Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0031 | 0.4286 | 0.3182 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0031 | 0.4286 | 0.4286 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0031 | 0.4286 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.4286 | 0.048 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3998 | 0.2838 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.3998 | 0.2838 |
Brugia malayi | cathepsin L-like precursor | 0.0031 | 0.4286 | 0.4286 |
Echinococcus granulosus | cathepsin l1 | 0.0031 | 0.4286 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0024 | 0.162 | 0.162 |
Brugia malayi | Cathepsin L-like precursor | 0.0031 | 0.4286 | 0.4286 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0031 | 0.4286 | 0.3182 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3998 | 0.2838 |
Brugia malayi | Cathepsin L-like precursor | 0.0031 | 0.4286 | 0.4286 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.4286 | 0.048 |
Brugia malayi | hypothetical protein | 0.003 | 0.3998 | 0.3998 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3998 | 0.2838 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.4286 | 0.048 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3998 | 0.2838 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.3998 | 0.2838 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0031 | 0.4286 | 0.3182 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0031 | 0.4286 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0024 | 0.162 | 0.162 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.