Detailed information for compound 1396351

Basic information

Technical information
  • TDR Targets ID: 1396351
  • Name: 4-dimethylamino-2-(4-fluorophenoxy)pyridine-3 -carbonitrile
  • MW: 257.263 | Formula: C14H12FN3O
  • H donors: 0 H acceptors: 2 LogP: 2.66 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(nccc1N(C)C)Oc1ccc(cc1)F
  • InChi: 1S/C14H12FN3O/c1-18(2)13-7-8-17-14(12(13)9-16)19-11-5-3-10(15)4-6-11/h3-8H,1-2H3
  • InChiKey: YZSZEUNYYYYRAT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-dimethylamino-2-(4-fluorophenoxy)-3-pyridinecarbonitrile
  • 4-dimethylamino-2-(4-fluorophenoxy)nicotinonitrile
  • Oprea1_739997
  • 4-(dimethylamino)-2-(4-fluorophenoxy)nicotinonitrile
  • MLS000326356
  • SMR000178932
  • 10M-061

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0087 0.0535 0.1869
Leishmania major cathepsin L-like protease 0.0161 0.1319 0.3851
Plasmodium vivax unspecified product 0.0087 0.0535 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1319 1
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0148 0.0516
Trypanosoma cruzi cysteine protease, putative 0.0087 0.0535 0.1869
Plasmodium falciparum cysteine proteinase falcipain 1 0.0087 0.0535 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Echinococcus granulosus cysteine protease 0.0087 0.0535 0.1869
Echinococcus granulosus cathepsin l1 0.011 0.0784 0.2741
Onchocerca volvulus 0.0161 0.1319 0.5679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0161 0.1319 0.1319
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2642 0.9231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Plasmodium vivax vivapain-2 0.0161 0.1319 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Echinococcus multilocularis cathepsin b 0.0306 0.2862 0.2862
Plasmodium vivax unspecified product 0.005 0.0148 0.112
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1319 0.4609
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.2862 1
Echinococcus granulosus prolyl endopeptidase 0.0255 0.2323 0.8116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1319 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0161 0.1319 1
Leishmania major cathepsin L-like protease 0.0161 0.1319 0.3851
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1319 1
Trypanosoma cruzi cysteine proteinase, putative 0.0087 0.0535 0.1869
Trypanosoma brucei cysteine peptidase C (CPC) 0.012 0.0885 0.196
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0161 0.1319 0.4609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1319 0.4609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Loa Loa (eye worm) cysteine protease 0.0161 0.1319 0.4609
Trypanosoma cruzi cruzipain precursor, putative 0.0161 0.1319 0.4609
Brugia malayi Cathepsin L-like precursor 0.011 0.0784 0.2741
Trypanosoma brucei oligopeptidase b 0.0102 0.0691 0.0872
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0535 0.1869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0535 0.4054
Loa Loa (eye worm) hypothetical protein 0.0255 0.2323 0.8116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Onchocerca volvulus 0.0161 0.1319 0.5679
Onchocerca volvulus 0.0058 0.0231 0.0993
Loa Loa (eye worm) hypothetical protein 0.011 0.0784 0.2741
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0255 0.2323 0.8116
Entamoeba histolytica cysteine proteinase, putative 0.011 0.0784 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Entamoeba histolytica cysteine proteinase 1, putative 0.0087 0.0535 0.4054
Leishmania major cathepsin L-like protease 0.0161 0.1319 0.3851
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Schistosoma mansoni hypothetical protein 0.0058 0.0231 0.0806
Brugia malayi Cathepsin L-like precursor 0.0161 0.1319 0.4609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Onchocerca volvulus Cathepsin L homolog 0.0161 0.1319 0.5679
Echinococcus granulosus cathepsin b 0.0306 0.2862 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Brugia malayi cathepsin L-like precursor 0.011 0.0784 0.2741
Entamoeba histolytica cysteine proteinase 2 0.0087 0.0535 0.4054
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0255 0.2323 1
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.0535 0.1869
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0102 0.0691 0.0872
Schistosoma mansoni cathepsin F (C01 family) 0.0161 0.1319 0.4609
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1319 0.4609
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.005 0.0148 0.0516
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2642 0.2642
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0148 0.0516
Onchocerca volvulus Prolyl endopeptidase homolog 0.0255 0.2323 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Trypanosoma cruzi oligopeptidase b 0.0102 0.0691 0.2413
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.0535 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.0161 0.1319 0.1319
Schistosoma mansoni cathepsin s 0.005 0.0148 0.0516
Trypanosoma cruzi cruzipain precursor, putative 0.005 0.0148 0.0516
Loa Loa (eye worm) hypothetical protein 0.005 0.0148 0.0516
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0231 0.0806
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.012 0.0885 0.1192
Loa Loa (eye worm) hypothetical protein 0.011 0.0784 0.2741
Onchocerca volvulus 0.0161 0.1319 0.5679
Plasmodium vivax vivapain-2 0.0161 0.1319 1
Echinococcus multilocularis prolyl endopeptidase 0.0255 0.2323 0.2323
Entamoeba histolytica cysteine proteinase, putative 0.0161 0.1319 1
Brugia malayi Cathepsin L-like precursor 0.0161 0.1319 0.4609
Loa Loa (eye worm) hypothetical protein 0.0286 0.2642 0.9231
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.2862 1
Echinococcus granulosus cathepsin L cysteine protease 0.0087 0.0535 0.1869
Toxoplasma gondii cathepsin B 0.012 0.0885 0.3811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Onchocerca volvulus 0.0161 0.1319 0.5679
Trypanosoma cruzi cysteine proteinase, putative 0.0087 0.0535 0.1869
Loa Loa (eye worm) cathepsin B 0.012 0.0885 0.3093
Brugia malayi Cathepsin L-like cysteine proteinase 0.011 0.0784 0.2741
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0161 0.1319 0.1319
Brugia malayi Cathepsin L-like precursor 0.0161 0.1319 0.4609
Echinococcus multilocularis cathepsin b 0.0306 0.2862 0.2862
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Loa Loa (eye worm) hypothetical protein 0.005 0.0148 0.0516
