Detailed information for compound 1294956

Basic information

Technical information
  • TDR Targets ID: 1294956
  • Name: (2E)-2-[(3,4-dihydroxyphenyl)methylidene]-6,7 ,8,9-tetrahydro-5H-imidazo[3,2-a]azepin-3-one
  • MW: 272.299 | Formula: C15H16N2O3
  • H donors: 2 H acceptors: 3 LogP: 1.58 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1/C(=C\c2ccc(c(c2)O)O)/N=C2N1CCCCC2
  • InChi: 1S/C15H16N2O3/c18-12-6-5-10(9-13(12)19)8-11-15(20)17-7-3-1-2-4-14(17)16-11/h5-6,8-9,18-19H,1-4,7H2/b11-8+
  • InChiKey: BEWNXCQREHNWDR-DHZHZOJOSA-N  


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Synonyms

  • (2E)-2-[(3,4-dihydroxyphenyl)methylene]-6,7,8,9-tetrahydro-5H-imidazo[3,2-a]azepin-3-one
  • (2E)-2-(3,4-dihydroxybenzylidene)-6,7,8,9-tetrahydro-5H-imidazo[3,2-a]azepin-3-one
  • SMR000364264
  • MLS000773557

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Simian virus 40 Large T antigen Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens Rac GTPase activating protein 1 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Rac GTPase-activating protein 1, putative Get druggable targets OG5_132551 All targets in OG5_132551
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi DnaJ domain containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis Rac GTPase activating protein 1 Get druggable targets OG5_132551 All targets in OG5_132551
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K09536 DnaJ homolog, subfamily C, member 16, putative Get druggable targets OG5_132364 All targets in OG5_132364
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia Rho GAP, putative Get druggable targets OG5_132551 All targets in OG5_132551
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni rac gtpase activating protein Get druggable targets OG5_132551 All targets in OG5_132551
Loa Loa (eye worm) DnaJ domain-containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132551 All targets in OG5_132551
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis protein kinase inhibitor, putative Get druggable targets OG5_132364 All targets in OG5_132364
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi RhoGAP domain containing protein Get druggable targets OG5_132551 All targets in OG5_132551
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site;IPR008936,Rho GTPase activation protein,domain-containing Get druggable targets OG5_132551 All targets in OG5_132551
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_132551 All targets in OG5_132551
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132364 All targets in OG5_132364
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RhoGAP domain containing protein Get druggable targets OG5_132551 All targets in OG5_132551
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132551 All targets in OG5_132551
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus Rac GTPase activating protein 1 Get druggable targets OG5_132551 All targets in OG5_132551
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_132364 All targets in OG5_132364
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0389 0.0357
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0388 0.0422
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1166 0.1119
Trypanosoma cruzi fatty acid desaturase, putative 0.0198 0.5347 0.9125
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0828 0.0814
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.5303 0.5277
Echinococcus multilocularis Fatty acid desaturase, type 1 0.0017 0.0062 0.0009
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0233 0.0209
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.2754 0.2994
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.2754 0.2994
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2886 0.3137
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0233 0.0353
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.2754 0.2994
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0828 0.0779
Leishmania major DNA polymerase kappa, putative 0.0023 0.0233 0.0353
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0828 0.09
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0828 0.1373
Loa Loa (eye worm) hypothetical protein 0.0021 0.0177 0.0193
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0198 0.5347 1
Trypanosoma brucei sphingolipid delta 4 desaturase, putative 0.0017 0.0062 0.007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0438 0.0386
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0438 0.0476
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0233 0.0181
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0438 0.0476
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0565 0.0614
Schistosoma mansoni hypothetical protein 0.0075 0.1741 0.1697
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0438 0.0476
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9868 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0828 0.0814
Loa Loa (eye worm) Smad1 0.0017 0.0053 0.0058
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0438 0.0386
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0438 0.0704
