Detailed information for compound 1294403

Basic information

Technical information
  • TDR Targets ID: 1294403
  • Name: [(4S,6R)-4-cyclohexyl-6-[[4-(hydroxymethyl)ph enyl]methoxy]-5,6-dihydro-4H-pyran-2-yl]-morp holin-4-ylmethanone
  • MW: 415.523 | Formula: C24H33NO5
  • H donors: 1 H acceptors: 2 LogP: 3.61 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1ccc(cc1)CO[C@H]1C[C@H](C=C(O1)C(=O)N1CCOCC1)C1CCCCC1
  • InChi: 1S/C24H33NO5/c26-16-18-6-8-19(9-7-18)17-29-23-15-21(20-4-2-1-3-5-20)14-22(30-23)24(27)25-10-12-28-13-11-25/h6-9,14,20-21,23,26H,1-5,10-13,15-17H2/t21-,23+/m0/s1
  • InChiKey: QEJWIHNSEFSFMH-JTHBVZDNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(4S,6R)-4-cyclohexyl-6-[[4-(hydroxymethyl)phenyl]methoxy]-5,6-dihydro-4H-pyran-2-yl]-morpholino-methanone
  • [(4S,6R)-4-cyclohexyl-6-[[4-(hydroxymethyl)phenyl]methoxy]-5,6-dihydro-4H-pyran-2-yl]-morpholinomethanone
  • [(4S,6R)-4-cyclohexyl-6-(4-methylolbenzyl)oxy-5,6-dihydro-4H-pyran-2-yl]-morpholino-methanone
  • [(4S,6R)-4-cyclohexyl-6-[[4-(hydroxymethyl)phenyl]methoxy]-5,6-dihydro-4H-pyran-2-yl]-morpholin-4-yl-methanone
  • ((2R,4S)-4-cyclohexyl-2-(4-(hydroxymethyl)benzyloxy)-3,4-dihydro-2H-pyran-6-yl)(morpholino)methanone
  • MLS000834369
  • SMR000389675

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0106 0.0375
Entamoeba histolytica cysteine protease, putative 0.0048 0.0106 0.1115
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0099 0.0256
Echinococcus multilocularis cpg binding protein 0.0039 0.0069 0.0069
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0113 0.0397
Schistosoma mansoni hypothetical protein 0.03 0.1119 0.3943
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.006 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0052 0.0544
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.021 0.0739
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0614 0.2376 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0106 0.0375
Loa Loa (eye worm) hypothetical protein 0.0077 0.0224 0.0943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0048 0.0106 0.0375
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.006 0.006
Giardia lamblia Cathepsin B precursor 0.0048 0.0106 0.2018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0106 0.1115
Echinococcus granulosus JmjC domain containing protein 4 0.0049 0.0112 0.0204
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0117 0.0167
Brugia malayi hypothetical protein 0.0155 0.0536 0.2255
Brugia malayi MH2 domain containing protein 0.0034 0.005 0.0209
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0374 0.0565
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0099 0.018
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0106 0.0375
Leishmania major cathepsin L-like protease 0.0259 0.0954 0.2462
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.014 0.0254
Loa Loa (eye worm) MH2 domain-containing protein 0.0495 0.1899 0.7992
Brugia malayi Cathepsin L-like precursor 0.0086 0.0258 0.1087
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0255 0.0938 0.3947
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1896 0.1896
Brugia malayi Bromodomain containing protein 0.0159 0.0551 0.2319
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.006 0.0624
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0116 0.0299
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0112 0.0472
Onchocerca volvulus 0.0255 0.0938 0.9825
Onchocerca volvulus Alhambra homolog 0.0153 0.0527 0.5477
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0049 0.0112 0.1176
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0224 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0099 0.0256
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0099 0.104
Echinococcus granulosus beta LACTamase domain containing family member 0.0255 0.0938 0.1704
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0048 0.0106 0.1115
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0054 0.0226
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0099 0.104
Loa Loa (eye worm) hypothetical protein 0.0255 0.0938 0.3947
Echinococcus granulosus jumonji domain containing protein 0.0213 0.0767 0.1394
Plasmodium falciparum serine repeat antigen 3 0.0048 0.0106 0.1115
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0448
Toxoplasma gondii histone lysine methyltransferase SET1 0.0072 0.0202 0.2116
Trichomonas vaginalis D-aminoacylase, putative 0.0255 0.0938 0.9827
Toxoplasma gondii cathepsin CPC1 0.0048 0.0106 0.1115
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.001 0.0105
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0098 0.1026
Brugia malayi CHE-14 protein 0.0042 0.0085 0.0357
Giardia lamblia Cathepsin B precursor 0.0048 0.0106 0.2018
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.0695 0.0695
Giardia lamblia Cysteine protease 0.0048 0.0106 0.2018
Loa Loa (eye worm) Smad1 0.0034 0.005 0.0209
Echinococcus granulosus cathepsin l1 0.0174 0.0611 0.111
Brugia malayi Bromodomain containing protein 0.0079 0.0232 0.0976
Leishmania major importin beta-1 subunit, putative 0.0023 0.0009 0.0022
Mycobacterium ulcerans esterase/lipase LipP 0.0255 0.0938 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0374 0.0565
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0106 0.0448
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0224 0.079
Trypanosoma cruzi cysteine peptidase, putative 0.0988 0.3876 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0113 0.0397
Schistosoma mansoni jumonji domain containing protein 0.0049 0.0112 0.0396
Plasmodium vivax serine-repeat antigen (SERA) 0.0048 0.0106 0.1115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0474
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0048 0.0106 0.0375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1
Schistosoma mansoni cpg binding protein 0.0039 0.0069 0.0244
Loa Loa (eye worm) hypothetical protein 0.0056 0.014 0.0589
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0259 0.0954 1
Echinococcus multilocularis jumonji domain containing 1A 0.0049 0.0112 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0173 0.0611
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.005 0.0209
Echinococcus granulosus peregrin 0.0159 0.0551 0.1001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0061 0.0644
