Detailed information for compound 1295135

Basic information

Technical information
  • TDR Targets ID: 1295135
  • Name: 4-(6-bromo-3-hydroxy-4-oxoquinazolin-2-yl)ben zonitrile
  • MW: 342.147 | Formula: C15H8BrN3O2
  • H donors: 1 H acceptors: 3 LogP: 2.45 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)c1nc2ccc(cc2c(=O)n1O)Br
  • InChi: 1S/C15H8BrN3O2/c16-11-5-6-13-12(7-11)15(20)19(21)14(18-13)10-3-1-9(8-17)2-4-10/h1-7,21H
  • InChiKey: HVVKADDIBUZARF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(6-bromo-3-hydroxy-4-oxo-quinazolin-2-yl)benzonitrile
  • 4-(6-bromo-3-hydroxy-4-oxo-2-quinazolinyl)benzonitrile
  • 4-(6-bromo-3-hydroxy-4-keto-quinazolin-2-yl)benzonitrile
  • 2K-602S
  • ZINC01382212
  • Oprea1_122324

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cathepsin B precursor 0.0055 0.0218 0.0694
Mycobacterium leprae Probable lipase LipE 0.004 0.0063 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0218 0.0897
Loa Loa (eye worm) hypothetical protein 0.0646 0.6474 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0238 0.2153 0.3261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Plasmodium vivax vivapain-3 0.012 0.0912 0.455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0218 0.0897
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.2351 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0218 0.0897
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Loa Loa (eye worm) hypothetical protein 0.0151 0.1235 0.1908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0216 0.1928 0.8942
Brugia malayi cathepsin L precursor 0.0055 0.0218 0.0265
Giardia lamblia Hypothetical protein 0.0055 0.0218 0.0694
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0238 0.2153 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0218 0.0265
Trypanosoma cruzi cysteine peptidase, putative 0.012 0.0912 0.1324
Brugia malayi Cathepsin L-like precursor 0.0216 0.1928 0.2926
Echinococcus granulosus cysteine protease 0.012 0.0912 0.1344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0222 0.0272
Toxoplasma gondii preprocathepsin c precursor, putative 0.0055 0.0218 0.0745
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Echinococcus multilocularis cysteine protease 0.0216 0.1928 0.1889
Echinococcus granulosus cathepsin l cysteine peptidase 0.0216 0.1928 0.2926
Brugia malayi Cathepsin L-like precursor 0.0216 0.1928 0.2926
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0055 0.0218 0.0835
Schistosoma mansoni ap endonuclease 0.0041 0.0074 0.0041
Brugia malayi beta-lactamase 0.004 0.0063 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0055 0.0218 0.0897
Brugia malayi beta-lactamase family protein 0.004 0.0063 0.0023
Toxoplasma gondii cathepsin CPC1 0.0055 0.0218 0.0745
Leishmania major cathepsin L-like protease 0.0216 0.1928 0.8924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0218 0.0897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0097
Giardia lamblia Cysteine protease 0.0055 0.0218 0.0694
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.012 0.0912 0.1344
Brugia malayi cathepsin Z-like cysteine proteinase 0.0055 0.0218 0.0265
Brugia malayi cathepsin Z-like cysteine proteinase 0.0055 0.0218 0.0265
Plasmodium falciparum serine repeat antigen 2 0.0055 0.0218 0.0778
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0063 0.0023
Brugia malayi Cathepsin L-like precursor 0.0216 0.1928 0.2926
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0055 0.0011
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0055 0.0218 0.0778
Giardia lamblia Cathepsin L-like protease 0.0055 0.0218 0.0694
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0055 0.0218 0.0835
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0074 0.0055
Trypanosoma cruzi cysteine proteinase, putative 0.012 0.0912 0.1324
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0331 0.0419
Loa Loa (eye worm) hypothetical protein 0.0216 0.1928 0.2978
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0074 0.0018
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0055 0.0218 0.0265
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0063 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0055 0.0218 0.0835
Entamoeba histolytica cysteine proteinase, putative 0.0151 0.1235 0.6314
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0055 0.0218 0.0835
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0063 0.0165
Plasmodium vivax vivapain-2 0.0216 0.1928 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1235 0.1908
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0055 0.0218 0.0265
Onchocerca volvulus 0.0216 0.1928 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0055 0.0218 0.0835
Entamoeba histolytica cysteine protease, putative 0.0055 0.0218 0.0907
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0063 0.0165
Leishmania major cysteine peptidase A (CPA) 0.0216 0.1928 0.8924
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0093 0.0071
Leishmania major cathepsin L-like protease 0.0216 0.1928 0.8924
Giardia lamblia Cathepsin L precursor 0.0055 0.0218 0.0694
Trichomonas vaginalis esterase, putative 0.004 0.0063 0.0165
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0097
Echinococcus multilocularis cathepsin L 0.0055 0.0218 0.0171
Onchocerca volvulus 0.0216 0.1928 1
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0074 0.0026
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0055 0.0007
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0055 0.0218 0.0835
