Detailed information for compound 1293979

Basic information

Technical information
  • TDR Targets ID: 1293979
  • Name: (E)-N-(2-ethylhexyl)-3-(4-fluorophenyl)prop-2 -enamide
  • MW: 277.377 | Formula: C17H24FNO
  • H donors: 1 H acceptors: 1 LogP: 4.85 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(CNC(=O)/C=C/c1ccc(cc1)F)CC
  • InChi: 1S/C17H24FNO/c1-3-5-6-14(4-2)13-19-17(20)12-9-15-7-10-16(18)11-8-15/h7-12,14H,3-6,13H2,1-2H3,(H,19,20)/b12-9+
  • InChiKey: XCKOFHRRUIVYRF-FMIVXFBMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-ethylhexyl)-3-(4-fluorophenyl)prop-2-enamide
  • N-(2-ethylhexyl)-3-(4-fluorophenyl)acrylamide
  • (E)-N-(2-ethylhexyl)-3-(4-fluorophenyl)acrylamide
  • MLS000626978
  • SMR000272102
  • IVK/9443129

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0432 0.113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0307 0.0702
Schistosoma mansoni pyruvate kinase 0.0035 0.0703 0.0688
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1464 0.145
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0679 0.6646
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.01 0.0112
Loa Loa (eye worm) hypothetical protein 0.0033 0.0651 0.1706
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.1194 0.3175
Echinococcus granulosus dna polymerase kappa 0.0019 0.0307 0.0292
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0405 0.1038
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.304 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0307 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0307 0.0505
Loa Loa (eye worm) cysteine protease 0.0034 0.0679 0.178
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0679 0.0664
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0797 0.237
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.3609 0.3599
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0979 1
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0679 0.6646
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0271 0.0582
Schistosoma mansoni hypothetical protein 0.0034 0.0685 0.067
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0797 0.0782
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0307 0.0358
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0513 0.3079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1352 0.1338
Onchocerca volvulus 0.0034 0.0679 0.9195
Loa Loa (eye worm) hypothetical protein 0.0034 0.0679 0.178
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0405 0.039
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0307 0.0505
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0685 0.1797
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0205 0.05
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.3718 0.3708
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.00000000021182 0.0000000021629
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0271 0.2279
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0405 0.4139
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1077 0.2857
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0271 0.0678
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0797 0.8548
Schistosoma mansoni cytochrome P450 0.0015 0.0205 0.019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0401 0.1029
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Brugia malayi Cathepsin L-like precursor 0.0034 0.0679 0.178
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0679 0.178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Trypanosoma cruzi cruzipain precursor, putative 0.0011 0.0116 0.0054
Onchocerca volvulus 0.0034 0.0679 0.9195
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0771 0.0756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0679 0.693
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0513 0.1405
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0352 0.0897
Echinococcus multilocularis dna polymerase eta 0.0044 0.0925 0.0911
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0104
Loa Loa (eye worm) hypothetical protein 0.0011 0.0116 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Brugia malayi cathepsin L-like precursor 0.0023 0.0401 0.1029
Entamoeba histolytica cysteine protease, putative 0.0034 0.0679 0.7411
Brugia malayi Cytochrome P450 family protein 0.0024 0.0432 0.1114
Onchocerca volvulus 0.0034 0.0679 0.9195
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0271 0.2279
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0797 0.8137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0679 0.693
Brugia malayi Latrophilin receptor protein 2 0.0016 0.023 0.0567
Leishmania major cathepsin L-like protease 0.0034 0.0679 0.167
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0441 0.4422
Onchocerca volvulus 0.0034 0.0679 0.9195
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0307 0.0505
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0703 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0797 0.0782
Brugia malayi hypothetical protein 0.0037 0.0771 0.2029
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0405 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2199 0.2187
Plasmodium vivax unspecified product 0.0017 0.0271 0.2036
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0651 0.1706
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0679 0.0664
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0513 0.4756
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1464 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0282 0.0267
Echinococcus multilocularis lamin dm0 0.0033 0.0651 0.0637
Echinococcus multilocularis geminin 0.0182 0.4374 0.4366
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0578
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Schistosoma mansoni DNA helicase recq1 0.0021 0.0352 0.0337
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0797 0.0782
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.023 0.0215
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0271 0.0582
Entamoeba histolytica hypothetical protein 0.0037 0.0771 0.8572
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0432 0.1114
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.1464 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0274 0.0685
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0925 0.2446
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0432 0.1114
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0797 0.0782
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0205 0.0838
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0432 0.113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0271 0.2769
Brugia malayi Cathepsin L-like precursor 0.0023 0.0401 0.1029
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.01 0.0073
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0352 0.1906
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1285 0.87
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0307 0.0702
Echinococcus granulosus pyruvate kinase 0.0018 0.0282 0.0267
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Echinococcus multilocularis pyruvate kinase 0.0035 0.0703 0.0688