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0062 0.0159
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0328 0.3437
Echinococcus granulosus cathepsin b 0.0048 0.0106 0.0193
Schistosoma mansoni cpg binding protein 0.0035 0.0054 0.0189
Giardia lamblia Cathepsin B precursor 0.0048 0.0106 0.2018
Echinococcus multilocularis expressed conserved protein 0.0093 0.0287 0.0287
Brugia malayi Cathepsin L-like precursor 0.0259 0.0954 0.4016
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0085 0.0888
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0481 0.0481
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0311 0.326
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0048 0.0106 0.0375
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0106 0.0375
Plasmodium vivax hypothetical protein, conserved 0.0255 0.0938 0.9827
Brugia malayi MH2 domain containing protein 0.0034 0.005 0.0209
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0085 0.0085
Plasmodium vivax unspecified product 0.0134 0.045 0.4717
Loa Loa (eye worm) hypothetical protein 0.0259 0.0954 0.4016
Schistosoma mansoni cathepsin C 0.0048 0.0106 0.0375
Brugia malayi fibroinase precursor 0.0048 0.0106 0.0448
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0275
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0048 0.0106 0.0375
Toxoplasma gondii ABC1 family protein 0.0255 0.0938 0.9827
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Plasmodium vivax glutathione reductase, putative 0.005 0.0116 0.1213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0014 0.0148
Loa Loa (eye worm) hypothetical protein 0.0153 0.0527 0.2219
Brugia malayi glutathione reductase 0.005 0.0116 0.0487
Schistosoma mansoni Smad4 0.0034 0.005 0.0175
Echinococcus multilocularis smad 0.0034 0.005 0.005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0194 0.0693 0.126
Plasmodium falciparum glutathione reductase 0.005 0.0116 0.1213
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0048 0.0106 0.1115
Echinococcus granulosus cathepsin L 0.0134 0.045 0.0818
Entamoeba histolytica cysteine protease, putative 0.0048 0.0106 0.1115
Trypanosoma cruzi cruzipain precursor, putative 0.0988 0.3876 1
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0074 0.0777
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0258 0.0666
Onchocerca volvulus 0.0155 0.0536 0.5568
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0048 0.0106 0.1115
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0052 0.0544
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0024 0.025
Plasmodium falciparum thioredoxin reductase 0.005 0.0116 0.1213
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0113 0.0113
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0112 0.0472
Mycobacterium tuberculosis Conserved protein 0.0255 0.0938 0.144
Plasmodium falciparum cysteine proteinase falcipain 3 0.0259 0.0954 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0134 0.045 0.1587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0014 0.015
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0056 0.0101
Schistosoma mansoni jumonji/arid domain-containing protein 0.0189 0.0672 0.2368
Schistosoma mansoni cathepsin S (C01 family) 0.0048 0.0106 0.0375
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0098 0.0178
Loa Loa (eye worm) latrophilin receptor protein 2 0.0194 0.0693 0.2918
Trypanosoma cruzi cysteine peptidase, putative 0.0988 0.3876 1
Brugia malayi mbt repeat family protein 0.0049 0.0113 0.0474
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.005 0.0115 0.1203
Giardia lamblia Cathepsin B precursor 0.0048 0.0106 0.2018
Loa Loa (eye worm) hypothetical protein 0.0069 0.0193 0.081
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0172 0.0172
Mycobacterium leprae conserved hypothetical protein 0.0255 0.0938 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0048 0.0106 0.1115
Brugia malayi CXXC zinc finger family protein 0.0035 0.0054 0.0226
Plasmodium falciparum serine repeat antigen 9 0.0048 0.0106 0.1115
Brugia malayi jmjC domain containing protein 0.0049 0.0112 0.0472
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0062 0.0159
Toxoplasma gondii hypothetical protein 0.0027 0.0021 0.0221
Schistosoma mansoni smad1 5 8 and 0.0034 0.005 0.0175
Trichomonas vaginalis esterase, putative 0.0255 0.0938 0.9827
Echinococcus granulosus PHD finger protein rhinoceros 0.0153 0.0527 0.0958
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0117 0.0213
Trypanosoma cruzi cysteine proteinase, putative 0.0134 0.045 0.1161
Echinococcus granulosus lysine specific demethylase 6a 0.0049 0.0112 0.0204
Plasmodium falciparum serine repeat antigen 8 0.0048 0.0106 0.1115
Echinococcus multilocularis Smad4 0.0034 0.005 0.005
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0429 0.0779
Echinococcus granulosus cathepsin l cysteine peptidase 0.0259 0.0954 0.1734
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0259 0.0954 1
Brugia malayi MH1 domain containing protein 0.0034 0.005 0.0209
Schistosoma mansoni lamin 0.0193 0.0688 0.2426
Schistosoma mansoni transcription factor LCR-F1 0.0186 0.0659 0.2323
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0002 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0255 0.0938 0.3306
Schistosoma mansoni bromodomain containing protein 0.0068 0.0186 0.0655
Plasmodium falciparum cysteine proteinase falcipain 1 0.0134 0.045 0.4717
Giardia lamblia Cathepsin B precursor 0.0048 0.0106 0.2018
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Brugia malayi Calcitonin receptor-like protein seb-1 0.0614 0.2376 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0048 0.0106 0.2018
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0106 0.0375
Schistosoma mansoni hypothetical protein 0.0194 0.0693 0.2444
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.006 0.0624
Loa Loa (eye worm) RNA binding protein 0.0065 0.0173 0.0729
Entamoeba histolytica hypothetical protein 0.0186 0.0659 0.6905
Loa Loa (eye worm) hypothetical protein 0.0054 0.013 0.0548
Brugia malayi PHD-finger family protein 0.003 0.0035 0.0147
Loa Loa (eye worm) hypothetical protein 0.0255 0.0938 0.3947
Echinococcus multilocularis jumonji domain containing protein 0.0213 0.0767 0.0767
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.006 0.0624
