Detailed information for compound 1295547

Basic information

Technical information
  • TDR Targets ID: 1295547
  • Name: N-[(3-methoxyphenyl)methyl]-3-oxo-4H-1,4-benz othiazine-6-sulfonamide
  • MW: 364.439 | Formula: C16H16N2O4S2
  • H donors: 2 H acceptors: 3 LogP: 1.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CNS(=O)(=O)c1ccc2c(c1)NC(=O)CS2
  • InChi: 1S/C16H16N2O4S2/c1-22-12-4-2-3-11(7-12)9-17-24(20,21)13-5-6-15-14(8-13)18-16(19)10-23-15/h2-8,17H,9-10H2,1H3,(H,18,19)
  • InChiKey: DHAFVNWPILJXTG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-keto-N-(3-methoxybenzyl)-4H-1,4-benzothiazine-6-sulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.002 0.0056
Schistosoma mansoni Smad4 0.0078 0.0094 0.0266
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Echinococcus granulosus smad 0.0174 0.0262 0.1629
Brugia malayi hypothetical protein 0.0145 0.0211 0.0211
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0564 0.0944 0.0939
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0151 0.0222 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0225 0.0351 0.493
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0719 0.1215 0.1215
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0431 0.0711 0.4416
Schistosoma mansoni hypothetical protein 0.0945 0.161 0.4564
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0431 0.0711 0.4416
Echinococcus multilocularis mothers against decapentaplegic 6 0.0078 0.0094 0.0583
Schistosoma mansoni tar DNA-binding protein 0.0719 0.1215 0.3444
Schistosoma mansoni glutaminase 0.1096 0.1874 0.5313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0049 0.0138
Echinococcus multilocularis mothers against decapentaplegic 2 0.0078 0.0094 0.0583
Brugia malayi MH1 domain containing protein 0.0096 0.0126 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.002 0.0056
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0092 0.0233
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0431 0.0711 1
Loa Loa (eye worm) hypothetical protein 0.0564 0.0944 0.0944
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0049 0.0138
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0092 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0006 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0049 0.0138
Echinococcus granulosus snurportin 1 0.035 0.057 0.3543
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0092 0.057
Brugia malayi Calcitonin receptor-like protein seb-1 0.2986 0.518 0.518
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0101 0.0134 0.0832
Schistosoma mansoni tar DNA-binding protein 0.0719 0.1215 0.3444
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0431 0.0711 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0126 0.0126
Schistosoma mansoni tar DNA-binding protein 0.0719 0.1215 0.3444
Schistosoma mansoni hypothetical protein 0.035 0.057 0.1617
Leishmania major isocitrate dehydrogenase, putative 0.0052 0.0049 0.0693
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0151 0.0222 0.2647
Schistosoma mansoni hypothetical protein 0.0945 0.161 0.4564
Leishmania major importin beta-1 subunit, putative 0.0027 0.0004 0.006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0945 0.161 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0004 0.0023
Onchocerca volvulus 0.0245 0.0387 0.0381
Echinococcus granulosus mothers against decapentaplegic 2 0.0078 0.0094 0.0583
Loa Loa (eye worm) Smad1 0.0174 0.0262 0.0262
Brugia malayi Latrophilin receptor protein 2 0.0945 0.161 0.161
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0092 0.026
Brugia malayi MH2 domain containing protein 0.0078 0.0094 0.0094
Brugia malayi MH1 domain containing protein 0.0174 0.0262 0.0262
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0052 0.0049 0.2082
Schistosoma mansoni Smad4 0.0174 0.0262 0.0743
Brugia malayi hypothetical protein 0.0094 0.0123 0.0123
Schistosoma mansoni smad 0.0174 0.0262 0.0743
Plasmodium vivax importin-beta 2, putative 0.0033 0.0015 0.0213
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0015 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0208 0.0321 0.4516
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0006 0.0039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0049 0.0049
Brugia malayi TAR-binding protein 0.0719 0.1215 0.1215
