Detailed information for compound 1297441

Basic information

Technical information
  • TDR Targets ID: 1297441
  • Name: 1-[2-[[5-(1,3-benzodioxol-5-yl)-1,2-oxazol-3- yl]methoxy]acetyl]piperidine-4-carboxamide
  • MW: 387.387 | Formula: C19H21N3O6
  • H donors: 1 H acceptors: 3 LogP: 0.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)C1CCN(CC1)C(=O)COCc1noc(c1)c1ccc2c(c1)OCO2
  • InChi: 1S/C19H21N3O6/c20-19(24)12-3-5-22(6-4-12)18(23)10-25-9-14-8-16(28-21-14)13-1-2-15-17(7-13)27-11-26-15/h1-2,7-8,12H,3-6,9-11H2,(H2,20,24)
  • InChiKey: CUVFXEGTTBZECY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-[[5-(1,3-benzodioxol-5-yl)isoxazol-3-yl]methoxy]acetyl]piperidine-4-carboxamide
  • 1-[2-[[5-(1,3-benzodioxol-5-yl)-3-isoxazolyl]methoxy]-1-oxoethyl]-4-piperidinecarboxamide
  • 1-[2-[[5-(1,3-benzodioxol-5-yl)isoxazol-3-yl]methoxy]acetyl]isonipecotamide
  • 1-[2-[[5-(1,3-benzodioxol-5-yl)-1,2-oxazol-3-yl]methoxy]ethanoyl]piperidine-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ISWI complex protein 0.0037 0.0264 0.0975
Echinococcus granulosus tar DNA binding protein 0.007 0.0751 0.0694
Brugia malayi Muscleblind-like protein 0.0136 0.1718 0.1849
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0386 0.0353
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0225 0.0165
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0071 0.0773 1
Brugia malayi hypothetical protein 0.004 0.0309 0.0333
Schistosoma mansoni alpha-glucosidase 0.0168 0.2191 0.2307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Loa Loa (eye worm) glutaminase 0.0653 0.9292 1
Onchocerca volvulus 0.0034 0.0225 0.0206
Entamoeba histolytica hypothetical protein 0.004 0.0309 0.8211
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0411 0.0379
Brugia malayi PHD-finger family protein 0.0035 0.0237 0.0255
Echinococcus granulosus geminin 0.0154 0.1985 0.1936
Leishmania major cathepsin L-like protease 0.0034 0.0225 0.0713
Leishmania major cathepsin L-like protease 0.0034 0.0225 0.0713
Loa Loa (eye worm) hypothetical protein 0.0035 0.0237 0.0191
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0085 0.0981 0.0774
Leishmania major cathepsin L-like protease 0.0129 0.1618 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.3338 0.355
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0497 0.701 0.7528
Echinococcus granulosus survival motor neuron protein 1 0.0215 0.2878 0.2834
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0363 0.1638
Loa Loa (eye worm) TAR-binding protein 0.007 0.0751 0.0748
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0411 0.0379
Trypanosoma brucei ISWI complex protein 0.0037 0.0264 0.0975
Onchocerca volvulus 0.0034 0.0225 0.0206
Trypanosoma cruzi ISWI complex protein 0.0037 0.0264 0.0975
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0225 0.0165
Echinococcus granulosus muscleblind protein 0.0136 0.1718 0.1667
Schistosoma mansoni tar DNA-binding protein 0.007 0.0751 0.0748
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0085 0.0981 0.0926
Onchocerca volvulus 0.0085 0.0973 0.1147
Loa Loa (eye worm) hypothetical protein 0.0034 0.0225 0.0178
Echinococcus granulosus cathepsin l1 0.0034 0.0225 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0225 0.0178
Brugia malayi TAR-binding protein 0.007 0.0751 0.0808
Loa Loa (eye worm) ctsf protein 0.0034 0.0225 0.0178
Schistosoma mansoni tar DNA-binding protein 0.007 0.0751 0.0748
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.027 0.3686 0.3967
Echinococcus multilocularis lysosomal alpha glucosidase 0.0195 0.2589 0.2419
Entamoeba histolytica hypothetical protein 0.004 0.0309 0.8211
Brugia malayi glutaminase DH11.1 0.0653 0.9292 1
Onchocerca volvulus 0.0034 0.0225 0.0206
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0386 0.0416
Echinococcus multilocularis peregrin 0.004 0.032 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0386 0.0353
Plasmodium falciparum phd finger protein, putative 0.0035 0.0237 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0309 0.025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0112 0.137 0.1171
Echinococcus granulosus lysine specific demethylase 5A 0.0047 0.0411 0.0352
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0086 0.0986 0.0931
Schistosoma mansoni methyl-cpg binding protein mbd 0.0041 0.0325 0.0287
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0086 0.0986 0.0779
Echinococcus granulosus lysosomal alpha glucosidase 0.0195 0.2589 0.2544
Onchocerca volvulus 0.0044 0.0371 0.039
Brugia malayi Bromodomain containing protein 0.0091 0.1069 0.115
Echinococcus multilocularis zinc finger protein 0.0047 0.0414 0.0193
Loa Loa (eye worm) hypothetical protein 0.0059 0.06 0.0584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0195 0.2589 0.2419
Schistosoma mansoni bromodomain containing protein 0.0151 0.1943 0.2039
Mycobacterium ulcerans glutaminase 0.0653 0.9292 0.5