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0259 0.0954 0.4016
Schistosoma mansoni cathepsin s 0.0086 0.0258 0.0911
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.005 0.0115 0.0296
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0113 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0072 0.0757
Loa Loa (eye worm) hypothetical protein 0.0204 0.0732 0.3082
Trichomonas vaginalis penicillin-binding protein, putative 0.0255 0.0938 0.9827
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0194 0.0693 0.126
Onchocerca volvulus 0.0255 0.0938 0.9825
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0099 0.0418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0259 0.0954 1
Toxoplasma gondii cathepsin B 0.0048 0.0106 0.1115
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0103 0.0329 0.1385
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.005 0.009
Echinococcus granulosus cathepsin L cysteine protease 0.0134 0.045 0.0818
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0614 0.2376 1
Schistosoma mansoni thyroid hormone receptor 0.0138 0.047 0.1657
Echinococcus multilocularis thyroid hormone receptor alpha 0.0138 0.047 0.047
Plasmodium vivax ataxin-2 like protein, putative 0.0103 0.0328 0.3437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0259 0.0954 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0328 0.0846
Onchocerca volvulus 0.0259 0.0954 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0174 0.0611 0.257
Loa Loa (eye worm) transcription factor SMAD2 0.0495 0.1899 0.7992
Onchocerca volvulus Cathepsin L homolog 0.0259 0.0954 1
Brugia malayi jmjC domain containing protein 0.05 0.1921 0.8085
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0255 0.0938 1
Schistosoma mansoni zinc finger protein 0.0025 0.0014 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0052 0.0544
Plasmodium vivax vivapain-3 0.0134 0.045 0.4717
Schistosoma mansoni hypothetical protein 0.0194 0.0693 0.2444
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.014 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0025 0.0261
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.045 0.4717
Echinococcus granulosus phd:f box containing protein 0.0049 0.0112 0.0204
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0448
Leishmania major hypothetical protein, conserved 0.0255 0.0938 0.2419
Trypanosoma brucei hypothetical protein, conserved 0.0255 0.0938 0.2419
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0374 0.0565
Brugia malayi Cathepsin L-like precursor 0.0259 0.0954 0.4016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0099 0.0418
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0048 0.0106 0.0448
Trypanosoma brucei PAB1-binding protein , putative 0.0103 0.0328 0.0846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0098 0.1026
Loa Loa (eye worm) jmjC domain-containing protein 0.0315 0.118 0.4964
Schistosoma mansoni alpha-glucosidase 0.014 0.0477 0.1682
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.0516 0.2171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0174 0.0611 0.6398
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0568 0.2391
Schistosoma mansoni jumonji domain containing protein 0.0397 0.1509 0.5319
Schistosoma mansoni hypothetical protein 0.0186 0.0659 0.2323
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0009 0.0091
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.0258 0.1087
Leishmania major cathepsin L-like protease 0.0259 0.0954 0.2462
Echinococcus multilocularis cysteine protease 0.0259 0.0954 0.0954
Loa Loa (eye worm) fibroinase 0.0259 0.0954 0.4016
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0052 0.0123 0.1291
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0011 0.0039
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0049 0.0112 0.1176
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0448
Brugia malayi cathepsin F-like cysteine proteinase 0.0048 0.0106 0.0448
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0085 0.0154
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0053 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.009 0.0274 0.1152
Giardia lamblia Cathepsin L-like protease 0.0048 0.0106 0.2018
Loa Loa (eye worm) hypothetical protein 0.0155 0.0536 0.2255
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0123 0.1291
Schistosoma mansoni hypothetical protein 0.0128 0.0429 0.1512
Onchocerca volvulus Cathepsin F homolog 0.0259 0.0954 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0106 0.1115
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0255 0.0938 0.3306
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0011 0.0011
Brugia malayi cathepsin Z-like cysteine proteinase 0.0048 0.0106 0.0448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0025 0.0261
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0224 0.0407
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0134 0.045 0.1587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0052 0.0544
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.005 0.009
Brugia malayi cathepsin L-like precursor 0.0174 0.0611 0.257
Loa Loa (eye worm) hypothetical protein 0.0194 0.0693 0.2918
Schistosoma mansoni hypothetical protein 0.0041 0.0079 0.0277
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0448
Echinococcus multilocularis lamin 0.0193 0.0688 0.0688
Leishmania major hypothetical protein, conserved 0.0049 0.0112 0.029
Onchocerca volvulus 0.0255 0.0938 0.9825
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0173 0.0729
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0009 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0106 0.1115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0186 0.0659 0.0659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0258 0.1087
Brugia malayi jmjC domain containing protein 0.0049 0.0112 0.0472
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.005 0.0209
Giardia lamblia Cathepsin L precursor 0.0048 0.0106 0.2018
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.01 0.01
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0425 0.0644
Brugia malayi mbt repeat family protein 0.0049 0.0113 0.0474
Loa Loa (eye worm) hypothetical protein 0.0042 0.0085 0.0357
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1896 0.3446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0099 0.104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.014 0.0589
