Detailed information for compound 1396791

Basic information

Technical information
  • TDR Targets ID: 1396791
  • Name: 3-[[1-(1,3-benzodioxol-5-ylmethyl)tetrazol-5- yl]-pyrrolidin-1-ylmethyl]-6,8-dimethyl-1H-qu inolin-2-one
  • MW: 458.512 | Formula: C25H26N6O3
  • H donors: 1 H acceptors: 5 LogP: 4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c2c(c1)cc(c(n2)O)C(c1nnnn1Cc1ccc2c(c1)OCO2)N1CCCC1
  • InChi: 1S/C25H26N6O3/c1-15-9-16(2)22-18(10-15)12-19(25(32)26-22)23(30-7-3-4-8-30)24-27-28-29-31(24)13-17-5-6-20-21(11-17)34-14-33-20/h5-6,9-12,23H,3-4,7-8,13-14H2,1-2H3,(H,26,32)
  • InChiKey: BMWFDPQGQFDPHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[1-(1,3-benzodioxol-5-ylmethyl)tetrazol-5-yl]-pyrrolidin-1-yl-methyl]-6,8-dimethyl-1H-quinolin-2-one
  • 3-[[1-(1,3-benzodioxol-5-ylmethyl)-5-tetrazolyl]-1-pyrrolidinylmethyl]-6,8-dimethyl-1H-quinolin-2-one
  • 3-[[1-(1,3-benzodioxol-5-ylmethyl)tetrazol-5-yl]-pyrrolidin-1-yl-methyl]-6,8-dimethyl-carbostyril
  • 3-[[1-(1,3-benzodioxol-5-ylmethyl)-1,2,3,4-tetrazol-5-yl]-pyrrolidin-1-yl-methyl]-6,8-dimethyl-1H-quinolin-2-one
  • ASN 05340598
  • Oprea1_177608
  • 3-[(1-Benzo[1,3]dioxol-5-ylmethyl-1H-tetrazol-5-yl)-pyrrolidin-1-yl-methyl]-6,8-dimethyl-1H-quinolin-2-one
  • MLS000031245
  • SMR000004439

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0153 0.0486
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0471 0.0413
Brugia malayi hypothetical protein 0.002 0.0111 0.0111
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0054 0.0502 0.1013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0502 0.0502
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0054 0.0502 0.2315
Plasmodium falciparum serine repeat antigen 9 0.0054 0.0502 0.2315
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0054 0.0502 0.0502
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0557 0.1469
Loa Loa (eye worm) cysteine protease 0.018 0.1969 0.1969
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0036
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0054 0.0502 0.1013
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.1097 0.2551
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0381 0.1056
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Leishmania major cysteine peptidase A (CPA) 0.018 0.1969 0.5647
Schistosoma mansoni lamin 0.0028 0.0206 0.0206
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.1097 0.1097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Leishmania major cathepsin L-like protease 0.023 0.2549 0.7364
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0381 0.1056
Echinococcus granulosus cathepsin l1 0.0129 0.1374 0.1374
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0381 0.0323
Mycobacterium ulcerans hypothetical protein 0.0043 0.0381 0.1766
Plasmodium falciparum serine repeat antigen 1 0.0054 0.0502 0.2315
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1087 0.471
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Echinococcus multilocularis RUN 0.0024 0.0153 0.0153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Echinococcus granulosus axis inhibition protein axin 0.002 0.0111 0.0111
Schistosoma mansoni cathepsin F (C01 family) 0.018 0.1969 0.1969
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1087 0.3374
Schistosoma mansoni inositol transporter 0.004 0.0345 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0502 0.1129
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0414 0.0414
Entamoeba histolytica cysteine proteinase, putative 0.0129 0.1374 0.3269
Trypanosoma cruzi cysteine peptidase, putative 0.018 0.1969 0.192
Plasmodium vivax vivapain-1 0.0105 0.1097 0.5431
Onchocerca volvulus 0.0028 0.0206 0.0643
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Echinococcus multilocularis lamin 0.0028 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Schistosoma mansoni rab6-interacting 0.0024 0.0153 0.0153
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Plasmodium falciparum serine repeat antigen 2 0.0054 0.0502 0.2315
Brugia malayi Pre-SET motif family protein 0.0252 0.2803 0.2803
Schistosoma mansoni cathepsin s 0.0051 0.0471 0.0471
Schistosoma mansoni cpg binding protein 0.003 0.0227 0.0227
Brugia malayi cathepsin L precursor 0.0054 0.0502 0.0502
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0054 0.0502 0.2315
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0395 0.0855
Toxoplasma gondii cathepsin CPC1 0.0054 0.0502 0.1307
Onchocerca volvulus 0.018 0.1969 0.614
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.006 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0227 0.0227
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0303 0.0718
Toxoplasma gondii cathepsin CPC2 0.0054 0.0502 0.1307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Brugia malayi PXA domain containing protein 0.002 0.0111 0.0111
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0681 0.1837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Brugia malayi cathepsin F-like cysteine proteinase 0.0054 0.0502 0.0502
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.3975 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0414 0.0414
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0111 0.0111
Leishmania major trypanothione reductase 0.0046 0.0407 0.1026
Echinococcus granulosus cathepsin L cysteine proteinase 0.018 0.1969 0.1969
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.2549 0.2504
Echinococcus granulosus GPCR family 2 0.0033 0.0262 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1087 0.3374
Echinococcus multilocularis dnaJ subfamily B 0.043 0.4876 0.4876
Mycobacterium ulcerans lipase LipD 0.0043 0.0381 0.1766