Leishmania major cathepsin L-like protease 0.0129 0.1618 1
Echinococcus granulosus GPCR family 2 0.0085 0.0981 0.0926
Trichomonas vaginalis glutaminase, putative 0.0653 0.9292 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0414 0.0383
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0363 0.0328
Loa Loa (eye worm) RNA binding protein 0.007 0.0751 0.0748
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0225 0.0178
Schistosoma mansoni hypothetical protein 0.0154 0.1985 0.2085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Brugia malayi Cathepsin L-like precursor 0.0034 0.0225 0.0242
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0054 0.0517 0.03
Brugia malayi Cathepsin L-like precursor 0.0023 0.0061 0.0065
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0225 0.5414
Onchocerca volvulus 0.0034 0.0225 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0071 0.0773 0.0772
Schistosoma mansoni hypothetical protein 0.0085 0.0981 0.0997
Brugia malayi Heterochromatin protein 1 0.0084 0.0952 0.1024
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0225 0.8971
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0085 0.0981 0.0774
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0225 0.0242
Schistosoma mansoni hypothetical protein 0.0085 0.0981 0.0997
Toxoplasma gondii cathepsin CPL 0.0034 0.0225 0.1632
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0237 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.027 0.3686 0.3967
Loa Loa (eye worm) hypothetical protein 0.0185 0.2434 0.2571
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0237 0.1819
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0225 0.8971
Echinococcus multilocularis chromobox protein 1 0.0084 0.0952 0.0744
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0062
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0363 0.0328
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0363 0.375
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0237 0.1819
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0225 0.0206
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.1618 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0751 0.0748
Brugia malayi chromobox protein homolog 3 0.0047 0.0414 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0225 0.0178
Trichomonas vaginalis chromobox protein, putative 0.005 0.0466 0.044
Loa Loa (eye worm) hypothetical protein 0.0097 0.1154 0.1184
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0225 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0363 0.1638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Brugia malayi jmjC domain containing protein 0.0047 0.0411 0.0442
Onchocerca volvulus 0.0034 0.0225 0.0206
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0363 1
Brugia malayi Bromodomain containing protein 0.004 0.032 0.0344
Onchocerca volvulus 0.0103 0.1232 0.1473
Schistosoma mansoni tar DNA-binding protein 0.007 0.0751 0.0748
Loa Loa (eye worm) hypothetical protein 0.0047 0.0414 0.0383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0112 0.137 0.1418
Brugia malayi Pre-SET motif family protein 0.0497 0.701 0.7544
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0225 0.0206
Schistosoma mansoni zinc finger protein 0.0047 0.0414 0.0382
Giardia lamblia PHD finger protein 15 0.0035 0.0237 0.5
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0225 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Onchocerca volvulus 0.0037 0.0266 0.0258
Schistosoma mansoni tar DNA-binding protein 0.007 0.0751 0.0748
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0143 0.1817 0.1629
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0952 0.0965
Trypanosoma brucei glucosidase, putative 0.0043 0.0363 0.1638
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0436 0.0216
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0778 0.0777
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0952 0.0965
Brugia malayi Cathepsin L-like precursor 0.0034 0.0225 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0112 0.137 0.1418
Echinococcus granulosus peregrin 0.004 0.032 0.0261
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.1214 0.7305
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0237 0.0191
Brugia malayi Latrophilin receptor protein 2 0.0085 0.0981 0.1056
Leishmania major cathepsin L-like protease 0.0129 0.1618 1
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.1618 1
Schistosoma mansoni hypothetical protein 0.0154 0.1985 0.2085
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0071 0.0773 0.0561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0225 0.0178
Echinococcus granulosus methyl CpG binding domain protein 2 0.0041 0.0325 0.0266
Echinococcus multilocularis tar DNA binding protein 0.007 0.0751 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0414 0.0383
Loa Loa (eye worm) hypothetical protein 0.0136 0.1718 0.1795