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0052 0.0049 0.0306
Schistosoma mansoni regulator of G protein signaling 0.0028 0.0006 0.0018
Plasmodium falciparum importin beta, putative 0.0033 0.0015 0.0213
Loa Loa (eye worm) hypothetical protein 0.0225 0.0351 0.0351
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0006 0.0039
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0052 0.0049 0.0263
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0092 0.129
Entamoeba histolytica hypothetical protein 0.0027 0.0004 0.0873
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.002 0.0123
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0092 0.129
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0923 0.1572 0.9762
Echinococcus multilocularis mothers against decapentaplegic 5 0.0174 0.0262 0.1629
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.002 0.0123
Brugia malayi MH2 domain containing protein 0.0174 0.0262 0.0262
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0049 0.0303
Loa Loa (eye worm) MH2 domain-containing protein 0.2555 0.4427 0.4427
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0052 0.0049 0.0049
Brugia malayi RNA binding protein 0.0719 0.1215 0.1215
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Brugia malayi hypothetical protein 0.0225 0.0351 0.0351
Toxoplasma gondii hypothetical protein 0.0028 0.0006 0.0089
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0052 0.0049 0.014
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0101 0.0134 0.0832
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0092 0.057
Schistosoma mansoni smad1 5 8 and 0.0174 0.0262 0.0743
Echinococcus multilocularis GPCR, family 2 0.0945 0.161 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0431 0.0711 0.4416
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.002 0.0123
Schistosoma mansoni unc-13 (munc13) 0.0052 0.0049 0.014
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0015 0.0094
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0004 0.006
Schistosoma mansoni z-protein (S1r protein) 0.0028 0.0006 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.2041 0.3528 0.3528
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0006 0.0039
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0092 0.129
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0431 0.0711 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0092 0.0233
Brugia malayi MH1 domain containing protein 0.0174 0.0262 0.0262
Echinococcus granulosus TGF beta signal transducer SmadC 0.0174 0.0262 0.1629
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0945 0.161 1
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0052 0.0049 0.0056
Loa Loa (eye worm) pigment dispersing factor receptor c 0.2986 0.518 0.518
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0174 0.0262 0.0743
Toxoplasma gondii LsmAD domain-containing protein 0.0225 0.0351 0.493
Loa Loa (eye worm) MH1 domain-containing protein 0.0174 0.0262 0.0262
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0018 0.0109
Loa Loa (eye worm) hypothetical protein 0.0094 0.0123 0.0123
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0006 0.0006
Schistosoma mansoni smad 0.0078 0.0094 0.0266
Brugia malayi Importin beta-1 subunit 0.0033 0.0015 0.0015
Schistosoma mansoni importin beta-1 0.0033 0.0015 0.0043
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.002 0.0279
Loa Loa (eye worm) hypothetical protein 0.0078 0.0094 0.0094
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0945 0.161 0.161
Onchocerca volvulus 0.0036 0.002 0.0014
Brugia malayi glutaminase DH11.1 0.1096 0.1874 0.1874
Brugia malayi MH1 domain containing protein 0.0096 0.0126 0.0126
Toxoplasma gondii isocitrate dehydrogenase 0.0431 0.0711 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0225 0.0351 0.493
Mycobacterium ulcerans glutaminase 0.1096 0.1874 1
Schistosoma mansoni hypothetical protein 0.2041 0.3528 1
Echinococcus granulosus Smad4 0.0174 0.0262 0.1629
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0431 0.0711 1
Brugia malayi Probable isocitrate dehydrogenase 0.0052 0.0049 0.0049
Echinococcus multilocularis Smad4 0.0174 0.0262 0.1629
Loa Loa (eye worm) hypothetical protein 0.2986 0.518 0.518
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0151 0.0222 0.1183
