Detailed information for compound 1294381

Basic information

Technical information
  • TDR Targets ID: 1294381
  • Name: 3-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-1- methyl-6-piperidin-1-ylsulfonylquinolin-4-one
  • MW: 465.565 | Formula: C25H27N3O4S
  • H donors: 0 H acceptors: 4 LogP: 2.89 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cn(C)c2c(c1=O)cc(cc2)S(=O)(=O)N1CCCCC1)N1CCc2c(C1)cccc2
  • InChi: 1S/C25H27N3O4S/c1-26-17-22(25(30)27-14-11-18-7-3-4-8-19(18)16-27)24(29)21-15-20(9-10-23(21)26)33(31,32)28-12-5-2-6-13-28/h3-4,7-10,15,17H,2,5-6,11-14,16H2,1H3
  • InChiKey: OWOWYPMMAGXIPA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-1-methyl-6-(1-piperidylsulfonyl)quinolin-4-one
  • 3-(3,4-dihydro-1H-isoquinolin-2-yl-oxomethyl)-1-methyl-6-(1-piperidylsulfonyl)-4-quinolinone
  • 3-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-1-methyl-6-piperidinosulfonyl-4-quinolone
  • 3-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-1-methyl-6-piperidin-1-ylsulfonyl-quinolin-4-one
  • MLS000521882
  • SMR000132290
  • EU-0026683

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0075 0.0317 0.0898
Loa Loa (eye worm) hypothetical protein 0.0045 0.0146 0.0412
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.022 0.1431
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0024 0.0059
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0244 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.1041 0.3874
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0418 0.1601
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0082 0.02
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0365 0.5016
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0244 0.1591
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0158 0.1029
Brugia malayi hypothetical protein 0.0054 0.0198 0.0735
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0062 0.0244 0.2245
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0122 0.0584 0.0584
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0143 0.5762
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.01 0.0915
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0062 0.0244 0.0935
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.01 0.0648
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0146 0.0146
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0078 0.0078
Onchocerca volvulus Heterochromatin protein 1 homolog 0.008 0.0346 0.2639
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0346 0.2252
Echinococcus multilocularis chromobox protein 2 0.0023 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0263 0.0641
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.1088 1
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0317 0.4289
Echinococcus multilocularis snurportin 1 0.064 0.3533 0.3533
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0255 0.095
Brugia malayi Thioredoxin reductase 0.0037 0.0099 0.0369
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0008 0.0021
Entamoeba histolytica hypothetical protein 0.0049 0.0168 0.1094
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0227 0.0227
Schistosoma mansoni cpg binding protein 0.0162 0.0815 0.1987
Brugia malayi jmjC domain containing protein 0.0082 0.0358 0.1332
Mycobacterium ulcerans hypothetical protein 0.0024 0.0029 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0213 0.1388
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0012 0.0034
Echinococcus multilocularis Chromo domain 0.0023 0.0024 0.0024
Onchocerca volvulus 0.0056 0.0211 0.1533
Brugia malayi RNA, U transporter 1 0.0171 0.0862 0.3205
Plasmodium falciparum thioredoxin reductase 0.0037 0.0099 0.3961
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0174 0.0425
Plasmodium vivax SET domain protein, putative 0.0033 0.0078 0.1846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0371 0.2 0.4875
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0263 0.0744
Schistosoma mansoni chromobox protein 0.0023 0.0024 0.0059
Echinococcus granulosus mixed lineage leukemia protein mll 0.0039 0.0112 0.0273
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.0484 0.3152
Brugia malayi beta-lactamase family protein 0.0075 0.0317 0.1181
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0194 0.0992 0.2418
Schistosoma mansoni hypothetical protein 0.0064 0.0255 0.0622
Entamoeba histolytica hypothetical protein 0.002 0.0004 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0021 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0039 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0043 0.0137 0.0333
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0227 0.0644
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0034 0.0127
Trichomonas vaginalis esterase, putative 0.0075 0.0317 0.2067
Brugia malayi F/Y-rich N-terminus family protein 0.0069 0.0282 0.1049
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0263 0.0977
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1536 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.01 0.0915
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.0493 0.1202
Brugia malayi CHE-14 protein 0.0045 0.0146 0.0542
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0317 0.2917
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0087 0.0567
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0233 0.2137
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.01 0.0915
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0082 0.0082
Mycobacterium tuberculosis Conserved protein 0.0024 0.0029 0.0112
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0024 0.0157
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0024 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0087 0.0567
Brugia malayi hypothetical protein 0.0171 0.0866 0.3221
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.01 0.01
Leishmania major hypothetical protein, conserved 0.021 0.1088 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0062 0.0244 0.1591
