Detailed information for compound 1295465

Basic information

Technical information
  • TDR Targets ID: 1295465
  • Name: 2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl) sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
  • MW: 309.41 | Formula: C12H15N5OS2
  • H donors: 1 H acceptors: 4 LogP: 1.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(SCC(=O)Nc2nccs2)nnc1C1CC1
  • InChi: 1S/C12H15N5OS2/c1-2-17-10(8-3-4-8)15-16-12(17)20-7-9(18)14-11-13-5-6-19-11/h5-6,8H,2-4,7H2,1H3,(H,13,14,18)
  • InChiKey: PMIYNYLLDQGURR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-thiazol-2-yl-acetamide
  • 2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)thio]-N-(2-thiazolyl)acetamide
  • 2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)thio]-N-thiazol-2-yl-acetamide
  • 2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-(1,3-thiazol-2-yl)ethanamide
  • ZINC06742492
  • IVK/0023997

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0722 0.6462
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1221 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0546 0.1646
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0546 0.1646
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0722 0.2202
Loa Loa (eye worm) hypothetical protein 0.002 0.036 0.0335
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0692 0.0667
Plasmodium falciparum acyl-CoA synthetase 0.002 0.036 0.3102
Plasmodium vivax importin-beta 2, putative 0.0035 0.0764 0.6179
Loa Loa (eye worm) TAR-binding protein 0.0072 0.1778 0.1756
Schistosoma mansoni hypothetical protein 0.0032 0.0692 0.0667
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0512 0.4514
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.2744 0.8601
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0722 0.2202
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1221 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0584 0.1765
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0546 0.1646
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.2744 0.8601
Loa Loa (eye worm) hypothetical protein 0.002 0.036 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1778 0.1756
Brugia malayi RNA, U transporter 1 0.0099 0.2524 0.5452
Echinococcus granulosus importin subunit beta 1 0.0035 0.0764 0.074
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0722 0.2202
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0546 0.1646
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.1778 0.1756
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.2744 0.8601
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0722 0.5826
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1715 0.3686
Brugia malayi serine/threonine-protein kinase plk-2 0.0107 0.2744 0.5933
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1221 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0764 0.1611
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0722 0.2202
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0764 0.2399
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.4608 1
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.2744 0.8601
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.3187 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.2597 0.561
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.2744 0.8601
Leishmania major importin beta-1 subunit, putative 0.0028 0.0584 0.1765
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0546 0.1646
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0546 0.1646
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0123 0.3187 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0722 0.2202
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0546 0.1646
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.033 0.0962
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.3187 0.3169
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.3187 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0512 0.1608
Echinococcus granulosus GPCR family 2 0.0032 0.0692 0.0667
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0107 0.2744 0.2725
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.2597 0.2577
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0546 0.1646
Entamoeba histolytica Ran family GTPase 0.0026 0.0512 0.1539
Mycobacterium ulcerans hypothetical protein 0.0027 0.0546 0.1646
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.3187 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0722 0.6462
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0764 0.2399
Schistosoma mansoni hypothetical protein 0.0032 0.0692 0.0667
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.3187 1
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.3187 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1221 0.378
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0026 0.0082
Schistosoma mansoni kinase 0.0054 0.1301 0.1279
Brugia malayi RNA binding protein 0.0072 0.1778 0.3823
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.2744 0.8601
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.3187 0.3169
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.3187 0.3169
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1778 0.1756
Schistosoma mansoni ran 0.0026 0.0512 0.0488
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0546 0.1136
Loa Loa (eye worm) hypothetical protein 0.0102 0.2597 0.2577
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0764 0.6179
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1778 0.1756
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.4608 0.4594
Loa Loa (eye worm) hypothetical protein 0.0027 0.0546 0.0522
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.3187 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.033 0.0962
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0722 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0546 0.1646
Brugia malayi TAR-binding protein 0.0072 0.1778 0.3823
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0546 0.1136
Onchocerca volvulus Serine\/threonine kinase homolog 0.0107 0.2744 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1103 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0764 0.074
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0512 0.0488
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.3187 1