Plasmodium vivax SET domain protein, putative 0.0036 0.002 0.0279
Leishmania major hypothetical protein, conserved 0.0208 0.0321 0.4516
Schistosoma mansoni hypothetical protein 0.0101 0.0134 0.038
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0015 0.0213
Schistosoma mansoni Smad4 0.0078 0.0094 0.0266
Brugia malayi Smad1 0.0174 0.0262 0.0262
Brugia malayi N-terminal motif family protein 0.0564 0.0944 0.0944
Loa Loa (eye worm) glutaminase 2 0.1096 0.1874 0.1874
Schistosoma mansoni hypothetical protein 0.0945 0.161 0.4564
Loa Loa (eye worm) pax transcription factor protein 2 0.0245 0.0387 0.0387
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0092 0.5
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0431 0.0711 0.2016
Leishmania major hypothetical protein, conserved 0.0225 0.0351 0.493
Loa Loa (eye worm) hypothetical protein 0.0094 0.0123 0.0123
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0028 0.0006 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0431 0.0711 0.4416
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0052 0.0049 0.0049
Schistosoma mansoni smad1 5 8 and 0.0174 0.0262 0.0743
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0049 0.0303
Brugia malayi MH2 domain containing protein 0.0174 0.0262 0.0262
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0431 0.0711 0.4416
Loa Loa (eye worm) DIX domain-containing protein 0.0028 0.0006 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0174 0.0262 0.0262
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0092 0.5
Echinococcus multilocularis tar DNA binding protein 0.0719 0.1215 0.7545
Brugia malayi hypothetical protein 0.0028 0.0006 0.0006
Brugia malayi Probable ClpP-like protease 0.0077 0.0092 0.0092
Schistosoma mansoni isocitrate dehydrogenase 0.0052 0.0049 0.014
Loa Loa (eye worm) hypothetical protein 0.2041 0.3528 0.3528
Onchocerca volvulus 0.0282 0.0451 0.0445
Loa Loa (eye worm) latrophilin receptor protein 2 0.0945 0.161 0.161
Echinococcus multilocularis snurportin 1 0.035 0.057 0.3543
Schistosoma mansoni microtubule-associated protein tau 0.0821 0.1393 0.395
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0049 0.0303
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.035 0.057 0.057
Entamoeba histolytica tartrate dehydrogenase, putative 0.0052 0.0049 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0006 0.0039
Trypanosoma cruzi PAB1-binding protein , putative 0.0225 0.0351 0.493
Loa Loa (eye worm) transcription factor SMAD2 0.2555 0.4427 0.4427
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0015 0.0213
Schistosoma mansoni hypothetical protein 0.0945 0.161 0.4564
Echinococcus multilocularis isocitrate dehydrogenase 0.0431 0.0711 0.4416
Echinococcus granulosus mothers against decapentaplegic 5 0.0174 0.0262 0.1629
Loa Loa (eye worm) isocitrate dehydrogenase 0.0431 0.0711 0.0711
Loa Loa (eye worm) hypothetical protein 0.0052 0.0049 0.0049
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0006 0.0006
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0052 0.0049 0.0306
Trypanosoma brucei PAB1-binding protein , putative 0.0225 0.0351 0.493
Brugia malayi hypothetical protein 0.0028 0.0006 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.0821 0.1393 0.8654
Loa Loa (eye worm) glutaminase 0.1096 0.1874 0.1874
Loa Loa (eye worm) TAR-binding protein 0.0719 0.1215 0.1215
Trypanosoma brucei hypothetical protein, conserved 0.0208 0.0321 0.4516
Loa Loa (eye worm) MH2 domain-containing protein 0.0078 0.0094 0.0094
Brugia malayi Pre-SET motif family protein 0.0036 0.002 0.002
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0151 0.0222 0.0945
Echinococcus granulosus tar DNA binding protein 0.0719 0.1215 0.7545
Echinococcus granulosus importin subunit beta 1 0.0033 0.0015 0.0094
Toxoplasma gondii hypothetical protein 0.0026 0.0004 0.0055
Loa Loa (eye worm) MH1 domain-containing protein 0.0078 0.0094 0.0094
Brugia malayi MH2 domain containing protein 0.2555 0.4427 0.4427
Loa Loa (eye worm) hypothetical protein 0.0077 0.0092 0.0092
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0006 0.0039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0004 0.0023
Brugia malayi RNA, U transporter 1 0.0093 0.0121 0.0121
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0052 0.0049 0.0306
