Detailed information for compound 1313944

Basic information

Technical information
  • TDR Targets ID: 1313944
  • Name: 6-amino-4-furan-2-yl-3-thiophen-2-yl-2,4-dihy dropyrano[6,5-c]pyrazole-5-carbonitrile
  • MW: 310.331 | Formula: C15H10N4O2S
  • H donors: 2 H acceptors: 2 LogP: 2.4 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)Oc2c(C1c1ccco1)c(n[nH]2)c1cccs1
  • InChi: 1S/C15H10N4O2S/c16-7-8-11(9-3-1-5-20-9)12-13(10-4-2-6-22-10)18-19-15(12)21-14(8)17/h1-6,11H,17H2,(H,18,19)
  • InChiKey: QWWLKDHKBJHNSI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-amino-4-(2-furyl)-3-(2-thienyl)-2,4-dihydropyrano[6,5-c]pyrazole-5-carbonitrile
  • A2707/0115181
  • 6-amino-4-(2-furyl)-3-(2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
  • MLS000096747
  • Oprea1_356854
  • SMR000074040

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Starlite/ChEMBL No references
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Chlamydia trachomatis replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Mycobacterium ulcerans recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Treponema pallidum recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. Get druggable targets OG5_130095 All targets in OG5_130095
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Wolbachia endosymbiont of Brugia malayi recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Get druggable targets OG5_131890 All targets in OG5_131890
Treponema pallidum replicative DNA helicase (dnaB) Get druggable targets OG5_131890 All targets in OG5_131890
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Get druggable targets OG5_130095 All targets in OG5_130095
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Chlamydia trachomatis recombinase RecA Get druggable targets OG5_130095 All targets in OG5_130095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans replicative DNA helicase DnaB Get druggable targets OG5_131890 All targets in OG5_131890
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0029 0.0018 0.0234
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0017 0.0016
Trypanosoma brucei cytochrome P450, putative 0.0101 0.0143 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0081 0.0109 0.0109
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0049 0.3419
Schistosoma mansoni hypothetical protein 0.0046 0.0048 0.0048
Echinococcus granulosus muscleblind protein 0.018 0.0282 0.0282
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0405 0.0404
Brugia malayi jmjC domain containing protein 0.0071 0.0091 0.0091
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0088 0.1133
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0091 0.0091
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0017 0.1515
Schistosoma mansoni hypothetical protein 0.0331 0.0544 0.0544
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0029 0.0018 0.0234
Loa Loa (eye worm) cytochrome P450 family protein 0.0101 0.0143 0.0142
Trypanosoma brucei unspecified product 0.0032 0.0024 0.166
Mycobacterium tuberculosis Probable reductase 0.0122 0.018 0.0253
Leishmania major cytochrome p450-like protein 0.0101 0.0143 1
Brugia malayi jmjC domain containing protein 0.0071 0.0091 0.0091
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0029 0.0018 0.0234
Plasmodium vivax glutathione reductase, putative 0.0053 0.0061 0.5552
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0001 0.0054
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0061 0.006
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0029 0.0018 0.0234
Loa Loa (eye worm) hypothetical protein 0.0054 0.0062 0.0061
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0061 0.0086
Mycobacterium leprae putative cytochrome p450 0.0029 0.0018 0.0007
Plasmodium falciparum thioredoxin reductase 0.0053 0.0061 0.5552
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0088 0.1133
Giardia lamblia Ceramide glucosyltransferase 0.2613 0.4516 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.0161 0.0161
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0061 0.0085
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0002 0.0169
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0061 0.0085
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0109 0.1402
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0582 1
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0467 0.078 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0062 0.0062
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0051 0.0051
Brugia malayi Cytochrome P450 family protein 0.0101 0.0143 0.0143
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0001 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0062 0.0062
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.0582 0.1289
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.0203 0.0287
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0049 0.0841
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1418 0.1418
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Echinococcus granulosus expressed conserved protein 0.0104 0.0149 0.0149
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0074 0.0074
Schistosoma mansoni patched 1 0.0048 0.0051 0.0051
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0051 0.005
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0001 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0029 0.0018 0.0026
Treponema pallidum replicative DNA helicase (dnaB) 0.0467 0.078 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0018 0.1275
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0029 0.0018 0.0026
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0018 0.1275
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0109 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0137 0.0137
Echinococcus multilocularis dna polymerase eta 0.0077 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.006 0.0073 0.0072
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0062 0.0062
Onchocerca volvulus 0.0036 0.0031 0.0014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0582 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0051 0.0873
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0019 0.0001 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0029 0.0018 0.0026
Onchocerca volvulus 0.0286 0.0466 0.045
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0088 0.0125
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0091 0.0091
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0109 0.1402
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0029 0.0018 0.0026
Echinococcus granulosus lamin dm0 0.0028 0.0017 0.0017