Echinococcus granulosus chromobox protein 1 0.0143 0.0702 0.1711
Entamoeba histolytica hypothetical protein 0.0122 0.0584 0.3802
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0062 0.0244 0.2245
Brugia malayi Importin beta-1 subunit 0.006 0.0233 0.0865
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0222 0.0541
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0058 0.022 0.1431
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.1088 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0143 0.131
Loa Loa (eye worm) hypothetical protein 0.0075 0.0317 0.0898
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0317 0.2067
Schistosoma mansoni hypothetical protein 0.064 0.3533 0.8614
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0024 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0129 0.0841
Schistosoma mansoni transcription factor LCR-F1 0.0122 0.0584 0.1423
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0034 0.0222
Schistosoma mansoni patched 1 0.0045 0.0146 0.0355
Entamoeba histolytica hypothetical protein 0.0023 0.0024 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0087 0.0567
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0158 0.4564
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0317 0.1215
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0317 0.2067
Leishmania major trypanothione reductase 0.0037 0.0099 0.0912
Schistosoma mansoni ran 0.0044 0.0143 0.0347
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0024 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0371 0.2 0.4875
Schistosoma mansoni ap endonuclease 0.0062 0.0244 0.0596
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0143 0.131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.022 0.1431
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0227 0.0554
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0317 0.0774
Echinococcus multilocularis GPCR, family 2 0.0064 0.0255 0.0255
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.0484 0.0484
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0198 0.5917
Brugia malayi SET domain containing protein 0.0028 0.0049 0.0183
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0029 0.0269
Brugia malayi Smad1 0.0034 0.0082 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0346 0.2252
Echinococcus granulosus tyrosine protein kinase shark 0.0436 0.2369 0.5776
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0143 0.0403
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.1536 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0034 0.0314
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0168 0.1094
Toxoplasma gondii thioredoxin reductase 0.0037 0.0099 0.0625
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0034 0.0491
Echinococcus granulosus GPCR family 2 0.0064 0.0255 0.0622
Onchocerca volvulus 0.0171 0.0866 0.6906
Onchocerca volvulus 0.0075 0.0317 0.2407
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0263 0.0263
Mycobacterium ulcerans hypothetical protein 0.0024 0.0029 0.0421
Schistosoma mansoni hypothetical protein 0.002 0.0008 0.0018
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0298 0.0298
Brugia malayi MH1 domain containing protein 0.0034 0.0082 0.0305
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0062 0.0244 0.2245
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0168 0.1094
Echinococcus granulosus lysine specific demethylase 5A 0.0082 0.0358 0.0873
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0001 0.0011
Echinococcus granulosus Chromobox protein 3 0.0023 0.0024 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0024 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0371 0.2 0.4875
Echinococcus granulosus tar DNA binding protein 0.0065 0.0263 0.0641
Schistosoma mansoni smad1 5 8 and 0.0034 0.0082 0.02
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0082 0.02
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0054 0.1016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0097
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0255 0.095
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0198 0.1816
Mycobacterium ulcerans hypothetical protein 0.0025 0.0034 0.0491
Loa Loa (eye worm) hypothetical protein 0.008 0.0346 0.0979
Loa Loa (eye worm) hypothetical protein 0.0101 0.0467 0.1323
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0034 0.0127
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0029 0.0421
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.01 0.0627
Schistosoma mansoni importin beta-1 0.006 0.0233 0.0567
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0001 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0371 0.2 0.4875
Echinococcus granulosus chromobox protein 2 0.0023 0.0024 0.0059
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0158 0.1
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0317 0.4569
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0034 0.0491
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0658
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.006 0.006
Leishmania major importin beta-1 subunit, putative 0.0049 0.0168 0.1544
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0024 0.0833
Mycobacterium tuberculosis Conserved protein 0.0075 0.0317 0.1215
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.006 0.0146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0068
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0024 0.0157
Schistosoma mansoni jumonji domain containing protein 0.0154 0.0766 0.1867
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0174 0.0425
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0062 0.0244 1
Echinococcus granulosus expressed conserved protein 0.0098 0.0448 0.1092
Loa Loa (eye worm) jmjC domain-containing protein 0.0082 0.0358 0.1013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1536 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1536 1
Brugia malayi Bromodomain containing protein 0.0042 0.0128 0.0476
