Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.4701 | 0.4701 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.4701 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.4701 | 0.4701 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4701 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.4701 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.4701 | 0.4701 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.4701 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.4701 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.4701 | 0.4701 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4701 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.4701 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4701 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4701 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4701 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.4701 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4701 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.4701 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.4701 | 0.5 |
Schistosoma mansoni | kinase | 0.0058 | 0.0219 | 0.0465 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4701 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.8876 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.