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0381 0.0381
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0395 0.0337
Onchocerca volvulus 0.0024 0.0153 0.0477
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0111 0.0111
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0153 0.0153
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.004 0.0345 0.0345
Giardia lamblia Cathepsin L-like protease 0.0054 0.0502 0.1129
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Echinococcus granulosus cathepsin l cysteine peptidase 0.018 0.1969 0.1969
Trypanosoma cruzi cysteine peptidase, putative 0.0105 0.1097 0.1043
Schistosoma mansoni loxhd1 0.0024 0.0153 0.0153
Onchocerca volvulus 0.018 0.1969 0.614
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3975 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0054 0.0502 0.2315
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0111 0.0111
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0024 0.0153 0.0153
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0681 0.0681
Brugia malayi beta-lactamase 0.0043 0.0381 0.0381
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0153 0.0153
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0395 0.0991
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0502 0.0502
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0502 0.1129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.1097 0.3067
Plasmodium falciparum serine repeat antigen 8 0.0054 0.0502 0.2315
Mycobacterium tuberculosis Conserved protein 0.0043 0.0381 0.1056
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.0345 0.0345
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1087 0.3374
Brugia malayi GH02984p 0.0366 0.4125 0.4125
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0111 0.0111
Toxoplasma gondii ABC1 family protein 0.0043 0.0381 0.095
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0395 0.0855
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.018 0.1969 0.1969
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0111 0.0111
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0381 0.1766
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Echinococcus granulosus RUN 0.0024 0.0153 0.0153
Leishmania major cathepsin L-like protease 0.018 0.1969 0.5647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0054 0.0502 0.1129
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0381 0.1683
Onchocerca volvulus Cathepsin L homolog 0.018 0.1969 0.614
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0111 0.0129
Onchocerca volvulus Cathepsin L homolog 0.018 0.1969 0.614
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0728 0.2195
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.006 0.006
Loa Loa (eye worm) ctsf protein 0.018 0.1969 0.1969
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0381 0.082
Plasmodium vivax unspecified product 0.0105 0.1097 0.5431
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0381 0.082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Brugia malayi Papain family cysteine protease containing protein 0.0105 0.1097 0.1097
Echinococcus multilocularis expressed protein 0.0393 0.4439 0.4439
Entamoeba histolytica cysteine proteinase, putative 0.018 0.1969 0.4808
Trypanosoma cruzi cysteine proteinase, putative 0.0105 0.1097 0.1043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.4125 0.4125
Schistosoma mansoni inositol transporter 0.004 0.0345 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Entamoeba histolytica cysteine proteinase 1, putative 0.0105 0.1097 0.2551
Echinococcus multilocularis cpg binding protein 0.0032 0.0247 0.0247
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Schistosoma mansoni hypothetical protein 0.043 0.4876 0.4876
Echinococcus granulosus cysteine protease 0.0105 0.1097 0.1097
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0502 0.0502
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0395 0.0395
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.006 0.5
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0395 0.0395
Brugia malayi hypothetical protein 0.0024 0.0153 0.0153
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.1097 0.2551
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0054 0.0502 0.1129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Giardia lamblia Encystation-specific protease 0.0054 0.0502 0.1129
Schistosoma mansoni cathepsin F (C01 family) 0.018 0.1969 0.1969
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.018 0.1969 0.4874
Loa Loa (eye worm) fibroinase 0.018 0.1969 0.1969
Schistosoma mansoni axis inhibition protein axin 0.002 0.0111 0.0111
Loa Loa (eye worm) beta-lactamase 0.0043 0.0381 0.0381
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0709 0.0709
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0111 0.0111
Loa Loa (eye worm) papain family cysteine protease containing protein 0.018 0.1969 0.1969
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0395 0.0395
Loa Loa (eye worm) glutathione reductase 0.0046 0.0407 0.0407
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1879 0.5978
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0381 0.1056
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0111 0.0111
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Onchocerca volvulus 0.0287 0.3206 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0303 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0111 0.0111
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Giardia lamblia Cathepsin B precursor 0.0307 0.344 0.8632
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0395 0.0395
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0262 0.0262
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.028 0.028