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0047 0.3251
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0029 0.0018 0.0234
Entamoeba histolytica hypothetical protein 0.0041 0.0038 0.0631
Loa Loa (eye worm) MBCTL1 0.0061 0.0074 0.0074
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0029 0.0018 0.0026
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0088 0.0088
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0109 0.1402
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0029 0.0018 0.0234
Trypanosoma brucei trypanothione reductase 0.0053 0.0061 0.4241
Loa Loa (eye worm) cytochrome P450 0.0029 0.0018 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0039 0.0039
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.0582 0.7463
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0001 0.0001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0002 0.0024
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0038
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0018 0.0017
Schistosoma mansoni DNA polymerase eta 0.0077 0.0102 0.0102
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0049 0.0841
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.4093 0.709 1
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0038 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0582 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0001 0.0071
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0061 0.0061
Plasmodium vivax SET domain protein, putative 0.0036 0.0031 0.2795
Loa Loa (eye worm) glutathione reductase 0.0053 0.0061 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Brugia malayi Pre-SET motif family protein 0.0036 0.0031 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0029 0.0018 0.0026
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0216 0.0344 0.0344
Toxoplasma gondii thioredoxin reductase 0.0053 0.0061 0.5552
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0102 0.0102
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0061 0.0061
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0029 0.0018 0.0234
Trypanosoma cruzi DNA repair protein, putative 0.004 0.0038 0.2629
Loa Loa (eye worm) hypothetical protein 0.0077 0.0102 0.0102
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0001 0.0071
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.0161 0.0161
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0029 0.0018 0.0026
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.018 0.0253
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0002 0.0003
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0088 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0582 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0024 0.166
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0016
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0062 0.0062
Echinococcus granulosus intermediate filament protein 0.0028 0.0017 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0049 0.0627
Echinococcus multilocularis lamin 0.0028 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0031 0.0031
Echinococcus granulosus Niemann Pick C1 protein 0.0159 0.0244 0.0244
Echinococcus granulosus dna polymerase eta 0.0077 0.0102 0.0102
Toxoplasma gondii exonuclease III APE 0.002 0.0002 0.0169
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.0203 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0062 0.0062
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0001 0.0001
Echinococcus multilocularis lamin dm0 0.0028 0.0017 0.0017
Brugia malayi hypothetical protein 0.0041 0.0038 0.0038
Loa Loa (eye worm) cytochrome P450 family protein 0.0101 0.0143 0.0142
Echinococcus multilocularis expressed conserved protein 0.0104 0.0149 0.0149
Chlamydia trachomatis replicative DNA helicase 0.0467 0.078 1
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0061 0.5552
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0049 0.0049
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.018 0.0253
Echinococcus granulosus GPCR family 2 0.0019 0.0001 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0582 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1418 0.1418
Wolbachia endosymbiont of Brugia malayi recombinase A 0.013 0.0195 0.2495
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0024 0.166
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0062 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0029 0.0018 0.0026
Brugia malayi MH2 domain containing protein 0.0135 0.0202 0.0202
Onchocerca volvulus 0.006 0.0072 0.0055
Giardia lamblia DINP protein human, muc B family 0.0047 0.0049 0.0108
Schistosoma mansoni cytochrome P450 0.0029 0.0018 0.0018
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.008 0.0079
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0109 0.0109
Plasmodium falciparum glutathione reductase 0.0053 0.0061 0.5552
Echinococcus multilocularis tumor protein p63 0.0408 0.0678 0.0678
Leishmania major DNA polymerase eta, putative 0.0045 0.0047 0.3251
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0002 0.0129
Loa Loa (eye worm) hypothetical protein 0.006 0.0072 0.0071
Schistosoma mansoni ap endonuclease 0.002 0.0002 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0137 0.0137
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0001 0.0001
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0029 0.0018 0.0026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0001 0.0001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0049 0.0049
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0062 0.0045
Trypanosoma cruzi cytochrome P450, putative 0.0101 0.0143 1
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0001 0.0001
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0074 0.0074
Leishmania major trypanothione reductase 0.0053 0.0061 0.4241
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0061 0.0061
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0018 0.0018
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.018 0.0253
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.004 0.0038 0.2629
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0062 0.0061
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0029 0.0018 0.0234
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0216 0.0344 0.0344
Leishmania major DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0001 0.0001
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0109 0.1402
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0029 0.0018 0.0234
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0002 0.0129
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0074 0.0074
Entamoeba histolytica hypothetical protein 0.0041 0.0038 0.0631
