Detailed information for compound 1296627

Basic information

Technical information
  • TDR Targets ID: 1296627
  • Name: 8-chloro-6-(2-methoxyphenyl)-1-methyl-4H-[1,2 ,4]triazolo[4,3-a][1,4]benzodiazepine
  • MW: 338.791 | Formula: C18H15ClN4O
  • H donors: 0 H acceptors: 2 LogP: 3.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C1=NCc2n(c3c1cc(Cl)cc3)c(nn2)C
  • InChi: 1S/C18H15ClN4O/c1-11-21-22-17-10-20-18(13-5-3-4-6-16(13)24-2)14-9-12(19)7-8-15(14)23(11)17/h3-9H,10H2,1-2H3
  • InChiKey: IWGYOYNUHOOQIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AE-641/30154042
  • MLS000703864
  • SMR000224986
  • ZINC00347721

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mannose-6-phosphate isomerase 0.0587 0.5881 0.6471
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0066 0.007
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.0512 0.0541
Trichomonas vaginalis esterase, putative 0.0043 0.0171 0.0181
Mycobacterium tuberculosis Conserved protein 0.0043 0.0171 0.041
Loa Loa (eye worm) hypothetical protein 0.0078 0.0538 0.0551
Schistosoma mansoni 6-phosphogluconolactonase 0.0034 0.0071 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0239 0.2226 0.2361
Echinococcus multilocularis heat shock protein 90 0.0047 0.0206 0.0172
Schistosoma mansoni zinc finger protein 0.0047 0.021 0.0195
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0538 0.0557
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0129 0.1072 0.1041
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0089 0.0058
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0582 0.5824 0.6164
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0344 0.0365
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.008 0.0046
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0891 0.9069 0.9066
Chlamydia trachomatis 6-phosphogluconolactonase 0.0034 0.0071 0.0006
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1248 0.1313
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0066 0.007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0366 0.0334
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Loa Loa (eye worm) hypothetical protein 0.0085 0.0607 0.0627
Schistosoma mansoni heat shock protein 0.0047 0.0206 0.019
Plasmodium falciparum heat shock protein 90 0.0047 0.0206 0.0219
Loa Loa (eye worm) bromodomain containing protein 0.0043 0.0169 0.0142
Echinococcus granulosus mannose 6 phosphate isomerase 0.0587 0.5881 0.6475
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0206 0.0183
Trypanosoma brucei hypothetical protein, conserved 0.0878 0.8937 0.9853
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0423 0.0423
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0176 0.0187
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0171 0.041
Trichomonas vaginalis CAMK family protein kinase 0.0239 0.2226 0.2361
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0401 0.0418
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.0206 0.0183
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0044 0.0176 1
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.2853 0.3096
Entamoeba histolytica hypothetical protein 0.0072 0.0473 0.0503
Echinococcus granulosus geminin 0.0173 0.1534 0.1671
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0066 0.0034
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.2047 0.2172
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0151 0.0122
Schistosoma mansoni hypothetical protein 0.0042 0.0151 0.0129
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0089 0.0054
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0137 0.0103
Trichomonas vaginalis set domain proteins, putative 0.0242 0.2258 0.2396
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0089 0.0054
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.0206 0.0183
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0423 0.039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0059
Plasmodium vivax phosphomannomutase, putative 0.0131 0.1091 0.1125
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.2047 0.2172
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0034 0.0071 0.0033
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0223 0.0584
Echinococcus multilocularis 6 phosphofructokinase 0.0222 0.2047 0.202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2853 0.3027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0066 0.0027
Echinococcus multilocularis RUN 0.004 0.0137 0.0103
Trypanosoma brucei heat shock protein, putative 0.0047 0.0206 0.0183
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0344 0.0365
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0483 0.4789 0.5258
Echinococcus granulosus transcription factor btf3 0.0036 0.0089 0.0074
Trypanosoma brucei heat shock protein, putative 0.0047 0.0206 0.0183
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0607 0.0634
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0066 0.007
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.1223 0.1327
Giardia lamblia PHD finger protein 15 0.006 0.034 0.0293
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2853 0.3027
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1248 0.394
Loa Loa (eye worm) hypothetical protein 0.061 0.6122 0.6735
Entamoeba histolytica hypothetical protein 0.0072 0.0473 0.0503
Schistosoma mansoni microtubule-associated protein tau 0.0706 0.7127 0.785
Brugia malayi 6-phosphogluconolactonase family protein 0.0034 0.0071 0.004
Schistosoma mansoni smad1 5 8 and 0.0042 0.0151 0.0129
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0925 0.9426 1
Entamoeba histolytica hypothetical protein 0.0072 0.0473 0.0503
Giardia lamblia Grp94/Hsp90 0.0044 0.0176 0.0118
Schistosoma mansoni endoplasmin 0.0047 0.0206 0.019
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0167 0.0159
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0059
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0151 0.0122
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0849 0.8636 0.9159
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0066 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0401 0.0405
Trypanosoma brucei 6-phosphogluconolactonase 0.0034 0.0071 0.0033