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.2199 0.2187
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0307 0.0505
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0352 0.3595
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.2355 0.7669
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0703 0.7178
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0703 0.1882
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0703 0.1882
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0405 0.1041
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0979 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0797 0.0782
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0405 0.0706
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0797 0.8137
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0797 0.2208
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0307 0.0505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0401 0.4093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0307 0.0505
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.2199 0.2187
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0703 0.6892
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2199 0.2187
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0651 0.1706
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0703 0.1846
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0552 0.1437
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.023 0.0215
Loa Loa (eye worm) hypothetical protein 0.0034 0.0685 0.1797
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0925 0.2805
Schistosoma mansoni pyruvate kinase 0.0018 0.0282 0.0267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0679 0.693
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0307 0.0806
Schistosoma mansoni pyruvate kinase 0.0035 0.0703 0.0688
Schistosoma mansoni hypothetical protein 0.0182 0.4374 0.4366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0116 0.0259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0271 0.0382
Echinococcus multilocularis 0.0015 0.0205 0.019
Schistosoma mansoni hypothetical protein 0.0037 0.0771 0.0756
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0679 0.0664
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0405 0.159
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0679 0.178
Echinococcus granulosus cysteine protease 0.0017 0.0271 0.0256
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0679 0.0664
Loa Loa (eye worm) ctsf protein 0.0034 0.0679 0.178
Schistosoma mansoni lamin 0.0033 0.0651 0.0637
Loa Loa (eye worm) acetyltransferase 0.0155 0.3718 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0884 1
Leishmania major cathepsin L-like protease 0.0034 0.0679 0.167
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0679 0.0664
Brugia malayi Cytochrome P450 family protein 0.0054 0.1194 0.3175
Brugia malayi Cathepsin L-like precursor 0.0034 0.0679 0.178
Trypanosoma cruzi cruzipain precursor, putative 0.0128 0.304 1
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0352 0.0337
Loa Loa (eye worm) fibroinase 0.0034 0.0679 0.178
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0271 0.2279
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0352 0.3297
Echinococcus multilocularis cysteine protease 0.0034 0.0679 0.0664
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0797 0.8899
Brugia malayi Cathepsin L-like precursor 0.0034 0.0679 0.178
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.2762 0.9055
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.304 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0141 0.0126
Onchocerca volvulus 0.0034 0.0679 0.9195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Onchocerca volvulus 0.0033 0.0651 0.8292
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0231 0.0215
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.00000000021182 0.0000000021629
Brugia malayi hypothetical protein 0.0017 0.0274 0.0685
Schistosoma mansoni hypothetical protein 0.0012 0.0141 0.0126
Echinococcus granulosus cathepsin l1 0.0034 0.0679 0.0664
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0679 0.9195
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0432 0.0942
Loa Loa (eye worm) hypothetical protein 0.0011 0.0116 0.0259
Loa Loa (eye worm) hypothetical protein 0.0016 0.023 0.0567
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0205 0.0357
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0405 0.3969
Entamoeba histolytica hypothetical protein 0.0037 0.0771 0.8572
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0797 0.2087
Giardia lamblia Pyruvate kinase 0.0035 0.0703 0.6989
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0352 0.1161
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0405 0.0848
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0307 0.0806
Brugia malayi CXXC zinc finger family protein 0.0029 0.0552 0.1437
Echinococcus multilocularis lamin 0.0033 0.0651 0.0637
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0141 0.0126
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0271 0.0256
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0056 0.0097
Echinococcus granulosus cathepsin l1 0.0023 0.0401 0.0386
Leishmania major cathepsin L-like protease 0.0128 0.304 1
Leishmania major cathepsin L-like protease 0.0034 0.0679 0.167
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0703 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0703 0.1846
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0703 0.7178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.2199 0.2187
Loa Loa (eye worm) hypothetical protein 0.0015 0.0216 0.0528
Loa Loa (eye worm) hypothetical protein 0.0009 0.0065 0.0122
Leishmania major cathepsin L-like protease 0.0128 0.304 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0352 0.0897
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0513 0.1222
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0307 0.0806
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0513 0.3945
Plasmodium falciparum pyruvate kinase 0.0035 0.0703 0.7043
Echinococcus granulosus geminin 0.0182 0.4374 0.4366
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0679 0.1968
Loa Loa (eye worm) hypothetical protein 0.0024 0.0441 0.1138
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0271 0.2279
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0271 0.0256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0405 0.159
Leishmania major hypothetical protein, conserved 0.0027 0.0513 0.1086
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0116 0.0259
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0703 0.1846
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0352 0.0518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Plasmodium vivax unspecified product 0.0011 0.0116 0.0292
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0405 0.1041
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0703 0.2051
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.2199 0.5892
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.01 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0679 0.7411
Leishmania major pyruvate kinase 0.0035 0.0703 0.1756
