Detailed information for compound 1396991

Basic information

Technical information
  • TDR Targets ID: 1396991
  • Name: ethyl 2-[2-(1,2-oxazol-5-yl)phenoxy]acetate
  • MW: 247.247 | Formula: C13H13NO4
  • H donors: 0 H acceptors: 2 LogP: 2.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)COc1ccccc1c1ccno1
  • InChi: 1S/C13H13NO4/c1-2-16-13(15)9-17-11-6-4-3-5-10(11)12-7-8-14-18-12/h3-8H,2,9H2,1H3
  • InChiKey: KQKQDESNIIVFAK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-(2-isoxazol-5-ylphenoxy)acetate
  • 2-[2-(5-isoxazolyl)phenoxy]acetic acid ethyl ester
  • 2-(2-isoxazol-5-ylphenoxy)acetic acid ethyl ester
  • ethyl 2-[2-(1,2-oxazol-5-yl)phenoxy]ethanoate
  • Oprea1_303562
  • MLS000325005
  • SMR000164135
  • ethyl [2-(5-isoxazolyl)phenoxy]acetate
  • AK-820/12462007
  • ZINC00482018

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.0064 0.0064
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0141 0.1422 1
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.0615 0.4054
Onchocerca volvulus 0.0141 0.1422 1
Plasmodium vivax unspecified product 0.0083 0.0615 0.4322
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0871 0.2627
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.1422 0.4419
Plasmodium vivax serine-repeat antigen (SERA) 0.0044 0.0064 0.0451
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.1422 0.1422
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0141 0.1422 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.1422 0.4419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Giardia lamblia Cathepsin B precursor 0.0263 0.3137 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0263 0.3137 0.3137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0064 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Onchocerca volvulus Cathepsin L homolog 0.0141 0.1422 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0225 0.0162
Loa Loa (eye worm) hypothetical protein 0.0101 0.0871 0.0871
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.1422 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Trypanosoma cruzi cysteine protease, putative 0.0083 0.0615 0.0615
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.1422 0.4419
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0064 0.0064
Echinococcus granulosus cathepsin L cysteine protease 0.0083 0.0615 0.0554
Toxoplasma gondii cathepsin CPL 0.0141 0.1422 0.4419
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0141 0.1422 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Brugia malayi Cathepsin L-like precursor 0.0141 0.1422 0.1422
Toxoplasma gondii cathepsin B 0.0263 0.3137 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0044 0.0064 0.0064
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0044 0.0064 0.0451
Entamoeba histolytica cysteine protease, putative 0.0141 0.1422 1
Entamoeba histolytica cysteine proteinase, putative 0.0141 0.1422 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0225 0.0225
Loa Loa (eye worm) fibroinase 0.0141 0.1422 0.1422
Echinococcus granulosus cathepsin L 0.0083 0.0615 0.0554
Onchocerca volvulus 0.0141 0.1422 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0225 0.0162
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0225 0.0225
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0615 0.0615
Schistosoma mansoni cathepsin F (C01 family) 0.0141 0.1422 0.1422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Giardia lamblia Cathepsin B precursor 0.0263 0.3137 1
Onchocerca volvulus Cathepsin F homolog 0.0141 0.1422 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0044 0.0064 0.0064
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0044 0.0064 0.0064
Plasmodium vivax vivapain-1 0.0083 0.0615 0.4322
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0044 0.0064 0.0451
Onchocerca volvulus 0.0141 0.1422 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0141 0.1422 1
Brugia malayi cathepsin L-like precursor 0.0101 0.0871 0.0871
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.1422 0.1422
Onchocerca volvulus 0.0141 0.1422 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.1422 0.1422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0871 0.2627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0263 0.3137 0.3137
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0263 0.3137 1
Onchocerca volvulus 0.0141 0.1422 1
Trypanosoma cruzi cruzipain precursor, putative 0.0141 0.1422 0.1422
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Echinococcus multilocularis cysteine protease 0.0141 0.1422 0.1367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.1422 0.4419
Brugia malayi Cathepsin L-like cysteine proteinase 0.0101 0.0871 0.0871
Echinococcus granulosus cathepsin l1 0.0101 0.0871 0.0813
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0225 0.0162
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.1422 0.4419
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0064
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0044 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.1422 0.4419
Loa Loa (eye worm) hypothetical protein 0.0101 0.0871 0.0871
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0044 0.0064 0.0451
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Plasmodium vivax vivapain-2 0.0141 0.1422 1
Brugia malayi Cathepsin L-like precursor 0.0101 0.0871 0.0871
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.0615 0.4054
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0064
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Brugia malayi Cathepsin L-like precursor 0.0141 0.1422 0.1422
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0044 0.0064 0.0064
Loa Loa (eye worm) cysteine protease 0.0141 0.1422 0.1422
Brugia malayi Cathepsin L-like precursor 0.0101 0.0871 0.0871
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0615 0.0615
Brugia malayi Cathepsin L-like precursor 0.0141 0.1422 0.1422
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0044 0.0064 0.0451
Schistosoma mansoni cathepsin S (C01 family) 0.0044 0.0064 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0225 0.0162