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0786 0.0832
Trypanosoma cruzi phosphomannose isomerase, putative 0.0587 0.5881 0.6468
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0223 0.0584
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.008 0.005
Echinococcus multilocularis caspase 0.0102 0.078 0.0748
Plasmodium falciparum thioredoxin reductase 0.0033 0.0066 0.007
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0101 0.0776 0.0814
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0849 0.8636 0.952
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0538 0.057
Loa Loa (eye worm) hypothetical protein 0.0391 0.3823 0.4189
Mycobacterium ulcerans lipase LipD 0.0043 0.0171 0.0117
Onchocerca volvulus 0.004 0.0137 0.0169
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0318 0.3057 1
Onchocerca volvulus Hexokinase homolog 0.036 0.3493 0.5682
Brugia malayi Bm-MIF-1, identical 0.0849 0.8636 0.9521
Echinococcus granulosus microtubule associated protein 2 0.0706 0.7127 0.7853
Brugia malayi Hexokinase family protein 0.0177 0.1578 0.1708
Onchocerca volvulus Serine\/threonine kinase homolog 0.0483 0.4789 0.781
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0607 0.0646
Trypanosoma brucei hexokinase, putative 0.0574 0.5738 0.631
Echinococcus granulosus GPCR family 2 0.0078 0.0538 0.057
Schistosoma mansoni lipoxygenase 0.0104 0.0811 0.086
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.008 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0223 0.0202
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0223 0.0175
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0473 0.0498
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.2047 0.2334
Entamoeba histolytica hexokinase 1 0.0574 0.5738 0.6628
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0073 0.0087
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0309 0.2959 0.9675
Leishmania major ATP-dependent phosphofructokinase 0.0222 0.2047 0.2222
Onchocerca volvulus 0.0242 0.2258 0.3653
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.2047 0.2334
Plasmodium falciparum glutathione reductase 0.0097 0.0729 0.0773
Toxoplasma gondii ABC1 family protein 0.0043 0.0171 0.0145
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0366 0.0334
Toxoplasma gondii thioredoxin reductase 0.0097 0.0729 0.0739
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2853 0.3027
Brugia malayi Muscleblind-like protein 0.018 0.1609 0.1742
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0218 0.2008 0.2179
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0066 0.0027
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.034 0.0338
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0047 0.005
Echinococcus multilocularis muscleblind protein 1 0.018 0.1609 0.158
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0034 0.0071 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0366 0.038
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.022 0.2029 0.6586
Leishmania major hypothetical protein, conserved 0.0043 0.0171 0.0144
Schistosoma mansoni smad1 5 8 and 0.0042 0.0151 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0849 0.8636 0.9162
Echinococcus granulosus phosphomannomutase 0.0131 0.1091 0.1181
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0287 0.2724 0.2972
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0066 0.0061
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0041 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0483 0.4789 0.508
Brugia malayi glutaminase DH11.1 0.0545 0.5442 0.5985
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0092 0.068 0.0687
Brugia malayi isocitrate dehydrogenase 0.0032 0.0047 0.0014
Schistosoma mansoni smad 0.0042 0.0151 0.0129
Onchocerca volvulus 0.0048 0.0223 0.0309
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0101 0.0776 0.0814
Loa Loa (eye worm) PHD-finger family protein 0.006 0.034 0.0331
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0195 0.1764 0.1924
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0066 0.0027
Schistosoma mansoni zinc finger protein 0.0031 0.0042 0.0009
Schistosoma mansoni caspase-3 (C14 family) 0.0102 0.078 0.0825
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0034 0.0071 0.0006
Loa Loa (eye worm) beta-lactamase 0.0043 0.0171 0.0144
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0066 0.0027
Brugia malayi acetyltransferase, GNAT family protein 0.0301 0.2876 0.3145
Loa Loa (eye worm) hypothetical protein 0.0043 0.0171 0.0144
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0344 0.0309
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0401 0.0367
Mycobacterium tuberculosis Conserved protein 0.0043 0.0171 0.041
Loa Loa (eye worm) endoplasmin 0.0047 0.0206 0.0183
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0223 0.0202
Trypanosoma cruzi hypothetical protein, conserved 0.0878 0.8937 0.9853
Mycobacterium tuberculosis Probable dehydrogenase 0.022 0.2029 0.6586
Echinococcus multilocularis transcription factor btf3 0.0036 0.0089 0.0055
Schistosoma mansoni hypothetical protein 0.0042 0.0151 0.0129
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0047 0.0007
Schistosoma mansoni hypothetical protein 0.0031 0.0042 0.0009
Brugia malayi beta-lactamase family protein 0.0043 0.0171 0.0151
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.1223 0.1193
Entamoeba histolytica hypothetical protein 0.0072 0.0473 0.0503
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0089 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0878 0.8937 0.9853
Brugia malayi MH2 domain containing protein 0.0042 0.0151 0.0129
Trypanosoma cruzi polo-like protein kinase, putative 0.0483 0.4789 0.5258
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0223 0.0175
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0301 0.2876 0.2852
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0223 0.0175
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0047 0.0027
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0206 0.0183
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0729 0.0762
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0223 0.0208