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0054 0.0502 0.1129
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0681 0.0681
Schistosoma mansoni cathepsin B (C01 family) 0.0054 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0111 0.0111
Onchocerca volvulus 0.0043 0.0381 0.119
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1087 0.3374
Plasmodium falciparum cysteine proteinase falcipain 2b 0.018 0.1969 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0853 0.9788 0.9788
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0054 0.0502 0.0502
Echinococcus granulosus axis inhibition protein axin 0.002 0.0111 0.0111
Giardia lamblia Cysteine protease 0.0054 0.0502 0.1129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Giardia lamblia Cathepsin L-like protease 0.0054 0.0502 0.1129
Brugia malayi Cathepsin L-like precursor 0.0129 0.1374 0.1374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Loa Loa (eye worm) hypothetical protein 0.0105 0.1095 0.1095
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0054 0.0502 0.2315
Plasmodium falciparum serine repeat antigen 4 0.0054 0.0502 0.2315
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Brugia malayi Pre-SET motif family protein 0.0037 0.0303 0.0303
Leishmania major hypothetical protein, conserved 0.0043 0.0381 0.095
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0307 0.344 0.8632
Echinococcus multilocularis cathepsin L cysteine protease 0.018 0.1969 0.1969
Leishmania major cathepsin L-like protease 0.018 0.1969 0.5647
Giardia lamblia Cathepsin B precursor 0.0054 0.0502 0.1129
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0381 0.1056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Brugia malayi beta-lactamase family protein 0.0043 0.0381 0.0381
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0728 0.3672
Loa Loa (eye worm) hypothetical protein 0.0159 0.1723 0.1723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.0345 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Toxoplasma gondii thioredoxin reductase 0.0046 0.0407 0.1026
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0262 0.0262
Giardia lamblia Hypothetical protein 0.0054 0.0502 0.1129
Entamoeba histolytica cysteine proteinase 2 0.0105 0.1097 0.2551
Onchocerca volvulus 0.0129 0.1374 0.4286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Mycobacterium tuberculosis Probable reductase 0.0104 0.1087 0.3374
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0381 0.0381
Schistosoma mansoni high-affinity choline transporter 0.0366 0.4125 0.4125
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Brugia malayi hypothetical protein 0.0024 0.0153 0.0153
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1097 0.2647
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0111 0.0111
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0728 0.3672
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0111 0.0111
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0395 0.0991
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1222 0.5611
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0111 0.0111
Echinococcus granulosus cathepsin L 0.0054 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.0345 0.0843
Trypanosoma cruzi major cysteine proteinase, putative 0.0104 0.1082 0.1028
Leishmania major cathepsin L-like protease 0.018 0.1969 0.5647
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Giardia lamblia Cathepsin B precursor 0.0054 0.0502 0.1129
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0111 0.0111
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0728 0.3672
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0307 0.344 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0054 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Mycobacterium tuberculosis Conserved protein 0.0043 0.0381 0.1056
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.02
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0502 0.0502
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0381 0.1056
Echinococcus multilocularis cathepsin L cysteine protease 0.018 0.1969 0.1969
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.006 0.006
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0502 0.0502
Brugia malayi Cathepsin L-like precursor 0.0051 0.0471 0.0471
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0627 0.0627
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0036 0.0036
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Brugia malayi Papain family cysteine protease containing protein 0.018 0.1969 0.1969
Trypanosoma cruzi cruzipain precursor, putative 0.023 0.2549 0.2504
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0407 0.0349
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Plasmodium vivax vivapain-2 0.018 0.1969 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Echinococcus multilocularis cathepsin L 0.0105 0.1097 0.1097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Loa Loa (eye worm) hypothetical protein 0.0129 0.1374 0.1374
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0381 0.0381
Schistosoma mansoni hypothetical protein 0.0072 0.0709 0.0709
Schistosoma mansoni intermediate filament proteins 0.0028 0.0206 0.0206
Schistosoma mansoni cpg binding protein 0.0032 0.0247 0.0247
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.003
Brugia malayi intermediate filament protein 0.0028 0.0206 0.0206
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0502 0.0502
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Plasmodium falciparum glutathione reductase 0.0046 0.0407 0.1817
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0111 0.0111