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.022 0.1431
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0143 0.0347
Brugia malayi Heterochromatin protein 1 0.0143 0.0702 0.2612
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0213 0.1388
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0365 0.1399
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0359 0.0875
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0168 0.1094
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1536 1
Schistosoma mansoni hypothetical protein 0.0043 0.0137 0.0333
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0298 0.0726
Toxoplasma gondii ABC1 family protein 0.0075 0.0317 0.2018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0317 0.1181
Echinococcus granulosus fetal alzheimer antigen falz 0.0031 0.0067 0.0165
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0034 0.0314
Schistosoma mansoni jumonji/arid domain-containing protein 0.0082 0.0358 0.0873
Plasmodium falciparum glutathione reductase 0.0037 0.0099 0.3961
Schistosoma mansoni cpg binding protein 0.0152 0.0755 0.1841
Schistosoma mansoni bromodomain containing protein 0.0075 0.0318 0.0775
Echinococcus granulosus Smad4 0.0034 0.0082 0.02
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0082 0.02
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0244 0.7508
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.1536 1
Brugia malayi Bromodomain containing protein 0.0065 0.0262 0.0974
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0158 0.0385
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0084 0.0205
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0146 0.0355
Echinococcus multilocularis peregrin 0.0065 0.0262 0.0262
Leishmania major hypothetical protein, conserved 0.0075 0.0317 0.2917
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0062 0.0244 0.0596
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0146 0.0412
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0122 0.0584 0.1423
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0418 0.1601
Leishmania major hypothetical protein, conserved 0.0054 0.0198 0.1816
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0078 0.0491
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0034 0.0127
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0227 0.1443
Brugia malayi beta-lactamase 0.0075 0.0317 0.1181
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0317 0.1215
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0024 0.0833
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0317 0.2067
Loa Loa (eye worm) hypothetical protein 0.0059 0.0227 0.0644
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0097
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.01 0.0648
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0317 0.2917
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0317 0.1215
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0034 0.0491
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0034 0.0222
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.01 0.0243
Plasmodium falciparum importin beta, putative 0.006 0.0233 0.9511
Onchocerca volvulus 0.0238 0.1243 1
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0317 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1536 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0024 0.0157
Loa Loa (eye worm) hypothetical protein 0.0104 0.0484 0.137
Schistosoma mansoni ran 0.0044 0.0143 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0087 0.0567
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0029 0.0112
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0233 0.1476
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0087 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0024 0.0157
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0102 0.0249
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0068
Echinococcus granulosus geminin 0.074 0.4102 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1536 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0094 0.0094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.1041 0.3874
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0034 0.0131
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0198 0.8057
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0024 0.0157
Mycobacterium tuberculosis Conserved protein 0.0075 0.0317 0.1215
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0024 0.0059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0115 0.0747
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.022 0.1431
Brugia malayi glutathione reductase 0.0037 0.0099 0.0369
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0194 0.0992 0.0992
Schistosoma mansoni hypothetical protein 0.0043 0.0137 0.0333
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0233 0.2137
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0024 0.0157
Brugia malayi MH2 domain containing protein 0.0034 0.0082 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0087 0.0567
Echinococcus granulosus cpg binding protein 0.0162 0.0815 0.1987
Loa Loa (eye worm) MH2 domain-containing protein 0.0492 0.2688 0.7607
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0024 0.0833
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0034 0.0491
Loa Loa (eye worm) hypothetical protein 0.0171 0.0866 0.245
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0003
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0029 0.0421
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0024 0.009
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.01 0.1433
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0029 0.007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0371 0.2 0.744
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0143 0.4037
Plasmodium vivax glutathione reductase, putative 0.0037 0.0099 0.2562
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0244 0.1591
