Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysine specific demethylase 5A | 0.0039 | 0.0834 | 0.0819 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.0762 | 0.2985 |
Schistosoma mansoni | jumonji domain containing protein | 0.0085 | 0.2147 | 0.2147 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0039 | 0.0834 | 0.0944 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0762 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0148 | 0.3976 | 0.3976 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0045 | 0.1005 | 0.099 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0.0635 | 0.8341 |
Brugia malayi | jmjC domain containing protein | 0.0107 | 0.2783 | 0.3151 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0107 | 0.2783 | 0.2771 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.01 | 0.2583 | 0.2571 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.0062 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0856 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0202 | 0.5536 | 0.7189 |
Plasmodium falciparum | thioredoxin reductase | 0.0013 | 0.0062 | 0.0819 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0013 | 0.0062 | 0.0819 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.067 | 0.0758 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.01 | 0.2583 | 0.2571 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0013 | 0.0062 | 0.0819 |
Plasmodium falciparum | glutathione reductase | 0.0013 | 0.0062 | 0.0819 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0224 | 0.2814 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0762 | 0.0863 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.2133 | 0.8837 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.2583 | 0.2925 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.2133 | 0.8837 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0416 | 0.0471 |
Trichomonas vaginalis | set domain proteins, putative | 0.0268 | 0.7452 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0013 | 0.0062 | 0.0819 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.2133 | 0.8837 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0067 | 0.164 | 0.1857 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.01 | 0.2583 | 0.2571 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0416 | 0.5463 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0416 | 0.5059 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.5536 | 0.6269 |
Brugia malayi | N-terminal motif family protein | 0.0202 | 0.5536 | 0.6269 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0148 | 0.3976 | 0.3976 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0159 | 0.018 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0856 | 0.0856 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0416 | 0.5059 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0856 | 0.0841 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.2583 | 0.2583 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0762 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.0762 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0107 | 0.2783 | 0.2771 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0013 | 0.0062 | 0.0819 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0316 | 0.8831 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0216 | 0.5939 | 0.5939 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.0635 | 0.8341 |
Brugia malayi | hypothetical protein | 0.004 | 0.0856 | 0.097 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0013 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0224 | 0.0253 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0148 | 0.3976 | 0.3966 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.01 | 0.2583 | 0.2571 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0416 | 0.5463 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0148 | 0.3976 | 0.3966 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0416 | 0.5463 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.3537 | 0.4005 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0224 | 0.2935 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0013 | 0.0062 | 0.0819 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.01 | 0.2583 | 0.2925 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0039 | 0.0834 | 0.0819 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0012 | 0.0036 | 0.0036 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0013 | 0.0062 | 0.0046 |
Echinococcus multilocularis | peregrin | 0.0033 | 0.0635 | 0.062 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.0762 | 1 |
Echinococcus granulosus | peregrin | 0.0033 | 0.0635 | 0.062 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0148 | 0.3976 | 0.3966 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0416 | 0.5463 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0224 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0039 | 0.0834 | 0.0944 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0634 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.067 | 0.0758 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0216 | 0.5939 | 0.6725 |
Onchocerca volvulus | 0.0268 | 0.7452 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.0235 | 0.651 | 0.7372 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0316 | 0.8831 | 1 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0762 | 0.0863 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0013 | 0.0062 | 0.0819 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.067 | 0.8789 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0013 | 0.0062 | 0.0819 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0856 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.5939 | 0.6725 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0762 | 0.0863 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0834 | 0.0834 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0033 | 0.0635 | 0.0719 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0416 | 0.0471 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.3537 | 0.4005 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.067 | 0.067 |
Echinococcus granulosus | GPCR family 2 | 0.01 | 0.2583 | 0.2571 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.2133 | 0.8837 |
Echinococcus granulosus | jumonji domain containing protein | 0.0045 | 0.1005 | 0.099 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0856 | 0.0856 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0224 | 0.2935 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0224 | 0.2305 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.067 | 0.0654 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0224 | 0.0688 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0416 | 0.5059 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.0062 | 0.0071 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0148 | 0.3976 | 0.3966 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0224 | 0.0224 |
Brugia malayi | Latrophilin receptor protein 2 | 0.01 | 0.2583 | 0.2925 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0224 | 0.0218 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.2583 | 0.2583 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.2133 | 0.8837 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0148 | 0.3976 | 0.4503 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0224 | 0.0224 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0416 | 0.5463 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0013 | 0.0062 | 0.0819 |
Brugia malayi | Bromodomain containing protein | 0.0033 | 0.0635 | 0.0719 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0856 | 1 |
Leishmania major | trypanothione reductase | 0.0037 | 0.0762 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0224 | 0.2305 |
Plasmodium falciparum | phd finger protein, putative | 0.0033 | 0.0635 | 0.8341 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0094 | 0.2405 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0856 | 0.0841 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0316 | 0.8831 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.067 | 0.8789 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.0776 | 0.0761 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0224 | 0.2305 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.3537 | 0.4005 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0762 | 0.0863 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0094 | 0.2405 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0635 | 0.0719 |
Echinococcus multilocularis | GPCR, family 2 | 0.01 | 0.2583 | 0.2571 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.067 | 0.0654 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0148 | 0.3976 | 0.3976 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0013 | 0.0062 | 0.0046 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0834 | 0.0834 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0148 | 0.3976 | 0.4503 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0856 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0224 | 1 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.2583 | 0.2583 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0094 | 0.2405 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0224 | 0.0207 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.8831 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0224 | 0.2935 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.0776 | 0.0761 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0762 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0224 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0013 | 0.0062 | 0.0819 |
Giardia lamblia | PHD finger protein 15 | 0.0033 | 0.0635 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.067 | 0.067 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0762 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.0635 | 0.8341 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.067 | 0.0654 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0033 | 0.0635 | 0.0635 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0033 | 0.0635 | 0.062 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.067 | 0.067 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0013 | 0.0062 | 0.0819 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.01 | 0.2583 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.131 | 0.1483 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0235 | 0.651 | 0.7372 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0033 | 0.0635 | 0.062 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0012 | 0.0036 | 0.0041 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0224 | 0.0207 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0224 | 0.0253 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0635 | 0.0635 |
Onchocerca volvulus | 0.0034 | 0.067 | 0.005 | |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.2583 | 0.2583 |
Brugia malayi | PHD-finger family protein | 0.0033 | 0.0635 | 0.0719 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0224 | 0.2935 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0224 | 0.0218 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.2133 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0094 | 0.2405 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.067 | 0.067 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0762 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.