Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | karyopherin (importin) beta 1 | No references | |
Homo sapiens | snurportin 1 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.2591 | 0.2477 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0603 | 0.1849 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0207 | 1 |
Onchocerca volvulus | 0.0035 | 0.0207 | 0.5 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0226 | 0.5755 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0207 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0207 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0192 | 0.004 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0207 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0207 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0207 | 0.5 |
Schistosoma mansoni | importin beta-1 | 0.0035 | 0.0192 | 0.004 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0207 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0207 | 0.0016 |
Onchocerca volvulus | 0.0035 | 0.0207 | 0.5 | |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0207 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0207 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0207 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0207 | 0.0226 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0207 | 1 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0207 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0207 | 0.0056 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0207 | 0.0056 |
Brugia malayi | RNA, U transporter 1 | 0.0099 | 0.2061 | 0.7824 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0207 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0207 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0207 | 0.0056 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0207 | 0.0056 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0207 | 0.0226 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0603 | 0.1849 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0207 | 0.0056 |
Brugia malayi | Importin beta-1 subunit | 0.0035 | 0.0192 | 0.0162 |
Plasmodium falciparum | importin beta, putative | 0.0035 | 0.0192 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.2591 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0207 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0207 | 0.0056 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0603 | 0.0458 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0207 | 0.0056 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.2591 | 0.2477 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0207 | 0.0056 |
Onchocerca volvulus | 0.0035 | 0.0207 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0207 | 0.0056 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0207 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0603 | 0.0458 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0207 | 0.0016 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0207 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0207 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0207 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.