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0386 0.0328
Echinococcus granulosus histone lysine methyltransferase setb 0.0112 0.137 0.1317
Schistosoma mansoni hypothetical protein 0.0185 0.2434 0.2571
Schistosoma mansoni hypothetical protein 0.0085 0.0981 0.0997
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0061 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0225 0.0178
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0414 0.0445
Schistosoma mansoni glutaminase 0.0653 0.9292 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0363 0.0142
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0195 0.2589 0.2739
Onchocerca volvulus 0.0113 0.1383 0.1662
Schistosoma mansoni survival motor neuron protein 0.0044 0.0371 0.0336
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0363 0.0328
Brugia malayi cathepsin L-like precursor 0.0023 0.0061 0.0065
Loa Loa (eye worm) hypothetical protein 0.0136 0.1718 0.1795
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0386 0.0353
Entamoeba histolytica cysteine protease, putative 0.0034 0.0225 0.5414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0952 0.0744
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0363 0.0328
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0363 0.0391
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0363 0.1638
Brugia malayi Bromodomain containing protein 0.0179 0.2352 0.2532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Echinococcus granulosus chromobox protein 1 0.0084 0.0952 0.0897
Onchocerca volvulus 0.0034 0.0225 0.0206
Loa Loa (eye worm) hypothetical protein 0.0092 0.1071 0.1095
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0118 0.1454 0.8907
Entamoeba histolytica hypothetical protein 0.004 0.0309 0.8211
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0309 0.0269
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0085 0.0981 0.1056
Brugia malayi jmjC domain containing protein 0.0114 0.1393 0.1499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0225 0.0178
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0309 0.0087
Plasmodium vivax vivapain-2 0.0034 0.0225 0.1632
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0386 0.0328
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.0466 0.051
Brugia malayi Cathepsin L-like precursor 0.0034 0.0225 0.0242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0225 0.0178
Schistosoma mansoni alpha glucosidase 0.0043 0.0363 0.0328
Plasmodium vivax vivapain-2 0.0034 0.0225 0.1632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Loa Loa (eye worm) fibroinase 0.0034 0.0225 0.0178
Schistosoma mansoni hypothetical protein 0.0044 0.0371 0.0336
Brugia malayi Pre-SET motif family protein 0.0071 0.0773 0.0832
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Echinococcus multilocularis muscleblind protein 0.0136 0.1718 0.1528
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.3338 0.355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0751 0.0748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Loa Loa (eye worm) hypothetical protein 0.0215 0.2878 0.3052
Brugia malayi Glycosyl hydrolases family 31 protein 0.0195 0.2589 0.2786
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0386 0.0353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Brugia malayi MH2 domain containing protein 0.0246 0.3338 0.3592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0114 0.1393 0.134
Trichomonas vaginalis set domain proteins, putative 0.0566 0.8016 0.8617
Loa Loa (eye worm) hypothetical protein 0.0112 0.137 0.1418
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0952 0.0965
Echinococcus multilocularis survival motor neuron protein 1 0.0215 0.2878 0.2714
Echinococcus granulosus fetal alzheimer antigen falz 0.0054 0.0517 0.046
Loa Loa (eye worm) PHD-finger family protein 0.0049 0.0451 0.0422
Loa Loa (eye worm) latrophilin receptor protein 2 0.0085 0.0981 0.0997
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0114 0.1393 0.1195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0363 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0225 0.0178
Schistosoma mansoni hypothetical protein 0.0049 0.0451 0.0422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0386 0.0165
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0363 0.0328
Schistosoma mansoni hypothetical protein 0.0037 0.0264 0.022
Leishmania major cathepsin L-like protease 0.0034 0.0225 0.0713
Loa Loa (eye worm) hypothetical protein 0.0037 0.0266 0.0223
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0044 0.0371 0.0399
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.1618 1
Leishmania major cathepsin L-like protease 0.0034 0.0225 0.0713
Schistosoma mansoni hypothetical protein 0.0085 0.0981 0.0997
Trypanosoma cruzi cruzipain precursor, putative 0.0129 0.1618 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0237 0.1819