Brugia malayi Cathepsin L-like precursor 0.0011 0.0116 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.00000000021182 0.0000000021629
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.00000000021182 0.0000000021629
Leishmania major cytochrome p450-like protein 0.0024 0.0432 0.0801
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0679 0.0664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0271 0.2279
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0352 0.3595
Schistosoma mansoni intermediate filament proteins 0.0033 0.0651 0.0637
Loa Loa (eye worm) hypothetical protein 0.0023 0.0401 0.1029
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0405 0.3544
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0282 0.0178
Schistosoma mansoni DNA polymerase eta 0.0044 0.0925 0.0911
Plasmodium vivax vivapain-3 0.0017 0.0271 0.2036
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0884 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0205 0.0357
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0205 0.0357
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0679 0.693
Loa Loa (eye worm) hypothetical protein 0.0021 0.0352 0.0897
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0703 0.2051
Schistosoma mansoni hypothetical protein 0.0015 0.0205 0.019
Brugia malayi Cytochrome P450 family protein 0.0024 0.0432 0.1114
Echinococcus granulosus lamin 0.0033 0.0651 0.0637
Echinococcus granulosus bloom syndrome protein 0.0021 0.0352 0.0337
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0271 0.0582
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0432 0.1114
Onchocerca volvulus 0.0034 0.0679 0.9195
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0405 0.1038
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0307 0.0806
Loa Loa (eye worm) hypothetical protein 0.0032 0.0637 0.1666
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0307 0.0702
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0271 0.0582
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0307 0.0702
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0271 0.0256
Schistosoma mansoni DNA helicase recq5 0.0021 0.0352 0.0337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0271 0.0382
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0352 0.0663
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.01 0.0215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2199 0.2187
Echinococcus granulosus dna polymerase eta 0.0044 0.0925 0.0911
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0307 0.0505
Toxoplasma gondii cathepsin CPL 0.0034 0.0679 0.4284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.023 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0679 0.693
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.00000000021182 0.0000000021629
Trypanosoma cruzi cysteine peptidase, putative 0.0011 0.0116 0.0054
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0401 0.3912
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0703 0.3955
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0703 0.1846
Loa Loa (eye worm) hypothetical protein 0.0038 0.0797 0.21
Brugia malayi Cathepsin L-like precursor 0.0034 0.0679 0.178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.00000000021182 0.0000000021629
Echinococcus granulosus lamin dm0 0.0033 0.0651 0.0637
Schistosoma mansoni hypothetical protein 0.0182 0.4374 0.4366
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0979 1
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.023 0.0567
Echinococcus granulosus pyruvate kinase 0.0018 0.0282 0.0267
Loa Loa (eye worm) hypothetical protein 0.0011 0.0116 0.0259
Loa Loa (eye worm) hypothetical protein 0.001 0.01 0.0215
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0282 0.2159
Plasmodium vivax vivapain-1 0.0017 0.0271 0.2036
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0352 0.1906
Leishmania major DNA polymerase kappa, putative 0.0019 0.0307 0.0358
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0797 0.0782
Onchocerca volvulus 0.0029 0.0552 0.4997
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0282 0.0267
Echinococcus multilocularis cathepsin L 0.0017 0.0271 0.0256
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.1464 0.444
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0271 0.2279
Leishmania major DNA polymerase eta, putative 0.0044 0.0925 0.2538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Brugia malayi Cathepsin L-like precursor 0.0034 0.0679 0.178
Brugia malayi Cathepsin L-like precursor 0.0023 0.0401 0.1029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0231 0.0568
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0797 0.0782
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0307 0.0292
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0703 0.3955
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0513 0.1405
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.023 0.0567
Onchocerca volvulus 0.0034 0.0679 0.9195
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0352 0.0337
Brugia malayi intermediate filament protein 0.0033 0.0651 0.1706
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0771 0.0756
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0703 1
Echinococcus multilocularis musashi 0.0033 0.0651 0.0637
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0271 0.0678
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0703 0.1846
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1077 0.2857
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0979 0.6473
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.023 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.00000000021182 0.0000000021629
Echinococcus granulosus pyruvate kinase 0.0035 0.0703 0.0688
Echinococcus multilocularis GPCR, family 2 0.0016 0.023 0.0215
Schistosoma mansoni ap endonuclease 0.0023 0.0405 0.039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0797 0.8137
Brugia malayi cytochrome P450 0.0015 0.0205 0.05
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.1464 0.145
Echinococcus granulosus cathepsin L 0.0017 0.0271 0.0256
Loa Loa (eye worm) hypothetical protein 0.0023 0.0401 0.1029
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0405 0.5
Echinococcus multilocularis pyruvate kinase 0.0027 0.0521 0.0506
Leishmania major DNA polymerase eta, putative 0.0031 0.0602 0.1399
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Entamoeba histolytica hypothetical protein 0.0037 0.0771 0.8572
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0797 0.21
Onchocerca volvulus 0.0033 0.0651 0.8292
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0925 0.2652
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.1464 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0282 0.0267
Echinococcus multilocularis pyruvate kinase 0.0018 0.0282 0.0267
Echinococcus multilocularis cysteine protease 0.0034 0.0679 0.0664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0405 0.2046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0352 0.0337
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0231 0.0215
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0205 0.0153
