TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.447 | Formula: C21H25FN4O2
H donors: 1 H acceptors: 3 LogP: 2.35 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NC1CC(C)(C)Cc2c1cnn2c1cccc(c1)F)CN1CCCC1=O
InChi: 1S/C21H25FN4O2/c1-21(2)10-17(24-19(27)13-25-8-4-7-20(25)28)16-12-23-26(18(16)11-21)15-6-3-5-14(22)9-15/h3,5-6,9,12,17H,4,7-8,10-11,13H2,1-2H3,(H,24,27)
InChiKey: NIUDXRUONYUMEC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	snurportin 1		No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	karyopherin (importin) beta 1		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0152	0.375	0.375
Brugia malayi	ABC transporter	0.005	0.0843	0.2249
Loa Loa (eye worm)	hypothetical protein	0.005	0.0843	0.0843
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0152	0.375	0.8372
Schistosoma mansoni	multidrug resistance protein	0.0061	0.117	0.117
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0152	0.375	1
Plasmodium vivax	ABC transporter B family member 3, putative	0.005	0.0843	0.1925
Trichomonas vaginalis	ABC transporter, putative	0.0152	0.375	1
Echinococcus granulosus	ATP binding cassette sub family B	0.005	0.0843	0.0843
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.005	0.0843	0.2249
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0152	0.375	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0152	0.375	1
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0061	0.117	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.445	0.445
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0152	0.375	1
Schistosoma mansoni	smdr1	0.005	0.0843	0.0843
Plasmodium falciparum	ABC transporter B family member 4, putative	0.005	0.0843	0.1925
Echinococcus granulosus	ATP binding cassette sub family B	0.005	0.0843	0.0843
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.005	0.0843	0.1925
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0412	0.2567
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0027	0.0202	0.0202
Plasmodium vivax	ABC transporter B family member 7, putative	0.005	0.0843	0.1925
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0993	0.0993
Schistosoma mansoni	smdr2	0.0152	0.375	0.375
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0152	0.375	1
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0061	0.117	0.117
Loa Loa (eye worm)	multidrug resistance protein 3	0.0152	0.375	0.375
Brugia malayi	RNA, U transporter 1	0.0099	0.2239	0.5971
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0152	0.375	0.375
Brugia malayi	ABC transporter transmembrane region family protein	0.0061	0.117	0.3119
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0061	0.117	0.2831
Plasmodium falciparum	multidrug resistance-associated protein 1	0.005	0.0843	0.1925
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.005	0.0843	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0027	0.0202	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0152	0.375	0.375
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0082	0.1761	0.4695
Brugia malayi	ABC transporter transmembrane region family protein	0.0048	0.0794	0.2117
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0794	0.0794
Giardia lamblia	Multidrug resistance-associated protein 1	0.0061	0.117	1
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0061	0.117	0.117
Giardia lamblia	MRP-like ABC transporter	0.0061	0.117	1
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0084	0.1798	0.4578
Giardia lamblia	Hypothetical protein	0.0048	0.0794	0.6313
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0048	0.0794	0.2117
Schistosoma mansoni	ran	0.0026	0.0151	0.0151
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0151	0.0401
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0152	0.375	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0061	0.117	0.237
Brugia malayi	multidrug resistance protein 3	0.0152	0.375	1
Plasmodium vivax	ABC transporter B family member 4, putative	0.005	0.0843	0.1925
Schistosoma mansoni	multidrug resistance protein	0.0152	0.375	0.375
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0152	0.375	1
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0061	0.117	0.2831
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0152	0.375	0.5
Leishmania major	ATP-binding cassette protein subfamily B, member 3, putative	0.005	0.0843	0.1925
Trypanosoma brucei	multidrug resistance protein E	0.0061	0.117	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.005	0.0843	0.1611
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0993	0.0993
Entamoeba histolytica	P-glycoprotein 5, putative	0.0152	0.375	1
Entamoeba histolytica	hypothetical protein	0.0061	0.117	0.2831
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0993	0.0993
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0104	0.2378	0.634
Entamoeba histolytica	P-glycoprotein-1	0.0152	0.375	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0048	0.0794	0.2117
Trichomonas vaginalis	ran, putative	0.0026	0.0151	0.0401
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0048	0.0794	0.2117
Leishmania major	p-glycoprotein	0.0152	0.375	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.005	0.0843	0.0843
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.005	0.0843	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0152	0.375	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0061	0.117	1
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0061	0.117	0.2831
Toxoplasma gondii	ATP-binding cassette sub-family B member 5	0.005	0.0843	0.1611
Trypanosoma brucei	ABC transporter, mitochondrial, putative	0.005	0.0843	0.6799
Giardia lamblia	ABC transporter, putative	0.0061	0.117	1
Trypanosoma brucei	p-glycoprotein	0.0061	0.117	1
Trichomonas vaginalis	ABC transporter, putative	0.0152	0.375	1
Trypanosoma brucei	ABC transporter of the mitochondrion, putative	0.005	0.0843	0.6799
Trypanosoma cruzi	ABC transporter, mitochondrial, putative	0.005	0.0843	0.6799
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0225	0.0206
Loa Loa (eye worm)	ABC transporter	0.005	0.0843	0.0843