Echinococcus multilocularis muscleblind protein 0.018 0.0282 0.0282
Trypanosoma brucei unspecified product 0.0047 0.0049 0.3419
Entamoeba histolytica hypothetical protein 0.0041 0.0038 0.0631
Brugia malayi Cytochrome P450 family protein 0.0029 0.0018 0.0018
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0109 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0137 0.0137
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0073 0.0073
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0268 0.3434
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.018 0.0695
Brugia malayi Probable ClpP-like protease 0.0081 0.0109 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0031 0.0031
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0031 0.0031
Trypanosoma cruzi cytochrome P450, putative 0.0101 0.0143 1
Schistosoma mansoni hypothetical protein 0.0046 0.0048 0.0048
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0137 0.0137
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0029 0.0018 0.0234
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0049 0.0049
Mycobacterium leprae Conserved hypothetical protein 0.1376 0.2362 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.0203 0.0796
Brugia malayi cytochrome P450 0.0029 0.0018 0.0018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0029 0.0018 0.0234
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0091 0.0091
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0001 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0466 0.8
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0002 0.0024
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0018 0.1275
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0029 0.0018 0.0234
Toxoplasma gondii hypothetical protein 0.0028 0.0017 0.1515
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0915 0.1561 0.1561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0582 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0268 0.1071
Echinococcus multilocularis protein dispatched 1 0.0054 0.0063 0.0063
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0467 0.078 0.3254
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0061 0.0074 0.0074
Treponema pallidum recombinase A 0.013 0.0195 0.2495
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0031 0.2795
Echinococcus granulosus tumor protein p63 0.0408 0.0678 0.0678
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0029 0.0018 0.0026
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0061 0.0061
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0029 0.0018 0.0234
Brugia malayi Muscleblind-like protein 0.018 0.0282 0.0282
Echinococcus granulosus phd:f box containing protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0111 0.0161 0.016
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0062 0.0062
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0029 0.0018 0.0234
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0038 0.0038
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0109 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0002 0.0129
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.013 0.0195 0.0759
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0002 0.0002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0109 0.1402
Schistosoma mansoni hypothetical protein 0.0046 0.0048 0.0048
Echinococcus multilocularis 0.0029 0.0018 0.0018
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0051 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0582 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Loa Loa (eye worm) twinkle helicase 0.0133 0.02 0.0199
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0137 0.0136
Entamoeba histolytica hypothetical protein 0.0041 0.0038 0.0631
Brugia malayi jmjC domain containing protein 0.0019 0.0001 0.0001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0029 0.0018 0.0026
Schistosoma mansoni lamin 0.0028 0.0017 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0073 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.003
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0031 0.0031
Onchocerca volvulus 0.0054 0.0062 0.0045
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0017 0.1515
Trypanosoma cruzi DNA repair protein, putative 0.004 0.0038 0.2629
Brugia malayi Pre-SET motif family protein 0.0251 0.0405 0.0405
Echinococcus multilocularis protein patched 0.0048 0.0051 0.0051
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0002 0.0002
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0051 0.0051
Brugia malayi mbt repeat family protein 0.0054 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.018 0.0282 0.0281
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0061 0.4241
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.0018 0.1669
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0028 0.0028
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0018 0.1275
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0102 0.716
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0019 0.0001 0.0001
Mycobacterium leprae Conserved hypothetical protein 0.0029 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0072 0.0093 0.0092
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.0203 0.0287
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0049 0.0069
Loa Loa (eye worm) hypothetical protein 0.018 0.0282 0.0281
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0049 0.0049
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0017 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0002 0.0032
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0029 0.0018 0.0234
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0091 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0029 0.0018 0.0026
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0109 1
Schistosoma mansoni hypothetical protein 0.0046 0.0048 0.0048
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.0161 0.2747
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0029 0.0018 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0137 0.0137
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0017 0.0212
Echinococcus granulosus lamin 0.0028 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0029 0.0018 0.0026
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0102 0.716
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0072 0.0072
Brugia malayi CHE-14 protein 0.0048 0.0051 0.0051
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0002 0.0169
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0049 0.0049
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0001 0.0001
