Detailed information for compound 1295258

Basic information

Technical information
  • TDR Targets ID: 1295258
  • Name: T5551814
  • MW: 288.729 | Formula: C15H13ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 2.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cn1)C(=O)NC1CCOc2c1cccc2
  • InChi: 1S/C15H13ClN2O2/c16-14-6-5-10(9-17-14)15(19)18-12-7-8-20-13-4-2-1-3-11(12)13/h1-6,9,12H,7-8H2,(H,18,19)
  • InChiKey: XMSRQSRERLLENS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis heat shock protein 90 0.0045 0.1917 0.1917
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Brugia malayi MH2 domain containing protein 0.0008 0.0058 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.4171 0.4171
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0631 0.3292
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0826 0.4646
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.1778 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.053 0.0717
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.4171 0.564
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0483 0.2715
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0826 0.4646
Brugia malayi Smad1 0.0008 0.0058 0.0078
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.1917 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0826 0.1117
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0631 0.0853
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0058 0.0058
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0826 0.1117
Echinococcus granulosus smad 0.0008 0.0058 0.0058
Schistosoma mansoni smad 0.0008 0.0058 0.0058
Toxoplasma gondii Hsp90 domain-containing protein 0.0169 0.8222 1
Schistosoma mansoni endoplasmin 0.0045 0.1917 0.1917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.4171 0.4171
Echinococcus multilocularis muscleblind protein 1 0.0153 0.7396 0.7396
Echinococcus granulosus heat shock protein 0.0045 0.1917 0.1917
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Echinococcus granulosus muscleblind protein 0.0153 0.7396 0.7396
Loa Loa (eye worm) hypothetical protein 0.0017 0.053 0.0717
Schistosoma mansoni endoplasmin 0.0045 0.1917 0.1917
Loa Loa (eye worm) Smad1 0.0008 0.0058 0.0078
Loa Loa (eye worm) hypothetical protein 0.0049 0.2118 0.2864
Trypanosoma brucei heat shock protein, putative 0.0045 0.1917 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0826 0.4646
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.4171 0.4171
Loa Loa (eye worm) hypothetical protein 0.0015 0.0435 0.0589
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0826 0.4646
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.159 0.8297
Brugia malayi RNA binding protein 0.0062 0.2784 0.3765
Brugia malayi Endoplasmin precursor 0.0045 0.1917 0.2592
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.1158 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0058 0.0058
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0058 0.0078
Schistosoma mansoni heat shock protein 0.003 0.1158 0.1158
Plasmodium vivax endoplasmin, putative 0.0045 0.1917 0.2331
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0826 0.4646
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.1917 1
Brugia malayi MH1 domain containing protein 0.0008 0.0058 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2784 0.2784
Echinococcus granulosus tar DNA binding protein 0.0062 0.2784 0.2784
Schistosoma mansoni ap endonuclease 0.0019 0.0631 0.0631
Mycobacterium ulcerans hypothetical protein 0.0023 0.0826 0.4646
Schistosoma mansoni hypothetical protein 0.0015 0.0435 0.0435
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.053 0.5
Toxoplasma gondii heat shock protein HSP90 0.0045 0.1917 0.2331
Schistosoma mansoni hypothetical protein 0.0015 0.0435 0.0435
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0826 0.4646
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0826 0.4646
Loa Loa (eye worm) heat shock protein 75 0.003 0.1158 0.1566
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2784 0.2784
Giardia lamblia Grp94/Hsp90 0.0042 0.1778 0.892
Loa Loa (eye worm) hypothetical protein 0.0153 0.7396 1
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.5545 0.7497
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0058 0.0078
Echinococcus multilocularis muscleblind protein 0.0153 0.7396 0.7396
Plasmodium vivax heat shock protein 86, putative 0.0045 0.1917 0.2331
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.1917 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.1917 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.1778 0.9276
Echinococcus granulosus Smad4 0.0008 0.0058 0.0058
Trypanosoma brucei heat shock protein, putative 0.0045 0.1917 1
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.1778 1
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.1917 1
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.1917 1
Echinococcus granulosus heat shock protein 90 0.0045 0.1917 0.1917
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0631 0.3292
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0435 0.0589
Schistosoma mansoni heat shock protein 0.0045 0.1917 0.1917
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Trichomonas vaginalis heat shock protein, putative 0.0042 0.1778 0.9276
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0826 0.431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.2118 0.2864
Echinococcus multilocularis Smad4 0.0008 0.0058 0.0058
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.1778 1
Plasmodium falciparum heat shock protein 90 0.0045 0.1917 0.2331
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0826 0.4646
Trypanosoma brucei heat shock protein 84, putative 0.003 0.1158 0.6042
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.1917 1
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0631 0.3292
Trypanosoma brucei heat shock protein, putative 0.0045 0.1917 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.1339 0.1811
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0631 0.3292
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.1917 1
Echinococcus multilocularis endoplasmin 0.0042 0.1778 0.1778
Schistosoma mansoni smad1 5 8 and 0.0008 0.0058 0.0058
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0826 0.431
Onchocerca volvulus 0.0023 0.0826 0.7133
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0058 0.0058
Trichomonas vaginalis heat shock protein, putative 0.0042 0.1778 0.9276
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.1158 0.1158
Loa Loa (eye worm) hypothetical protein 0.0017 0.053 0.0717
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.2784 0.3765
Schistosoma mansoni hypothetical protein 0.0015 0.0435 0.0435
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0631 0.0767
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0826 0.431
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0435 0.0435
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0631 0.3292