Schistosoma mansoni ap endonuclease 0.0023 0.0405 0.039
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0679 0.6646
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0352 0.1319
Loa Loa (eye worm) hypothetical protein 0.001 0.01 0.0215
Schistosoma mansoni cathepsin s 0.0011 0.0116 0.0101
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0771 0.0756
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0307 0.0505
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.3718 1
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0679 0.9195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0679 0.693
Trypanosoma brucei unspecified product 0.0019 0.0307 0.0505
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0205 0.019
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0703 0.1846
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0679 0.693
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0979 0.6473
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0401 0.0386
Loa Loa (eye worm) RecQ helicase 0.0021 0.0352 0.0897
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0307 0.0505
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Echinococcus granulosus intermediate filament protein 0.0033 0.0651 0.0637
Loa Loa (eye worm) hypothetical protein 0.0015 0.0216 0.0528
Leishmania major cathepsin L-like protease 0.0128 0.304 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.3718 0.3708
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1464 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0679 0.693
Leishmania major cathepsin L-like protease 0.0034 0.0679 0.167
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.304 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0679 0.178
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0679 0.0664
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0513 0.3945
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0405 0.039
Loa Loa (eye worm) hypothetical protein 0.0044 0.0925 0.2446
Leishmania major pyruvate kinase 0.0035 0.0703 0.1756
Loa Loa (eye worm) hypothetical protein 0.005 0.1077 0.2857
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0307 0.0505
Echinococcus granulosus GPCR family 2 0.0016 0.023 0.0215
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0401 0.1029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0401 0.4093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0271 0.2769
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1464 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0307 0.0292
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0797 0.0782
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0271 0.0256
Brugia malayi hypothetical protein 0.0027 0.0513 0.1332
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0651 0.1706
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1077 0.2857
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0307 0.0505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0679 0.693
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0352 0.0857
Schistosoma mansoni cpg binding protein 0.0029 0.0552 0.0537
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0703 0.4461
Giardia lamblia DINP protein human, muc B family 0.0019 0.0307 0.0407
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0307 0.3131
Leishmania major cathepsin L-like protease 0.0034 0.0679 0.167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.304 1
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.2199 0.2187
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0307 0.2726
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0679 0.178
Plasmodium vivax vivapain-2 0.0034 0.0679 0.6618
Entamoeba histolytica recQ family DNA helicase 0.001 0.01 0.0126
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0679 0.7411
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0441 0.1138
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0405 0.4139
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0432 0.1805
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0307 0.0505
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.00000000021182 0.0000000021629
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0405 0.2188
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0352 0.0897
Schistosoma mansoni lamin 0.0033 0.0651 0.0637
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0352 0.1319
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0679 0.693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0679 0.693
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.1464 0.145
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0602 0.1706
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0307 0.0292
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0282 0.1397
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.2199 0.5892
Echinococcus granulosus pyruvate kinase 0.0035 0.0703 0.0688
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0352 0.3595
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0271 0.0582
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0307 0.0505
Chlamydia trachomatis pyruvate kinase 0.0035 0.0703 0.5
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1464 0.145
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0602 0.3725
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0703 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0352 0.0337
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0307 0.0774
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0307 0.3131
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.009 0.0075
Entamoeba histolytica hypothetical protein 0.0037 0.0771 0.8572
Echinococcus multilocularis cpg binding protein 0.003 0.0593 0.0578
Toxoplasma gondii exonuclease III APE 0.0023 0.0405 0.2294
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0307 0.0292
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0352 0.0337
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0884 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0797 0.237
Plasmodium vivax vivapain-2 0.0034 0.0679 0.6618
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0979 0.0965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0679 0.693
Loa Loa (eye worm) cytochrome P450 0.0015 0.0205 0.05
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0679 0.0664
Loa Loa (eye worm) hypothetical protein 0.0027 0.0513 0.1332
Entamoeba histolytica cysteine protease, putative 0.0017 0.0271 0.2279
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0116 0.0259
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0679 0.167
Echinococcus multilocularis pyruvate kinase 0.0035 0.0703 0.0688
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0679 0.9195
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0352 0.0897
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0307 0.0774
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0274 0.0685
Echinococcus granulosus cpg binding protein 0.003 0.0593 0.0578

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0126 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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