Detailed information for compound 1296354

Basic information

Technical information
  • TDR Targets ID: 1296354
  • Name: (5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)-[ 3-[4-(2-methylphenyl)piperazin-1-yl]piperidin -1-yl]methanone
  • MW: 432.561 | Formula: C25H32N6O
  • H donors: 0 H acceptors: 3 LogP: 3.47 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)n2c(n1)cc(n2)C(=O)N1CCCC(C1)N1CCN(CC1)c1ccccc1C
  • InChi: 1S/C25H32N6O/c1-18-7-4-5-9-23(18)29-13-11-28(12-14-29)21-8-6-10-30(17-21)25(32)22-16-24-26-19(2)15-20(3)31(24)27-22/h4-5,7,9,15-16,21H,6,8,10-14,17H2,1-3H3
  • InChiKey: UVFOFVOMZGDMQT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)-[3-[4-(2-methylphenyl)piperazin-1-yl]-1-piperidyl]methanone
  • (5,7-dimethyl-2-pyrazolo[1,5-a]pyrimidinyl)-[3-[4-(2-methylphenyl)-1-piperazinyl]-1-piperidinyl]methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi CXXC zinc finger family protein 0.0035 0.0606 0.1742
Echinococcus granulosus pyruvate kinase 0.0019 0.0292 0.0268
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.013 0.0372
Schistosoma mansoni ap endonuclease 0.0021 0.0331 0.0307
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0331 0.3486
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0331 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.095 0.6617
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0209 0.0184
Echinococcus granulosus cpg binding protein 0.0037 0.0647 0.0623
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.095 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1107 0.3181
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0667 0.3738
Brugia malayi MH2 domain containing protein 0.0135 0.2654 0.7631
Schistosoma mansoni hypothetical protein 0.0191 0.381 0.3794
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0292 0.0746
Schistosoma mansoni ap endonuclease 0.0021 0.0331 0.0307
Echinococcus granulosus Smad4 0.0009 0.0085 0.006
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0085 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0806 0.0783
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0209 0.0598
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.1066 0.1044
Schistosoma mansoni cpg binding protein 0.0037 0.0647 0.0623
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0249 0.0225
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0209 0.0184
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0667 0.4094
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0209 0.0184
Brugia malayi MH2 domain containing protein 0.0009 0.0085 0.0241
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.007
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0113 0.0324
Loa Loa (eye worm) pyruvate kinase 0.0008 0.0059 0.0168
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.0059 0.0168
Echinococcus multilocularis pyruvate kinase 0.003 0.0505 0.0481
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.3477 1
Brugia malayi jmjC domain containing protein 0.0059 0.1107 0.3181
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0667 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0806 0.2317
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0116 0.0092
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0667 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.0598
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.0598
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.3376 0.336
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0073 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0434 0.1247
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0667 1
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0292 0.1279
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.095 0.0927
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0434 0.1939
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.123 0.1208
Brugia malayi jmjC domain containing protein 0.0015 0.0209 0.0598
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0331 0.095
Brugia malayi jmjC domain containing protein 0.0057 0.1066 0.3065
Brugia malayi jmjC domain containing protein 0.0015 0.0209 0.0598
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0331 0.2671
Giardia lamblia Pyruvate kinase 0.0038 0.0667 0.6581
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0209 0.0184
Schistosoma mansoni smad1 5 8 and 0.0009 0.0085 0.006
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0667 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0331 0.2671
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0667 0.1917
Toxoplasma gondii exonuclease III APE 0.0021 0.0331 0.1094
Leishmania major pyruvate kinase 0.0038 0.0667 0.4489
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.1328 1
Echinococcus multilocularis pyruvate kinase 0.0038 0.0667 0.0644
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0331 0.3066
Plasmodium falciparum pyruvate kinase 0.0038 0.0667 0.7018
Echinococcus multilocularis pyruvate kinase 0.0038 0.0667 0.0644
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0667 0.1917
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0209 0.0184
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0292 0.3077
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0667 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.095 0.6617
Echinococcus multilocularis pyruvate kinase 0.0019 0.0292 0.0268
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0209 0.0184
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0116 0.0333
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0667 0.1917
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0209 0.0184
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0862 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0085 0.006
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0085 0.0241
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.1107 0.1084
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0073 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0806 0.0783
Brugia malayi jmjC domain containing protein 0.0015 0.0209 0.0598
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0606 0.1742
Echinococcus multilocularis pyruvate kinase 0.0019 0.0292 0.0268
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0667 0.6833