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2886 0.4903
Trypanosoma cruzi fatty acid desaturase, putative 0.0216 0.5858 1
Brugia malayi Bromodomain containing protein 0.0035 0.0581 0.0631
Echinococcus granulosus intermediate filament protein 0.0029 0.0388 0.0337
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.9868 1
Plasmodium falciparum stearoyl-CoA desaturase 0.0198 0.5347 1
Giardia lamblia Kinase, PLK 0.0114 0.2886 0.2753
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0438 0.0386
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0565 0.0514
Brugia malayi Smad1 0.0017 0.0053 0.0058
Schistosoma mansoni protein phosphatase 2C 0.003 0.0438 0.0386
Mycobacterium ulcerans glutaminase 0.033 0.9201 1
Brugia malayi Delta5 fatty acid desaturase 0.0017 0.0062 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0389 0.0357
Schistosoma mansoni alpha-glucosidase 0.0169 0.4502 0.4472
Brugia malayi jmjC domain containing protein 0.003 0.0438 0.0476
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0581 0.6774
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.9868 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2886 0.2848
Mycobacterium ulcerans hypothetical protein 0.0029 0.0389 0.0357
Brugia malayi Fatty acid desaturase family protein 0.0017 0.0062 0.0068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1166 0.1119
Brugia malayi RhoGAP domain containing protein 0.0077 0.1792 0.1948
Echinococcus granulosus dnaJ subfamily C 6 0.0074 0.1714 0.1669
Echinococcus granulosus dna polymerase kappa 0.0023 0.0233 0.0181
Loa Loa (eye worm) hypothetical protein 0.0023 0.0233 0.0253
Schistosoma mansoni hypothetical protein 0.0035 0.0565 0.0514
Onchocerca volvulus Alhambra homolog 0.0035 0.0581 0.095
Loa Loa (eye worm) acyl-CoA desaturase 0.0198 0.5347 0.5812
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0828 0.0814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1166 0.1119
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0828 0.0814
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0438 0.0386
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.6913 0.7514
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0177 0.0254
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0388 0.0422
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0389 0.0422
Trypanosoma brucei cytochrome b5-dependent oleate desaturase 0.0017 0.0062 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0233 0.0353
Trypanosoma brucei glucosidase, putative 0.0044 0.0828 0.1382
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0233 0.0209
Schistosoma mansoni phd/f-box containing protein 0.003 0.0438 0.0386
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0053 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1166 0.1119
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0351 0.0555
Schistosoma mansoni DNA polymerase eta 0.0023 0.0233 0.0181
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0565 0.0514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9868 1
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0984 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0233 0.0362
Schistosoma mansoni lamin 0.0029 0.0388 0.0337
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0017 0.0062 0.006
Brugia malayi hypothetical protein 0.0027 0.0351 0.0381
Onchocerca volvulus 0.0017 0.0062 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0351 0.0555
Brugia malayi MH2 domain containing protein 0.0252 0.6913 0.7514
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0233 0.0362
Echinococcus multilocularis musashi 0.0029 0.0388 0.0337
Echinococcus granulosus Fatty acid desaturase type 1 0.0017 0.0062 0.0009
Onchocerca volvulus 0.0216 0.5858 1
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0233 0.0181
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0438 0.0504
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0438 0.0386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1166 0.1119
Loa Loa (eye worm) hypothetical protein 0.003 0.0438 0.0476
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.5303 0.5277
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0233 0.0362
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1166 0.1268
Loa Loa (eye worm) hypothetical protein 0.0021 0.0177 0.0193
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0438 0.0713
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0828 0.0814
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2886 0.4903
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2886 0.2905
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0233 0.0362
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0581 0.6774
Trypanosoma cruzi sphingolipid delta 4 desaturase, putative 0.0017 0.0062 0.006
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0027 0.0009
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0233 0.0181
Leishmania major stearic acid desaturase, putative 0.0216 0.5858 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0389 0.0422
Schistosoma mansoni alpha-glucosidase 0.0169 0.4502 0.4472