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0222 0.2047 0.6619
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0044 0.0176 0.015
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0034 0.0071 0.0035
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0206 0.0183
Brugia malayi hexokinase 0.0574 0.5738 0.6313
Mycobacterium ulcerans hypothetical protein 0.0101 0.0776 0.0789
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0089 0.0095
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0066 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0066 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0223 0.0175
Schistosoma mansoni bromodomain containing protein 0.0137 0.1149 0.1233
Trypanosoma cruzi ISWI complex protein 0.0031 0.0042 0.0002
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0223 0.0175
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.077 0.0738
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0206 0.015
Mycobacterium ulcerans 6-phosphofructokinase 0.0222 0.2047 0.2201
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0607 0.0574
Trypanosoma brucei beta lactamase 0.013 0.1081 0.1152
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0269 0.2538 0.2905
Toxoplasma gondii phosphomannomutase 0.0131 0.1091 0.1125
Echinococcus granulosus tar DNA binding protein 0.0195 0.1757 0.1917
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0423 0.043
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0553 0.052
Plasmodium vivax heat shock protein, putative 0.0178 0.1579 0.1645
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0206 0.0183
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0849 0.8636 0.9162
Entamoeba histolytica hypothetical protein 0.0036 0.0089 0.0057
Brugia malayi MH2 domain containing protein 0.0611 0.6128 0.6744
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.0202
Echinococcus granulosus histone acetyltransferase KAT2B 0.0092 0.068 0.0726
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0094 0.01
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0101 0.0776 0.2421
Plasmodium falciparum glutathione reductase 0.0033 0.0066 0.007
Brugia malayi CHE-14 protein 0.0043 0.0167 0.0147
Mycobacterium ulcerans hypothetical protein 0.0101 0.0776 0.0789
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0171 0.0181
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0151 0.0142
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0223 0.0509
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0483 0.4789 0.5268
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.0344 0.0309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2853 0.3027
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0891 0.9069 1
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0124 0.0112
Toxoplasma gondii phosphomannose isomerase type I protein 0.0587 0.5881 0.6225
Brugia malayi hexokinase type II 0.0182 0.1629 0.1765
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0171 0.0181
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.0206 0.0183
Echinococcus multilocularis peregrin 0.0072 0.0467 0.0434
Echinococcus multilocularis geminin 0.0173 0.1534 0.1505
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0066 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0066 0.0027
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.0729 0.0781
Brugia malayi PHD-finger family protein 0.006 0.034 0.0338
Trypanosoma brucei heat shock protein, putative 0.0047 0.0206 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2853 0.3027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.195 0.2114
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0089 0.0054
Onchocerca volvulus 0.0043 0.0171 0.0223
Brugia malayi phosphofructokinase 0.0222 0.2047 0.2228
Toxoplasma gondii 6-phosphofructokinase 0.006 0.0344 0.033
Loa Loa (eye worm) hypothetical protein 0.0145 0.1232 0.1319
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0171 0.041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0512 0.0529
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0041 0.0006
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0423 0.0442
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0171 0.0145
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.004 0.0135 0.0124
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.2853 0.2978
Giardia lamblia Kinase, PLK 0.0483 0.4789 0.5045
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0092 0.068 0.0687
Echinococcus multilocularis endoplasmin 0.0044 0.0176 0.0142
Plasmodium vivax heat shock protein 86, putative 0.0047 0.0206 0.0183
Toxoplasma gondii heat shock protein HSP90 0.0047 0.0206 0.0183
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.0344 0.0365
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0587 0.5881 0.6459
Loa Loa (eye worm) hypothetical protein 0.006 0.034 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0089 0.0095
Onchocerca volvulus Putative phosphomannomutase 0.0131 0.1091 0.1736
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0129 0.1072 0.116
Leishmania major phosphomannose isomerase 0.0587 0.5881 0.6468
Brugia malayi hypothetical protein 0.004 0.0137 0.0114
Leishmania major hexokinase, putative 0.0574 0.5738 0.631
Schistosoma mansoni serine/threonine protein kinase 0.0483 0.4789 0.5262
Echinococcus multilocularis caspase 3 0.0074 0.0495 0.0462
Loa Loa (eye worm) hypothetical protein 0.018 0.1609 0.1737
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0587 0.5881 0.6468
Brugia malayi Bromodomain containing protein 0.0161 0.14 0.1511
Echinococcus granulosus muscleblind protein 0.018 0.1609 0.1753
Plasmodium vivax hypothetical protein, conserved 0.006 0.034 0.0325
Brugia malayi Thioredoxin reductase 0.0097 0.0729 0.0769
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.2047 0.2172
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0047 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2853 0.3027
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0891 0.9069 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0538 0.0505
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0176 0.0187
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0137 0.011
