Detailed information for compound 1396262

Basic information

Technical information
  • TDR Targets ID: 1396262
  • Name: 2-[(3-cyano-5-hydroxy-7-oxo-4H-thieno[4,5-b]p yridin-2-yl)sulfanyl]-N-[3-(trifluoromethyl)p henyl]acetamide
  • MW: 425.405 | Formula: C17H10F3N3O3S2
  • H donors: 3 H acceptors: 5 LogP: 3.93 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(SCC(=O)Nc2cccc(c2)C(F)(F)F)sc2c1nc(O)cc2O
  • InChi: 1S/C17H10F3N3O3S2/c18-17(19,20)8-2-1-3-9(4-8)22-13(26)7-27-16-10(6-21)14-15(28-16)11(24)5-12(25)23-14/h1-5H,7H2,(H,22,26)(H2,23,24,25)
  • InChiKey: VSSJGFHQKOSBOQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(3-cyano-5-hydroxy-7-oxo-4H-thieno[4,5-b]pyridin-2-yl)thio]-N-[3-(trifluoromethyl)phenyl]acetamide
  • 2-[(3-cyano-5-hydroxy-7-keto-4H-thieno[4,5-b]pyridin-2-yl)thio]-N-[3-(trifluoromethyl)phenyl]acetamide
  • 2-[(3-cyano-5-hydroxy-7-oxo-4H-thieno[4,5-b]pyridin-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]ethanamide
  • ASN 14403760