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0317 0.0774
Loa Loa (eye worm) hypothetical protein 0.0075 0.0317 0.0898
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0317 0.4569
Brugia malayi hypothetical protein 0.0035 0.0089 0.0332
Entamoeba histolytica hypothetical protein 0.0023 0.0024 0.0157
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0024 0.0146
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0317 0.0898
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1536 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0062 0.0244 0.3517
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0146 0.0949
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0034 0.0222
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0024 0.0157
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0365 0.1399
Schistosoma mansoni myst-related protein 0.002 0.0004 0.001
Trypanosoma brucei trypanothione reductase 0.0037 0.0099 0.0912
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0143 0.0928
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0048 0.0165 0.0402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1536 1
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0099 0.2562
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0124 0.4973
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0024 0.0157
Loa Loa (eye worm) hypothetical protein 0.0138 0.0678 0.1918
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0024 0.0157
Onchocerca volvulus 0.0152 0.0755 0.5998
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0143 0.0902
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0024 0.0157
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0034 0.0314
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0039 0.0112 0.0273
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0168 0.1544
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0024 0.0157
Onchocerca volvulus 0.0075 0.0317 0.2407
Trichomonas vaginalis chromobox protein, putative 0.0086 0.038 0.2476
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0263 0.0641
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0034 0.0491
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0062 0.0244 0.0244
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.01 0.0915
Schistosoma mansoni cpg binding protein 0.0162 0.0815 0.1987
Loa Loa (eye worm) helicase 0.0023 0.0024 0.0068
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0255 0.0622
Echinococcus granulosus peregrin 0.0065 0.0262 0.0638
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0479 0.2613 1
Echinococcus granulosus Chromo domain 0.0023 0.0024 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0371 0.2 0.2
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0078 0.0191
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0042 0.0129 0.0841
Loa Loa (eye worm) hypothetical protein 0.0075 0.0317 0.0898
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0173
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1243 0.8093
Brugia malayi MH2 domain containing protein 0.0034 0.0082 0.0305
Mycobacterium ulcerans beta-lactamase 0.0075 0.0317 0.4569
Schistosoma mansoni tyrosine kinase 0.0426 0.2312 0.5637
Echinococcus multilocularis smad 0.0034 0.0082 0.0082
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.0484 0.118
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0024 0.0024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0152 0.0755 0.2137
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0062 0.0244 0.2245
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0317 0.2067
Trichomonas vaginalis ran, putative 0.0044 0.0143 0.0928
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0062 0.0244 0.1591
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0048 0.0165 0.0165
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0124 0.0805
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0695 1
Loa Loa (eye worm) Smad1 0.0034 0.0082 0.0232
Echinococcus granulosus importin subunit beta 1 0.006 0.0233 0.0567
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0227 0.6931
Schistosoma mansoni myst-related protein 0.002 0.0004 0.001
Schistosoma mansoni hypothetical protein 0.0059 0.0227 0.0554
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0024 0.0059
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0304
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.0484 0.1801
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0255 0.0255
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0365 0.1399
Schistosoma mansoni hypothetical protein 0.0064 0.0255 0.0622
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0418 0.5817
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0695 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0056 0.0211 0.0514
Loa Loa (eye worm) CHromoDomain protein family member 0.0034 0.0084 0.0238
Echinococcus granulosus zinc finger protein 0.0032 0.0072 0.0175
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0198 0.1816
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0024 0.0157
Schistosoma mansoni chromobox protein 0.0143 0.0702 0.1711
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0359 0.0359
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0024 0.0157
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0317 0.1215
Brugia malayi jmjC domain containing protein 0.0194 0.0992 0.369
Schistosoma mansoni inositol monophosphatase 0.0037 0.01 0.0243
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.0766 0.0766
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0099 0.0912
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0034 0.0084 0.0084
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0024 0.009
Brugia malayi MH2 domain containing protein 0.0492 0.2688 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0053 0.013
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0263 0.0744
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0198 0.1253