Mycobacterium tuberculosis Conserved protein 0.0255 0.0938 0.144
Entamoeba histolytica cysteine protease, putative 0.0259 0.0954 1
Schistosoma mansoni phd/f-box containing protein 0.0049 0.0112 0.0396
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0116 0.1213
Echinococcus granulosus cathepsin L 0.0048 0.0106 0.0193
Brugia malayi cathepsin L precursor 0.0048 0.0106 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.045 0.4717
Echinococcus multilocularis musashi 0.0193 0.0688 0.0688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0014 0.015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0153 0.0527 0.1859
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0481 0.0875
Trypanosoma cruzi hypothetical protein, conserved 0.0255 0.0938 0.2419
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0374 0.0565
Schistosoma mansoni hypothetical protein 0.0728 0.2836 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0174 0.0611 0.257
Brugia malayi hypothetical protein 0.0103 0.0328 0.1381
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0224 0.2306
Giardia lamblia Cathepsin L precursor 0.0048 0.0106 0.2018
Mycobacterium leprae Probable lipase LipE 0.0255 0.0938 1
Loa Loa (eye worm) glutathione reductase 0.005 0.0116 0.0487
Loa Loa (eye worm) hypothetical protein 0.0255 0.0938 0.3947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0099 0.104
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0093 0.0288 0.0523
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0224 0.2347
Brugia malayi Cathepsin L-like precursor 0.0174 0.0611 0.257
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0106 0.1115
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0021 0.0221
Toxoplasma gondii LsmAD domain-containing protein 0.0103 0.0328 0.3437
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0134 0.045 0.1587
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.006 0.0154
Giardia lamblia Cathepsin L precursor 0.0048 0.0106 0.2018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Entamoeba histolytica cysteine proteinase, putative 0.0174 0.0611 0.6398
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Plasmodium falciparum importin beta, putative 0.0029 0.0031 0.0321
Brugia malayi Importin beta-1 subunit 0.0029 0.0031 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0174 0.0611 0.6398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0259 0.0954 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.001 0.0105
Echinococcus granulosus cathepsin L cysteine proteinase 0.0259 0.0954 0.1734
Loa Loa (eye worm) MBCTL1 0.0056 0.014 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0106 0.1115
Echinococcus granulosus snurportin 1 0.0309 0.1155 0.2098
Brugia malayi Cathepsin L-like precursor 0.0174 0.0611 0.257
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0048 0.0106 0.0274
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.0516 0.1819
Giardia lamblia Cathepsin B precursor 0.0048 0.0106 0.2018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0056 0.0056
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0048 0.0106 0.2018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0106 0.1115
Brugia malayi beta-lactamase 0.0255 0.0938 0.3947
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.006 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0061 0.0644
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.045 0.4717
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0009 0.0022
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.05 0.1921 0.3492
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0048 0.0106 0.1115
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0021 0.012
Echinococcus multilocularis GPCR, family 2 0.0194 0.0693 0.0693
Entamoeba histolytica hypothetical protein 0.0048 0.0106 0.1115
Schistosoma mansoni hypothetical protein 0.0194 0.0693 0.2444
Loa Loa (eye worm) acetyltransferase 0.015 0.0516 0.2171
Trichomonas vaginalis D-aminoacylase, putative 0.0255 0.0938 0.9827
Loa Loa (eye worm) hypothetical protein 0.0049 0.0112 0.0472
Loa Loa (eye worm) hypothetical protein 0.0103 0.0328 0.1381
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0048 0.0106 0.1115
Plasmodium falciparum serine repeat antigen 5 0.0048 0.0106 0.1115
Brugia malayi jmjC domain containing protein 0.0189 0.0672 0.2826
Brugia malayi Cathepsin L-like precursor 0.0259 0.0954 0.4016
Schistosoma mansoni patched 1 0.0042 0.0085 0.0299
Echinococcus granulosus expressed conserved protein 0.0093 0.0287 0.0522
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0098 0.1026
Mycobacterium ulcerans lipase LipD 0.0255 0.0938 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0288 0.1212
Onchocerca volvulus Cathepsin L homolog 0.0048 0.0106 0.1021
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.0954 1
Echinococcus multilocularis geminin 0.0728 0.2836 0.2836
Schistosoma mansoni lamin 0.0193 0.0688 0.2426
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0117 0.0117
Giardia lamblia Cathepsin B precursor 0.0048 0.0106 0.2018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0052 0.0544
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Plasmodium vivax vivapain-2 0.0259 0.0954 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0274 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0061 0.0644
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.006 0.0624
Echinococcus multilocularis cathepsin L 0.0048 0.0106 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0106 0.1115
Schistosoma mansoni thyroid hormone receptor 0.0138 0.047 0.1657
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0048 0.0106 0.2018
Plasmodium falciparum serine repeat antigen 4 0.0048 0.0106 0.1115
Trypanosoma cruzi cysteine protease, putative 0.0134 0.045 0.1161
Schistosoma mansoni hypothetical protein 0.0041 0.0079 0.0277
Brugia malayi cathepsin Z-like cysteine proteinase 0.0048 0.0106 0.0448
Brugia malayi beta-lactamase family protein 0.0255 0.0938 0.3947
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.001 0.0105
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0049 0.0112 0.029
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0048 0.0106 0.2018
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.006 0.0154
Loa Loa (eye worm) PHD-finger family protein 0.0153 0.0527 0.2219