Giardia lamblia Cathepsin B precursor 0.0307 0.344 0.8632
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Brugia malayi Papain family cysteine protease containing protein 0.0105 0.1097 0.1097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1097 0.2647
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.0345 0.0345
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0502 0.0502
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0728 0.0728
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0111 0.0111
Brugia malayi Doublecortin family protein 0.0024 0.0153 0.0153
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0471 0.0413
Brugia malayi Cathepsin L-like cysteine proteinase 0.0129 0.1374 0.1374
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0111 0.0111
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0054 0.0502 0.2315
Onchocerca volvulus 0.018 0.1969 0.614
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0381 0.0323
Plasmodium vivax vivapain-3 0.0105 0.1097 0.5431
Trypanosoma brucei cysteine peptidase C (CPC) 0.0307 0.344 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0054 0.0502 0.1129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0471 0.0471
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.006 0.006
Onchocerca volvulus 0.0054 0.0502 0.1566
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0024 0.0153 0.0153
Giardia lamblia Cysteine protease 0.0054 0.0502 0.1129
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Onchocerca volvulus Cathepsin F homolog 0.018 0.1969 0.614
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0262 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0728 0.0728
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0395 0.0395
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Onchocerca volvulus 0.0028 0.0206 0.0643
Plasmodium falciparum cysteine proteinase falcipain 1 0.0105 0.1097 0.5431
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0012 0.0012
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0105 0.1097 0.1043
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.2549 0.2504
Echinococcus granulosus expressed protein 0.0393 0.4439 0.4439
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.006 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0381 0.082
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1879 1
Onchocerca volvulus 0.0159 0.1723 0.5375
Schistosoma mansoni lipoxygenase 0.0067 0.0651 0.0651
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0407 0.114
Loa Loa (eye worm) hypothetical protein 0.0051 0.0471 0.0471
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0054 0.0502 0.2315
Loa Loa (eye worm) RGS-3 protein 0.002 0.0111 0.0111
Brugia malayi cathepsin Z-like cysteine proteinase 0.0054 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0054 0.0502 0.1129
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0636 0.0636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Toxoplasma gondii preprocathepsin c precursor, putative 0.0054 0.0502 0.1307
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0651 0.0651
Leishmania major cathepsin L-like protease 0.018 0.1969 0.5647
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Onchocerca volvulus 0.0043 0.0381 0.119
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0681 0.204
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Schistosoma mansoni lipoxygenase 0.0024 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0502 0.1129
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Brugia malayi PXA domain containing protein 0.002 0.0111 0.0111
Echinococcus granulosus cathepsin L 0.0105 0.1097 0.1097
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0054 0.0502 0.2315
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0502 0.0444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1087 0.3374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.1374 0.3356
Echinococcus multilocularis GPCR, family 2 0.0033 0.0262 0.0262
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0111 0.0111
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1095 0.1095
Mycobacterium tuberculosis Conserved protein 0.0043 0.0381 0.1056
Brugia malayi hypothetical protein 0.002 0.0111 0.0111
Entamoeba histolytica cysteine protease, putative 0.018 0.1969 0.4808
Loa Loa (eye worm) hypothetical protein 0.0072 0.0709 0.0709
Brugia malayi glutathione reductase 0.0046 0.0407 0.0407
Onchocerca volvulus 0.0037 0.0303 0.0944
Giardia lamblia Cysteine protease 0.0054 0.0502 0.1129
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Brugia malayi fibroinase precursor 0.0054 0.0502 0.0502
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2803 0.2803
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0303 0.0303
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1879 1
Trichomonas vaginalis esterase, putative 0.0043 0.0381 0.082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Echinococcus multilocularis cysteine protease 0.018 0.1969 0.1969
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0111 0.0111
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0111 0.0111
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0054 0.0502 0.2315
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.0345 0.0345
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0262 0.0262
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0728 0.1976
Schistosoma mansoni cathepsin S (C01 family) 0.0054 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1222 0.3818
Onchocerca volvulus 0.003 0.0227 0.071
Loa Loa (eye worm) cathepsin B 0.0307 0.344 0.344
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0651 0.0651
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0395 0.0855
