0.0149
Echinococcus multilocularis calpain A 0.0066 0.0372 0.0372
Echinococcus multilocularis lamin 0.0033 0.0123 0.0123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.022 0.022
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0149 0.3354
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0227 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0142 0.3202
Brugia malayi calpain family protein 1 0.0063 0.0349 0.0659
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0224 0.0224
Brugia malayi MH1 domain containing protein 0.005 0.025 0.0472
Brugia malayi RNA recognition motif domain containing protein 0.0261 0.1819 0.3439
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0046 0.0046
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0445 1
Brugia malayi Inositol-1 0.0036 0.0149 0.0282
Mycobacterium ulcerans lipase LipD 0.0035 0.0142 0.6269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.059 0.1098
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0445 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.002 0.0454
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0224 0.5042
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0224 0.5042
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.3237 0.3237
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0142 0.0918
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0751 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0224 0.0404
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0227 0.5107
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.002 0.002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0751 0.4845
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.002 0.0454
Entamoeba histolytica hypothetical protein 0.0035 0.0142 0.5895
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0209 0.0376
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0249
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0244
Onchocerca volvulus 0.0044 0.0209 0.9185
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0372 0.0372
Loa Loa (eye worm) transcription factor SMAD2 0.0728 0.5291 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0046 0.0046
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0134 0.0134
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0123 0.0233
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0244
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0224 0.0224
Brugia malayi MH2 domain containing protein 0.0022 0.0046 0.0087
Plasmodium vivax calpain, putative 0.0019 0.002 0.0454
Trypanosoma brucei kinesin, putative 0.0019 0.002 0.0454
Schistosoma mansoni hypothetical protein 0.0095 0.059 0.059
Schistosoma mansoni tar DNA-binding protein 0.0261 0.1819 0.1819
Mycobacterium ulcerans hypothetical protein 0.0047 0.0227 1
Brugia malayi hypothetical protein 0.0049 0.0245 0.0463
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.002 0.0454
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0227 1
Schistosoma mansoni hypothetical protein 0.0095 0.059 0.059
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0664 0.8614
Echinococcus granulosus Smad4 0.005 0.025 0.025
Echinococcus granulosus tar DNA binding protein 0.0261 0.1819 0.1819
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0011 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0142 0.9547
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.002 0.0454
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0249
Entamoeba histolytica hypothetical protein 0.0035 0.0142 0.5895
Brugia malayi calpain 5 0.0019 0.002 0.0038
Plasmodium falciparum thioredoxin reductase 0.0046 0.0224 0.5042
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0249
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0142 0.9547
Schistosoma mansoni smad1 5 8 and 0.005 0.025 0.025
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0149 0.3354
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0751 0.4845
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0046 0.0066
Schistosoma mansoni Smad4 0.0022 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0095 0.059 0.059
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.002 0.0454
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0142 0.9547
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.002 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.022 0.022
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.5766 0.5766
Brugia malayi MH1 domain containing protein 0.0027 0.0085 0.0161
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0126 0.081
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.002 0.0454
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0142 0.0269
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0227 0.1683
Loa Loa (eye worm) beta-lactamase 0.0035 0.0142 0.0249
Loa Loa (eye worm) inositol-1 0.0036 0.0149 0.0262
Toxoplasma gondii ABC1 family protein 0.0035 0.0142 0.3202
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0261 0.1819 0.3425
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.025 0.0452
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.002 0.0454
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0046 0.0046
Plasmodium vivax glutathione reductase, putative 0.0046 0.0224 0.5042
Schistosoma mansoni smad1 5 8 and 0.005 0.025 0.025
Brugia malayi beta-lactamase family protein 0.0035 0.0142 0.0269
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0445 1
Brugia malayi intermediate filament protein 0.0033 0.0123 0.0233
Brugia malayi RNA binding protein 0.0261 0.1819 0.3439
Echinococcus granulosus calpain A 0.0019 0.002 0.002
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0142 0.6269
Mycobacterium tuberculosis Probable reductase 0.0105 0.0664 0.4282
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.022 0.0416
Onchocerca volvulus 0.0047 0.0227 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.002 0.0454
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.014 0.6148
Trypanosoma brucei calpain-like protein, putative 0.0019 0.002 0.0454
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0142 0.9547
Onchocerca volvulus 0.0035 0.0142 0.6084
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.059 0.059
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0149 1
Echinococcus granulosus calpain 7 C02 family 0.0019 0.002 0.002
Schistosoma mansoni calpain C (C02 family) 0.0019 0.002 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0126 0.081
Loa Loa (eye worm) hypothetical protein 0.0027 0.0085 0.014
Schistosoma mansoni hypothetical protein 0.0095 0.059 0.059
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0445 1
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0445 1
Brugia malayi Smad1 0.005 0.025 0.0472
Loa Loa (eye worm) hypothetical protein 0.0206 0.1413 0.2657
Loa Loa (eye worm) hypothetical protein 0.0063 0.0349 0.064
Loa Loa (eye worm) hypothetical protein 0.0032 0.0119 0.0205