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0259 0.0954 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0224 0.2347
Schistosoma mansoni jumonji/arid domain-containing protein 0.0189 0.0672 0.2368
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.045 0.4717
Echinococcus multilocularis cathepsin b 0.0048 0.0106 0.0106
Plasmodium vivax serine-repeat antigen (SERA) 0.0048 0.0106 0.1115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0255 0.0938 0.9827
Schistosoma mansoni cathepsin B (C01 family) 0.0048 0.0106 0.0375
Schistosoma mansoni hypothetical protein 0.0419 0.1597 0.5631
Schistosoma mansoni intermediate filament proteins 0.0193 0.0688 0.2426
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.0042
Toxoplasma gondii thioredoxin reductase 0.005 0.0116 0.1213
Giardia lamblia PHD finger protein 15 0.0153 0.0527 1
Giardia lamblia Cysteine protease 0.0048 0.0106 0.2018
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0106 0.0375
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0429 0.0429
Brugia malayi RNA binding protein 0.0065 0.0173 0.0729
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0048 0.0106 0.1115
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.0954 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0106 0.1115
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0086 0.0258 0.1087
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0425 0.4472
Giardia lamblia Hypothetical protein 0.0048 0.0106 0.2018
Loa Loa (eye worm) hypothetical protein 0.0174 0.0611 0.257
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0134 0.045 0.1161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0259 0.0954 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0189 0.0672 0.2826
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0031 0.0321
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.014 0.0494
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.014 0.0254
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0224 0.2347
Loa Loa (eye worm) hypothetical protein 0.0419 0.1597 0.6722
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.0042
Loa Loa (eye worm) cysteine protease 0.0259 0.0954 0.4016
Onchocerca volvulus 0.0259 0.0954 1
Schistosoma mansoni hypothetical protein 0.0153 0.0527 0.1859
Schistosoma mansoni hypothetical protein 0.0041 0.0079 0.0277
Echinococcus multilocularis PHD finger protein rhinoceros 0.0153 0.0527 0.0527
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0193 0.0688 0.2896
Loa Loa (eye worm) ctsf protein 0.0259 0.0954 0.4016
Mycobacterium tuberculosis Probable lipase LipE 0.0255 0.0938 0.144
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0048 0.0106 0.1115
Schistosoma mansoni smad1 5 8 and 0.0034 0.005 0.0175
Entamoeba histolytica hypothetical protein 0.0186 0.0659 0.6905
Brugia malayi F/Y-rich N-terminus family protein 0.0062 0.0165 0.0693
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Brugia malayi Cathepsin L-like precursor 0.0259 0.0954 0.4016
Brugia malayi jmjC domain containing protein 0.0049 0.0112 0.0472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0106 0.1115
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0106 0.0375
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0425 0.0644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.045 0.1161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0224 0.5
Trypanosoma brucei cysteine peptidase C (CPC) 0.0048 0.0106 0.0274
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0099 0.0256
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0259 0.0954 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0172 0.0312
Trypanosoma brucei trypanothione reductase 0.005 0.0116 0.0299
Schistosoma mansoni alpha-glucosidase 0.014 0.0477 0.1682
Brugia malayi Intermediate filament tail domain containing protein 0.0193 0.0688 0.2896
Entamoeba histolytica cysteine protease, putative 0.0048 0.0106 0.1115
Giardia lamblia Cysteine protease 0.0048 0.0106 0.2018
Mycobacterium ulcerans hypothetical protein 0.0255 0.0938 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1
Leishmania major cysteine peptidase A (CPA) 0.0259 0.0954 0.2462
Plasmodium vivax JmjC domain containing protein 0.0049 0.0112 0.1176
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.0112 0.029
Brugia malayi RNA, U transporter 1 0.0082 0.0245 0.103
Echinococcus multilocularis beta LACTamase domain containing family member 0.0255 0.0938 0.0938
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.045 0.4717
Echinococcus multilocularis snurportin 1 0.0309 0.1155 0.1155
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0255 0.0938 0.3947
Loa Loa (eye worm) hypothetical protein 0.0193 0.0688 0.2896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0099 0.104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.005 0.0115 0.0296
Echinococcus granulosus zinc finger protein 0.0025 0.0014 0.0025
Entamoeba histolytica cysteine protease, putative 0.0048 0.0106 0.1115
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0048 0.0106 0.1115
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.0516 0.0516
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0048 0.0106 0.1115
Schistosoma mansoni cathepsin F (C01 family) 0.0259 0.0954 0.3365
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0194 0.0693 0.0693
Plasmodium falciparum serine repeat antigen 2 0.0048 0.0106 0.1115
Brugia malayi intermediate filament protein 0.0193 0.0688 0.2896
Giardia lamblia Encystation-specific protease 0.0048 0.0106 0.2018
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.0042
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0448
Mycobacterium tuberculosis Probable lipase LipD 0.0255 0.0938 0.144
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0328 0.3437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0259 0.0954 1
Entamoeba histolytica cysteine protease, putative 0.0048 0.0106 0.1115
Echinococcus multilocularis lamin dm0 0.0193 0.0688 0.0688
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0112 0.0472
Toxoplasma gondii PHD-finger domain-containing protein 0.0153 0.0527 0.5524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0014 0.015
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.1155 0.4859
Onchocerca volvulus 0.0259 0.0954 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0048 0.0106 0.1115