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) pip kinase 2 Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_131617 All targets in OG5_131617
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Pip kinase protein 2 Get druggable targets OG5_131617 All targets in OG5_131617
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 406 aa 341 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1681
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0797 0.0783
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0797 0.0783
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2185 0.5373
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0016 0.0162 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0147 0.0027
Loa Loa (eye worm) beta-lactamase 0.0043 0.0733 0.1681
Brugia malayi beta-lactamase family protein 0.0043 0.0733 0.1687
Brugia malayi polk-prov protein 0.0014 0.0136 0.0199
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.4067 0.6916
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2185 0.2173
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0016 0.0162 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0733 0.1802
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.5553 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0733 0.1681
Brugia malayi Phosphoglycerate kinase 0.0206 0.4067 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.0162 0.0147
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0015 0.0147 0.0131
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0733 0.1518
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Brugia malayi CXXC zinc finger family protein 0.0035 0.0552 0.1236
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.3877 0.3867
Onchocerca volvulus 0.0043 0.0733 0.0544
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0016 0.0162 0.0147
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2185 0.5213
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0015 0.0147 0.0131
Giardia lamblia Hypothetical protein 0.0016 0.0162 0.0067
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0016 0.0162 0.0067
Leishmania major DNA polymerase eta, putative 0.0045 0.0769 0.161
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0733 0.1518
Leishmania major DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Loa Loa (eye worm) hypothetical protein 0.0014 0.0136 0.0192
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0147 0.0027
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.139 0.3192
Leishmania major DNA polymerase eta, putative 0.0077 0.143 0.3292
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1352 0.1338
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0733 0.0718
Mycobacterium ulcerans lipase LipD 0.0043 0.0733 0.1518
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1681
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.0162 0.0147
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0059 0.0044
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0162 0.0067
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.4067 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.139 0.3192
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0147 0.0027
Echinococcus granulosus dna polymerase kappa 0.0047 0.0797 0.0783
Loa Loa (eye worm) pip kinase 2 0.0196 0.3877 0.9526
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.0162 0.0067
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0769 0.161
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0162 0.0067
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.0162 0.0067
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.4067 1
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.0162 0.0147
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0162 0.0067
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0016 0.0162 0.0067
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2185 0.5213
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.139 0.3192
Schistosoma mansoni cpg binding protein 0.0035 0.0552 0.0537
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.0162 0.0067
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0016 0.0162 0.0147
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.139 0.3192
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.4067 1
Brugia malayi Pip kinase protein 1 0.0016 0.0162 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0733 0.1518
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0797 0.166
Echinococcus granulosus dna polymerase eta 0.0077 0.143 0.1417
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Trichomonas vaginalis dullard protein, putative 0.0015 0.0147 0.0361
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.4067 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.4067 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2185 0.5308
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2185 0.2173
Trichomonas vaginalis esterase, putative 0.0043 0.0733 0.1802
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.4067 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.05 0.0925
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0016 0.0162 0.0067
Onchocerca volvulus 0.0196 0.3877 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0797 0.1842
Schistosoma mansoni hypothetical protein 0.0015 0.0143 0.0127
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0162 0.04
Brugia malayi Pip kinase protein 2 0.0196 0.3877 0.9526
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0733 0.1518
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1681
Brugia malayi beta-lactamase family protein 0.0043 0.0733 0.1687
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1681
Loa Loa (eye worm) hypothetical protein 0.0077 0.143 0.3421
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0733 0.1802
Echinococcus multilocularis dna polymerase eta 0.0077 0.143 0.1417
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Loa Loa (eye worm) pip kinase 1 0.0016 0.0162 0.0258
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0797 0.1682
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0797 0.0134
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0797 0.1682
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.3877 0.3867
Toxoplasma gondii ABC1 family protein 0.0043 0.0733 0.1518
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.05 0.0925
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0016 0.0162 0.0067
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0162 0.0067
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0797 0.0783
Trypanosoma brucei unspecified product 0.0032 0.05 0.0925
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0016 0.0162 0.0147
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1 0.2459
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.3877 0.3867
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.4067 1
Giardia lamblia Phosphoglycerate kinase 0.0206 0.4067 1
Echinococcus granulosus CTD small phosphatase protein like 0.0015 0.0147 0.0131
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0552 0.123
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.4067 1
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0162 0.004
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.4067 0.4057
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0147 0.0131
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.119 0.2682
Onchocerca volvulus 0.0043 0.0733 0.0544
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0162 0.0067
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0147 0.0361
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2185 0.5305
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0162 0.04
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2185 0.5373
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.4067 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0733 0.1802
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0162 0.0067
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0797 0.196
Loa Loa (eye worm) hypothetical protein 0.0196 0.3877 0.9526
Loa Loa (eye worm) hypothetical protein 0.0015 0.0147 0.0218
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2185 0.4912
Mycobacterium ulcerans beta-lactamase 0.0043 0.0733 0.1518
Mycobacterium ulcerans hypothetical protein 0.0043 0.0733 0.1518
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0797 0.0783
Entamoeba histolytica phosphoinositide kinase, putative 0.0016 0.0162 0.004
Trypanosoma brucei polo-like protein kinase 0.0114 0.2185 0.5213
Schistosoma mansoni DNA polymerase eta 0.0077 0.143 0.1417
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0016 0.0162 0.0265
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0733 0.1518
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0797 0.0783
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Onchocerca volvulus 0.0043 0.0733 0.0544
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0733 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0797 0.1848
Leishmania major hypothetical protein, conserved 0.0015 0.0147 0.0027
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0733 0.0718
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.0162 0.0067
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0147 0.0361
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.139 0.3192
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0797 0.1682
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0016 0.0162 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.05 0.0925
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0769 0.161
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0162 0.0067
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2185 0.52
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0797 0.0134
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.4067 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0593 0.0578
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0733 0.1802
Schistosoma mansoni cpg binding protein 0.0037 0.0593 0.0578
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.3877 0.3867
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0733 0.0718
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0162 0.0067
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0162 0.0067
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0797 0.1682
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.0147 0.0225
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2185 0.5373
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.139 0.3192
Giardia lamblia DINP protein human, muc B family 0.0047 0.0797 0.1682
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1 0.2459
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.139 0.3192
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0015 0.0147 0.0027
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2185 0.5213
Trichomonas vaginalis dullard protein, putative 0.0015 0.0147 0.0361
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.4067 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2185 0.5373
Treponema pallidum phosphoglycerate kinase 0.0206 0.4067 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0059 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0797 0.1682
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.4067 1
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0162 0.0067
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1681
Schistosoma mansoni cpg binding protein 0.0037 0.0593 0.0578
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.4067 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0733 0.1687
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0016 0.0162 0.0067
Schistosoma mansoni kinase 0.0058 0.1031 0.1017
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.4067 0.4057
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2185 0.5373
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.143 0.3292
Brugia malayi Phosphoglycerate kinase 0.0075 0.139 0.3327
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0147 0.0361
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.4067 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0136 0.0121
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.4067 0.5
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0016 0.0162 0.0258
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.0147 0.0027
Brugia malayi beta-lactamase 0.0043 0.0733 0.1687
Giardia lamblia Kinase, PLK 0.0114 0.2185 0.5213
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0015 0.0147 0.0027
Echinococcus granulosus cpg binding protein 0.0037 0.0593 0.0578
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0147 0.0361
Loa Loa (eye worm) hypothetical protein 0.0015 0.0143 0.0209
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2185 0.2173
Trypanosoma brucei unspecified product 0.0047 0.0797 0.1682
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.4067 1
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0016 0.0162 0.0067
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0733 0.1518
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2185 0.5373
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0733 0.1802
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.139 0.3192
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0162 0.0067
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.0162 0.0147
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1681
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0797 0.196
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0797 0.1682
Echinococcus multilocularis 0.0015 0.0147 0.0131
Loa Loa (eye worm) FYVE zinc finger family protein 0.0016 0.0162 0.0258
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.4067 1
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.4067 0.4057
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.4067 1
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.143 0.3426
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2185 0.5373
Trichomonas vaginalis dullard protein, putative 0.0015 0.0147 0.0361
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0797 0.1682
Leishmania major hypothetical protein, conserved 0.0043 0.0733 0.1518
Trypanosoma brucei unspecified product 0.0032 0.05 0.0925
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0147 0.0131
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.143 0.3292
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.4067 0.4057
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0015 0.0147 0.0027

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10.363 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 13.3714 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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