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0389 0.0357
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0828 0.0814
Brugia malayi Muscleblind-like protein 0.018 0.4824 0.5244
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0233 0.0377
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.0017 0.0062 0.006
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0351 0.3766
Leishmania major fatty acid desaturase, putative 0.0017 0.0062 0.006
Loa Loa (eye worm) hypothetical protein 0.011 0.2754 0.2994
Plasmodium falciparum phd finger protein, putative 0.0035 0.0581 0.0781
Loa Loa (eye worm) hypothetical protein 0.0029 0.0388 0.0422
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2886 0.4903
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9868 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2886 0.2905
Brugia malayi jmjC domain containing protein 0.003 0.0438 0.0476
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2886 0.2848
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0233 0.0362
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.9868 1
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.6913 0.7514
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0389 0.0357
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0053 0.0058
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0233 0.0181
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0581 0.0781
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0565 0.0514
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.4591 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0373 0.0405
Echinococcus granulosus GPCR family 2 0.0035 0.0565 0.0514
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0828 0.1373
Echinococcus multilocularis dnaJ subfamily C 6 0.0074 0.1714 0.1669
Loa Loa (eye worm) glutaminase 2 0.033 0.9201 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0438 0.4902
Schistosoma mansoni hypothetical protein 0.0035 0.0581 0.053
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0389 0.0422
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0233 0.0209
Loa Loa (eye worm) hypothetical protein 0.0077 0.1792 0.1948
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0438 0.0704
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2886 0.2905
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0581 0.053
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0233 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0233 0.0362
Schistosoma mansoni hypothetical protein 0.0035 0.0565 0.0514
Leishmania major hypothetical protein, conserved 0.003 0.0438 0.0704
Echinococcus granulosus lysine specific demethylase 5A 0.0114 0.2873 0.2835
Brugia malayi MH1 domain containing protein 0.0017 0.0053 0.0058
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0351 0.0336
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0581 0.0631
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0186 0.4998 0.4971
Brugia malayi intermediate filament protein 0.0029 0.0388 0.0422
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.5303 0.5277
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0177 0.0126
Loa Loa (eye worm) hypothetical protein 0.0075 0.1741 0.1892
Schistosoma mansoni rac gtpase activating protein 0.0089 0.2148 0.2106
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1677 0.1822
Leishmania major delta-12 fatty acid desaturase 0.0017 0.0062 0.006
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0581 0.053
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0233 0.0362
Echinococcus granulosus phd:f box containing protein 0.003 0.0438 0.0386
Loa Loa (eye worm) hypothetical protein 0.0089 0.2148 0.2334
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0233 0.0362
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2886 0.4903
Echinococcus granulosus muscleblind protein 0.018 0.4824 0.4797
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0233 0.0181
Trichomonas vaginalis protein kinase inhibitor, putative 0.0074 0.1714 0.1714
Brugia malayi MH1 domain containing protein 0.0017 0.0053 0.0058
Loa Loa (eye worm) hypothetical protein 0.0079 0.187 0.2032
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0389 0.062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9868 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0388 0.0422
Trypanosoma cruzi fatty acid desaturase, putative 0.0198 0.5347 0.9125
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0828 0.1373
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0017 0.0062 0.006
Schistosoma mansoni fatty acid desaturase 0.0017 0.0062 0.0009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.4591 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0233 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0233 0.0362
Onchocerca volvulus 0.0029 0.0388 0.062
Schistosoma mansoni hypothetical protein 0.0035 0.0565 0.0514
Loa Loa (eye worm) hypothetical protein 0.018 0.4824 0.5244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9868 1
Brugia malayi jmjC domain containing protein 0.003 0.0438 0.0476
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9868 1
Schistosoma mansoni glutaminase 0.033 0.9201 0.9196
