TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 291.278 | Formula: C14H14FN3O3
H donors: 2 H acceptors: 3 LogP: 2.15 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCc1noc(c1C(=O)NNC(=O)c1ccc(cc1)F)C
InChi: 1S/C14H14FN3O3/c1-3-11-12(8(2)21-18-11)14(20)17-16-13(19)9-4-6-10(15)7-5-9/h4-7H,3H2,1-2H3,(H,16,19)(H,17,20)
InChiKey: IAGPKLHWXCOLSG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	snurportin 1		No references
Homo sapiens	karyopherin (importin) beta 1		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0086	0.1501	0.1501
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0039	0.0103	0.0103
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0227	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0227	0.0227
Brugia malayi	Cytochrome P450 family protein	0.0054	0.0529	0.0678
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0103	0.0143
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0227	0.0227
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0039	0.0103	0.5
Trypanosoma brucei	cAMP response protein 1, putative	0.0039	0.0103	0.1953
Schistosoma mansoni	voltage-gated potassium channel	0.0086	0.1501	0.1501
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0103	0.1953
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0227	0.0315
Trypanosoma brucei	protein kinase A regulatory subunit	0.0039	0.0103	0.1953
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0227	0.0315
Schistosoma mansoni	voltage-gated potassium channel	0.0325	0.8612	0.8612
Brugia malayi	beta-lactamase	0.0043	0.0227	0.0291
Trypanosoma cruzi	cytochrome P450, putative	0.0054	0.0529	1
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0039	0.0103	0.1953
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0103	0.0103
Schistosoma mansoni	60S ribosomal protein L21	0.0047	0.033	0.033
Echinococcus multilocularis	voltage gated potassium channel	0.0086	0.1501	0.1501
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0278	0.7215	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0059	0.0687	0.0687
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0227	0.0227
Trypanosoma cruzi	Flagellar Member 6	0.0039	0.0103	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0227	0.0227
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.7203	1
Schistosoma mansoni	voltage-gated potassium channel	0.0059	0.0687	0.0687
Mycobacterium ulcerans	transmembrane transport protein	0.0039	0.0103	0.1953
Mycobacterium ulcerans	lipase LipD	0.0043	0.0227	0.4294
Mycobacterium ulcerans	transcriptional regulatory protein	0.0039	0.0103	0.1953
Brugia malayi	RNA, U transporter 1	0.0099	0.1881	0.2412
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0039	0.0103	0.1953
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0039	0.0103	0.0143
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0039	0.0103	0.0103
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0039	0.0103	0.4548
Loa Loa (eye worm)	cytochrome P450 family protein	0.0054	0.0529	0.0529
Loa Loa (eye worm)	CYP4Cod1	0.0054	0.0529	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0103	0.0103
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0103	0.0103
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0059	0.0687	0.0687
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0059	0.0687	0.0687
Brugia malayi	Egg laying defective protein 4	0.0039	0.0103	0.0132
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0039	0.0103	0.1953
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0039	0.0103	0.0103
Brugia malayi	beta-lactamase family protein	0.0043	0.0227	0.0291
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0278	0.7215	1
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0039	0.0103	0.0103
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0039	0.0103	0.4548
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0039	0.0103	0.0103
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0059	0.0687	0.0687
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0054	0.0529	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.6627	0.6627
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0298	0.7798	0.7798
Brugia malayi	Cytochrome P450 family protein	0.0054	0.0529	0.0678
Leishmania major	hypothetical protein, conserved	0.0043	0.0227	0.4294
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0227	0.4294
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0227	0.4294
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0227	0.0174
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0227	0.4294
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0059	0.0687	0.0687
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0227	0.0291
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0059	0.0687	0.0687
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0227	0.0315
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0039	0.0103	0.0103
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0227	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0227	0.0227
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0039	0.0103	0.0132
Trypanosoma cruzi	cytochrome P450, putative	0.0054	0.0529	1
Onchocerca volvulus		0.0043	0.0227	1
Echinococcus granulosus	cGMP dependent protein kinase	0.0039	0.0103	0.0103
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0059	0.0687	0.0687
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0039	0.0103	0.0103
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0039	0.0103	0.0143
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0227	0.0174
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0227	0.4294
Echinococcus granulosus	hyperpolarization activated cyclic	0.0059	0.0687	0.0687
Leishmania major	protein kinase, putative	0.0039	0.0103	0.1953
Schistosoma mansoni	hypothetical protein	0.0039	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0227	0.0227