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0218 0.0897
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0216 0.1928 0.8942
Entamoeba histolytica cysteine proteinase 1, putative 0.012 0.0912 0.4593
Schistosoma mansoni cathepsin C 0.0055 0.0218 0.0265
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0097
Plasmodium vivax serine-repeat antigen (SERA) 0.0055 0.0218 0.0835
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0216 0.1928 0.1889
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0063 0.0023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0222 0.0344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0222 0.0272
Plasmodium falciparum serine repeat antigen 4 0.0055 0.0218 0.0778
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Brugia malayi fibroinase precursor 0.0055 0.0218 0.0265
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0063 0.0023
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0055 0.0218 0.0835
Loa Loa (eye worm) cathepsin B 0.0238 0.2153 0.3326
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0218 0.0897
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Giardia lamblia Cathepsin B precursor 0.0238 0.2153 1
Giardia lamblia Cathepsin L precursor 0.0055 0.0218 0.0694
Onchocerca volvulus 0.0151 0.1235 0.6284
Brugia malayi Cathepsin L-like precursor 0.0216 0.1928 0.2926
Giardia lamblia Cathepsin L precursor 0.0055 0.0218 0.0694
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0055 0.0218 0.0694
Brugia malayi Cathepsin L-like precursor 0.0216 0.1928 0.2926
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Toxoplasma gondii exonuclease III APE 0.0041 0.0074 0.0055
Echinococcus multilocularis cathepsin L cysteine protease 0.0216 0.1928 0.1889
Loa Loa (eye worm) hypothetical protein 0.0055 0.0218 0.0337
Entamoeba histolytica cysteine protease, putative 0.0216 0.1928 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0222 0.0175
Echinococcus granulosus cathepsin b 0.0646 0.6474 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0216 0.1928 0.8942
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0218 0.0897
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0218 0.0897
Giardia lamblia Cathepsin B precursor 0.0055 0.0218 0.0694
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0063 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Schistosoma mansoni cathepsin S (C01 family) 0.0055 0.0218 0.0265
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0238 0.2153 0.3276
Echinococcus granulosus cathepsin L cysteine protease 0.012 0.0912 0.1344
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0074 0.5
Onchocerca volvulus Cathepsin L homolog 0.0216 0.1928 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0055 0.0218 0.0337
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0151 0.1235 0.1829
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0218 0.0337
Onchocerca volvulus 0.0216 0.1928 1
Giardia lamblia Cysteine protease 0.0055 0.0218 0.0694
Leishmania major cathepsin L-like protease 0.0216 0.1928 0.8924
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0055 0.0085
Onchocerca volvulus 0.0216 0.1928 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0218 0.0243
Brugia malayi Cathepsin L-like precursor 0.0151 0.1235 0.1847
Giardia lamblia Hypothetical protein 0.0055 0.0218 0.0694
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0216 0.1928 0.1889
Entamoeba histolytica cysteine proteinase, putative 0.0216 0.1928 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0216 0.1928 0.8942
Brugia malayi Cathepsin L-like precursor 0.0066 0.0331 0.0441
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0222 0.0272
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0055 0.0218 0.0835
Onchocerca volvulus Cathepsin L homolog 0.0216 0.1928 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Echinococcus granulosus cathepsin L cysteine proteinase 0.0216 0.1928 0.2926
Schistosoma mansoni cathepsin B (C01 family) 0.0055 0.0218 0.0265
Echinococcus granulosus cathepsin l1 0.0216 0.1928 0.2926
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0646 0.6474 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0216 0.1928 0.8942
Brugia malayi cathepsin L-like cysteine proteinase 0.0055 0.0218 0.0265
Entamoeba histolytica cysteine protease, putative 0.0055 0.0218 0.0907
Loa Loa (eye worm) hypothetical protein 0.0055 0.0218 0.0337
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0074 0.5
Leishmania major cathepsin L-like protease 0.0216 0.1928 0.8924
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0646 0.6474 1
Brugia malayi beta-lactamase family protein 0.004 0.0063 0.0023
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0074 0.0041
Plasmodium falciparum cysteine proteinase falcipain 1 0.012 0.0912 0.4517
Giardia lamblia Cathepsin L precursor 0.0055 0.0218 0.0694
Entamoeba histolytica cysteine protease, putative 0.0055 0.0218 0.0907
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0218 0.0897
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0222 0.0272
Entamoeba histolytica cysteine protease, putative 0.0055 0.0218 0.0907
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0063 0.0015
Giardia lamblia Cathepsin L precursor 0.0055 0.0218 0.0694
Mycobacterium leprae conserved hypothetical protein 0.004 0.0063 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0216 0.1928 0.2926
Toxoplasma gondii cathepsin CPL 0.0216 0.1928 0.8924
Loa Loa (eye worm) hypothetical protein 0.0151 0.1235 0.1908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Loa Loa (eye worm) hypothetical protein 0.0055 0.0218 0.0337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0218 0.0265