Echinococcus granulosus	multidrug resistance protein 1	0.0152	0.375	0.375
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0072	0.1472	0.3925
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.005	0.0843	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0202	0.0202
Loa Loa (eye worm)	ABC transporter	0.005	0.0843	0.0843
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.005	0.0843	0.5
Entamoeba histolytica	hypothetical protein	0.0028	0.0225	0.0206
Schistosoma mansoni	importin beta-1	0.0035	0.0412	0.0412
Schistosoma mansoni	voltage-gated potassium channel	0.0089	0.1963	0.1963
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0412	0.2567
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0152	0.375	0.375
Toxoplasma gondii	hypothetical protein	0.0177	0.445	1
Echinococcus multilocularis		0.005	0.0843	0.0843
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0061	0.117	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.005	0.0843	0.1611
Brugia malayi	ABC transporter family protein	0.005	0.0843	0.2249
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0152	0.375	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0061	0.117	0.2831
Entamoeba histolytica	P-glycoprotein-2	0.0152	0.375	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0152	0.375	1
Echinococcus multilocularis	sodium channel protein	0.0084	0.1798	0.1798
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0152	0.375	1
Leishmania major	ABC-thiol transporter	0.0061	0.117	0.2831
Leishmania major	pentamidine resistance protein 1	0.0061	0.117	0.2831
Brugia malayi	hypothetical protein	0.005	0.0843	0.2249
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0072	0.1472	0.3925
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0061	0.117	1
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0177	0.445	0.445
Brugia malayi	multidrug resistance related protein 1	0.0061	0.117	0.3119
Echinococcus multilocularis	ATP binding cassette sub family B	0.005	0.0843	0.0843
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0993	0.0993
Brugia malayi	ABC transporter family protein	0.005	0.0843	0.2249
Entamoeba histolytica	P-glycoprotein 5, putative	0.0048	0.0794	0.1787
Schistosoma mansoni	multidrug resistance protein	0.0061	0.117	0.117
Brugia malayi	P-glycoprotein-like protein	0.005	0.0843	0.2249
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0061	0.117	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.445	0.445
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0082	0.1761	0.1761
Echinococcus granulosus	multidrug resistance associated protein 7	0.0061	0.117	0.117
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0152	0.375	0.8372
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.005	0.0843	0.1611
Entamoeba histolytica	P-glyco protein 6, putative	0.0152	0.375	1
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.005	0.0843	0.5
Schistosoma mansoni	multidrug resistance protein	0.0152	0.375	0.375
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.005	0.0843	0.1925
Entamoeba histolytica	P-glycoprotein 6, putative	0.005	0.0843	0.1925
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0048	0.0794	0.0794
Brugia malayi	ABC transporter family protein	0.005	0.0843	0.2249
Echinococcus multilocularis	multidrug resistance protein 1	0.0152	0.375	0.375
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0225	0.0599
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0061	0.117	0.2831
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.005	0.0843	0.5
Schistosoma mansoni	multidrug resistance protein	0.0048	0.0794	0.0794
Trichomonas vaginalis	abcb9, putative	0.0152	0.375	1
Brugia malayi	ABC transporter family protein	0.0152	0.375	1
Plasmodium falciparum	multidrug resistance protein 2	0.005	0.0843	0.1925
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0152	0.375	1
Toxoplasma gondii	ABC transporter family protein	0.005	0.0843	0.1611
Echinococcus granulosus	multidrug resistance protein 1	0.0152	0.375	0.375
Plasmodium vivax	multidrug resistance protein 1, putative	0.0152	0.375	1
Onchocerca volvulus		0.0152	0.375	0.5
Plasmodium vivax	multidrug resistance protein 2, putative	0.005	0.0843	0.1925
Entamoeba histolytica	P-glycoprotein-2	0.0152	0.375	1
Plasmodium falciparum	ABC transporter B family member 7, putative	0.005	0.0843	0.1925
Trichomonas vaginalis	abcb9, putative	0.0152	0.375	1
Entamoeba histolytica	multidrug resistance protein, putative	0.0061	0.117	0.2831
Echinococcus multilocularis	multidrug resistance protein 1	0.0152	0.375	0.375
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0993	0.0993
Brugia malayi	ABC transporter	0.0048	0.0794	0.2117
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0061	0.117	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.005	0.0843	0.0843
Plasmodium falciparum	ABC transporter B family member 5, putative	0.005	0.0843	0.1925
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0061	0.117	0.2831
Trichomonas vaginalis	ABC transporter, putative	0.0152	0.375	1
Giardia lamblia	Multidrug resistance-associated protein Mrp2	0.0048	0.0794	0.6313
Schistosoma mansoni	multidrug resistance protein	0.0061	0.117	0.117
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0082	0.1761	0.1761
Schistosoma mansoni	multidrug resistance protein	0.0152	0.375	0.375
Plasmodium vivax	ABC transporter B family member 5, putative	0.005	0.0843	0.1925
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0152	0.375	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0104	0.2378	0.2378
Trichomonas vaginalis	abcb9, putative	0.0152	0.375	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.117	0.117
Leishmania major	ATP-binding cassette protein subfamily B, member 1, putative	0.005	0.0843	0.1925
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0993	0.2648
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0082	0.1761	0.1761
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0152	0.375	0.375
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0151	0.0151
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0027	0.0202	0.0538
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.005	0.0843	0.1611
