Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei gambiense | phosphoglycerate kinase, putative | No references | |
Trypanosoma brucei | phosphoglycerate kinase | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0206 | 0.3752 | 0.5 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0206 | 0.3752 | 1 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0206 | 0.3752 | 0.3752 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0206 | 0.3752 | 0.5 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0206 | 0.3752 | 0.5 |
Brugia malayi | Phosphoglycerate kinase | 0.0206 | 0.3752 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.3752 | 1 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0206 | 0.3752 | 1 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0206 | 0.3752 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0206 | 0.3752 | 0.5 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0206 | 0.3752 | 0.5 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0206 | 0.3752 | 1 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0206 | 0.3752 | 1 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0206 | 0.3752 | 1 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0206 | 0.3752 | 1 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0206 | 0.3752 | 0.5 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0206 | 0.3752 | 1 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0206 | 0.3752 | 0.5 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0206 | 0.3752 | 0.5 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0206 | 0.3752 | 0.5 |
Giardia lamblia | Phosphoglycerate kinase | 0.0206 | 0.3752 | 0.5 |
Treponema pallidum | phosphoglycerate kinase | 0.0206 | 0.3752 | 0.5 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0206 | 0.3752 | 0.5 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0206 | 0.3752 | 0.5 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0206 | 0.3752 | 0.3752 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0206 | 0.3752 | 1 |
Brugia malayi | Phosphoglycerate kinase | 0.0075 | 0.0504 | 0.1345 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.