Detailed information for compound 1294415

Basic information

Technical information
  • TDR Targets ID: 1294415
  • Name: N-(phenylmethyl)-4-[(thiophen-2-ylsulfonylami no)methyl]cyclohexane-1-carboxamide
  • MW: 392.535 | Formula: C19H24N2O3S2
  • H donors: 2 H acceptors: 3 LogP: 3.14 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCC(CC1)CNS(=O)(=O)c1cccs1)NCc1ccccc1
  • InChi: 1S/C19H24N2O3S2/c22-19(20-13-15-5-2-1-3-6-15)17-10-8-16(9-11-17)14-21-26(23,24)18-7-4-12-25-18/h1-7,12,16-17,21H,8-11,13-14H2,(H,20,22)
  • InChiKey: MOCVUYYSCXJCHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(phenylmethyl)-4-[(2-thienylsulfonylamino)methyl]cyclohexane-1-carboxamide
  • N-(phenylmethyl)-4-[(2-thienylsulfonylamino)methyl]-1-cyclohexanecarboxamide
  • N-(benzyl)-4-[(2-thienylsulfonylamino)methyl]cyclohexane-1-carboxamide
  • EU-0058175
  • UNM000000825501

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0216 0.1026
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1385 0.2328
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0173 0.0317
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0491 0.1467
Loa Loa (eye worm) hypothetical protein 0.0072 0.1391 0.2616
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.2333 0.2198
Leishmania major trypanothione reductase 0.005 0.0902 0.6147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0216 0.0665
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0173 0.0517
Brugia malayi PHD-finger family protein 0.0025 0.0351 0.0661
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0173 0.0692
Schistosoma mansoni zinc finger protein 0.002 0.023 0.0688
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0163 0.0314
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.1385 0.1233
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0216 0.1026
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0401 0.2139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1884 0.3633
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0902 0.6021
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0216 0.0083
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.2205 0.4147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1884 0.5631
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0173 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0216 0.1026
Loa Loa (eye worm) hypothetical protein 0.0072 0.1385 0.2604
Plasmodium falciparum flap endonuclease 1 0.0028 0.0401 0.3125
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0216 0.1026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0216 0.1026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0551 0.1037
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0491 0.0946
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0173 0.0317
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.2333 0.2198
Echinococcus granulosus smad 0.0017 0.0163 0.0314
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0173 0.0692
Onchocerca volvulus 0.0049 0.0888 0.165
Onchocerca volvulus 0.0251 0.5379 1
Schistosoma mansoni zinc finger protein 0.0016 0.0133 0.0398
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0173 0.1249
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0551 0.1063
Trichomonas vaginalis esterase, putative 0.0072 0.1385 0.2328
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0254 0.0478
Mycobacterium ulcerans lipase LipD 0.0072 0.1385 1
Schistosoma mansoni hypothetical protein 0.0034 0.0551 0.1648
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.1385 0.1233
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1884 0.3633
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0216 0.0665
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0173 0.0517
Brugia malayi MH2 domain containing protein 0.0017 0.0163 0.0306
Brugia malayi MH1 domain containing protein 0.0017 0.0163 0.0306
Schistosoma mansoni smad1 5 8 and 0.0017 0.0163 0.0487
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.1385 0.1233
Brugia malayi N-terminal motif family protein 0.0195 0.4134 0.7774
Schistosoma mansoni hypothetical protein 0.0049 0.0888 0.2652
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0173 0.0692
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0888 0.1669
Loa Loa (eye worm) hypothetical protein 0.0072 0.1385 0.2604
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.1141 0.22
Loa Loa (eye worm) hypothetical protein 0.0095 0.1908 0.3589
Brugia malayi beta-lactamase family protein 0.0072 0.1385 0.2604
Onchocerca volvulus 0.0072 0.1385 0.2574
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0173 0.0317
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0173 0.0317
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0551 0.1037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.2617 0.2487
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0216 0.0665
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1385 0.4138
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0216 0.0359
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.1385 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0173 0.0317
Mycobacterium ulcerans beta-lactamase 0.0072 0.1385 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0216 0.0407
Brugia malayi hypothetical protein 0.0095 0.1908 0.3589
Schistosoma mansoni Smad4 0.0017 0.0163 0.0487
Loa Loa (eye worm) hypothetical protein 0.0072 0.1385 0.2604
Brugia malayi hypothetical protein 0.0242 0.5187 0.9754
Plasmodium falciparum thioredoxin reductase 0.005 0.0902 1
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1385 0.2328
Schistosoma mansoni smad 0.0017 0.0163 0.0487
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0163 0.0306
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0216 0.0044
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.007 0.0132
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.1385 0.267
Onchocerca volvulus 0.0072 0.1385 0.2574
Echinococcus multilocularis zinc finger protein 0.002 0.023 0.0444
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1884 0.3633
