Detailed information for compound 1396987

Basic information

Technical information
  • TDR Targets ID: 1396987
  • Name: 4-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-5-phen ylsulfonyl-2-pyridin-4-ylpyrimidine
  • MW: 470.566 | Formula: C25H18N4O2S2
  • H donors: 0 H acceptors: 6 LogP: 4.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(sc1c1nc(ncc1S(=O)(=O)c1ccccc1)c1ccncc1)c1ccccc1
  • InChi: 1S/C25H18N4O2S2/c1-17-23(32-25(28-17)19-8-4-2-5-9-19)22-21(33(30,31)20-10-6-3-7-11-20)16-27-24(29-22)18-12-14-26-15-13-18/h2-16H,1H3
  • InChiKey: SBWTZVRCUMHJBO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-methyl-2-phenyl-thiazol-5-yl)-5-phenylsulfonyl-2-(4-pyridyl)pyrimidine
  • 4-(4-methyl-2-phenyl-5-thiazolyl)-5-phenylsulfonyl-2-(4-pyridyl)pyrimidine
  • 4-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-5-phenylsulfonyl-2-pyridin-4-yl-pyrimidine
  • MLS000541518
  • ZINC01390140
  • 4-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-5-(phenylsulfonyl)-2-(4-pyridinyl)pyrimidine
  • 4R-1036
  • SMR000126376

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutaminase 0.033 0.1798 0.2654
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.1203 0.5218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0153 0.0724 0.5
Plasmodium falciparum serine repeat antigen 3 0.007 0.0225 0.1774
Echinococcus multilocularis cathepsin L cysteine protease 0.0232 0.1203 0.1203
Plasmodium vivax serine-repeat antigen (SERA) 0.007 0.0225 0.1774
Plasmodium vivax vivapain-2 0.0232 0.1203 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0066 0.0198 0.0292
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0264 0.039
Loa Loa (eye worm) hypothetical protein 0.006 0.0167 0.0246
Trypanosoma cruzi cysteine peptidase, putative 0.0279 0.1488 0.1962
Entamoeba histolytica cysteine proteinase 2 0.0136 0.0622 0.3427
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0232 0.1203 0.1776
Plasmodium vivax unspecified product 0.0136 0.0622 0.5109
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.007 0.0225 0.0755
Plasmodium falciparum serine repeat antigen 5 0.007 0.0225 0.1774
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0232 0.1203 0.1776
Loa Loa (eye worm) hypothetical protein 0.007 0.0225 0.0333
Echinococcus granulosus expressed conserved protein 0.0094 0.0367 0.0542
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.007 0.0225 0.0333
Loa Loa (eye worm) hypothetical protein 0.0166 0.0807 0.1191
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.006 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.1203 0.5218
Plasmodium falciparum serine repeat antigen 4 0.007 0.0225 0.1774
Leishmania major cathepsin L-like protease 0.0279 0.1488 0.2721
Brugia malayi Cathepsin L-like precursor 0.0066 0.0198 0.0292
Echinococcus multilocularis neuropeptide receptor A26 0.0561 0.3193 0.3193
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0153 0.0724 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.0622 0.0918
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0225 0.0755
Echinococcus multilocularis protein dispatched 1 0.0049 0.0096 0.0096
Echinococcus multilocularis cathepsin b 0.1153 0.6773 0.6773
Echinococcus granulosus cathepsin l cysteine peptidase 0.0232 0.1203 0.1776
Giardia lamblia Cathepsin L precursor 0.007 0.0225 0.0943
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0405 0.225 0.3122
Entamoeba histolytica cysteine proteinase, putative 0.0232 0.1203 0.7001
Brugia malayi hypothetical protein 0.0314 0.1702 0.2513
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Entamoeba histolytica cysteine proteinase, putative 0.0232 0.1203 0.7001
Giardia lamblia Cathepsin L precursor 0.007 0.0225 0.0943
Trypanosoma cruzi cysteine proteinase, putative 0.0136 0.0622 0.0644
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.007 0.0225 0.1774
Leishmania major cathepsin L-like protease 0.0279 0.1488 0.2721
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0264 0.0264
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.007 0.0225 0.1774
Loa Loa (eye worm) cysteine protease 0.0232 0.1203 0.1776
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.1691 0.7445
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.007 0.0225 0.1774
Echinococcus granulosus peregrin 0.0035 0.0014 0.0021
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.007 0.0225 0.1774
Brugia malayi hypothetical protein 0.0043 0.0064 0.0095
Schistosoma mansoni cathepsin S (C01 family) 0.007 0.0225 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.007 0.0225 0.0755
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0225 0.0755
Loa Loa (eye worm) hypothetical protein 0.007 0.0225 0.0333
Schistosoma mansoni cathepsin B (C01 family) 0.007 0.0225 0.0333
Entamoeba histolytica cysteine protease, putative 0.007 0.0225 0.099
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0232 0.1203 0.1776
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.007 0.0225 0.1774
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.023 0.034