Schistosoma mansoni zinc finger protein 0.0032 0.0072 0.0175
Loa Loa (eye worm) hypothetical protein 0.007 0.0289 0.0819
Loa Loa (eye worm) hypothetical protein 0.0055 0.0202 0.0571
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0024 0.0157
Schistosoma mansoni smad 0.0034 0.0082 0.02
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0039 0.0112 0.0112
Schistosoma mansoni smad1 5 8 and 0.0034 0.0082 0.02
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0024 0.009
Brugia malayi exodeoxyribonuclease III family protein 0.0062 0.0244 0.0909
Brugia malayi CHD4 protein 0.0034 0.0084 0.0313
Loa Loa (eye worm) histone methyltransferase 0.0048 0.0165 0.0466
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0068
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0365 0.1399
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0371 0.2 0.4875
Loa Loa (eye worm) RNA binding protein 0.0065 0.0263 0.0744
Brugia malayi CXXC zinc finger family protein 0.0152 0.0755 0.2809
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0087 0.0567
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0174 0.0174
Schistosoma mansoni chromobox protein 0.0023 0.0024 0.0059
Schistosoma mansoni Smad4 0.0034 0.0082 0.02
Schistosoma mansoni hypothetical protein 0.0023 0.0024 0.0059
Onchocerca volvulus 0.0025 0.0034 0.0082
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.01 0.0648
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0034 0.0084 0.0205
Trichomonas vaginalis helicase, putative 0.0034 0.0087 0.0567
Schistosoma mansoni hypothetical protein 0.074 0.4102 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0138 0.0678 0.1652
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0263 0.0641
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0099 0.0281
Loa Loa (eye worm) acetyltransferase 0.0154 0.0766 0.2167
Brugia malayi Pre-SET motif family protein 0.0209 0.1081 0.4022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0371 0.2 0.2
Brugia malayi PHD-finger family protein 0.0037 0.0102 0.0379
Echinococcus granulosus chromobox protein 1 0.0143 0.0702 0.1711
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0124 0.0805
Brugia malayi Pre-SET motif family protein 0.0033 0.0078 0.0291
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0097
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.1536 1
Echinococcus multilocularis expressed conserved protein 0.0098 0.0448 0.0448
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0365 0.1399
Loa Loa (eye worm) hypothetical protein 0.005 0.0174 0.0493
Toxoplasma gondii exonuclease III APE 0.0062 0.0244 0.1551
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0143 0.131
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0198 0.1816
Mycobacterium ulcerans hypothetical protein 0.0075 0.0317 0.4569
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0158 0.1029
Echinococcus multilocularis importin subunit beta 1 0.006 0.0233 0.0233
Echinococcus multilocularis protein dispatched 1 0.0051 0.0182 0.0182
Onchocerca volvulus 0.0075 0.0317 0.2407
Schistosoma mansoni smad1 5 8 and 0.0034 0.0082 0.02
Brugia malayi TAR-binding protein 0.0065 0.0263 0.0977
Trichomonas vaginalis chromobox protein, putative 0.0086 0.038 0.2476
Schistosoma mansoni hypothetical protein 0.074 0.4102 1
Schistosoma mansoni ap endonuclease 0.0062 0.0244 0.0596
Entamoeba histolytica Ran family GTPase 0.0044 0.0143 0.0928
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0024 0.009
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0146 0.0355
Plasmodium vivax importin-beta 2, putative 0.006 0.0233 0.7108
Brugia malayi PHD-finger family protein 0.0059 0.0227 0.0846
Onchocerca volvulus 0.0063 0.0248 0.1834
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0227 0.0554
Toxoplasma gondii histone lysine methyltransferase SET1 0.0295 0.1568 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0099 0.0281
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0029 0.0029
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0029 0.019
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0317 0.1215
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0024 0.0059
Brugia malayi Bromodomain containing protein 0.0087 0.0384 0.1427
Loa Loa (eye worm) hypothetical protein 0.0075 0.0317 0.0898
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.1536 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0034 0.0491
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0418 0.1601
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0031 0.0067 0.0067
Brugia malayi chromobox protein homolog 3 0.008 0.0346 0.1286
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.0738 0.18
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0094 0.0228
Schistosoma mansoni inositol monophosphatase 0.0037 0.01 0.0243
Echinococcus granulosus smad 0.0034 0.0082 0.02
Schistosoma mansoni hypothetical protein 0.0064 0.0255 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0024 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0143 0.0702 0.4571
Echinococcus multilocularis chromobox protein 1 0.0143 0.0702 0.0702
Echinococcus multilocularis cpg binding protein 0.0162 0.0815 0.0815
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.022 0.1431
Schistosoma mansoni jumonji/arid domain-containing protein 0.0082 0.0358 0.0873
Brugia malayi MH1 domain containing protein 0.0034 0.0082 0.0305
Brugia malayi Protein cec-1. 0.0023 0.0024 0.009
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0198 0.8057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0317 0.1215
Brugia malayi hypothetical protein 0.0122 0.0584 0.2172
Echinococcus multilocularis Smad4 0.0034 0.0082 0.0082
Mycobacterium ulcerans lipase LipD 0.0075 0.0317 0.4569
Echinococcus multilocularis geminin 0.074 0.4102 0.4102
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0143 0.053
Schistosoma mansoni hypothetical protein 0.0024 0.0029 0.007
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0317 0.1215
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0029 0.0421