Trichomonas vaginalis glutaminase, putative 0.0545 0.5442 0.5773
Onchocerca volvulus 0.0085 0.0607 0.094
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0271 0.2563 0.8358
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.2319 0.2523
Schistosoma mansoni heat shock protein 0.0047 0.0206 0.019
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0206 0.0183
Leishmania major hypothetical protein, conserved 0.0031 0.0042 0.0002
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.0729 0.0739
Echinococcus multilocularis phosphomannomutase 0.0131 0.1091 0.106
Trypanosoma cruzi phosphomannose isomerase, putative 0.0587 0.5881 0.6468
Leishmania major 6-phosphogluconolactonase 0.0034 0.0071 0.0033
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0171 0.0144
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0318 0.3057 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.022 0.2029 0.6586
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0245 0.2288 0.7444
Onchocerca volvulus 0.061 0.6122 1
Loa Loa (eye worm) Smad1 0.0042 0.0151 0.0122
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0925 0.9426 1
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0206 0.0192
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0171 0.041
Trypanosoma brucei trypanothione reductase 0.0097 0.0729 0.0762
Brugia malayi RNA binding protein 0.0195 0.1757 0.1907
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0423 0.0423
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0034 0.0071 0.0033
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0034 0.0071 0.0006
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0512 0.0522
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0587 0.5881 0.5866
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0101 0.0776 0.0789
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0066 0.0027
Schistosoma mansoni rab6-interacting 0.004 0.0137 0.0114
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0171 0.0181
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0094 0.0156
Schistosoma mansoni caspase-7 (C14 family) 0.0102 0.078 0.0825
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0044 0.0176 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0167 0.0177
Echinococcus granulosus smad 0.0042 0.0151 0.0142
Echinococcus granulosus caspase 0.0102 0.078 0.0837
Loa Loa (eye worm) hypothetical protein 0.0043 0.0171 0.0144
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2632 0.8587
Loa Loa (eye worm) doublecortin family protein 0.004 0.0137 0.0107
Echinococcus multilocularis GPCR, family 2 0.0078 0.0538 0.0505
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0587 0.5881 0.6471
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0089 0.0057
Echinococcus multilocularis protein patched 0.0043 0.0167 0.0133
Brugia malayi RNA recognition motif domain containing protein 0.0195 0.1757 0.1907
Brugia malayi beta-lactamase 0.0043 0.0171 0.0151
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.0344 0.0298
Mycobacterium tuberculosis Putative ferredoxin reductase 0.022 0.2029 0.6586
Giardia lamblia Macrophage migration inhibitory factor 0.0849 0.8636 0.9156
Entamoeba histolytica serine/threonine protein kinase, putative 0.0483 0.4789 0.5523
Loa Loa (eye worm) hypothetical protein 0.0043 0.0171 0.0144
Schistosoma mansoni hypothetical protein 0.0078 0.0538 0.0557
Schistosoma mansoni hypothetical protein 0.004 0.0137 0.0114
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.022 0.2029 0.6586
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0222 0.2047 0.6645
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0041 0.001
Echinococcus multilocularis Smad4 0.0042 0.0151 0.0117
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0849 0.8636 0.9159
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0538 0.0505
Brugia malayi 6-phosphofructokinase 0.0222 0.2047 0.2228
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0223 0.0212
Brugia malayi phosphomannomutase 2 0.0131 0.1091 0.1169
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0171 0.0144
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.013 0.1081 0.3384
Echinococcus granulosus expressed conserved protein 0.0094 0.0706 0.0755
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0034 0.0071 0.0033
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0034 0.0071 0.0033
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0151 0.0117
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.2319 0.2529
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0171 0.0117
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0171 0.0117
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0066 0.0033
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0362 0.352 0.3854
Plasmodium falciparum heat shock protein 90, putative 0.0178 0.1579 0.1675
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0047 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0047 0.0013
Toxoplasma gondii Hsp90 domain-containing protein 0.0178 0.1579 0.1645
Entamoeba histolytica phosphomannose isomerase, putative 0.0587 0.5881 0.6794
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0157 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0344 0.0365
Trichomonas vaginalis CAMK family protein kinase 0.0483 0.4789 0.508
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0585 0.0621
Plasmodium falciparum thioredoxin reductase 0.0097 0.0729 0.0773
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0177 0.1574 0.1545
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0483 0.4789 0.477
Schistosoma mansoni loxhd1 0.004 0.0137 0.0114
Echinococcus multilocularis citrate lyase subunit beta protein 0.0101 0.0776 0.0744
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0071 0.0075
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0301 0.2876 0.3145
Brugia malayi PHD-finger family protein 0.0058 0.0325 0.0321
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.2853 0.3272
Schistosoma mansoni hypothetical protein 0.0042 0.0151 0.0129
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0171 0.041
Leishmania major trypanothione reductase 0.0097 0.0729 0.0762