Leishmania major cysteine peptidase A (CPA) 0.0161 0.1319 0.3851
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Brugia malayi cathepsin B-like cysteine proteinase 0.0306 0.2862 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Brugia malayi hypothetical protein 0.0286 0.2642 0.9231
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0102 0.0691 0.5
Loa Loa (eye worm) ctsf protein 0.0161 0.1319 0.4609
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0161 0.1319 1
Brugia malayi cathepsin F-like cysteine proteinase 0.005 0.0148 0.0516
Onchocerca volvulus 0.011 0.0784 0.3377
Plasmodium vivax vivapain-3 0.0087 0.0535 0.4054
Brugia malayi prolyl oligopeptidase family protein 0.0255 0.2323 0.8116
Brugia malayi Cathepsin L-like precursor 0.0161 0.1319 0.4609
Onchocerca volvulus Cathepsin L homolog 0.0161 0.1319 0.5679
Leishmania major cathepsin L-like protease 0.0161 0.1319 0.3851
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Echinococcus multilocularis cysteine protease 0.0161 0.1319 0.1319
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.011 0.0784 0.2741
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0161 0.1319 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.012 0.0885 0.671
Echinococcus granulosus cathepsin l cysteine peptidase 0.0161 0.1319 0.4609
Leishmania major cathepsin L-like protease 0.0161 0.1319 0.3851
Loa Loa (eye worm) hypothetical protein 0.0161 0.1319 0.4609
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0102 0.0691 0.5
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0161 0.1319 0.4609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1319 1
Brugia malayi Papain family cysteine protease containing protein 0.0161 0.1319 0.4609
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.012 0.0885 0.3093
Leishmania major cathepsin L-like protease 0.0161 0.1319 0.3851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Entamoeba histolytica cysteine protease, putative 0.0161 0.1319 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1319 1
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.0535 0.4054
Loa Loa (eye worm) hypothetical protein 0.005 0.0148 0.0516
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0306 0.2862 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0102 0.0691 0.2413
Schistosoma mansoni survival motor neuron protein 0.0058 0.0231 0.0806
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.011 0.0784 0.5946
Leishmania major cathepsin L-like protease 0.0161 0.1319 0.3851
Onchocerca volvulus 0.0161 0.1319 0.5679
Loa Loa (eye worm) fibroinase 0.0161 0.1319 0.4609
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0102 0.0691 0.2413
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1319 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.012 0.0885 0.3093
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0255 0.2323 0.8116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.0535 0.1869
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1319 1
Echinococcus granulosus cathepsin L 0.0087 0.0535 0.1869
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1319 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Echinococcus granulosus cathepsin b 0.0306 0.2862 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0535 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.0535 0.4054
Trypanosoma brucei prolyl oligopeptidase, putative 0.0102 0.0691 0.0872
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.0535 0.1869
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0306 0.2862 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.0535 0.1869
Trypanosoma brucei prolyl endopeptidase 0.0255 0.2323 1
Toxoplasma gondii cathepsin CPL 0.0161 0.1319 0.5679
Onchocerca volvulus 0.0161 0.1319 0.5679
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0229 0.2039 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0161 0.1319 1
Giardia lamblia Cathepsin B precursor 0.012 0.0885 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1319 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Onchocerca volvulus 0.0161 0.1319 0.5679
Loa Loa (eye worm) hypothetical protein 0.0306 0.2862 1
Giardia lamblia Cathepsin B precursor 0.012 0.0885 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0161 0.1319 0.1319
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.0535 0.1869
Trypanosoma cruzi oligopeptidase b 0.0102 0.0691 0.2413
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1319 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Trypanosoma cruzi prolyl endopeptidase 0.0255 0.2323 0.8116
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1319 0.4609
Toxoplasma gondii prolyl endopeptidase 0.0255 0.2323 1
Leishmania major cathepsin L-like protease 0.0161 0.1319 0.3851
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0161 0.1319 0.4609
Echinococcus multilocularis cysteine protease 0.0161 0.1319 0.1319
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Onchocerca volvulus Cathepsin F homolog 0.0161 0.1319 0.5679
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.0535 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.011 0.0784 0.2741
Entamoeba histolytica cysteine proteinase, putative 0.0161 0.1319 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.0535 0.4054
Echinococcus granulosus cathepsin l1 0.0161 0.1319 0.4609
Giardia lamblia Cathepsin B precursor 0.012 0.0885 1
Plasmodium vivax vivapain-1 0.0087 0.0535 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Brugia malayi Cathepsin L-like precursor 0.005 0.0148 0.0516
Echinococcus granulosus cathepsin L cysteine proteinase 0.0161 0.1319 0.4609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1319 0.4387
Brugia malayi Cathepsin L-like precursor 0.0161 0.1319 0.4609
Brugia malayi Cathepsin L-like precursor 0.011 0.0784 0.2741
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0161 0.1319 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.011 0.0784 0.5946
Brugia malayi Cathepsin L-like precursor 0.0161 0.1319 0.4609
Echinococcus multilocularis cathepsin L 0.0087 0.0535 0.0535
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.2862 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0784 0.2741

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2239 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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