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0222 0.0272
Brugia malayi cathepsin L-like precursor 0.0151 0.1235 0.1847
Schistosoma mansoni cathepsin F (C01 family) 0.0151 0.1235 0.1847
Entamoeba histolytica cysteine protease, putative 0.0055 0.0218 0.0907
Brugia malayi Cathepsin L-like precursor 0.0151 0.1235 0.1847
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Brugia malayi cathepsin F-like cysteine proteinase 0.0055 0.0218 0.0265
Schistosoma mansoni cathepsin F (C01 family) 0.0216 0.1928 0.2926
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Loa Loa (eye worm) hypothetical protein 0.0066 0.0331 0.0511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0912 0.4061
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0055 0.0218 0.0694
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0331 0.0511
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0055 0.0218 0.0897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Loa Loa (eye worm) hypothetical protein 0.0066 0.0331 0.0511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0912 0.4159
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0074 0.0041
Echinococcus granulosus cathepsin L 0.012 0.0912 0.1344
Brugia malayi cathepsin B-like cysteine proteinase 0.0646 0.6474 1
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0331 0.0419
Echinococcus multilocularis cysteine protease 0.0216 0.1928 0.1889
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0912 0.4159
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0055 0.0218 0.0897
Trypanosoma cruzi cysteine peptidase, putative 0.0216 0.1928 0.291
Loa Loa (eye worm) cysteine protease 0.0216 0.1928 0.2978
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0646 0.6474 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.012 0.0912 0.1344
Echinococcus multilocularis cathepsin L cysteine protease 0.0216 0.1928 0.1889
Plasmodium vivax serine-repeat antigen (SERA) 0.0055 0.0218 0.0835
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0055 0.0218 0.0694
Echinococcus multilocularis cathepsin b 0.0646 0.6474 0.6457
Trypanosoma cruzi cysteine peptidase, putative 0.0216 0.1928 0.291
Plasmodium falciparum serine repeat antigen 8 0.0055 0.0218 0.0778
Brugia malayi Papain family cysteine protease containing protein 0.012 0.0912 0.1344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0218 0.0897
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0074 0.0018
Toxoplasma gondii cathepsin B 0.0238 0.2153 1
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0218 0.0835
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0074 0.0055
Entamoeba histolytica hypothetical protein 0.0055 0.0218 0.0907
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0216 0.1928 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Leishmania major cathepsin L-like protease 0.0216 0.1928 0.8924
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0074 0.0139
Plasmodium vivax vivapain-1 0.012 0.0912 0.455
Entamoeba histolytica cysteine proteinase, putative 0.012 0.0912 0.4593
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0218 0.0265
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0055 0.0218 0.0694
Giardia lamblia Cathepsin L-like protease 0.0055 0.0218 0.0694
Trypanosoma brucei cysteine peptidase C (CPC) 0.0238 0.2153 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1235 0.5681
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Schistosoma mansoni cathepsin F (C01 family) 0.0216 0.1928 0.2926
Brugia malayi Papain family cysteine protease containing protein 0.012 0.0912 0.1344
Giardia lamblia Cysteine protease 0.0055 0.0218 0.0694
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0097
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0055 0.0218 0.0835
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0218 0.0897
Entamoeba histolytica cysteine proteinase, putative 0.012 0.0912 0.4593
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0218 0.0265
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0055 0.0218 0.0265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0074 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0222 0.0175
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0055 0.0218 0.0907
Entamoeba histolytica cysteine proteinase, putative 0.012 0.0912 0.4593
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0238 0.2153 1
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0074 0.0218
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0055 0.0218 0.0265
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0218 0.0265
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0074 0.005
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0055 0.0218 0.0778
Echinococcus granulosus cathepsin l1 0.0151 0.1235 0.1847
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0646 0.6474 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0218 0.0337
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0066 0.0331 0.0441
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0216 0.1928 0.2978
Giardia lamblia Encystation-specific protease 0.0055 0.0218 0.0694
Plasmodium falciparum serine repeat antigen 5 0.0055 0.0218 0.0778
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0093 0.0071
Loa Loa (eye worm) hypothetical protein 0.0055 0.0218 0.0337
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0222 0.0272
Loa Loa (eye worm) fibroinase 0.0216 0.1928 0.2978