Loa Loa (eye worm) hypothetical protein 0.0314 0.1702 0.2513
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0405 0.225 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0225 0.0755
Onchocerca volvulus 0.0232 0.1203 0.7043
Brugia malayi cathepsin B-like cysteine proteinase 0.1153 0.6773 1
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0403 0.0596
Schistosoma mansoni hypothetical protein 0.0041 0.0051 0.0075
Mycobacterium ulcerans glutaminase 0.033 0.1798 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.007 0.0225 0.0333
Trypanosoma cruzi cysteine peptidase, putative 0.0279 0.1488 0.1962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0429 0.0633
Loa Loa (eye worm) hypothetical protein 0.007 0.0225 0.0333
Brugia malayi cathepsin L precursor 0.007 0.0225 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.0807 0.3409
Plasmodium falciparum serine repeat antigen 6 0.007 0.0225 0.1774
Echinococcus granulosus cathepsin b 0.1153 0.6773 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0696 0.1028
Giardia lamblia Cathepsin B precursor 0.007 0.0225 0.0943
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0225 0.0755
Loa Loa (eye worm) papain family cysteine protease containing protein 0.007 0.0225 0.0333
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.007 0.0225 0.0333
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.007 0.0225 0.1774
Entamoeba histolytica cysteine protease, putative 0.007 0.0225 0.099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.1691 0.7445
Loa Loa (eye worm) hypothetical protein 0.0166 0.0807 0.1191
Onchocerca volvulus 0.0232 0.1203 0.7043
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0499 0.0499
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.1691 1
Brugia malayi Cathepsin L-like precursor 0.0232 0.1203 0.1776
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.007 0.0225 0.0333
Brugia malayi jmjC domain containing protein 0.0043 0.0059 0.0088
Loa Loa (eye worm) hypothetical protein 0.007 0.0225 0.0333
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0241 0.0356
Entamoeba histolytica cysteine protease, putative 0.007 0.0225 0.099
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0225 0.0755
Brugia malayi Papain family cysteine protease containing protein 0.007 0.0225 0.0333
Schistosoma mansoni cathepsin s 0.0066 0.0198 0.0292
Plasmodium vivax vivapain-2 0.0232 0.1203 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0264 0.039
Schistosoma mansoni hypothetical protein 0.0043 0.0064 0.0095
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0232 0.1203 0.1203
Echinococcus granulosus neuropeptide s receptor 0.0561 0.3193 0.4714
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0225 0.0755
Echinococcus multilocularis protein patched 0.0043 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0181 0.0897 0.1324
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Giardia lamblia Hypothetical protein 0.007 0.0225 0.0943
Treponema pallidum fructose-bisphosphate aldolase 0.0312 0.1691 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Giardia lamblia Dipeptidyl-peptidase I precursor 0.007 0.0225 0.0943
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0264 0.039
Echinococcus granulosus Protein patched homolog 1 0.0043 0.006 0.0088
Echinococcus granulosus cathepsin L 0.007 0.0225 0.0333
Loa Loa (eye worm) hypothetical protein 0.0035 0.0014 0.0021
Echinococcus granulosus cathepsin L 0.0136 0.0622 0.0918
Giardia lamblia Cathepsin L precursor 0.007 0.0225 0.0943
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0198 0.0292
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0136 0.0622 0.0644
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.007 0.0225 0.1774
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0088
Giardia lamblia Cysteine protease 0.007 0.0225 0.0943
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0213 0.1092 0.1359
Echinococcus granulosus cathepsin l1 0.0232 0.1203 0.1776
Trypanosoma brucei cysteine peptidase C (CPC) 0.0405 0.225 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0136 0.0622 0.3427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Giardia lamblia Cathepsin L precursor 0.007 0.0225 0.0943
Entamoeba histolytica cysteine protease, putative 0.0232 0.1203 0.7001
Brugia malayi Papain family cysteine protease containing protein 0.007 0.0225 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Leishmania major cathepsin L-like protease 0.0279 0.1488 0.2721
Brugia malayi cathepsin F-like cysteine proteinase 0.0066 0.0198 0.0292
Onchocerca volvulus Cathepsin L homolog 0.0232 0.1203 0.7043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Onchocerca volvulus 0.0314 0.1702 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0198 0.0292
Giardia lamblia Cathepsin L precursor 0.007 0.0225 0.0943
Giardia lamblia Encystation-specific protease 0.007 0.0225 0.0943
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0225 0.0755
Onchocerca volvulus Cathepsin L homolog 0.007 0.0225 0.125