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.2617 0.2487
Brugia malayi Bromodomain containing protein 0.0076 0.1488 0.2798
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0551 0.1063
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1385 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0754 0.1418
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1884 0.3544
Echinococcus granulosus dna polymerase kappa 0.0019 0.0216 0.0417
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.5187 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0173 0.0317
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0173 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0491 0.3545
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0216 0.1026
Loa Loa (eye worm) Smad1 0.0017 0.0163 0.0306
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0173 0.5
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0173 0.0317
Brugia malayi Flap endonuclease-1 0.0028 0.0401 0.0754
Plasmodium vivax SET domain protein, putative 0.0032 0.0491 0.2624
Mycobacterium tuberculosis Conserved protein 0.0072 0.1385 0.1233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0878 0.2623
Treponema pallidum NADH oxidase 0.0017 0.0173 0.5
Echinococcus granulosus Smad4 0.0017 0.0163 0.0314
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0173 0.0317
Loa Loa (eye worm) hypothetical protein 0.0195 0.4134 0.7774
Schistosoma mansoni hypothetical protein 0.0034 0.0551 0.1648
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0163 0.0314
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1385 0.4138
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0173 0.0317
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0401 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1385 0.2328
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.2205 0.4147
Plasmodium vivax hypothetical protein, conserved 0.0072 0.1385 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0216 0.1026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0173 0.1249
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0902 0.174
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.1385 0.2604
Plasmodium vivax glutathione reductase, putative 0.005 0.0902 0.6021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0216 0.0044
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0298 0.0574
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0902 0.0742
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.1385 0.1233
Echinococcus multilocularis smad 0.0017 0.0163 0.0314
Brugia malayi MH2 domain containing protein 0.0017 0.0163 0.0306
Schistosoma mansoni hypothetical protein 0.0074 0.144 0.4302
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.1385 0.2604
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0401 0.0438
Loa Loa (eye worm) hypothetical protein 0.0242 0.5187 0.9754
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0216 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0216 0.1026
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1385 0.2328
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.2333 0.2198
Loa Loa (eye worm) hypothetical protein 0.0095 0.1908 0.3589
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0216 0.0665
Leishmania major hypothetical protein, conserved 0.0072 0.1385 1
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1385 1
Brugia malayi Thioredoxin reductase 0.005 0.0902 0.1697
Trichomonas vaginalis set domain proteins, putative 0.0251 0.5379 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0216 0.0665
Trypanosoma brucei ISWI complex protein 0.0016 0.0133 0.0387
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.2333 0.2198
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0216 0.0417
Schistosoma mansoni hypothetical protein 0.0034 0.0551 0.1648
Brugia malayi Pre-SET motif family protein 0.0032 0.0491 0.0923
Schistosoma mansoni DNA polymerase eta 0.0019 0.0216 0.0647
Brugia malayi MH1 domain containing protein 0.0017 0.0163 0.0306
Plasmodium falciparum glutathione reductase 0.005 0.0902 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0465 0.0896
Trypanosoma brucei unspecified product 0.0019 0.0216 0.1026
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0216 0.0647
Echinococcus granulosus dna polymerase eta 0.0019 0.0216 0.0417
Giardia lamblia DINP protein human, muc B family 0.0019 0.0216 0.1906
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.4134 0.7685
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.2333 0.2198
Loa Loa (eye worm) hypothetical protein 0.0072 0.1385 0.2604
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0173 0.0325
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.5187 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.2617 0.2487
Loa Loa (eye worm) hypothetical protein 0.0034 0.0551 0.1037
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1385 0.2328
Mycobacterium tuberculosis Conserved protein 0.0072 0.1385 0.1233
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0902 0.174
Loa Loa (eye worm) glutathione reductase 0.005 0.0902 0.1697
Loa Loa (eye worm) hypothetical protein 0.0019 0.0216 0.0407
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0551 0.1063
Schistosoma mansoni survival motor neuron protein 0.0049 0.0888 0.2652
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.5317 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0216 0.1026
Schistosoma mansoni bromodomain containing protein 0.0064 0.1222 0.3652
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0216 0.1026
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0173 0.0317
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0401 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0163 0.0487
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.1141 0.22
Schistosoma mansoni eyes absent homolog 0.0095 0.1908 0.5702
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0401 0.0773
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0173 0.0317