Echinococcus granulosus lysine specific demethylase 5A 0.0189 0.0672 0.122
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.001 0.0026
Giardia lamblia GTOR 0.0046 0.0099 0.1883
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0074 0.0777
Schistosoma mansoni hypothetical protein 0.0728 0.2836 1
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0074 0.1406
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0328 0.0846
Brugia malayi Probable ClpP-like protease 0.0077 0.0224 0.0943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0258 0.1087
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0098 0.1026
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0255 0.0938 0.144
Leishmania major trypanothione reductase 0.005 0.0116 0.0299
Toxoplasma gondii preprocathepsin c precursor, putative 0.0048 0.0106 0.1115
Leishmania major cathepsin L-like protease 0.0259 0.0954 0.2462
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.05 0.1921 0.1921
Plasmodium falciparum JmjC domain-containing protein, putative 0.0049 0.0112 0.1176
Mycobacterium tuberculosis Probable esterase LipL 0.0255 0.0938 0.144
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.005 0.005
Onchocerca volvulus 0.0259 0.0954 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0099 0.0256
Onchocerca volvulus 0.0048 0.0106 0.1021
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.0112 0.029
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0113 0.0474
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0224 0.2306
Plasmodium vivax hypothetical protein, conserved 0.0153 0.0527 0.5524
Echinococcus granulosus geminin 0.0728 0.2836 0.5155
Onchocerca volvulus 0.0204 0.0732 0.765
Entamoeba histolytica hypothetical protein 0.0186 0.0659 0.6905
Brugia malayi PHD-finger family protein 0.0153 0.0527 0.2219
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0568 0.2391
Entamoeba histolytica cysteine proteinase 1, putative 0.0134 0.045 0.4717
Brugia malayi MH1 domain containing protein 0.0034 0.005 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0106 0.1115
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0173 0.0611
Mycobacterium tuberculosis Probable reductase 0.0114 0.0374 0.0565
Brugia malayi cathepsin L-like cysteine proteinase 0.0048 0.0106 0.0448
Onchocerca volvulus 0.0174 0.0611 0.636
Leishmania major cathepsin L-like protease 0.0259 0.0954 0.2462
Mycobacterium tuberculosis Possible penicillin-binding protein 0.163 0.6452 1
Onchocerca volvulus 0.0193 0.0688 0.7182
Entamoeba histolytica cysteine proteinase 2 0.0134 0.045 0.4717
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0568 0.0568
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.006 0.0624
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0255 0.0938 0.144
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.006 0.0624
Brugia malayi Papain family cysteine protease containing protein 0.0134 0.045 0.1895
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0052 0.0544
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0194 0.0693 0.0693
Brugia malayi cytoplasmic intermediate filament protein 0.0103 0.0329 0.1385
Schistosoma mansoni cathepsin F (C01 family) 0.0174 0.0611 0.2153
Brugia malayi AMP-binding enzyme family protein 0.0024 0.001 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0106 0.1115
Giardia lamblia Cathepsin L precursor 0.0048 0.0106 0.2018
Echinococcus granulosus cysteine protease 0.0134 0.045 0.0818
Loa Loa (eye worm) hypothetical protein 0.0614 0.2376 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.001 0.0026
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0116 0.0487
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0049 0.0112 0.0396
Onchocerca volvulus 0.0259 0.0954 1
Onchocerca volvulus 0.0259 0.0954 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0129
Entamoeba histolytica cysteine protease, putative 0.0048 0.0106 0.1115
Brugia malayi Smad1 0.0034 0.005 0.0209
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0106 0.0375
Brugia malayi Thioredoxin reductase 0.005 0.0116 0.0487
Loa Loa (eye worm) hypothetical protein 0.0255 0.0938 0.3947
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.006 0.0251
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0117 0.1157
Giardia lamblia Hypothetical protein 0.0048 0.0106 0.2018
Schistosoma mansoni importin beta-1 0.0029 0.0031 0.0108
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0259 0.0954 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0034 0.0361
Loa Loa (eye worm) hypothetical protein 0.0262 0.0965 0.4061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Leishmania major cathepsin L-like protease 0.0988 0.3876 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0014 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0025 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0038 0.0403
Echinococcus granulosus GPCR family 2 0.0194 0.0693 0.126
Brugia malayi Latrophilin receptor protein 2 0.0194 0.0693 0.2918
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.006 0.0624
Brugia malayi Bromodomain containing protein 0.0041 0.008 0.0335
Toxoplasma gondii PHD-finger domain-containing protein 0.005 0.0115 0.1203
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0011 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1
Trypanosoma brucei glucosidase, putative 0.0036 0.006 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0255 0.0938 0.2419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Echinococcus multilocularis phd:f box containing protein 0.0049 0.0112 0.0112
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0113 0.0205
Trypanosoma cruzi major cysteine proteinase, putative 0.0776 0.3028 0.7812
Loa Loa (eye worm) hypothetical protein 0.0255 0.0938 0.3947
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0374 0.0565
Onchocerca volvulus 0.0049 0.0113 0.1086
Echinococcus multilocularis tumor protein p63 0.1393 0.5502 0.5502
Mycobacterium tuberculosis Conserved protein 0.0255 0.0938 0.144
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0031 0.0079
Schistosoma mansoni phosphatidylserine receptor 0.0049 0.0112 0.0396
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0113 0.1086
Mycobacterium tuberculosis Probable hydrolase 0.0255 0.0938 0.144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Echinococcus granulosus cathepsin b 0.0048 0.0106 0.0193