Plasmodium vivax serine-repeat antigen (SERA) 0.007 0.0225 0.1774
Loa Loa (eye worm) RNA binding protein 0.0076 0.0264 0.039
Toxoplasma gondii cathepsin CPC1 0.007 0.0225 0.0943
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0403 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.007 0.0225 0.1774
Brugia malayi glutaminase DH11.1 0.033 0.1798 0.2654
Schistosoma mansoni hypothetical protein 0.0041 0.0051 0.0075
Entamoeba histolytica cysteine protease, putative 0.007 0.0225 0.099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.1691 0.7445
Onchocerca volvulus 0.0166 0.0807 0.4694
Echinococcus granulosus cysteine protease 0.0136 0.0622 0.0918
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0531 0.0785
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.007 0.0225 0.0333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.1203 0.5218
Echinococcus multilocularis cathepsin L cysteine protease 0.0232 0.1203 0.1203
Brugia malayi Cathepsin L-like precursor 0.0166 0.0807 0.1191
Echinococcus multilocularis cathepsin L 0.007 0.0225 0.0225
Trypanosoma cruzi cysteine peptidase, putative 0.0279 0.1488 0.1962
Plasmodium falciparum cysteine proteinase falcipain 1 0.0136 0.0622 0.5109
Brugia malayi cathepsin L-like cysteine proteinase 0.007 0.0225 0.0333
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.0622 0.0918
Schistosoma mansoni hypothetical protein 0.0071 0.023 0.034
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.0622 0.0918
Toxoplasma gondii cathepsin B 0.0405 0.225 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.007 0.0225 0.1774
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.1203 0.5218
Plasmodium falciparum serine repeat antigen 9 0.007 0.0225 0.1774
Echinococcus granulosus cathepsin b 0.1153 0.6773 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0225 0.0333
Brugia malayi fibroinase precursor 0.007 0.0225 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Loa Loa (eye worm) hypothetical protein 0.0071 0.023 0.034
Giardia lamblia Cathepsin B precursor 0.007 0.0225 0.0943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Schistosoma mansoni cathepsin C 0.007 0.0225 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0264 0.039
Echinococcus multilocularis geminin 0.0181 0.0897 0.0897
Brugia malayi cahepsin L-like non-peptiedase homolog 0.007 0.0225 0.0333
Giardia lamblia Hypothetical protein 0.007 0.0225 0.0943
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0098 0.0098
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0264 0.039
Trypanosoma cruzi cysteine protease, putative 0.0136 0.0622 0.0644
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0232 0.1203 0.1203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.1691 0.7445
Entamoeba histolytica hypothetical protein 0.007 0.0225 0.099
Entamoeba histolytica cysteine protease, putative 0.007 0.0225 0.099
Giardia lamblia Cathepsin L precursor 0.007 0.0225 0.0943
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0405 0.225 1
Giardia lamblia Cathepsin B precursor 0.007 0.0225 0.0943
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.0622 0.0644
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0232 0.1203 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.007 0.0225 0.1774
Brugia malayi jmjC domain containing protein 0.0115 0.0499 0.0736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0225 0.0755
Loa Loa (eye worm) hypothetical protein 0.0166 0.0807 0.1191
Giardia lamblia Cathepsin B precursor 0.007 0.0225 0.0943
Brugia malayi Cathepsin L-like precursor 0.0232 0.1203 0.1776
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0232 0.1203 0.5218
Giardia lamblia Dipeptidyl-peptidase I precursor 0.007 0.0225 0.0943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.1691 0.7445
Trypanosoma cruzi cysteine peptidase, putative 0.0232 0.1203 0.1528
Loa Loa (eye worm) fibroinase 0.0232 0.1203 0.1776
Toxoplasma gondii preprocathepsin c precursor, putative 0.007 0.0225 0.0943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Giardia lamblia Cathepsin B precursor 0.0405 0.225 1
Plasmodium vivax unspecified product 0.0066 0.0198 0.1544
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.0807 0.3409
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.0622 0.3427
Loa Loa (eye worm) hypothetical protein 0.007 0.0225 0.0333
Entamoeba histolytica papain family cysteine protease domain containing protein 0.007 0.0225 0.099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0059 0.0088
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.007 0.0225 0.1774
Brugia malayi cathepsin Z-like cysteine proteinase 0.007 0.0225 0.0333
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.007 0.0225 0.0943
Brugia malayi CHE-14 protein 0.0043 0.006 0.0088
Plasmodium falciparum serine repeat antigen 1 0.007 0.0225 0.1774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.0622 0.2565
Brugia malayi TAR-binding protein 0.0076 0.0264 0.039
Loa Loa (eye worm) hypothetical protein 0.0148 0.0696 0.1028
Trypanosoma cruzi cysteine proteinase, putative 0.0136 0.0622 0.0644