Loa Loa (eye worm) hypothetical protein 0.0029 0.0389 0.0422
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0017 0.0062 0.006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0143 0.0178
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0233 0.0377
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.2873 0.2835
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0828 0.0814
Loa Loa (eye worm) hypothetical protein 0.0035 0.0581 0.0631
Brugia malayi jmjC domain containing protein 0.0186 0.4998 0.5432
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0438 0.0386
Echinococcus granulosus dna polymerase eta 0.0023 0.0233 0.0181
Trichomonas vaginalis glutaminase, putative 0.033 0.9201 0.9322
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0233 0.0362
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2886 0.2848
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1202 0.1194
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2886 0.2905
Loa Loa (eye worm) hypothetical protein 0.0021 0.0177 0.0193
Leishmania major hypothetical protein, conserved 0.0027 0.0351 0.0555
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0581 0.053
Leishmania major fatty-acid desaturase, putative 0.0216 0.5858 1
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0438 0.0386
Leishmania major fatty acid desaturase, putative 0.0017 0.0062 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1202 0.1194
Echinococcus multilocularis lamin 0.0029 0.0388 0.0337
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0143 0.0178
Trypanosoma cruzi fatty acid desaturase, putative 0.0017 0.0062 0.006
Echinococcus granulosus peregrin 0.0035 0.0581 0.053
Brugia malayi jmjC domain containing protein 0.0114 0.2873 0.3123
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0389 0.062
Brugia malayi RhoGAP domain containing protein 0.0089 0.2148 0.2334
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0351 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0233 0.0362
Trypanosoma cruzi fatty acid desaturase, putative 0.0017 0.0062 0.006
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0233 0.0187
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0233 0.0187
Loa Loa (eye worm) hypothetical protein 0.0035 0.0565 0.0614
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0438 0.0386
Echinococcus multilocularis phd:f box containing protein 0.003 0.0438 0.0386
Brugia malayi acyl-CoA desaturase 0.0198 0.5347 0.5812
Plasmodium vivax JmjC domain containing protein 0.003 0.0438 0.0504
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0186 0.4998 0.4971
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0565 0.0614
Brugia malayi MH2 domain containing protein 0.0017 0.0053 0.0058
Echinococcus multilocularis lamin dm0 0.0029 0.0388 0.0337
Brugia malayi MH2 domain containing protein 0.0017 0.0053 0.0058
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0233 0.0362
Schistosoma mansoni alpha glucosidase 0.0044 0.0828 0.0779
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0389 0.0721
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.4591 0.4956
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1166 0.1119
Leishmania major delta-6 fatty acid desaturase 0.0017 0.0062 0.006
Brugia malayi hypothetical protein 0.0018 0.0068 0.0073
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0828 0.0814
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.5303 0.5763
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.0017 0.0062 0.006
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0389 0.0367
Echinococcus multilocularis Rac GTPase activating protein 1 0.0089 0.2148 0.2106
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2886 0.2905
Trypanosoma brucei delta-4 fatty acid desaturase 0.0017 0.0062 0.007
Trypanosoma cruzi cytochrome b5-dependent oleate desaturase 0.0017 0.0062 0.006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0233 0.0253
Schistosoma mansoni lamin 0.0029 0.0388 0.0337
Schistosoma mansoni hypothetical protein 0.0074 0.1714 0.1669
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.003
Leishmania major delta-5 fatty acid desaturase 0.0017 0.0062 0.006
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0177 0.5
Echinococcus granulosus lamin dm0 0.0029 0.0388 0.0337
Brugia malayi Fatty acid desaturase family protein 0.0017 0.0062 0.0068
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0565 0.0614
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0984 0.0936
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0438 0.0386
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0828 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0351 0.0564
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0828 0.09
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.2873 0.2835
Schistosoma mansoni intermediate filament proteins 0.0029 0.0388 0.0337
Leishmania major delta-4 fatty acid desaturase 0.0017 0.0062 0.006
Trypanosoma brucei fatty acid desaturase, putative 0.0216 0.5858 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0389 0.0721
