Detailed information for compound 1297255

Basic information

Technical information
  • TDR Targets ID: 1297255
  • Name: N-(3,4-difluorophenyl)-3-ethyl-5-methyl-1,2-o xazole-4-carboxamide
  • MW: 266.243 | Formula: C13H12F2N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1noc(c1C(=O)Nc1ccc(c(c1)F)F)C
  • InChi: 1S/C13H12F2N2O2/c1-3-11-12(7(2)19-17-11)13(18)16-8-4-5-9(14)10(15)6-8/h4-6H,3H2,1-2H3,(H,16,18)
  • InChiKey: CJCAWBZLWUKXEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3,4-difluorophenyl)-3-ethyl-5-methyl-isoxazole-4-carboxamide
  • N-(3,4-difluorophenyl)-3-ethyl-5-methyl-4-isoxazolecarboxamide
  • IVK/0042247
  • ZINC08077418

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0209 0.0918 1
Echinococcus multilocularis GPCR, family 2 0.0618 0.3049 0.5624
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.1074 0.5422 0.5422
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0046 0.0072 0.0262
Loa Loa (eye worm) DIX domain-containing protein 0.0045 0.0068 0.0068
Loa Loa (eye worm) transcription factor SMAD2 0.1562 0.7966 0.7966
Schistosoma mansoni hypothetical protein 0.0193 0.0839 0.1236
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0072
Toxoplasma gondii isocitrate dehydrogenase 0.0125 0.0481 0.9312
Brugia malayi RNA binding protein 0.0388 0.1852 0.1852
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0046 0.0072 0.0262
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0048 0.008 0.0173
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0046 0.0072 0.0106
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0046 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0056 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0045 0.0068 0.0068
Echinococcus multilocularis tar DNA binding protein 0.0388 0.1852 0.3416
Trypanosoma cruzi PAB1-binding protein , putative 0.0131 0.0512 0.5577
Brugia malayi MH2 domain containing protein 0.0048 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0059 0.0137 0.0202
Loa Loa (eye worm) MH2 domain-containing protein 0.0106 0.0386 0.0386
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0046 0.0072 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1074 0.5422 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0919 0.4618 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0072
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0046 0.0072 0.0262
Echinococcus multilocularis regulator of G protein signaling 7 0.0045 0.0068 0.0125
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0125 0.0481 0.0888
Loa Loa (eye worm) isocitrate dehydrogenase 0.0125 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0618 0.3049 0.4496
Schistosoma mansoni hypothetical protein 0.0618 0.3049 0.4496
Schistosoma mansoni dep domain containing protein 0.0045 0.0068 0.01
Schistosoma mansoni smad 0.0048 0.008 0.0118
Echinococcus granulosus tumor protein p63 0.0386 0.1839 0.3392
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0045 0.0068 0.0146
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0045 0.0068 0.0068
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0046 0.0072 0.0262
Echinococcus granulosus expressed protein 0.0046 0.0072 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0322 0.1169
Schistosoma mansoni tar DNA-binding protein 0.0388 0.1852 0.2731
Brugia malayi MH1 domain containing protein 0.0106 0.0386 0.0386
Brugia malayi Latrophilin receptor protein 2 0.0618 0.3049 0.3049
Echinococcus multilocularis isocitrate dehydrogenase 0.0125 0.0481 0.0888
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0322 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0048 0.008 0.0147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1074 0.5422 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0046 0.0072 0.0133
Loa Loa (eye worm) nuclear factor I 0.0059 0.0139 0.0139
Leishmania major hypothetical protein, conserved 0.0131 0.0512 0.3189
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0046 0.0072 0.0262
Schistosoma mansoni glutaminase 0.0561 0.2752 0.4058
Echinococcus multilocularis geminin 0.0193 0.0839 0.1547
Plasmodium vivax ataxin-2 like protein, putative 0.0131 0.0512 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1074 0.5422 0.7994
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0046 0.0072 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0388 0.1852 0.2731
Trypanosoma brucei PAB1-binding protein , putative 0.0131 0.0512 0.3189
Brugia malayi hypothetical protein 0.0045 0.0068 0.0068
Echinococcus granulosus Smad4 0.0106 0.0386 0.0712
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0125 0.0481 0.0888
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0125 0.0481 0.2677
Brugia malayi TAR-binding protein 0.0388 0.1852 0.1852
Brugia malayi regulator of G-protein signaling egl-10 0.0045 0.0068 0.0068
Trypanosoma cruzi PAB1-binding protein , putative 0.0131 0.0512 0.5577
Loa Loa (eye worm) MH1 domain-containing protein 0.0106 0.0386 0.0386
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0045 0.0068 0.01
Echinococcus granulosus regulator of G protein signaling 7 0.0045 0.0068 0.0125
Toxoplasma gondii isocitrate dehydrogenase 0.0125 0.0481 0.9312
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1074 0.5422 1
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0046 0.0072 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0388 0.1852 0.2731
Schistosoma mansoni hypothetical protein 0.1335 0.6783 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0322 0.1169
Loa Loa (eye worm) MH2 domain-containing protein 0.0048 0.008 0.008