Echinococcus granulosus cathepsin L cysteine proteinase 0.0232 0.1203 0.1776
Brugia malayi hypothetical protein 0.0148 0.0696 0.1028
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1153 0.6773 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0064 0.0095
Giardia lamblia Cysteine protease 0.007 0.0225 0.0943
Toxoplasma gondii cathepsin CPL 0.0232 0.1203 0.5315
Brugia malayi PHD-finger family protein 0.0035 0.0014 0.0021
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0225 0.0333
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.1691 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.007 0.0225 0.099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.1203 0.5218
Giardia lamblia Dipeptidyl-peptidase I precursor 0.007 0.0225 0.0943
Entamoeba histolytica cysteine proteinase, putative 0.0166 0.0807 0.4564
Giardia lamblia Cathepsin L-like protease 0.007 0.0225 0.0943
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0021
Giardia lamblia Fructose-bisphosphate aldolase 0.0312 0.1691 0.7497
Plasmodium vivax vivapain-3 0.0136 0.0622 0.5109
Schistosoma mansoni cathepsin F (C01 family) 0.0166 0.0807 0.1191
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1153 0.6773 1
Brugia malayi Cathepsin L-like precursor 0.0232 0.1203 0.1776
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Plasmodium vivax vivapain-1 0.0136 0.0622 0.5109
Schistosoma mansoni cathepsin F (C01 family) 0.0232 0.1203 0.1776
Plasmodium falciparum serine repeat antigen 7 0.007 0.0225 0.1774
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0059 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Schistosoma mansoni hypothetical protein 0.0181 0.0897 0.1324
Giardia lamblia Cathepsin B precursor 0.0405 0.225 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Loa Loa (eye worm) hypothetical protein 0.007 0.0225 0.0333
Loa Loa (eye worm) hypothetical protein 0.0052 0.0118 0.0174
Echinococcus granulosus cathepsin l1 0.0166 0.0807 0.1191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.0622 0.0918
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0014 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.1691 0.7445
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0232 0.1203 1
Brugia malayi Cathepsin L-like precursor 0.0232 0.1203 0.1776
Schistosoma mansoni cathepsin F (C01 family) 0.0232 0.1203 0.1776
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Trichomonas vaginalis glutaminase, putative 0.033 0.1798 0.7933
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.007 0.0225 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0225 0.0755
Schistosoma mansoni glutaminase 0.033 0.1798 0.2654
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0264 0.039
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0014 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.007 0.0225 0.0755
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0356 0.0525
Echinococcus multilocularis cysteine protease 0.0232 0.1203 0.1203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0225 0.0755
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0232 0.1203 0.5218
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0059 0.0088
Plasmodium falciparum cysteine proteinase falcipain 3 0.0232 0.1203 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.1203 0.5218
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0403 0.0596
Echinococcus multilocularis expressed conserved protein 0.0094 0.0367 0.0367
Onchocerca volvulus 0.0232 0.1203 0.7043
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0225 0.0755
Echinococcus granulosus cathepsin L cysteine protease 0.0136 0.0622 0.0918
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.1691 0.7445
Echinococcus multilocularis cathepsin L 0.0136 0.0622 0.0622
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0499 0.0736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.0622 0.3427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1153 0.6773 1
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Brugia malayi cathepsin F-like cysteine proteinase 0.007 0.0225 0.0333
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.1691 0.7445
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0264 0.039
Loa Loa (eye worm) ctsf protein 0.0232 0.1203 0.1776
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0225 0.0333
Brugia malayi cathepsin Z-like cysteine proteinase 0.007 0.0225 0.0333
Giardia lamblia Cysteine protease 0.007 0.0225 0.0943
Echinococcus granulosus tar DNA binding protein 0.0076 0.0264 0.039
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0059 0.0059
Onchocerca volvulus 0.007 0.0225 0.125
Giardia lamblia Cathepsin B precursor 0.007 0.0225 0.0943
Loa Loa (eye worm) papain family cysteine protease containing protein 0.007 0.0225 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.0622 0.2565
Onchocerca volvulus Huntingtin homolog 0.0148 0.0696 0.4039
Plasmodium vivax unspecified product 0.007 0.0225 0.1774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0225 0.0755