Plasmodium falciparum serine repeat antigen 3 0.0054 0.0502 0.2315
Brugia malayi Cathepsin L-like precursor 0.0129 0.1374 0.1374
Brugia malayi beta-lactamase family protein 0.0043 0.0381 0.0381
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0054 0.0502 0.0502
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0303 0.0303
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0054 0.0502 0.2315
Schistosoma mansoni lamin 0.0028 0.0206 0.0206
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0054 0.0502 0.2315
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1222 0.3818
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1222 0.3818
Echinococcus granulosus high affinity choline transporter 1 0.0366 0.4125 0.4125
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0153 0.0486
Plasmodium falciparum serine repeat antigen 7 0.0054 0.0502 0.2315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Leishmania major cathepsin L-like protease 0.023 0.2549 0.7364
Giardia lamblia Cathepsin B precursor 0.0054 0.0502 0.1129
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0681 0.0681
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0502 0.1129
Plasmodium vivax unspecified product 0.0051 0.0471 0.2152
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.2549 0.2504
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0681 0.3413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.018 0.1969 0.4874
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0381 0.095
Entamoeba histolytica cysteine proteinase, putative 0.018 0.1969 0.4808
Plasmodium vivax SET domain protein, putative 0.0037 0.0303 0.1271
Echinococcus granulosus lamin 0.0028 0.0206 0.0206
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0153 0.0153
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0381 0.082
Loa Loa (eye worm) hypothetical protein 0.0051 0.0471 0.0471
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0111 0.0111
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0381 0.1766
Entamoeba histolytica hypothetical protein 0.0054 0.0502 0.1013
Onchocerca volvulus 0.018 0.1969 0.614
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0054 0.0502 0.0502
Brugia malayi hypothetical protein 0.0159 0.1723 0.1723
Trypanosoma brucei trypanothione reductase 0.0046 0.0407 0.1026
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0502 0.1129
Loa Loa (eye worm) hypothetical protein 0.0129 0.1374 0.1374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0502 0.1129
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0381 0.082
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.006 0.5
Echinococcus multilocularis solute carrier family 5 0.004 0.0345 0.0345
Schistosoma mansoni cathepsin C 0.0054 0.0502 0.0502
Onchocerca volvulus 0.018 0.1969 0.614
Toxoplasma gondii cathepsin CPL 0.018 0.1969 0.5647
Trypanosoma cruzi cysteine proteinase, putative 0.0105 0.1097 0.1043
Schistosoma mansoni cathepsin F (C01 family) 0.0129 0.1374 0.1374
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0681 0.3413
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0054 0.0502 0.2315
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0395 0.0395
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0111 0.0111
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0054 0.0502 0.2315
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0111 0.0111
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0036 0.0036
Giardia lamblia Cathepsin B precursor 0.0307 0.344 0.8632
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1095 0.1095
Loa Loa (eye worm) hypothetical protein 0.0045 0.0395 0.0395
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0381 0.1056
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0681 0.0681
Plasmodium falciparum cysteine proteinase falcipain 3 0.018 0.1969 1
Brugia malayi Thioredoxin reductase 0.0046 0.0407 0.0407
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.018 0.1969 0.1969
Echinococcus granulosus cathepsin L cysteine protease 0.0105 0.1097 0.1097
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.0345 0.0345
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.1097 0.3067
Echinococcus multilocularis cysteine protease 0.018 0.1969 0.1969
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0111 0.0111
Plasmodium falciparum cysteine proteinase falcipain 2a 0.018 0.1969 1
Giardia lamblia Cysteine protease 0.0054 0.0502 0.1129
Toxoplasma gondii cathepsin B 0.0307 0.344 1
Plasmodium falciparum serine repeat antigen 5 0.0054 0.0502 0.2315
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0054 0.0502 0.2315
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0054 0.0502 0.1129
Plasmodium vivax vivapain-2 0.018 0.1969 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0054 0.0502 0.0502
Giardia lamblia Hypothetical protein 0.0054 0.0502 0.1129
Onchocerca volvulus 0.018 0.1969 0.614
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0307 0.344 0.34
Echinococcus multilocularis cathepsin l cysteine peptidase 0.018 0.1969 0.1969
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3102 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Echinococcus multilocularis cathepsin L 0.0054 0.0502 0.0502
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0153 0.0153
Echinococcus multilocularis lamin dm0 0.0028 0.0206 0.0206
Giardia lamblia Cathepsin B precursor 0.0054 0.0502 0.1129
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.1097 0.1097
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0206
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0381 0.1056
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0381 0.0381
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1095 0.1095