Trypanosoma brucei ISWI complex protein 0.0031 0.0042 0.0002
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0423 0.043
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0177 0.1574 0.1715
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0512 0.0529
Onchocerca volvulus 0.004 0.0137 0.0169
Brugia malayi jmjC domain containing protein 0.0195 0.1764 0.1914
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0171 0.0181
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.4681 0.4663
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0587 0.5881 0.6468
Trypanosoma brucei phosphomannomutase 0.0131 0.1091 0.1163
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0223 0.0208
Loa Loa (eye worm) TAR-binding protein 0.0195 0.1757 0.1901
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0538 0.0551
Leishmania major basic transcription factor 3a, putative 0.0036 0.0089 0.0054
Leishmania major macrophage migration inhibitory factor-like protein 0.0849 0.8636 0.952
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0137 0.0146
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0094 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0401 0.0405
Mycobacterium ulcerans beta-lactamase 0.0043 0.0171 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1757 0.1907
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.2047 0.2172
Mycobacterium ulcerans hypothetical protein 0.0043 0.0171 0.0117
Echinococcus granulosus hexokinase type 2 0.0574 0.5738 0.6318
Echinococcus granulosus endoplasmin 0.0044 0.0176 0.0169
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0137 0.0127
Plasmodium falciparum hexokinase 0.0574 0.5738 0.6087
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0585 0.0552
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.2319 0.2529
Loa Loa (eye worm) hypothetical protein 0.0043 0.0171 0.0144
Echinococcus granulosus heat shock protein 90 0.004 0.0135 0.0124
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1757 0.1907
Echinococcus granulosus histone acetyltransferase KAT2B 0.0288 0.2738 0.3002
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0587 0.5881 0.6225
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0101 0.0776 0.0789
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0245 0.2288 0.7444
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.013 0.1081 0.3436
Brugia malayi MH1 domain containing protein 0.0042 0.0151 0.0129
Trypanosoma cruzi ISWI complex protein 0.0031 0.0042 0.0002
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0151 0.0129
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.034 0.0325
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0925 0.9426 1
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1757 0.1907
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0223 0.0175
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.1006 0.1069
Onchocerca volvulus 0.0574 0.5738 0.937
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0344 0.0365
Brugia malayi Bromodomain containing protein 0.0072 0.0467 0.0478
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0891 0.9069 1
Trypanosoma brucei polo-like protein kinase 0.0483 0.4789 0.5258
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0223 0.0175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2853 0.3027
Schistosoma mansoni Smad4 0.0042 0.0151 0.0129
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0137 0.0127
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0102 0.078 0.0837
Trypanosoma cruzi hexokinase, putative 0.0574 0.5738 0.631
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0092 0.068 0.0721
Trypanosoma brucei heat shock protein, putative 0.0047 0.0206 0.0183
Brugia malayi beta-NAC-like protein 0.0036 0.0089 0.0061
Schistosoma mansoni patched 1 0.0043 0.0167 0.0147
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0423 0.0423
Trypanosoma brucei hexokinase 0.0574 0.5738 0.631
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0271 0.2563 0.2773
Trypanosoma brucei hexokinase 0.0574 0.5738 0.631
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0218 0.2008 0.2179
Echinococcus granulosus Smad4 0.0042 0.0151 0.0142
Echinococcus granulosus heat shock protein 0.0047 0.0206 0.0203
Mycobacterium tuberculosis Conserved protein 0.0101 0.0776 0.2421
Loa Loa (eye worm) glutaminase 2 0.0545 0.5442 0.5982
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0066 0.0027
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.0344 0.033
Loa Loa (eye worm) hypothetical protein 0.0182 0.1629 0.1759
Trypanosoma brucei heat shock protein, putative 0.0047 0.0206 0.0183
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.0344 0.0353
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0344 0.0365
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0047 0.0013
Brugia malayi TAR-binding protein 0.0195 0.1757 0.1907
Echinococcus multilocularis hexokinase 0.0574 0.5738 0.5723
Plasmodium vivax glutathione reductase, putative 0.0097 0.0729 0.0739
Loa Loa (eye worm) hexokinase 0.0177 0.1578 0.1702
Schistosoma mansoni hypothetical protein 0.0042 0.0151 0.0129
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0066 0.0027
Loa Loa (eye worm) hexokinase type II 0.0574 0.5738 0.631
Trichomonas vaginalis phosphomannomutase, putative 0.0131 0.1091 0.1158
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0089 0.0058
Plasmodium falciparum phosphomannomutase, putative 0.0131 0.1091 0.1158
Schistosoma mansoni glutaminase 0.0545 0.5442 0.5985
Echinococcus granulosus hexokinase 0.0574 0.5738 0.6318
Brugia malayi hypothetical protein 0.0072 0.0473 0.0486
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0587 0.5881 0.6471
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0206 0.0192
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0171 0.041
Leishmania major phosphomannomutase, putative 0.0131 0.1091 0.1163
Echinococcus multilocularis protein dispatched 1 0.0049 0.0231 0.0197
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0092 0.068 0.0687
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0485 0.0511
Loa Loa (eye worm) hexokinase 0.036 0.3493 0.3824
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0151 0.0142