Schistosoma mansoni cathepsin s 0.0066 0.0331 0.0441
Onchocerca volvulus 0.0216 0.1928 1
Plasmodium vivax unspecified product 0.012 0.0912 0.455
Echinococcus granulosus cathepsin L 0.0055 0.0218 0.0265
Brugia malayi Cathepsin L-like precursor 0.0216 0.1928 0.2926
Plasmodium falciparum serine repeat antigen 1 0.0055 0.0218 0.0778
Giardia lamblia Cathepsin B precursor 0.0055 0.0218 0.0694
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0216 0.1928 0.8942
Trypanosoma cruzi cysteine peptidase, putative 0.0216 0.1928 0.291
Entamoeba histolytica cysteine proteinase 2 0.012 0.0912 0.4593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0055 0.0218 0.0778
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0097
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0063 0.0165
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.012 0.0912 0.1324
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0218 0.0243
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0063 0.0097
Entamoeba histolytica cysteine proteinase, putative 0.0216 0.1928 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1235 0.5681
Loa Loa (eye worm) hypothetical protein 0.0055 0.0218 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0055 0.0218 0.0897
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0216 0.1928 0.8942
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0055 0.0011
Echinococcus multilocularis cathepsin L 0.012 0.0912 0.0868
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0216 0.1928 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0063 0.0165
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0055 0.0218 0.0265
Giardia lamblia Cysteine protease 0.0055 0.0218 0.0694
Trypanosoma cruzi cruzipain precursor, putative 0.0216 0.1928 0.291
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0646 0.6474 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0216 0.1928 0.8942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0218 0.0897
Giardia lamblia Cathepsin B precursor 0.0238 0.2153 1
Echinococcus multilocularis cathepsin b 0.0646 0.6474 0.6457
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0218 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0912 0.4061
Giardia lamblia Cathepsin L precursor 0.0055 0.0218 0.0694
Loa Loa (eye worm) beta-lactamase 0.004 0.0063 0.0097
Onchocerca volvulus 0.0055 0.0218 0.0835
Loa Loa (eye worm) hypothetical protein 0.0066 0.0331 0.0511
Onchocerca volvulus 0.0216 0.1928 1
Giardia lamblia Cathepsin B precursor 0.0238 0.2153 1
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0218 0.0265
Leishmania major cathepsin L-like protease 0.0216 0.1928 0.8924
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0055 0.0218 0.0907
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0218 0.0337
Trypanosoma cruzi cysteine protease, putative 0.012 0.0912 0.1324
Entamoeba histolytica cysteine proteinase, putative 0.012 0.0912 0.4593
Trypanosoma cruzi cysteine peptidase, putative 0.0216 0.1928 0.291
Brugia malayi cathepsin F-like cysteine proteinase 0.0066 0.0331 0.0441
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0074 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0216 0.1928 0.8942
Plasmodium vivax unspecified product 0.0066 0.0331 0.1439
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.012 0.0912 0.1344
Giardia lamblia Cathepsin B precursor 0.0055 0.0218 0.0694
Plasmodium falciparum serine repeat antigen 3 0.0055 0.0218 0.0778
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1928 0.8924
Plasmodium vivax unspecified product 0.0055 0.0218 0.0835
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0216 0.1928 0.2978
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0218 0.0897
Loa Loa (eye worm) ctsf protein 0.0216 0.1928 0.2978
Trypanosoma cruzi cysteine proteinase, putative 0.012 0.0912 0.1324
Toxoplasma gondii cathepsin CPC2 0.0055 0.0218 0.0745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0218 0.0897
Plasmodium falciparum serine repeat antigen 9 0.0055 0.0218 0.0778
Entamoeba histolytica cysteine protease, putative 0.012 0.0912 0.4593
Schistosoma mansoni ap endonuclease 0.0041 0.0074 0.0041
Onchocerca volvulus Cathepsin F homolog 0.0216 0.1928 1
Onchocerca volvulus 0.0216 0.1928 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0216 0.1928 1
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0218 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1928 0.8942
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0216 0.1928 0.8942
Plasmodium falciparum serine repeat antigen 7 0.0055 0.0218 0.0778
Leishmania major cathepsin L-like protease 0.0216 0.1928 0.8924
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0218 0.0897
Echinococcus granulosus cathepsin b 0.0646 0.6474 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0055 0.0218 0.0835
Giardia lamblia Cathepsin B precursor 0.0055 0.0218 0.0694
Leishmania major cathepsin L-like protease 0.0216 0.1928 0.8924
Entamoeba histolytica cysteine protease, putative 0.0055 0.0218 0.0907
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0216 0.1928 0.8942
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0074 0.0218
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0074 0.0114
Brugia malayi Cathepsin L-like cysteine proteinase 0.0151 0.1235 0.1847
Plasmodium vivax vivapain-2 0.0216 0.1928 1
Plasmodium falciparum serine repeat antigen 6 0.0055 0.0218 0.0778

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.1962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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