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.3187 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.033 0.0962
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.2744 0.8601
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0546 0.1646
Schistosoma mansoni ran 0.0026 0.0512 0.0488
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.2744 0.8601
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0722 0.5826
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0692 0.0667
Loa Loa (eye worm) hypothetical protein 0.0032 0.0692 0.0667
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0546 0.1646
Echinococcus multilocularis GPCR, family 2 0.0032 0.0692 0.0667
Loa Loa (eye worm) hypothetical protein 0.0027 0.0546 0.0522
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0107 0.2744 0.2725
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0722 0.5826
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.2744 0.8601
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.3187 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0692 0.1452
Schistosoma mansoni hypothetical protein 0.0032 0.0692 0.0667
Loa Loa (eye worm) acetyltransferase 0.0175 0.4608 0.4594
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0026 0.0082
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.3187 0.3169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.033 0.0962
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0722 0.2202
Plasmodium falciparum importin beta, putative 0.0035 0.0764 0.6854
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.1263 0.3912
Loa Loa (eye worm) hypothetical protein 0.002 0.036 0.0335
Entamoeba histolytica serine/threonine protein kinase, putative 0.0107 0.2744 0.8601
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0692 0.1452
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0546 0.1646
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0692 0.0667
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.036 0.2796
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0692 0.0667
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.1263 0.3912
Echinococcus multilocularis tar DNA binding protein 0.0072 0.1778 0.1756
Loa Loa (eye worm) RNA binding protein 0.0072 0.1778 0.1756
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0546 0.1646
Loa Loa (eye worm) hypothetical protein 0.0027 0.0546 0.0522
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0546 0.1646
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1103 0.3408
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0722 0.5826
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0584 0.1765
Trichomonas vaginalis ran, putative 0.0026 0.0512 0.1539
Giardia lamblia Kinase, PLK 0.0107 0.2744 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.3187 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0107 0.2744 0.2725
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0107 0.2744 0.8601
Brugia malayi phosphofructokinase 0.0123 0.3187 0.6898
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.4473 0.4459
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0546 0.1646
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0692 0.0667
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0584 0.1765
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0584 0.1765
Loa Loa (eye worm) phosphofructokinase 0.0123 0.3187 0.3169
Schistosoma mansoni importin beta-1 0.0035 0.0764 0.074
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.1778 0.3823
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1103 0.2647
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1778 0.1756
Entamoeba histolytica hypothetical protein 0.0028 0.0584 0.1765
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0512 0.1539
Loa Loa (eye worm) hypothetical protein 0.002 0.036 0.0335
Brugia malayi 6-phosphofructokinase 0.0123 0.3187 0.6898
Loa Loa (eye worm) hypothetical protein 0.002 0.036 0.0335
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0512 0.0488
Trypanosoma brucei polo-like protein kinase 0.0107 0.2744 0.8612
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.036 0.1057
Onchocerca volvulus 0.0027 0.0546 0.1914
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.4608 0.4594
Schistosoma mansoni hypothetical protein 0.0069 0.1715 0.1693
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0512 0.407
Loa Loa (eye worm) hypothetical protein 0.0069 0.1715 0.1693
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0512 0.407
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.036 0.1057
Echinococcus granulosus tar DNA binding protein 0.0072 0.1778 0.1756
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0722 0.2202
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0722 0.5826
Brugia malayi 6-phosphofructokinase 0.0123 0.3187 0.6898
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.3187 0.3169
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1221 0.378
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0512 0.1539
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0722 0.094
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.3187 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0512 0.1061
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.3187 0.3169
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1778 0.1756
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.2597 0.561
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0546 0.1646
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1221 0.1198
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.3187 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0764 0.074
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.3187 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0546 0.1136
Leishmania major GTP-binding protein, putative 0.0026 0.0512 0.1539
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0722 1
Schistosoma mansoni hypothetical protein 0.0032 0.0692 0.0667
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0722 0.2202
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.2744 0.2725
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0512 0.0488
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0546 0.1646

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3981 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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