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0173 0.0729
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0173 0.0729
Schistosoma mansoni cellular tumor antigen P53 0.0204 0.0732 0.2582
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0106 0.0448
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0259 0.0954 0.4016
Echinococcus multilocularis cathepsin L cysteine protease 0.0259 0.0954 0.0954
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.049 0.0891
Echinococcus multilocularis cathepsin L cysteine protease 0.0259 0.0954 0.0954
Echinococcus granulosus cpg binding protein 0.0039 0.0069 0.0126
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0255 0.0938 0.144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0106 0.1115
Brugia malayi hypothetical protein 0.0186 0.0659 0.2773
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.014 0.014
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0048 0.0106 0.0274
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.006 0.0624
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0194 0.0693 0.2918
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.045 0.1161
Echinococcus multilocularis cathepsin L 0.0134 0.045 0.045
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.006 0.0624
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0099 0.0256
Schistosoma mansoni hypothetical protein 0.005 0.0115 0.0405
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0116 0.0164
Echinococcus granulosus lamin 0.0193 0.0688 0.1251
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0048 0.0106 0.0274
Echinococcus granulosus importin subunit beta 1 0.0029 0.0031 0.0056
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0173 0.0173
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0224 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0014 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0052 0.0544
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0259 0.0954 0.0954
Brugia malayi cathepsin F-like cysteine proteinase 0.0086 0.0258 0.1087
Brugia malayi cathepsin B-like cysteine proteinase 0.0048 0.0106 0.0448
Trichomonas vaginalis D-aminoacylase, putative 0.0255 0.0938 0.9827
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0099 0.0256
Brugia malayi Cathepsin L-like precursor 0.0259 0.0954 0.4016
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0021 0.0221
Schistosoma mansoni cathepsin F (C01 family) 0.0259 0.0954 0.3365
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.045 0.1161
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0116 0.021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0259 0.0954 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0106 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Schistosoma mansoni smad 0.0034 0.005 0.0175
Echinococcus multilocularis protein patched 0.0042 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0052 0.0123 0.0518
Brugia malayi Papain family cysteine protease containing protein 0.0134 0.045 0.1895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0061 0.0644
Onchocerca volvulus Cathepsin L homolog 0.0259 0.0954 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0186 0.0659 0.1198
Giardia lamblia Cathepsin L precursor 0.0048 0.0106 0.2018
Loa Loa (eye worm) hypothetical protein 0.0189 0.0674 0.2837
Plasmodium falciparum serine repeat antigen 6 0.0048 0.0106 0.1115
Leishmania major cathepsin L-like protease 0.0259 0.0954 0.2462
Echinococcus granulosus cathepsin l1 0.0259 0.0954 0.1734
Giardia lamblia Cathepsin L-like protease 0.0048 0.0106 0.2018
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0098 0.1026
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0311 0.0565
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0259 0.0954 0.0954
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.0258 0.0666
Leishmania major cathepsin L-like protease 0.0988 0.3876 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0106 0.0448
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0099 0.035
Schistosoma mansoni hypothetical protein 0.0309 0.1155 0.407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0224 0.2347
Echinococcus granulosus lamin dm0 0.0193 0.0688 0.1251
Brugia malayi Papain family cysteine protease containing protein 0.0259 0.0954 0.4016
Schistosoma mansoni protein phosphatase 2C 0.0049 0.0112 0.0396
Echinococcus granulosus tumor protein p63 0.1393 0.5502 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0053 0.0128 0.0232
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.006 0.0624
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0117 0.0167
Echinococcus multilocularis protein dispatched 1 0.0048 0.0109 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0173 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0106 0.1115
Echinococcus multilocularis JmjC domain containing protein 4 0.0049 0.0112 0.0112
Plasmodium vivax unspecified product 0.0086 0.0258 0.2706
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0048 0.0106 0.1115
Trypanosoma cruzi cysteine proteinase, putative 0.0134 0.045 0.1161
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0149 0.0526
Trypanosoma cruzi cysteine peptidase, putative 0.0259 0.0954 0.2462
Echinococcus multilocularis zinc finger protein 0.0025 0.0014 0.0014
Loa Loa (eye worm) intermediate filament protein 0.0193 0.0688 0.2896
Brugia malayi AMP-binding enzyme family protein 0.0024 0.001 0.0042
Loa Loa (eye worm) cathepsin B 0.0048 0.0106 0.0448
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0085 0.0154
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0902 0.3532 0.9113
Schistosoma mansoni hypothetical protein 0.0041 0.0079 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.001 0.0026
Plasmodium vivax unspecified product 0.0048 0.0106 0.1115
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0048 0.0106 0.1115
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.006 0.0251
Echinococcus granulosus tar DNA binding protein 0.0065 0.0173 0.0315
Loa Loa (eye worm) hypothetical protein 0.0044 0.0089 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0014 0.0148
Brugia malayi TAR-binding protein 0.0065 0.0173 0.0729
Brugia malayi AMP-binding enzyme family protein 0.0024 0.001 0.0042