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0152	0.375	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0151	0.0151
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0993	0.0993
Brugia malayi	ABC transporter transmembrane region family protein	0.005	0.0843	0.2249
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0152	0.375	1
Echinococcus granulosus	multidrug resistance associated protein 1	0.0061	0.117	0.117
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0152	0.375	0.375
Echinococcus granulosus	ATP binding cassette sub family B	0.0048	0.0794	0.0794
Entamoeba histolytica	P-glycoprotein-5	0.0152	0.375	1
Echinococcus granulosus	sodium channel protein	0.0084	0.1798	0.1798
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0225	0.0599
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0152	0.375	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0152	0.375	0.375
Plasmodium falciparum	importin beta, putative	0.0035	0.0412	0.0727
Toxoplasma gondii	ABC transporter, putative	0.005	0.0843	0.1611
Echinococcus granulosus	multidrug resistance protein 1	0.0104	0.2378	0.2378
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0152	0.375	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.005	0.0843	0.1611
Schistosoma mansoni	voltage-gated potassium channel	0.0027	0.0202	0.0202
Echinococcus multilocularis	voltage gated potassium channel	0.0027	0.0202	0.0202
Echinococcus granulosus	multidrug resistance protein 1	0.0152	0.375	0.375
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1471	0.1471
Plasmodium falciparum	multidrug resistance protein 1	0.0152	0.375	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0152	0.375	0.375
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0152	0.375	0.375
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.015	0.3701	0.3701
Echinococcus granulosus	multidrug resistance protein 1	0.0104	0.2378	0.2378
Echinococcus multilocularis	ATP binding cassette sub family B	0.015	0.3701	0.3701
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.005	0.0843	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0152	0.375	1
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0061	0.117	0.2831
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.005	0.0843	0.0843
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.005	0.0843	0.5
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0412	0.0609
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0152	0.375	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0152	0.375	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.112	0.112
Plasmodium falciparum	ABC transporter B family member 3, putative	0.005	0.0843	0.1925
Loa Loa (eye worm)	hypothetical protein	0.015	0.3701	0.3701
Trichomonas vaginalis	taga, putative	0.0152	0.375	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0152	0.375	1
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0794	0.2117
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0061	0.117	0.117
Loa Loa (eye worm)	hypothetical protein	0.0061	0.117	0.117
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0225	0.0599
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0412	0.0412
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0151	0.0151
Schistosoma mansoni	voltage-gated potassium channel	0.0027	0.0202	0.0202
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0993	0.0993
Leishmania major	p-glycoprotein e	0.0061	0.117	0.2831
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.005	0.0843	0.2249
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.005	0.0843	0.5
Entamoeba histolytica	P-glycoprotein-2, putative	0.0152	0.375	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0152	0.375	1
Loa Loa (eye worm)	ABC transporter	0.005	0.0843	0.0843
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0084	0.1798	0.1798
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0412	0.0412
Entamoeba histolytica	P-glycoprotein 6, putative	0.005	0.0843	0.1925
Giardia lamblia	Multidrug resistance-associated protein 1	0.006	0.112	0.9513
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0412	0.0412
Trichomonas vaginalis	ABC transporter, putative	0.0152	0.375	1
Schistosoma mansoni	multidrug resistance protein	0.0061	0.117	0.117
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0412	0.0727
Schistosoma mansoni	ran	0.0026	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0177	0.445	0.445
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0061	0.117	0.2831
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0152	0.375	0.375
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0225	0.0728
Schistosoma mansoni	multidrug resistance protein	0.005	0.0843	0.0843
Plasmodium falciparum	ABC transporter B family member 6, putative	0.005	0.0843	0.1925
Echinococcus granulosus	voltage gated potassium channel	0.0027	0.0202	0.0202
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0152	0.375	1
Trypanosoma cruzi	ABC transporter of the mitochondrion, putative	0.005	0.0843	0.6799
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0993	0.0993
Schistosoma mansoni	voltage-gated potassium channel	0.0089	0.1963	0.1963
Leishmania major	ATP-binding cassette protein subfamily C, member 8, putative	0.005	0.0843	0.1925
Entamoeba histolytica	ABC transporter, putative	0.0061	0.117	0.2831
Loa Loa (eye worm)	hypothetical protein	0.0152	0.375	0.375
Plasmodium falciparum	multidrug resistance-associated protein 2	0.005	0.0843	0.1925
Plasmodium vivax	ABC transporter B family member 6, putative	0.005	0.0843	0.1925
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0152	0.375	0.375
Entamoeba histolytica	P-glycoprotein-2, putative	0.0048	0.0794	0.1787
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0152	0.375	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.005	0.0843	0.0843
Brugia malayi	Importin beta-1 subunit	0.0035	0.0412	0.1099

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	= 100 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1460311

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1314767