Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.5014 | 1 |
Onchocerca volvulus | 0.0043 | 0.1256 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.1256 | 0.2505 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.1256 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.1256 | 0.5 | |
Brugia malayi | beta-lactamase | 0.0043 | 0.1256 | 0.2505 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.1256 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.1256 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.1256 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.1256 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1256 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.1256 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.1256 | 0.2505 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.1256 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.1256 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1256 | 0.2505 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1256 | 0.2505 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.5014 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1256 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.5014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.1256 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.1256 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1256 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.1256 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1256 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.1256 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.5623 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.