Brugia malayi MH2 domain containing protein 0.0042 0.0151 0.0129
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0344 0.033
Echinococcus multilocularis expressed conserved protein 0.0094 0.0706 0.0674
Brugia malayi Hexokinase family protein 0.036 0.3493 0.3828
Echinococcus multilocularis 6 phosphogluconolactonase 0.0034 0.0071 0.0036
Echinococcus multilocularis hexokinase 0.0574 0.5738 0.5723
Mycobacterium ulcerans lipoprotein LpqF 0.013 0.1081 0.1128
Brugia malayi Hexokinase family protein 0.0574 0.5738 0.6313
Echinococcus multilocularis hexokinase 0.0574 0.5738 0.5723
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0171 0.0163
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0344 0.033
Loa Loa (eye worm) RNA binding protein 0.0195 0.1757 0.1901
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0171 0.0334
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0366 0.0367
Brugia malayi Smad1 0.0042 0.0151 0.0129
Loa Loa (eye worm) glutaminase 0.0545 0.5442 0.5982
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0222 0.2047 0.2201
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0206 0.0219
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0047 0.0013
Loa Loa (eye worm) phosphofructokinase 0.0222 0.2047 0.2222
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0925 0.9426 1
Brugia malayi Bromodomain containing protein 0.0086 0.0612 0.0639
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Mycobacterium ulcerans heat shock protein 90 0.0044 0.0176 0.0122
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.2047 0.2334
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0101 0.0776 0.0814
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0366 0.0353
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0891 0.9069 1
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0034 0.0071 0.0006
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0222 0.2047 0.2222
Mycobacterium tuberculosis Probable reductase 0.022 0.2029 0.6586
Brugia malayi Hsp90 protein 0.0031 0.0041 0.0007
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0047 0.0007
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0925 0.9426 1
Treponema pallidum hexokinase (hxk) 0.0574 0.5738 0.63
Trypanosoma brucei phosphomannose isomerase 0.0587 0.5881 0.6468
Schistosoma mansoni kinase 0.0246 0.2293 0.25
Leishmania major macrophage migration inhibitory factor-like protein 0.0849 0.8636 0.952
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Entamoeba histolytica hexokinase 2 0.0574 0.5738 0.6628
Mycobacterium tuberculosis Probable oxidoreductase 0.0245 0.2288 0.7444
Echinococcus granulosus 6 phosphogluconolactonase 0.0034 0.0071 0.0053
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0223 0.0202
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0891 0.9069 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0089 0.0095
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0245 0.2288 0.7424
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0223 0.0212
Schistosoma mansoni polycystin 1-related 0.004 0.0137 0.0114
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0066 0.0033
Mycobacterium ulcerans glutaminase 0.0545 0.5442 0.5971
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0047 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0047 0.0013
Echinococcus granulosus RUN 0.004 0.0137 0.0127
Plasmodium falciparum phd finger protein, putative 0.006 0.034 0.036
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0034 0.0071 0.0033
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0135 0.0104
Schistosoma mansoni hypothetical protein 0.0173 0.1534 0.166
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0553 0.0586
Echinococcus multilocularis heat shock protein 90 0.004 0.0135 0.0101
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0047 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0483 0.4789 0.508
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.4681 0.515
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0344 0.0365
Echinococcus multilocularis heat shock protein 0.0047 0.0206 0.0172
Plasmodium falciparum macrophage migration inhibitory factor 0.0849 0.8636 0.9162
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.077 0.0848
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0137 0.0103
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0218 0.2008 0.2179
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0925 0.9426 1
Trichomonas vaginalis CAMK family protein kinase 0.0483 0.4789 0.508
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0171 0.0151
Schistosoma mansoni hypothetical protein 0.0173 0.1534 0.166
Loa Loa (eye worm) hypothetical protein 0.0091 0.0665 0.0691
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.034 0.0306
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0171 0.0144
Loa Loa (eye worm) hypothetical protein 0.017 0.1495 0.161
Loa Loa (eye worm) hypothetical protein 0.0094 0.0706 0.0736
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0047 0.0013
Loa Loa (eye worm) 6-phosphofructokinase 0.0222 0.2047 0.2222
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0066 0.0027
Loa Loa (eye worm) glutathione reductase 0.0097 0.0729 0.0762
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0034 0.0071 0.0033
Echinococcus granulosus citrate lyase subunit beta protein 0.0101 0.0776 0.0833
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.2853 0.3272
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0073 0.0087
Schistosoma mansoni jumonji domain containing protein 0.0155 0.1342 0.1448
Loa Loa (eye worm) hypothetical protein 0.0101 0.077 0.0807
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0171 0.041
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0107
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0483 0.4789 0.5258
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0066 0.0047
Schistosoma mansoni 6-phosphofructokinase 0.0222 0.2047 0.2228
Echinococcus multilocularis microtubule associated protein 2 0.0706 0.7127 0.7117
Loa Loa (eye worm) heat shock protein 90 0.0047 0.0206 0.0183
Loa Loa (eye worm) phosphomannomutase 2 0.0131 0.1091 0.1163
Loa Loa (eye worm) hypothetical protein 0.0182 0.1629 0.1759