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0029 0.0269
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0029 0.0269
Trichomonas vaginalis hypothetical protein 0.0023 0.0024 0.0157
Mycobacterium leprae Probable lipase LipE 0.0075 0.0317 0.4289
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0371 0.2 0.566
Loa Loa (eye worm) transcription factor SMAD2 0.0492 0.2688 0.7607
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0029 0.0054 0.2074
Loa Loa (eye worm) heterochromatin protein 1 0.0143 0.0702 0.1987
Brugia malayi beta-lactamase family protein 0.0075 0.0317 0.1181
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0298 0.0298
Echinococcus multilocularis tyrosine protein kinase shark 0.0436 0.2369 0.2369
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.1041 0.2947
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0263 0.0641
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.0738 0.0738
Echinococcus granulosus snurportin 1 0.064 0.3533 0.8614
Schistosoma mansoni hypothetical protein 0.0122 0.0584 0.1423
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0078 0.066
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0317 0.0774
Brugia malayi PHD-finger family protein 0.003 0.0061 0.0228
Schistosoma mansoni chromobox protein 0.0143 0.0702 0.1711
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0099 0.038
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0068
Loa Loa (eye worm) hypothetical protein 0.0055 0.0203 0.0574
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0024 0.0024
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.0766 0.1867
Loa Loa (eye worm) hypothetical protein 0.0044 0.0142 0.0401
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0063 0.0248 0.0701
Onchocerca volvulus 0.0023 0.0024 0.000000057715
Entamoeba histolytica hypothetical protein 0.0122 0.0584 0.3802
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0024 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0174 0.0425
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0695 0.2658
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0317 0.2917
Brugia malayi RNA binding protein 0.0065 0.0263 0.0977
Echinococcus multilocularis chromobox protein 1 0.0143 0.0702 0.0702
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0227 0.1443
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.0766 0.2849
Loa Loa (eye worm) inositol-1 0.0037 0.01 0.0282
Trypanosoma brucei hypothetical protein, conserved 0.021 0.1088 1
Onchocerca volvulus Alhambra homolog 0.0059 0.0227 0.1668
Entamoeba histolytica hypothetical protein 0.0122 0.0584 0.3802
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0087 0.0567
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0082 0.0232
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0678 0.2521
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0158 0.1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0062 0.0244 0.0691
Loa Loa (eye worm) hypothetical protein 0.0064 0.0255 0.0723
Mycobacterium tuberculosis Probable reductase 0.0083 0.0365 0.1399
Brugia malayi Inositol-1 0.0037 0.01 0.037
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0143 0.0143
Echinococcus multilocularis protein patched 0.0045 0.0146 0.0146
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0082 0.0232
Plasmodium falciparum phd finger protein, putative 0.0059 0.0227 0.9296
Echinococcus multilocularis zinc finger protein 0.0032 0.0072 0.0072
Entamoeba histolytica hypothetical protein 0.0023 0.0024 0.0157
Schistosoma mansoni hypothetical protein 0.0043 0.0137 0.0333
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0323 0.1729 0.4216
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0255 0.0723
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0034 0.0491
Schistosoma mansoni hypothetical protein 0.0064 0.0255 0.0622
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1081 0.306
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0086 0.038 0.2923
Giardia lamblia PHD finger protein 15 0.0059 0.0227 0.1481
Leishmania major GTP-binding protein, putative 0.0044 0.0143 0.131
Trichomonas vaginalis chromobox protein, putative 0.0143 0.0702 0.4571
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0317 0.2067
Brugia malayi AF-10 protein 0.0019 0.0001 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0255 0.0255
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.01 0.0648
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0068
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.0728 0.1776
Brugia malayi hypothetical protein 0.0023 0.0024 0.009
Loa Loa (eye worm) beta-lactamase 0.0075 0.0317 0.0898
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0058 0.022 0.1431
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0078 0.0297
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.064 0.3533 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0263 0.0641
Loa Loa (eye worm) hypothetical protein 0.0054 0.0198 0.0559
Mycobacterium tuberculosis Conserved protein 0.0075 0.0317 0.1215
Loa Loa (eye worm) hypothetical protein 0.0075 0.0317 0.0898
Loa Loa (eye worm) hypothetical protein 0.0202 0.1041 0.2947
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0029 0.0071
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0102 0.0102
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0317 0.0317
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.0585 0.1656
Schistosoma mansoni tyrosine kinase 0.0436 0.2369 0.5776
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0034 0.0131
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0255 0.0622
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.022 0.1431
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0031 0.0067 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0087 0.0567
Entamoeba histolytica hypothetical protein 0.0122 0.0584 0.3802

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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