Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.3839 | 0.399 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.9621 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.3839 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.3839 | 0.3839 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.3839 | 0.3839 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0053 | 0.9621 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.9621 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0053 | 0.9621 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0053 | 0.9621 | 0.9621 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.9621 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0053 | 0.9621 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0053 | 0.9621 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0053 | 0.9621 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0053 | 0.9621 | 0.9621 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.3839 | 0.399 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0053 | 0.9621 | 0.9621 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0053 | 0.9621 | 0.9621 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.9621 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.9621 | 0.9621 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0053 | 0.9621 | 0.9621 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.3839 | 0.3839 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0053 | 0.9621 | 0.9621 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.3839 | 0.399 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.9621 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0053 | 0.9621 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.3839 | 0.3839 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.3839 | 0.3839 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.2288 | 0.2288 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0053 | 0.9621 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0053 | 0.9621 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.3839 | 0.399 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.9621 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.