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0248 0.0391 0.0391
Schistosoma mansoni tar DNA-binding protein 0.0719 0.1215 0.3444
Toxoplasma gondii isocitrate dehydrogenase 0.0431 0.0711 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0049 0.0049
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0004 0.0055
Schistosoma mansoni dep domain containing protein 0.0028 0.0006 0.0018
Schistosoma mansoni dishevelled 0.0028 0.0006 0.0018
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0006 0.0039
Mycobacterium ulcerans hypothetical protein 0.0151 0.0222 0.0945
Schistosoma mansoni smad1 5 8 and 0.0174 0.0262 0.0743
Trichomonas vaginalis glutaminase, putative 0.1096 0.1874 1
Brugia malayi Isocitrate dehydrogenase 0.0431 0.0711 0.0711
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0431 0.0711 1
Schistosoma mansoni tar DNA-binding protein 0.0719 0.1215 0.3444
Trypanosoma cruzi hypothetical protein, conserved 0.0208 0.0321 0.4516
Brugia malayi isocitrate dehydrogenase 0.0431 0.0711 0.0711
Echinococcus granulosus microtubule associated protein 2 0.0821 0.1393 0.8654
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0004 0.0023
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0046 0.0283
Schistosoma mansoni eyes absent homolog 0.0094 0.0123 0.0348
Trichomonas vaginalis set domain proteins, putative 0.0282 0.0451 0.2404
Echinococcus granulosus GPCR family 2 0.0945 0.161 1
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0052 0.0049 0.0049
Brugia malayi Pax transcription factor protein 2 0.0245 0.0387 0.0387
Brugia malayi Pre-SET motif family protein 0.0248 0.0391 0.0391
Plasmodium vivax ataxin-2 like protein, putative 0.0225 0.0351 0.493
Echinococcus granulosus mothers against decapentaplegic 6 0.0078 0.0094 0.0583
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0431 0.0711 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0046 0.1912
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0028 0.0006 0.0006
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0052 0.0049 0.0306
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0092 0.129
Echinococcus granulosus Pleckstrin G protein interacting region 0.0028 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0945 0.161 0.161
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0174 0.0262 0.1629
Brugia malayi DIX domain containing protein 0.0028 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0033 0.0015 0.0015
Brugia malayi Probable isocitrate dehydrogenase 0.0052 0.0049 0.0049
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0431 0.0711 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0945 0.161 1
Loa Loa (eye worm) RNA binding protein 0.0719 0.1215 0.1215
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0092 0.4031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0049 0.0303
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.002 0.0056
Echinococcus multilocularis smad 0.0174 0.0262 0.1629
Brugia malayi regulator of G-protein signaling egl-10 0.0028 0.0006 0.0006
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0052 0.0049 0.0049
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0092 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0225 0.0351 0.493
Brugia malayi RNA recognition motif domain containing protein 0.0719 0.1215 0.1215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0945 0.161 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0046 0.0283
Loa Loa (eye worm) nuclear factor I 0.0096 0.0126 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.002 0.0056
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0028 0.0006 0.0018
Brugia malayi mothers against decapentaplegic homolog 3 0.0078 0.0094 0.0094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.2986 0.518 0.518
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0004 0.0055
Mycobacterium tuberculosis Probable aminotransferase 0.0151 0.0222 0.2647
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0006 0.0039
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0431 0.0711 1
Schistosoma mansoni dishevelled 0.0028 0.0006 0.0018
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0078 0.0094 0.0088

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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