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0064 0.0064
Schistosoma mansoni cathepsin B (C01 family) 0.0044 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0044 0.0064 0.0064
Echinococcus granulosus cathepsin L cysteine proteinase 0.0141 0.1422 0.1367
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.1422 0.4419
Onchocerca volvulus 0.0141 0.1422 1
Entamoeba histolytica cysteine proteinase, putative 0.0141 0.1422 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0044 0.0064 0.0064
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0101 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0064
Brugia malayi Cathepsin L-like precursor 0.0141 0.1422 0.1422
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0044 0.0064 0.0451
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Loa Loa (eye worm) ctsf protein 0.0141 0.1422 0.1422
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0141 0.1422 0.4419
Plasmodium vivax unspecified product 0.0044 0.0064 0.0451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Trypanosoma brucei cysteine peptidase C (CPC) 0.0263 0.3137 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.0615 0.4054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0141 0.1422 0.1367
Brugia malayi cathepsin Z-like cysteine proteinase 0.0044 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0044 0.0064 0.0451
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0044 0.0064 0.0451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0064 0.0064
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.0064 0.0064
Plasmodium falciparum cysteine proteinase falcipain 3 0.0141 0.1422 1
Schistosoma mansoni cathepsin F (C01 family) 0.0101 0.0871 0.0871
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.1422 0.4419
Brugia malayi Cathepsin L-like precursor 0.0141 0.1422 0.1422
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0044 0.0064 0.0064
Loa Loa (eye worm) cathepsin B 0.0263 0.3137 0.3137
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0083 0.0615 0.0615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0225 0.0225
Brugia malayi Papain family cysteine protease containing protein 0.0141 0.1422 0.1422
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0044 0.0064 0.0451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0064 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.0615 0.4054
Plasmodium vivax vivapain-2 0.0141 0.1422 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Giardia lamblia Cathepsin B precursor 0.0263 0.3137 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Echinococcus multilocularis cathepsin L cysteine protease 0.0141 0.1422 0.1367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0064 0.0064
Entamoeba histolytica cysteine proteinase 1, putative 0.0083 0.0615 0.4054
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0064
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.1422 0.1422
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0141 0.1422 0.1422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Plasmodium vivax vivapain-3 0.0083 0.0615 0.4322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0615 0.1791
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Echinococcus granulosus cathepsin l1 0.0141 0.1422 0.1367
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0615 0.0615
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0044 0.0064 0.0451
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0064 0.0064
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Echinococcus granulosus cysteine protease 0.0083 0.0615 0.0554
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0083 0.0615 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Brugia malayi Cathepsin L-like precursor 0.0141 0.1422 0.1422
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0141 0.1422 0.1422
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.1422 0.1422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1422 0.3201
Echinococcus granulosus cathepsin l cysteine peptidase 0.0141 0.1422 0.1367
Brugia malayi cathepsin Z-like cysteine proteinase 0.0044 0.0064 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0871 0.5946
Brugia malayi fibroinase precursor 0.0044 0.0064 0.0064
Echinococcus multilocularis cathepsin L 0.0083 0.0615 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419
Trypanosoma cruzi major cysteine proteinase, putative 0.0044 0.0064 0.0064
Trypanosoma cruzi cysteine proteinase, putative 0.0083 0.0615 0.0615
Entamoeba histolytica cysteine protease, putative 0.0083 0.0615 0.4054
Onchocerca volvulus 0.0141 0.1422 1
Onchocerca volvulus 0.0101 0.0871 0.5946
Brugia malayi cathepsin L precursor 0.0044 0.0064 0.0064
Plasmodium falciparum cysteine proteinase falcipain 1 0.0083 0.0615 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0083 0.0615 0.0615
Trypanosoma cruzi cysteine proteinase, putative 0.0083 0.0615 0.0615
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0263 0.3137 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0615 0.1791
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0044 0.0064 0.0451
Echinococcus multilocularis cathepsin L cysteine protease 0.0141 0.1422 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0141 0.1422 0.4419
Schistosoma mansoni cathepsin C 0.0044 0.0064 0.0064
Entamoeba histolytica cysteine proteinase 2 0.0083 0.0615 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0141 0.1422 0.1422
Echinococcus multilocularis cysteine protease 0.0141 0.1422 0.1367
Brugia malayi cathepsin F-like cysteine proteinase 0.0044 0.0064 0.0064
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0083 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0101 0.0871 0.0871
Plasmodium vivax serine-repeat antigen (SERA) 0.0044 0.0064 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1422 0.4419

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4467 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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