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0249
Echinococcus granulosus calpain 5 0.0019 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.022 0.022
Mycobacterium ulcerans hypothetical protein 0.0035 0.0142 0.6269
Loa Loa (eye worm) TAR-binding protein 0.0261 0.1819 0.3425
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0349 0.064
Entamoeba histolytica hypothetical protein 0.0035 0.0142 0.5895
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.002 0.0454
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.002 0.0454
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0249
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0149 0.3354
Loa Loa (eye worm) hypothetical protein 0.0063 0.0349 0.064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.022 0.022
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0445 1
Schistosoma mansoni calpain (C02 family) 0.0019 0.002 0.002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0751 0.4845
Echinococcus granulosus calpain 0.0019 0.002 0.002
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0227 0.0429
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0227 0.5107
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0142 0.3202
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.059 0.059
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.3237 0.3237
Schistosoma mansoni lamin 0.0033 0.0123 0.0123
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0142 0.0142
Trypanosoma brucei calpain-like protein, putative 0.0019 0.002 0.0454
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0142 0.0339
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0142 0.0142
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0227 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.002 0.0454
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0664 0.4282
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.002 0.002
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0664 0.4282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.022 0.022
Echinococcus multilocularis Smad4 0.005 0.025 0.025
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0209 0.0209
Schistosoma mansoni hypothetical protein 0.0034 0.0134 0.0134
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.002 0.002
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0123 0.0213
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0126 0.081
Schistosoma mansoni lamin 0.0033 0.0123 0.0123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.022 0.022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0142 0.0918
Schistosoma mansoni intermediate filament proteins 0.0033 0.0123 0.0123
Echinococcus granulosus c-Jun N-terminal kinases 0.0463 0.3323 0.3323
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0445 0.0822
Mycobacterium leprae Probable lipase LipE 0.0035 0.0142 0.0339
Schistosoma mansoni serine/threonine protein kinase 0.0463 0.3323 0.3323
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.025 0.025
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.014 0.314
Trypanosoma brucei calpain-like protein, putative 0.0019 0.002 0.0454
Schistosoma mansoni tar DNA-binding protein 0.0261 0.1819 0.1819
Schistosoma mansoni hypothetical protein 0.0206 0.1413 0.1413
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.2123 0.4012
Loa Loa (eye worm) hypothetical protein 0.0033 0.0123 0.0213
Loa Loa (eye worm) calpain 0.0019 0.002 0.0018
Leishmania major hypothetical protein, conserved 0.0035 0.0142 0.3202
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0046 0.0046
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.059 0.059
Echinococcus multilocularis hypothetical protein 0.0019 0.002 0.002
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.025 0.025
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0149 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0046 0.0066
Mycobacterium tuberculosis Conserved protein 0.0035 0.0142 0.0918
Brugia malayi beta-lactamase family protein 0.0035 0.0142 0.0269
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0664 0.4282
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0022 0.0046 0.1622
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.002 0.0454
Loa Loa (eye worm) hypothetical protein 0.0095 0.059 0.1098
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0142 0.9547
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.0046 0.0087
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0149 0.0149
Echinococcus granulosus smad 0.005 0.025 0.025
Schistosoma mansoni tar DNA-binding protein 0.0261 0.1819 0.1819
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0149 1
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.1413 0.2672
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0372 0.0372
Brugia malayi hypothetical protein 0.0035 0.0142 0.0269
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0372 0.0372
Brugia malayi calpain 7 0.0019 0.002 0.0038
Brugia malayi glutathione reductase 0.0046 0.0224 0.0424
Trypanosoma brucei calpain-like protein, putative 0.0019 0.002 0.0454
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0463 0.3323 0.6274
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0244
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0372 0.0372
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.2123 0.4012
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0121 0.0781
Schistosoma mansoni hypothetical protein 0.0035 0.0142 0.0142
Loa Loa (eye worm) calpain 5 0.0019 0.002 0.0018
Brugia malayi Thioredoxin reductase 0.0046 0.0224 0.0424
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.059 0.1116
Echinococcus granulosus lamin dm0 0.0033 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0047 0.0227 0.041
Leishmania major hypothetical protein, conserved 0.0076 0.0445 1
Brugia malayi MH2 domain containing protein 0.005 0.025 0.0472
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.014 1
Schistosoma mansoni Smad4 0.0022 0.0046 0.0046
Brugia malayi beta-lactamase 0.0035 0.0142 0.0269
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.025 0.0452
Echinococcus granulosus intermediate filament protein 0.0033 0.0123 0.0123
Brugia malayi hypothetical protein 0.0076 0.0445 0.0841
Onchocerca volvulus 0.0033 0.0123 0.5198
Brugia malayi calpain family protein 1 0.0063 0.0349 0.0659
Toxoplasma gondii thioredoxin reductase 0.0046 0.0224 0.5042
Schistosoma mansoni tar DNA-binding protein 0.0261 0.1819 0.1819
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0066
Schistosoma mansoni Smad4 0.005 0.025 0.025
Plasmodium falciparum glutathione reductase 0.0046 0.0224 0.5042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0142 0.0142

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0501 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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