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0216 0.0647
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0216 0.0665
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.5317 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0216 0.0407
Echinococcus granulosus zinc finger protein 0.002 0.023 0.0444
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0878 0.1693
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0163 0.0314
Loa Loa (eye worm) hypothetical protein 0.0072 0.1385 0.2604
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0173 0.0692
Schistosoma mansoni hypothetical protein 0.0016 0.0133 0.0398
Loa Loa (eye worm) hypothetical protein 0.0074 0.144 0.2707
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0878 0.2623
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0401 0.1881
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0216 0.1026
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0601 0.116
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0163 0.0314
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0216 0.0407
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0163 0.0306
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.47 0.8839
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.2617 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0216 0.0417
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0216 0.0083
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.1385 0.1233
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0401 0.0754
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0401 0.2443
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.1385 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0163 0.0487
Brugia malayi glutathione reductase 0.005 0.0902 0.1697
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0878 0.1693
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.2205 0.4147
Loa Loa (eye worm) hypothetical protein 0.0041 0.071 0.1336
Onchocerca volvulus 0.0072 0.1385 0.2574
Schistosoma mansoni hypothetical protein 0.0021 0.0254 0.076
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0551 0.1037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1884 0.5631
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.1385 0.1233
Loa Loa (eye worm) hypothetical protein 0.0108 0.2205 0.4147
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0173 0.0317
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0173 0.5
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0902 0.6147
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.2333 0.7694
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.1385 1
Echinococcus multilocularis GPCR, family 2 0.0034 0.0551 0.1063
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0216 0.0665
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0491 0.1467
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0173 0.0333
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0298 0.0574
Loa Loa (eye worm) hypothetical protein 0.0049 0.0878 0.1651
Toxoplasma gondii thioredoxin reductase 0.005 0.0902 0.6517
Trypanosoma brucei trypanothione reductase 0.005 0.0902 0.6296
Echinococcus granulosus GPCR family 2 0.0034 0.0551 0.1063
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.144 0.2707
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0173 0.0317
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0298 0.0889
Leishmania major DNA polymerase kappa, putative 0.0019 0.0216 0.0665
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0173 0.0517
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0187 0.0352
Mycobacterium ulcerans hypothetical protein 0.0072 0.1385 1
Echinococcus multilocularis Smad4 0.0017 0.0163 0.0314
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0173 0.0334
Toxoplasma gondii ABC1 family protein 0.0072 0.1385 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0551 0.1063
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0216 0.1026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0173 0.0333
Brugia malayi Smad1 0.0017 0.0163 0.0306
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.007 0.0132
Loa Loa (eye worm) hypothetical protein 0.0039 0.0657 0.1235
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.1385 0.1233
Loa Loa (eye worm) hypothetical protein 0.0072 0.1385 0.2604
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1884 0.3633
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0902 0.1697
Brugia malayi Bromodomain containing protein 0.0039 0.0655 0.1232
Mycobacterium tuberculosis Probable reductase 0.0114 0.2333 0.2198
Loa Loa (eye worm) beta-lactamase 0.0072 0.1385 0.2604
Brugia malayi Pre-SET motif family protein 0.022 0.47 0.8839
Echinococcus granulosus flap endonuclease 1 0.0028 0.0401 0.0773
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0216 0.0359
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1884 0.5631
Schistosoma mansoni hypothetical protein 0.0034 0.0551 0.1648
Brugia malayi beta-lactamase family protein 0.0072 0.1385 0.2604
Onchocerca volvulus 0.0032 0.0491 0.0913
Brugia malayi beta-lactamase 0.0072 0.1385 0.2604
Schistosoma mansoni flap endonuclease-1 0.0025 0.0342 0.1021
Mycobacterium tuberculosis Conserved protein 0.0072 0.1385 0.1233
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0216 0.1026
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0401 0.2895
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.1385 0.267
Brugia malayi MH2 domain containing protein 0.0248 0.5317 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0163 0.0487
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0401 0.2139
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0216 0.0417
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0216 0.1026
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1884 0.3544
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0601 0.116

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2079 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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