Schistosoma mansoni 6-phosphofructokinase 0.0222 0.2047 0.2228
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0849 0.8636 1
Entamoeba histolytica phosphomannomutase, putative 0.0131 0.1091 0.1222
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0423 0.0423
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Trypanosoma brucei heat shock protein, putative 0.0047 0.0206 0.0183
Trichomonas vaginalis heat shock protein, putative 0.004 0.0135 0.0143
Loa Loa (eye worm) acetyltransferase 0.0301 0.2876 0.314
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0473 0.0486
Trypanosoma cruzi hexokinase, putative 0.0574 0.5738 0.631
Loa Loa (eye worm) hypothetical protein 0.0065 0.0401 0.0398
Trichomonas vaginalis CAMK family protein kinase 0.0483 0.4789 0.508
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0171 0.0151
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.0202
Echinococcus multilocularis muscleblind protein 0.018 0.1609 0.158
Schistosoma mansoni hypothetical protein 0.006 0.034 0.0338
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0366 0.036
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0089 0.0095
Treponema pallidum heat shock protein 90 0.0044 0.0176 0.0122
Plasmodium falciparum endoplasmin, putative 0.0034 0.0071 0.0075
Brugia malayi beta-lactamase family protein 0.0043 0.0171 0.0151
Brugia malayi glutathione reductase 0.0097 0.0729 0.0769
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0066 0.0027
Onchocerca volvulus 0.0043 0.0171 0.0223
Schistosoma mansoni hypothetical protein 0.0078 0.0538 0.0557
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0034 0.0071 0.004
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0206 0.0183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0366 0.0334
Loa Loa (eye worm) hypothetical protein 0.0043 0.0171 0.0144
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0066 0.0031
Toxoplasma gondii hexokinase 0.0574 0.5738 0.6073
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.034 0.035
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0101 0.0776 0.0789
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.4681 0.4663
Schistosoma mansoni transcription factor btf3 0.0036 0.0089 0.0061
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0094 0.0063
Leishmania major hypothetical protein, conserved 0.0878 0.8937 0.9853
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0198 0.0181
Leishmania major hypothetical protein, conserved 0.0218 0.2008 0.2179
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0925 0.9426 1
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0195 0.1764 0.1735
Loa Loa (eye worm) hexokinase 0.0574 0.5738 0.631
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0198 0.0194
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0471 0.0438
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.0202
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0044 0.0176 0.0428
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0151 0.0117
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0366 0.106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0073 0.0087
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0344 0.0365
Onchocerca volvulus Alhambra homolog 0.006 0.034 0.0501
Echinococcus granulosus peregrin 0.0072 0.0467 0.0491
Brugia malayi glucose-6-phosphate dehydrogenase 0.0891 0.9069 1
Onchocerca volvulus 0.0574 0.5738 0.937
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0538 0.0557
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0473 0.044
Echinococcus granulosus hexokinase 0.0574 0.5738 0.6318
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0587 0.5881 0.6239
Brugia malayi hypothetical protein 0.004 0.0137 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0171 0.0181
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0034 0.0071 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0483 0.4789 0.508
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0059
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.034 0.0325
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0102 0.078 0.0748
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0066 0.0033
Leishmania major hexokinase, putative 0.0574 0.5738 0.631
Schistosoma mansoni smad1 5 8 and 0.0042 0.0151 0.0129
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0362 0.352 0.3854
Mycobacterium leprae Probable lipase LipE 0.0043 0.0171 0.0334
Trypanosoma cruzi polo-like protein kinase, putative 0.0483 0.4789 0.5258
Echinococcus multilocularis tar DNA binding protein 0.0195 0.1757 0.1729
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0171 0.0144
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0195 0.1757 0.1901
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0587 0.5881 0.6239
Brugia malayi Doublecortin family protein 0.004 0.0137 0.0114
Loa Loa (eye worm) 6-phosphofructokinase 0.0222 0.2047 0.2222
Echinococcus multilocularis zinc finger protein 0.0047 0.021 0.0176
Onchocerca volvulus 0.036 0.3493 0.5682
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0223 0.0509
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.077 0.0826
Echinococcus granulosus zinc finger protein 0.0047 0.021 0.0207
Echinococcus multilocularis hexokinase type 2 0.0574 0.5738 0.5723
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0041 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0344 0.0365
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0047 0.0014
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0891 0.9069 1
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0167 0.0159
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0171 0.0151
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0485 0.0452
Schistosoma mansoni hexokinase 0.0574 0.5738 0.6313
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0047 0.0007
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0041 0.0007
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0053 0.0269 0.0253
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0034 0.0071 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0059
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0101 0.0776 0.0823