Echinococcus multilocularis lysine specific demethylase 5A 0.0185 0.0656 0.0656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0052 0.0544
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0048 0.0106 0.1115
Brugia malayi hypothetical protein 0.0067 0.0181 0.0764
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0048 0.0106 0.1115
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.006 0.0154
Loa Loa (eye worm) hypothetical protein 0.0099 0.0311 0.1309
Echinococcus granulosus Smad4 0.0034 0.005 0.009
Echinococcus multilocularis cathepsin b 0.0048 0.0106 0.0106
Plasmodium falciparum serine repeat antigen 1 0.0048 0.0106 0.1115
Toxoplasma gondii cathepsin CPL 0.0259 0.0954 1
Plasmodium falciparum serine repeat antigen 7 0.0048 0.0106 0.1115
Onchocerca volvulus 0.0193 0.0688 0.7182
Schistosoma mansoni hypothetical protein 0.0046 0.01 0.0353
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0031 0.0031
Brugia malayi jmjC domain containing protein 0.0049 0.0112 0.0472
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0568 0.1033
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0224 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0259 0.0954 1
Echinococcus granulosus smad 0.0034 0.005 0.009
Loa Loa (eye worm) beta-lactamase 0.0255 0.0938 0.3947
Schistosoma mansoni hypothetical protein 0.0194 0.0693 0.2444
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0048 0.0106 0.0448
Loa Loa (eye worm) hypothetical protein 0.0049 0.0112 0.0472
Onchocerca volvulus 0.0094 0.0293 0.2993
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0062 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.045 0.4717
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0048 0.0106 0.1115
Echinococcus multilocularis cysteine protease 0.0259 0.0954 0.0954
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0106 0.0375
Brugia malayi Cathepsin L-like precursor 0.0259 0.0954 0.4016
Leishmania major hypothetical protein, conserved 0.0103 0.0328 0.0846
Brugia malayi MH2 domain containing protein 0.0495 0.1899 0.7992
Loa Loa (eye worm) hypothetical protein 0.0086 0.0258 0.1087
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0311 0.1309
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0113 0.0397
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0031 0.0079
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0224 0.2306
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0374 0.392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0954 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0048 0.0106 0.1115
Schistosoma mansoni alpha glucosidase 0.0036 0.006 0.021
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0048 0.0106 0.1115
Echinococcus multilocularis lysine specific demethylase 6a 0.0049 0.0112 0.0112
Echinococcus granulosus jumonji domain containing 1A 0.0049 0.0112 0.0204
Plasmodium vivax importin-beta 2, putative 0.0029 0.0031 0.0321
Entamoeba histolytica cysteine protease, putative 0.0134 0.045 0.4717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0024 0.025
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.0695 0.1263
Schistosoma mansoni hypothetical protein 0.0494 0.1896 0.6684
Entamoeba histolytica hypothetical protein 0.0186 0.0659 0.6905
Giardia lamblia Cysteine protease 0.0048 0.0106 0.2018
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0048 0.0106 0.0375
Toxoplasma gondii cathepsin CPC2 0.0048 0.0106 0.1115
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0093 0.0288 0.0288
Plasmodium falciparum phd finger protein, putative 0.0153 0.0527 0.5524
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0048 0.0106 0.1115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0061 0.0644
Toxoplasma gondii PHD-finger domain-containing protein 0.0153 0.0527 0.5524
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0173 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0259 0.0954 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.01 0.0182
Echinococcus multilocularis peregrin 0.0159 0.0551 0.0551
Giardia lamblia Cathepsin L precursor 0.0048 0.0106 0.2018
Plasmodium vivax vivapain-1 0.0134 0.045 0.4717
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.005 0.0175
Schistosoma mansoni cpg binding protein 0.0039 0.0069 0.0244
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0311 0.0311
Schistosoma mansoni smad1 5 8 and 0.0034 0.005 0.0175
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0009 0.0091
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0085 0.0357
Loa Loa (eye worm) hypothetical protein 0.0174 0.0611 0.257
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0425 0.0644
Plasmodium vivax vivapain-2 0.0259 0.0954 1
Brugia malayi beta-lactamase family protein 0.0255 0.0938 0.3947
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0106 0.1115
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0568 0.0568
Onchocerca volvulus 0.0259 0.0954 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0106 0.1115
Brugia malayi PHD-finger family protein 0.0054 0.013 0.0548
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0448
Entamoeba histolytica hypothetical protein 0.0023 0.0009 0.0091
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0099 0.0099
Leishmania major cathepsin L-like protease 0.0988 0.3876 1
Loa Loa (eye worm) hypothetical protein 0.0255 0.0938 0.3947
Onchocerca volvulus 0.0035 0.0054 0.0462
Giardia lamblia Cathepsin B precursor 0.0048 0.0106 0.2018
Brugia malayi latrophilin 2 splice variant baaae 0.0419 0.1597 0.6722
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0173 0.0611
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0106 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0106 0.1115
Mycobacterium ulcerans beta-lactamase 0.0255 0.0938 1
Brugia malayi AF-10 protein 0.005 0.0115 0.0483
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.006 0.0624
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0116 0.0116
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0317 0.1118
Echinococcus granulosus intermediate filament protein 0.0193 0.0688 0.1251
Trypanosoma cruzi cysteine peptidase, putative 0.0988 0.3876 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0106 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.3876 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.2643 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.