Echinococcus granulosus mothers against decapentaplegic 6 0.0048 0.008 0.0147
Schistosoma mansoni hypothetical protein 0.0618 0.3049 0.4496
Loa Loa (eye worm) Smad1 0.0106 0.0386 0.0386
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1074 0.5422 1
Brugia malayi RNA recognition motif domain containing protein 0.0388 0.1852 0.1852
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0072
Schistosoma mansoni GTP-binding protein alpha subunit 0.0046 0.0072 0.0106
Echinococcus multilocularis mothers against decapentaplegic 6 0.0048 0.008 0.0147
Brugia malayi hypothetical protein 0.0046 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0072
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0106 0.0386 0.0712
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0046 0.0072 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0322 0.1169
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0125 0.0481 0.2677
Echinococcus multilocularis mothers against decapentaplegic 5 0.0106 0.0386 0.0712
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0045 0.0068 0.0068
Loa Loa (eye worm) MH1 domain-containing protein 0.0048 0.008 0.008
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0059 0.0137 0.0253
Echinococcus multilocularis Smad4 0.0106 0.0386 0.0712
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0046 0.0072 0.0133
Brugia malayi Isocitrate dehydrogenase 0.0125 0.0481 0.0481
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0046 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0158 0.0653 0.0653
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0125 0.0481 0.2677
Onchocerca volvulus 0.0056 0.0126 0.0273
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0322 0.3505
Schistosoma mansoni tar DNA-binding protein 0.0388 0.1852 0.2731
Trichomonas vaginalis glutaminase, putative 0.0561 0.2752 1
Onchocerca volvulus 0.0045 0.0068 0.0146
Echinococcus granulosus mothers against decapentaplegic 5 0.0106 0.0386 0.0712
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0125 0.0481 0.5244
Schistosoma mansoni smad1 5 8 and 0.0106 0.0386 0.0569
Schistosoma mansoni kinase 0.0048 0.0081 0.0119
Leishmania major hypothetical protein, conserved 0.0209 0.0918 1
Loa Loa (eye worm) G protein alpha subunit 3 0.0046 0.0072 0.0072
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0046 0.0072 0.0072
Echinococcus multilocularis tumor protein p63 0.0386 0.1839 0.3392
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0046 0.0072 0.0072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0618 0.3049 0.5624
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0618 0.3049 0.5624
Echinococcus multilocularis segment polarity protein dishevelled 0.0045 0.0068 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0074 0.0271
Schistosoma mansoni hypothetical protein 0.0618 0.3049 0.4496
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.1074 0.5422 0.5422
Echinococcus granulosus Pleckstrin G protein interacting region 0.0045 0.0068 0.0125
Onchocerca volvulus 0.0046 0.0072 0.0156
Brugia malayi MH2 domain containing protein 0.0106 0.0386 0.0386
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0046 0.0072 0.0072
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0125 0.0481 0.0888
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0046 0.0072 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1074 0.5422 0.7994
Schistosoma mansoni Smad4 0.0048 0.008 0.0118
Entamoeba histolytica G protein alpha subunit, putative 0.0046 0.0072 0.2243
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0388 0.1852 0.1852
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0046 0.0072 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.0918 1
Toxoplasma gondii LsmAD domain-containing protein 0.0131 0.0512 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0125 0.0481 0.5
Loa Loa (eye worm) hypothetical protein 0.1335 0.6783 0.6783
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0045 0.0068 0.0068
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0126 0.0186
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0046 0.0072 0.0072
Echinococcus granulosus smad 0.0106 0.0386 0.0712
Brugia malayi isocitrate dehydrogenase 0.0125 0.0481 0.0481
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0106 0.0386 0.0569
Onchocerca volvulus 0.0046 0.0072 0.0156
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0046 0.0072 0.0072
Schistosoma mansoni Smad4 0.0048 0.008 0.0118
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0046 0.0072 0.0133
Brugia malayi G-protein alpha subunit 0.0046 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0618 0.3049 0.3049
Loa Loa (eye worm) hypothetical protein 0.0045 0.0068 0.0068
Brugia malayi MH2 domain containing protein 0.0106 0.0386 0.0386
Echinococcus granulosus regulator of G protein signaling 7 0.0045 0.0068 0.0125
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0046 0.0072 0.0262
Mycobacterium ulcerans glutaminase 0.0561 0.2752 0.5
Loa Loa (eye worm) hypothetical protein 0.0919 0.4618 0.4618
Brugia malayi latrophilin 2 splice variant baaae 0.1335 0.6783 0.6783
Echinococcus granulosus tar DNA binding protein 0.0388 0.1852 0.3416
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0046 0.0072 0.0072
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0322 0.0322
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0046 0.0072 0.0072
Loa Loa (eye worm) glutaminase 2 0.0561 0.2752 0.2752
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1074 0.5422 0.7994
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0046 0.0072 0.0133
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0125 0.0481 0.0888