Loa Loa (eye worm) hypothetical protein 0.0102 0.0787 0.0826
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0222 0.2047 0.2222
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0066 0.007
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0137 0.0103
Brugia malayi Pre-SET motif family protein 0.0213 0.195 0.212
Mycobacterium ulcerans hypothetical protein 0.0048 0.0223 0.0175
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0066 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0223 0.0212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2853 0.3027
Trypanosoma cruzi heat shock protein 85, putative 0.004 0.0135 0.0104
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0891 0.9069 1
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0891 0.9069 1
Onchocerca volvulus 0.0043 0.0171 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1757 0.1907
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0538 0.057
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0344 0.0309
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0124 0.009
Echinococcus granulosus heat shock protein 90 0.0047 0.0206 0.0203
Echinococcus multilocularis smad 0.0042 0.0151 0.0117
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.0344 0.033
Trichomonas vaginalis CAMK family protein kinase 0.0483 0.4789 0.508
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.1495 0.1616
Schistosoma mansoni hypothetical protein 0.0042 0.0157 0.0135
Loa Loa (eye worm) hypothetical protein 0.0248 0.2319 0.2523
Plasmodium vivax hexokinase, putative 0.0574 0.5738 0.6073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0171 0.0137
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0366 0.0367
Brugia malayi hypothetical protein 0.061 0.6122 0.6737
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0137 0.0127
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0066 0.0027
Brugia malayi 6-phosphofructokinase 0.0222 0.2047 0.2228
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0891 0.9069 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0066 0.0034
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.008 0.005
Schistosoma mansoni hypothetical protein 0.0078 0.0538 0.0557
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0066 0.0027
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.0729 0.0762
Giardia lamblia Heat shock protein HSP 90-alpha 0.004 0.0135 0.0074
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1248 0.3988
Loa Loa (eye worm) hexokinase 0.0574 0.5738 0.631
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0366 0.0333
Schistosoma mansoni rab6-interacting 0.004 0.0137 0.0114
Trichomonas vaginalis bromodomain-containing protein, putative 0.0092 0.068 0.0721
Schistosoma mansoni lipoxygenase 0.0177 0.1574 0.1704
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0094 0.0032
Brugia malayi jmjC domain containing protein 0.0076 0.0512 0.0529
Loa Loa (eye worm) hypothetical protein 0.0043 0.0167 0.014
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0198 0.0164
Trypanosoma cruzi phosphomannomutase, putative 0.0131 0.1091 0.1163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0073 0.0087
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0167 0.0133
Schistosoma mansoni phosphomannomutase 0.0131 0.1091 0.1169
Schistosoma mansoni heat shock protein 0.0031 0.0041 0.0007
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.0729 0.0697
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0047 0.0013
Schistosoma mansoni endoplasmin 0.0047 0.0206 0.019
Brugia malayi MH1 domain containing protein 0.0042 0.0151 0.0129
Brugia malayi Endoplasmin precursor 0.0047 0.0206 0.019
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0167 0.014
Loa Loa (eye worm) hypothetical protein 0.018 0.1609 0.1737
Loa Loa (eye worm) MH2 domain-containing protein 0.0611 0.6128 0.6742
Echinococcus granulosus 6 phosphofructokinase 0.0222 0.2047 0.2238
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.0729 0.2265
Loa Loa (eye worm) hypothetical protein 0.0078 0.0538 0.055
Plasmodium vivax endoplasmin, putative 0.0047 0.0206 0.0183
Echinococcus granulosus caspase 3 0.0074 0.0495 0.0522
Loa Loa (eye worm) transcription factor SMAD2 0.0611 0.6128 0.6742
Loa Loa (eye worm) hypothetical protein 0.0043 0.0171 0.0144
Trichomonas vaginalis endoplasmin, putative 0.0034 0.0071 0.0075
Echinococcus granulosus neuropeptide s receptor 0.0473 0.4681 0.515
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0607 0.0634
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0047 0.0007
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0423 0.0445
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.077 0.0814
Schistosoma mansoni hypothetical protein 0.0078 0.0538 0.0557
Brugia malayi heat shock protein 90 0.0047 0.0206 0.019
Schistosoma mansoni 6-phosphogluconolactonase 0.0034 0.0071 0.004
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0553 0.0595
Onchocerca volvulus 0.0574 0.5738 0.937
Trypanosoma brucei heat shock protein, putative 0.0047 0.0206 0.0183
Echinococcus granulosus hexokinase 0.0574 0.5738 0.6318
Trypanosoma brucei heat shock protein, putative 0.0047 0.0206 0.0183
Schistosoma mansoni hypothetical protein 0.017 0.1495 0.1616
Schistosoma mansoni hypothetical protein 0.0072 0.0473 0.0486
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0223 0.0208
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0047 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1757 0.1907
Mycobacterium tuberculosis Conserved protein 0.0043 0.0171 0.041
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0582 0.5824 0.6396
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0171 0.041
Leishmania major heat shock protein 83-1 0.0047 0.0206 0.0183
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.022 0.2029 0.6558
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0295 0.2814 0.3071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0066 0.0027
Brugia malayi serine/threonine-protein kinase plk-2 0.0483 0.4789 0.5262

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (binding) 0.8913 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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