Mycobacterium ulcerans heat shock protein 90 0.0042 0.1778 1
Schistosoma mansoni hypothetical protein 0.0033 0.1339 0.1339
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0058 0.0058
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Schistosoma mansoni heat shock protein 0.0045 0.1917 0.1917
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0435 0.0589
Echinococcus multilocularis smad 0.0008 0.0058 0.0058
Brugia malayi Muscleblind-like protein 0.0153 0.7396 1
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Echinococcus granulosus GPCR family 2 0.0015 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0023 0.0826 0.1117
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0483 0.2715
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0826 0.431
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.4171 0.564
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2784 0.2784
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.5545 0.7497
Trichomonas vaginalis heat shock protein, putative 0.0038 0.159 0.8297
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0631 0.0767
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Schistosoma mansoni hypothetical protein 0.0015 0.0435 0.0435
Brugia malayi TAR-binding protein 0.0062 0.2784 0.3765
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0435 0.0435
Schistosoma mansoni ap endonuclease 0.0019 0.0631 0.0631
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.2784 0.3765
Echinococcus multilocularis heat shock protein 0.0045 0.1917 0.1917
Plasmodium vivax heat shock protein, putative 0.0169 0.8222 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.097 0.5063
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0631 0.3292
Trichomonas vaginalis heat shock protein, putative 0.0045 0.1917 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0631 0.0631
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.053 0.0645
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0631 0.3292
Treponema pallidum heat shock protein 90 0.0042 0.1778 1
Echinococcus multilocularis heat shock protein 90 0.0038 0.159 0.159
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.1917 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.4171 0.4171
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0631 0.0631
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.053 0.0645
Toxoplasma gondii exonuclease III APE 0.0019 0.0631 0.0767
Loa Loa (eye worm) hypothetical protein 0.0017 0.053 0.0717
Loa Loa (eye worm) heat shock protein 90 0.0045 0.1917 0.2592
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0483 0.2715
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.097 0.118
Brugia malayi Hsp90 protein 0.003 0.1158 0.1566
Leishmania major heat shock protein, putative 0.003 0.1158 0.6042
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0826 0.4646
Loa Loa (eye worm) RNA binding protein 0.0062 0.2784 0.3765
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.1917 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.1917 1
Brugia malayi heat shock protein 90 0.0045 0.1917 0.2592
Toxoplasma gondii heat shock protein 75, putative 0.003 0.1158 0.1409
Trypanosoma brucei heat shock protein, putative 0.0045 0.1917 1
Schistosoma mansoni Smad4 0.0008 0.0058 0.0058
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.1917 1
Echinococcus granulosus heat shock protein 90 0.0038 0.159 0.159
Brugia malayi MH1 domain containing protein 0.0008 0.0058 0.0078
Brugia malayi MH2 domain containing protein 0.0008 0.0058 0.0078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.2118 0.2864
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.4171 0.4171
Loa Loa (eye worm) hypothetical protein 0.0153 0.7396 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2784 0.2784
Brugia malayi MH2 domain containing protein 0.0116 0.5545 0.7497
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0631 0.0853
Loa Loa (eye worm) endoplasmin 0.0045 0.1917 0.2592
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.1158 0.1158
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0435 0.0435
Trypanosoma brucei heat shock protein, putative 0.0045 0.1917 1
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0058 0.0058
Trypanosoma brucei heat shock protein, putative 0.0045 0.1917 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0826 0.431
Loa Loa (eye worm) hypothetical protein 0.0023 0.0826 0.1117
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0826 0.431
Plasmodium falciparum endoplasmin, putative 0.0032 0.1297 0.1577
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0631 0.3549
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0826 0.1117
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0435 0.0435
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.159 0.746
Echinococcus multilocularis tar DNA binding protein 0.0062 0.2784 0.2784
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0603 0.3146
Trichomonas vaginalis endoplasmin, putative 0.0032 0.1297 0.6767
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2784 0.2784
Loa Loa (eye worm) hypothetical protein 0.0017 0.053 0.0717
Echinococcus granulosus endoplasmin 0.0042 0.1778 0.1778
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.053 0.2983
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0058 0.0058
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.1917 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.2118 0.2864
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.4171 0.4171
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0435 0.0589
Trichomonas vaginalis heat shock protein, putative 0.0032 0.1297 0.6767
Plasmodium falciparum heat shock protein 90, putative 0.0169 0.8222 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.1158 0.6042
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1339 0.1811
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0826 0.4646
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0826 0.4646
Plasmodium vivax heat shock protein 90, putative 0.003 0.1158 0.1409
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.1917 0.2331
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.159 0.8297
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0483 0.2715
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0058 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.4171 0.4171
Echinococcus multilocularis GPCR, family 2 0.0015 0.0435 0.0435
Loa Loa (eye worm) TAR-binding protein 0.0062 0.2784 0.3765
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0631 0.3549
Loa Loa (eye worm) hypothetical protein 0.0023 0.0826 0.1117
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.053 0.2983
Leishmania major heat shock protein 83-1 0.0045 0.1917 1
Trypanosoma cruzi heat shock protein, putative 0.003 0.1158 0.6042
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.159 0.159

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.0323 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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