Onchocerca volvulus 0.0158 0.0653 0.1413
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0125 0.0481 0.0888
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0125 0.0481 0.071
Echinococcus granulosus geminin 0.0193 0.0839 0.1547
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0322 0.0593
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0322 0.0593
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0322 0.0474
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0322 0.1169
Brugia malayi mothers against decapentaplegic homolog 3 0.0048 0.008 0.008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0618 0.3049 0.5624
Loa Loa (eye worm) RNA binding protein 0.0388 0.1852 0.1852
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0046 0.0072 0.0106
Brugia malayi N-terminal motif family protein 0.0919 0.4618 0.4618
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0046 0.0072 0.0106
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0046 0.0072 0.0072
Onchocerca volvulus 0.0046 0.0072 0.0156
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0046 0.0072 0.0106
Brugia malayi Smad1 0.0106 0.0386 0.0386
Schistosoma mansoni smad 0.0106 0.0386 0.0569
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.0918 1
Brugia malayi hypothetical protein 0.0131 0.0512 0.0512
Brugia malayi MH2 domain containing protein 0.1562 0.7966 0.7966
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0322 0.3505
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0046 0.0072 0.0133
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0046 0.0072 0.0106
Echinococcus multilocularis mothers against decapentaplegic 2 0.0048 0.008 0.0147
Loa Loa (eye worm) hypothetical protein 0.0131 0.0512 0.0512
Schistosoma mansoni dishevelled 0.0045 0.0068 0.01
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0046 0.0072 0.0133
Plasmodium falciparum ataxin-2 like protein, putative 0.0131 0.0512 1
Brugia malayi hypothetical protein 0.0045 0.0068 0.0068
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0125 0.0481 0.5244
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0618 0.3049 0.5624
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0046 0.0072 0.0106
Schistosoma mansoni smad1 5 8 and 0.0106 0.0386 0.0569
Schistosoma mansoni z-protein (S1r protein) 0.0045 0.0068 0.01
Schistosoma mansoni GTP-binding protein alpha subunit 0.0046 0.0072 0.0106
Echinococcus granulosus TGF beta signal transducer SmadC 0.0106 0.0386 0.0712
Loa Loa (eye worm) glutaminase 0.0561 0.2752 0.2752
Echinococcus multilocularis expressed protein 0.0046 0.0072 0.0133
Schistosoma mansoni regulator of G protein signaling 0.0045 0.0068 0.01
Echinococcus multilocularis smad 0.0106 0.0386 0.0712
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0322 0.1169
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0046 0.0072 0.0133
Loa Loa (eye worm) hypothetical protein 0.0048 0.008 0.008
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0046 0.0072 0.0072
Brugia malayi MH1 domain containing protein 0.0059 0.0139 0.0139
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0059 0.0137 0.0253
Schistosoma mansoni dishevelled 0.0045 0.0068 0.01
Brugia malayi MH1 domain containing protein 0.0059 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0193 0.0839 0.1236
Plasmodium falciparum ataxin-2 like protein, putative 0.0131 0.0512 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0046 0.0072 0.0262
Brugia malayi hypothetical protein 0.0158 0.0653 0.0653
Loa Loa (eye worm) latrophilin receptor protein 2 0.0618 0.3049 0.3049
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0074 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0322 0.1169
Schistosoma mansoni tar DNA-binding protein 0.0388 0.1852 0.2731
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0046 0.0072 0.0106
Brugia malayi DIX domain containing protein 0.0045 0.0068 0.0068
Giardia lamblia Kinase, PLK 0.0094 0.0322 0.5
Schistosoma mansoni Smad4 0.0106 0.0386 0.0569
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0046 0.0072 0.0072
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0618 0.3049 0.3049
Echinococcus multilocularis segment polarity protein dishevelled 0.0045 0.0068 0.0125
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0046 0.0072 0.0262
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0322 0.0697
Brugia malayi hypothetical protein 0.0084 0.0271 0.0271
Schistosoma mansoni smad1 5 8 and 0.0106 0.0386 0.0569
Loa Loa (eye worm) TAR-binding protein 0.0388 0.1852 0.1852
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0045 0.0068 0.0125
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0046 0.0072 0.0133
Brugia malayi MH1 domain containing protein 0.0106 0.0386 0.0386
Echinococcus granulosus segment polarity protein dishevelled 0.0045 0.0068 0.0125
Loa Loa (eye worm) hypothetical protein 0.0059 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0045 0.0068 0.0068
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0046 0.0072 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0322 0.1169
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0322 0.0322
Loa Loa (eye worm) MH2 domain-containing protein 0.1562 0.7966 0.7966
Brugia malayi glutaminase DH11.1 0.0561 0.2752 0.2752
Echinococcus multilocularis regulator of G protein signaling 7 0.0045 0.0068 0.0125
Echinococcus granulosus segment polarity protein dishevelled 0.0045 0.0068 0.0125
Echinococcus granulosus GPCR family 2 0.0618 0.3049 0.5624

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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