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0027 0.003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0389 0.0367
Loa Loa (eye worm) fatty acid desaturase 0.0017 0.0062 0.0068
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0233 0.0353
Echinococcus multilocularis dna polymerase eta 0.0023 0.0233 0.0181
Echinococcus multilocularis GPCR, family 2 0.0035 0.0565 0.0514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0143 0.0178
Loa Loa (eye worm) hypothetical protein 0.0029 0.0389 0.0422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1166 0.1119
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0828 0.0814
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0233 0.0253
Onchocerca volvulus 0.0216 0.5858 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0828 0.0779
Loa Loa (eye worm) glutaminase 0.033 0.9201 1
Brugia malayi jmjC domain containing protein 0.003 0.0438 0.0476
Echinococcus granulosus Sphingolipid delta4 desaturase DES1 0.0017 0.0062 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2886 0.2905
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.5303 0.5763
Loa Loa (eye worm) hypothetical protein 0.0021 0.0177 0.0193
Loa Loa (eye worm) hypothetical protein 0.0021 0.0177 0.0193
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9868 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2886 0.2905
Onchocerca volvulus 0.0029 0.0389 0.062
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0389 0.0357
Giardia lamblia Rho GAP, putative 0.0077 0.1792 0.1618
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0389 0.062
Echinococcus multilocularis peregrin 0.0035 0.0581 0.053
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0438 0.4902
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2886 0.3137
Echinococcus multilocularis muscleblind protein 0.018 0.4824 0.4797
Brugia malayi glutaminase DH11.1 0.033 0.9201 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0389 0.0357
Onchocerca volvulus 0.0114 0.2878 0.4889
Loa Loa (eye worm) fatty acid desaturase 0.0017 0.0062 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0143 0.0178
Schistosoma mansoni kinase 0.0058 0.1246 0.1199
Onchocerca volvulus 0.0029 0.0388 0.062
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0828 0.0814
Loa Loa (eye worm) DnaJ domain-containing protein 0.0074 0.1714 0.1863
Loa Loa (eye worm) hypothetical protein 0.0029 0.0389 0.0422
Loa Loa (eye worm) FAT-3 protein 0.0017 0.0062 0.0068
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0565 0.0514
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0351 0.0336
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1166 0.1268
Echinococcus granulosus Rac GTPase activating protein 1 0.0089 0.2148 0.2106
Trypanosoma brucei unspecified product 0.0023 0.0233 0.0362
Trypanosoma brucei polo-like protein kinase 0.0114 0.2886 0.4908
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0233 0.0353
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0828 0.0814
Loa Loa (eye worm) hypothetical protein 0.003 0.0438 0.0476
Echinococcus multilocularis lysine specific demethylase 5A 0.0114 0.2873 0.2835
Schistosoma mansoni jumonji domain containing protein 0.0163 0.4305 0.4275
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2886 0.2905
Echinococcus multilocularis muscleblind protein 1 0.018 0.4824 0.4797
Echinococcus granulosus lamin 0.0029 0.0388 0.0337
Loa Loa (eye worm) jmjC domain-containing protein 0.0114 0.2873 0.3123
Brugia malayi DnaJ domain containing protein 0.0074 0.1714 0.1863
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0389 0.0367
Loa Loa (eye worm) hypothetical protein 0.0027 0.0351 0.0381
Leishmania major DNA polymerase eta, putative 0.0023 0.0233 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0233 0.0362
Loa Loa (eye worm) hypothetical protein 0.018 0.4824 0.5244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9868 1
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0017 0.0062 0.006
Schistosoma mansoni hypothetical protein 0.0035 0.0565 0.0514
Giardia lamblia PHD finger protein 15 0.0035 0.0581 0.0361
Trypanosoma brucei delta-6 fatty acid desaturase, putative 0.0017 0.0062 0.007
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.9868 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.1741 0.1892
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0017 0.0062 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0389 0.0357
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0233 0.0353
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0017 0.0062 0.0009
Schistosoma mansoni jumonji domain containing protein 0.003 0.0438 0.0386
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0438 0.0386
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0233 0.0253
Brugia malayi PHD-finger family protein 0.0035 0.0581 0.0631

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 6.68 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
IC50 (functional) 17.37 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.3714 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7407 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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