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0225 0.0178
Schistosoma mansoni methyl-cpg binding protein mbd 0.0041 0.0325 0.0287
Schistosoma mansoni chromobox protein 0.0084 0.0952 0.0965
Loa Loa (eye worm) hypothetical protein 0.027 0.3686 0.3927
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0363 0.0305
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0041 0.0325 0.0103
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0237 0.0191
Echinococcus multilocularis geminin 0.0154 0.1985 0.1801
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0054 0.0517 0.0495
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0411 0.0379
Echinococcus granulosus chromobox protein 1 0.0084 0.0952 0.0897
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0143 0.1817 0.1767
Loa Loa (eye worm) glutaminase 2 0.0653 0.9292 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.1232 0.1269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Plasmodium vivax SET domain protein, putative 0.0071 0.0773 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0225 0.0178
Onchocerca volvulus 0.0034 0.0225 0.0206
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0225 0.0178
Brugia malayi hypothetical protein 0.0027 0.0118 0.0126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0386 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Brugia malayi RNA binding protein 0.007 0.0751 0.0808
Brugia malayi Cathepsin L-like precursor 0.0023 0.0061 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0214 0.0166
Loa Loa (eye worm) hypothetical protein 0.0169 0.2203 0.2321
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0085 0.0973 0.0989
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0237 0.0177
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0363 0.0328
Brugia malayi Cathepsin L-like precursor 0.0034 0.0225 0.0242
Schistosoma mansoni hypothetical protein 0.0035 0.0237 0.0191
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0363 0.0328
Loa Loa (eye worm) bromodomain containing protein 0.0042 0.0347 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0225 0.0178
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0225 0.0713
Leishmania major cathepsin L-like protease 0.0034 0.0225 0.0713
Onchocerca volvulus Alhambra homolog 0.0035 0.0237 0.0221
Onchocerca volvulus 0.0566 0.8016 1
Brugia malayi latrophilin 2 splice variant baaae 0.0185 0.2434 0.2619
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0085 0.0981 0.0926
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0214 0.0166
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0344 0.0122
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0225 0.8971
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0363 0.0328
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0363 1
Echinococcus multilocularis muscleblind protein 1 0.0136 0.1718 0.1528
Echinococcus granulosus zinc finger protein 0.0047 0.0414 0.0355
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0225 0.0713
Loa Loa (eye worm) cysteine protease 0.0034 0.0225 0.0178
Brugia malayi Cathepsin L-like precursor 0.0034 0.0225 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Echinococcus multilocularis GPCR, family 2 0.0085 0.0981 0.0774
Loa Loa (eye worm) hypothetical protein 0.0085 0.0981 0.0997
Schistosoma mansoni zinc finger protein 0.0037 0.0264 0.022
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0225 0.0178
Schistosoma mansoni alpha-glucosidase 0.0168 0.2191 0.2307
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0436 0.0377
Brugia malayi hypothetical protein 0.0215 0.2878 0.3097
Trichomonas vaginalis chromobox protein, putative 0.005 0.0466 0.044
Schistosoma mansoni chromobox protein 0.0084 0.0952 0.0965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0225 0.0178
Schistosoma mansoni hypothetical protein 0.004 0.0309 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1618 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1221 0.1257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.027 0.3686 0.3927
Entamoeba histolytica hypothetical protein 0.004 0.0309 0.8211
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.1232 0.1269
Schistosoma mansoni jumonji domain containing protein 0.009 0.1051 0.1073
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0069 0.0735 0.0678
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0751 0.0808
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0225 0.5414
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0225 0.0206
Brugia malayi PHD-finger family protein 0.006 0.06 0.0646
Leishmania major hypothetical protein, conserved 0.0037 0.0264 0.0975
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0363 0.0328
Brugia malayi Cathepsin L-like precursor 0.0034 0.0225 0.0242

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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