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.3477 0.3461
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.1066 0.1044
Plasmodium vivax JmjC domain containing protein 0.0015 0.0209 0.2197
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0116 0.0092
Echinococcus granulosus geminin 0.0191 0.381 0.3794
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.095 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.1107 0.1084
Leishmania major pyruvate kinase 0.0038 0.0667 0.4489
Echinococcus multilocularis Smad4 0.0009 0.0085 0.006
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0667 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0073 0.0048
Brugia malayi pyruvate kinase 0.0008 0.0059 0.0168
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0331 0.0307
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.123 0.1208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0806 0.0783
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0667 0.3738
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0331 0.1199
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.2654 0.7631
Echinococcus multilocularis smad 0.0009 0.0085 0.006
Schistosoma mansoni smad 0.0009 0.0085 0.006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0085 0.006
Brugia malayi PHD-finger family protein 0.0006 0.0025 0.007
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.123 0.1208
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0085 0.006
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.1066 0.1044
Brugia malayi MH1 domain containing protein 0.0009 0.0085 0.0241
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0249 0.0225
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0667 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0331 0.5
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0331 0.0683
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.1917
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0667 0.1917
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0209 0.0184
Brugia malayi Smad1 0.0009 0.0085 0.0241
Brugia malayi Bromodomain containing protein 0.0006 0.0025 0.007
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0667 0.6833
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0862 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0331 0.2671
Brugia malayi MH2 domain containing protein 0.0009 0.0085 0.0241
Echinococcus granulosus pyruvate kinase 0.0019 0.0292 0.0268
Echinococcus multilocularis pyruvate kinase 0.0019 0.0292 0.0268
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.123 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0806 0.0783
Schistosoma mansoni cpg binding protein 0.0035 0.0606 0.0583
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0862 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0806 0.0783
Chlamydia trachomatis pyruvate kinase 0.0038 0.0667 0.5
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0209 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0806 0.0783
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0209 0.0184
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.1107 0.1084
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0085 0.006
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.123 0.9121
Echinococcus multilocularis geminin 0.0191 0.381 0.3794
Echinococcus granulosus pyruvate kinase 0.0019 0.0292 0.0268
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.123 1
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.2654 0.7631
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0073 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.123 1
Echinococcus granulosus smad 0.0009 0.0085 0.006
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0667 0.7025
Schistosoma mansoni Smad4 0.0009 0.0085 0.006
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.3477 0.3461
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0667 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0331 0.0307
Schistosoma mansoni pyruvate kinase 0.0038 0.0667 0.0644
Schistosoma mansoni cpg binding protein 0.0037 0.0647 0.0623
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0434 0.1247
Echinococcus granulosus phd:f box containing protein 0.0015 0.0209 0.0184
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.123 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0647 0.0623
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.123 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0209 0.0598
Schistosoma mansoni pyruvate kinase 0.0038 0.0667 0.0644
Echinococcus granulosus pyruvate kinase 0.0038 0.0667 0.0644
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0085 0.0241
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0073 0.0048
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0806 0.0783
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0209 0.0184
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.0598
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.095 1
Brugia malayi MH1 domain containing protein 0.0009 0.0085 0.0241
Brugia malayi jmjC domain containing protein 0.0015 0.0209 0.0598
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.123 0.1208
Loa Loa (eye worm) Smad1 0.0009 0.0085 0.0241
Schistosoma mansoni hypothetical protein 0.0191 0.381 0.3794
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.007
Schistosoma mansoni pyruvate kinase 0.0019 0.0292 0.0268
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0209 0.0598
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0331 0.3066
Loa Loa (eye worm) acetyltransferase 0.0175 0.3477 1
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0667 0.1917
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0085 0.006
Schistosoma mansoni jumonji domain containing protein 0.0057 0.1066 0.1044
Echinococcus granulosus pyruvate kinase 0.0038 0.0667 0.0644
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0331 0.1875
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0209 0.0184
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0806 0.2317
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1401 0.138
Schistosoma mansoni smad1 5 8 and 0.0009 0.0085 0.006
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0331 0.095

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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