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0531 0.0785
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0064 0.0095
Entamoeba histolytica cysteine protease, putative 0.007 0.0225 0.099
Onchocerca volvulus Huntingtin homolog 0.0148 0.0696 0.4039
Onchocerca volvulus 0.0232 0.1203 0.7043
Loa Loa (eye worm) glutaminase 2 0.033 0.1798 0.2654
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.0225 0.0042
Echinococcus multilocularis peregrin 0.0035 0.0014 0.0014
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.006 0.006
Giardia lamblia Cathepsin L-like protease 0.007 0.0225 0.0943
Schistosoma mansoni hypothetical protein 0.0041 0.0051 0.0075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0225 0.0333
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0225 0.0333
Brugia malayi Cathepsin L-like precursor 0.0166 0.0807 0.1191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0662 0.0977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0066 0.0198 0.0292
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.1203 0.5218
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.0622 0.3427
Brugia malayi Cathepsin L-like precursor 0.0232 0.1203 0.1776
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0662 0.0662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.1203 0.5218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0225 0.0755
Giardia lamblia Cathepsin B precursor 0.0405 0.225 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.0622 0.0918
Loa Loa (eye worm) hypothetical protein 0.0104 0.0429 0.0633
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.1203 0.5218
Schistosoma mansoni hypothetical protein 0.0041 0.0051 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0225 0.0755
Loa Loa (eye worm) hypothetical protein 0.01 0.0403 0.0596
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0264 0.039
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1153 0.6773 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.007 0.0225 0.1774
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0098 0.0144
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0403 0.2085
Trypanosoma cruzi major cysteine proteinase, putative 0.0117 0.051 0.0475
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0429 0.0633
Brugia malayi Cathepsin L-like cysteine proteinase 0.0166 0.0807 0.1191
Schistosoma mansoni patched 1 0.0043 0.006 0.0088
Loa Loa (eye worm) cathepsin B 0.0405 0.225 0.3323
Loa Loa (eye worm) hypothetical protein 0.0066 0.0198 0.0292
Brugia malayi MH2 domain containing protein 0.0121 0.0531 0.0785
Echinococcus granulosus neuropeptide receptor A26 0.0561 0.3193 0.4714
Brugia malayi Papain family cysteine protease containing protein 0.007 0.0225 0.0333
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0405 0.225 0.3323
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.0622 0.3427
Loa Loa (eye worm) hypothetical protein 0.1153 0.6773 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Onchocerca volvulus 0.0232 0.1203 0.7043
Giardia lamblia Cysteine protease 0.007 0.0225 0.0943
Onchocerca volvulus 0.0232 0.1203 0.7043
Echinococcus granulosus geminin 0.0181 0.0897 0.1324
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0429 0.0633
Brugia malayi RNA binding protein 0.0076 0.0264 0.039
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0413 0.0609
Brugia malayi cathepsin L-like precursor 0.0166 0.0807 0.1191
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0059 0.0088
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Onchocerca volvulus Cathepsin L homolog 0.0232 0.1203 0.7043
Onchocerca volvulus Cathepsin F homolog 0.0232 0.1203 0.7043
Echinococcus multilocularis cathepsin b 0.1153 0.6773 0.6773
Onchocerca volvulus 0.0232 0.1203 0.7043
Entamoeba histolytica cysteine protease, putative 0.0136 0.0622 0.3427
Brugia malayi Cathepsin L-like precursor 0.0232 0.1203 0.1776
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.006 0.0088
Brugia malayi Papain family cysteine protease containing protein 0.0232 0.1203 0.1776
Trypanosoma cruzi cruzipain precursor, putative 0.0279 0.1488 0.1962
Toxoplasma gondii cathepsin CPC2 0.007 0.0225 0.0943
Echinococcus multilocularis cysteine protease 0.0232 0.1203 0.1203
Brugia malayi Bromodomain containing protein 0.0035 0.0014 0.0021
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1153 0.6773 1
Echinococcus multilocularis neuropeptide s receptor 0.0561 0.3193 0.3193
Plasmodium falciparum serine repeat antigen 8 0.007 0.0225 0.1774
Plasmodium falciparum serine repeat antigen 2 0.007 0.0225 0.1774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.1203 0.5218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0225 0.0755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.1488 0.5319
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.007 0.0225 0.1774

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 141.2538 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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