Onchocerca volvulus 0.004 0.0345 0.1076
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0206 0.0206
Plasmodium vivax serine-repeat antigen (SERA) 0.0054 0.0502 0.2315
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0407 0.1817
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0111 0.0111
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0502 0.0502
Schistosoma mansoni sodium/solute symporter 0.004 0.0345 0.0345
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0262 0.0262
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0179 0.1954 0.1906
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.0345 0.0345
Echinococcus multilocularis cathepsin l cysteine peptidase 0.018 0.1969 0.1969
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0054 0.0502 0.1129
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0728 0.1976
Trypanosoma cruzi cysteine protease, putative 0.0105 0.1097 0.1043
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3975 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0012 0.0012
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.0345 0.0345
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0395 0.0337
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0381 0.0381
Schistosoma mansoni axis inhibition protein axin 0.002 0.0111 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0303 0.0303
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0111 0.0111
Leishmania major cathepsin L-like protease 0.018 0.1969 0.5647
Echinococcus granulosus cpg binding protein 0.0032 0.0247 0.0247
Schistosoma mansoni rab6-interacting 0.0024 0.0153 0.0153
Echinococcus granulosus lamin dm0 0.0028 0.0206 0.0206
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0153 0.0153
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0395 0.0855
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0053 0.0053
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0111 0.0111
Plasmodium vivax glutathione reductase, putative 0.0046 0.0407 0.1817
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0054 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0129 0.1374 0.1374
Plasmodium vivax unspecified product 0.0054 0.0502 0.2315
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0395 0.0736
Onchocerca volvulus 0.0024 0.0153 0.0477
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0262 0.0262
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.3975 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0303 0.0303
Echinococcus multilocularis musashi 0.0028 0.0206 0.0206
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0033 0.0262 0.0262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Echinococcus multilocularis high affinity choline transporter 1 0.0366 0.4125 0.4125
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Echinococcus granulosus cathepsin l1 0.018 0.1969 0.1969
Schistosoma mansoni cpg binding protein 0.0032 0.0247 0.0247
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0395 0.0395
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0054 0.0502 0.1129
Plasmodium falciparum serine repeat antigen 6 0.0054 0.0502 0.2315
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0111 0.0111
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0051 0.0471 0.0471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Brugia malayi cathepsin Z-like cysteine proteinase 0.0054 0.0502 0.0502
Giardia lamblia Cathepsin B precursor 0.0054 0.0502 0.1129
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.1097 0.1097
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0153 0.0153
Schistosoma mansoni polycystin 1-related 0.0024 0.0153 0.0153
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Brugia malayi Sodium:solute symporter family protein 0.004 0.0345 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0502 0.1129
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0307 0.344 0.344
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0395 0.0395
Plasmodium falciparum thioredoxin reductase 0.0046 0.0407 0.1817
Loa Loa (eye worm) hypothetical protein 0.0024 0.0153 0.0153
Echinococcus granulosus dnaJ subfamily B 0.043 0.4876 0.4876
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0053 0.0053
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0111 0.0111
Echinococcus granulosus intermediate filament protein 0.0028 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0502 0.1129
Mycobacterium ulcerans beta-lactamase 0.0043 0.0381 0.1766
Onchocerca volvulus 0.018 0.1969 0.614
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0206 0.0206
Plasmodium vivax serine-repeat antigen (SERA) 0.0054 0.0502 0.2315
Onchocerca volvulus 0.0043 0.0381 0.119
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3206 0.8035
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0407 0.0407
Leishmania major cathepsin L-like protease 0.023 0.2549 0.7364
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0502 0.1566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.1374 0.3356
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.1097 0.2551
Echinococcus granulosus solute carrier family 5 0.004 0.0345 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0502 0.1129
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0303 0.0303
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0395 0.0395
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Brugia malayi CXXC zinc finger family protein 0.003 0.0227 0.0227
Brugia malayi cathepsin L-like precursor 0.0129 0.1374 0.1374
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.1097 0.2551

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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