Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Starlite/ChEMBL | No references |
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | SUMO/sentrin specific peptidase family member 8 | Starlite/ChEMBL | No references |
Mycobacterium tuberculosis | RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Giardia intestinalis | Putative fructose-1,6-bisphosphate aldolase | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0006 | 0.0017 |
Echinococcus granulosus | sentrin specific protease 8 | 0.008 | 0.0215 | 0.0569 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0006 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0172 | 0.0653 | 0.0478 |
Wolbachia endosymbiont of Brugia malayi | recombinase A | 0.013 | 0.0453 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0121 | 0.1156 |
Brugia malayi | jmjC domain containing protein | 0.0114 | 0.0374 | 0.3629 |
Onchocerca volvulus | 0.0286 | 0.1191 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0006 | 0.0039 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0183 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0183 | 0.0483 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.01 | 0.0311 | 0.0817 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0172 | 0.0653 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0121 | 0.1156 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.003 | 0.0075 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.1508 | 1 |
Chlamydia trachomatis | recombinase RecA | 0.013 | 0.0453 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0114 | 0.0374 | 0.0983 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1508 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0006 | 0.0011 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.01 | 0.0311 | 0.3017 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0211 | 0.204 |
Brugia malayi | jmjC domain containing protein | 0.0186 | 0.0719 | 0.6993 |
Trypanosoma cruzi | hypothetical protein | 0.008 | 0.0215 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.018 | 0.1735 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.01 | 0.0311 | 0.0822 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0764 | 0.3458 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.003 | 0.0275 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.3785 | 1 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.008 | 0.0215 | 0.2081 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0121 | 0.1156 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0311 | 0.3017 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0183 | 0.0478 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1508 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0353 | 0.1508 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0172 | 0.0653 | 0.0664 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0006 | 0.0011 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0006 | 0.0011 |
Trypanosoma brucei | recA bacterial DNA recombination protein, putative | 0.004 | 0.0026 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.1508 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.01 | 0.0311 | 0.0817 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0114 | 0.0374 | 0.3629 |
Loa Loa (eye worm) | Ulp1 protease | 0.008 | 0.0215 | 0.2081 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0121 | 0.1156 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1508 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.3785 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0163 | 0.0606 | 0.1597 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0006 | 0.0011 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0068 | 0.0179 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0353 | 0.1508 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.003 | 0.0275 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.1191 | 0.7547 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0186 | 0.0719 | 0.1898 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.008 | 0.0215 | 0.0564 |
Onchocerca volvulus | 0.01 | 0.0311 | 0.2599 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.1027 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0114 | 0.0374 | 0.0983 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0.0002 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0006 | 0.0011 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.2014 | 0.9382 | 0.9371 |
Mycobacterium ulcerans | recombinase A | 0.013 | 0.0453 | 0.5751 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0186 | 0.0719 | 0.1893 |
Onchocerca volvulus | 0.0036 | 0.0006 | 0.0034 | |
Echinococcus granulosus | peregrin | 0.0035 | 0.0002 | 0.0006 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0114 | 0.0374 | 0.0983 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.1027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0006 | 0.0039 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0183 | 0.0478 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.3785 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1508 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1508 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1508 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1508 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0035 | 0.0002 | 0.0006 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0114 | 0.0374 | 0.0988 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.008 | 0.0215 | 0.0564 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1508 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0183 | 0.0478 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0068 | 0.0173 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0006 | 0.0221 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0006 | 0.0011 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | > 120 uM | PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] | ChEMBL. | No reference |
AC50 (functional) | > 380 uM | PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] | ChEMBL. | No reference |
EC50 (functional) | = 11.4 uM | PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950] | ChEMBL. | No reference |
IC50 (functional) | 4.12 uM | PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using Nedd8 Protein Substrate. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 17.3 uM | PubChem BioAssay. Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | > 50 um | PUBCHEM_BIOASSAY: HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate. (Class of assay: confirmatory) [Related pubchem assays: 1209 ] | ChEMBL. | No reference |
IC50 (functional) | 93.3 uM | PubChem BioAssay. Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 in a Caspase-3 Fluorescence assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.2936 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 1.1194 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | = 1.9953 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.2387 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Texas Red Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 9.4574 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 14.8453 um | PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) [Related pubchem assays: 1490 (qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)), 1819 (Probe Development Summary of Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase))] | ChEMBL. | No reference |
Potency (binding) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 24.1489 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 27.0955 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.