Brugia malayi Cytochrome P450 family protein 0.0029 0.0018 0.0018
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.018 0.0253
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0049 0.0812
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0088 0.0088
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0088 0.6175
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0001 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0038 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0582 1
Brugia malayi jmjC domain containing protein 0.0019 0.0001 0.0001
Echinococcus multilocularis musashi 0.0028 0.0017 0.0017
Echinococcus granulosus dna polymerase kappa 0.0047 0.0049 0.0049
Brugia malayi intermediate filament protein 0.0028 0.0017 0.0017
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0001 0.0071
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0029 0.0018 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0001 0.0054
Trypanosoma brucei unspecified product 0.0032 0.0024 0.166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0058 0.0069 0.0069
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0001 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0049 0.0048
Leishmania major cytochrome p450-like protein 0.0029 0.0018 0.1275
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0049 0.3419
Schistosoma mansoni Replicative DNA helicase 0.0467 0.078 0.078
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0088 0.0088
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0109 0.1402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0582 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0029 0.0018 0.0026
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0091 0.0091
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0029 0.0018 0.0234
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0029 0.0018 0.0234
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.0161 0.0161
Leishmania major cytochrome p450-like protein 0.0029 0.0018 0.1275
Echinococcus multilocularis muscleblind protein 1 0.018 0.0282 0.0282
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.0054
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0002 0.0001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0002 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0137 0.0137
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0049 0.0627
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0049 0.0069
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3756 0.6505 0.9174
Mycobacterium ulcerans recombinase A 0.013 0.0195 0.2495
Brugia malayi Thioredoxin reductase 0.0053 0.0061 0.0061
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0074 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Echinococcus multilocularis GPCR, family 2 0.0019 0.0001 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.0202 0.0202
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.018 0.0253
Plasmodium vivax JmjC domain containing protein 0.0019 0.0001 0.0071
Schistosoma mansoni lamin 0.0028 0.0017 0.0017
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0101 0.0143 0.1835
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0029 0.0018 0.0026
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0002 0.0024
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0582 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0047 0.4256
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0018 0.1275
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0109 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0074 0.0074
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0049 0.3419
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0109 0.0395
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0091 0.0091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0137 0.0137
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0002 0.0129
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0029 0.0018 0.0234
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0039
Leishmania major DNA polymerase eta, putative 0.0077 0.0102 0.716
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0029 0.0018 0.0026
Loa Loa (eye worm) CYP4Cod1 0.0101 0.0143 0.0142
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0091 0.0091
Chlamydia trachomatis recombinase RecA 0.013 0.0195 0.2495
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0061 0.0188
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.0202 0.0202
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0049 0.0049
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0041 0.0039 0.0039
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0268 0.0378
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.0164 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0049 0.3419
Schistosoma mansoni ap endonuclease 0.002 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0002 0.0032
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0109 0.0109
Brugia malayi Cytochrome P450 family protein 0.0101 0.0143 0.0143
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0467 0.078 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0159 0.0244 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0024 0.166
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0031 0.0031
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0029 0.0018 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0049 0.3419
Brugia malayi mbt repeat family protein 0.0054 0.0062 0.0062
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0029 0.0018 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0137 0.0137
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1418 0.1418
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0017 0.0016
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0074 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0029 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0048 0.0051 0.005
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0029 0.0018 0.0234
Brugia malayi glutathione reductase 0.0053 0.0061 0.0061
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0029 0.0018 0.0234

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 8.225 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
AC50 (functional) = 53.55 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
EC50 (functional) = 7.2 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950] ChEMBL. No reference
Potency (binding) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 12.5594 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 27.9687 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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