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0227	1
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0039	0.0103	0.0103
Trypanosoma brucei	cAMP binding protein, putative	0.0039	0.0103	0.1953
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0039	0.0103	0.0103
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0227	0.0315
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0039	0.0103	0.0103
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0103	0.1953
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0227	0.0174
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0227	0.0315
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0039	0.0103	0.0103
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0039	0.0103	0.0103
Treponema pallidum	cyclic nucleotide binding protein	0.0039	0.0103	0.5
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0039	0.0103	0.0103
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0059	0.0687	0.0687
Brugia malayi	beta-lactamase family protein	0.0043	0.0227	0.0291
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0227	0.4294
Mycobacterium ulcerans	regulatory protein	0.0039	0.0103	0.1953
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0039	0.0103	0.0103
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0039	0.0103	0.4548
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1501	0.1501
Plasmodium falciparum	cGMP-dependent protein kinase	0.0039	0.0103	0.5
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0227	0.0315
Trichomonas vaginalis	esterase, putative	0.0043	0.0227	0.0174
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0298	0.7798	0.7798
Treponema pallidum	catabolite gene activator	0.0039	0.0103	0.5
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0039	0.0103	0.1953
Trypanosoma brucei	cytochrome P450, putative	0.0054	0.0529	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0054	0.0529	0.0529
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0039	0.0103	0.4548
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0059	0.0687	0.0687
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0039	0.0103	0.0132
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0059	0.0687	0.0687
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0039	0.0103	0.1953
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0039	0.0103	0.0103
Treponema pallidum	catabolite gene activator (Crp)	0.0039	0.0103	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0227	0.0174
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0059	0.0687	0.0687
Loa Loa (eye worm)	cytochrome P450 family protein	0.0113	0.2302	0.2302
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0227	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0227	0.0227
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.033	0.033
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0227	0.0227
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0039	0.0103	0.4548
Trypanosoma cruzi	cAMP response protein 1, putative	0.0039	0.0103	0.1953
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0039	0.0103	0.0103
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0227	0.4294
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0039	0.0103	0.0143
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0039	0.0103	0.0103
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0298	0.7798	1
Brugia malayi	N-terminal motif family protein	0.0039	0.0103	0.0132
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0059	0.0687	0.0687
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0039	0.0103	0.1953
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0039	0.0103	0.0103
Echinococcus granulosus	voltage gated potassium channel	0.0086	0.1501	0.1501
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0103	0.0103
Trypanosoma cruzi	cAMP response protein 1	0.0039	0.0103	0.1953
Onchocerca volvulus		0.0043	0.0227	1
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0039	0.0103	0.0103
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0227	0.0315
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0227	0.0227
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0227	0.4294
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0059	0.0687	0.088
Mycobacterium leprae	Conserved hypothetical protein	0.0039	0.0103	0.4548
Leishmania major	protein kinase, putative	0.0039	0.0103	0.1953
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0039	0.0103	0.0103
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0039	0.0103	0.0103
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0059	0.0687	0.0687
Schistosoma mansoni	voltage-gated potassium channel	0.0086	0.1501	0.1501
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0298	0.7798	0.7798
Brugia malayi	Cytochrome P450 family protein	0.0113	0.2302	0.2952
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0687	0.0687
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0039	0.0103	0.0103
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0059	0.0687	0.0687
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0039	0.0103	0.0132
Echinococcus multilocularis	expressed conserved protein	0.0039	0.0103	0.0103
Leishmania major	hypothetical protein, unknown function	0.0039	0.0103	0.1953
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0227	0.0174
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0039	0.0103	0.0103
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0039	0.0103	0.0143
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0039	0.0103	0.0103
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0227	0.0315
Onchocerca volvulus		0.0043	0.0227	1
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0227	0.0227
Trypanosoma brucei	Flagellar Member 6	0.0039	0.0103	0.1953
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0039	0.0103	0.5
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0039	0.0103	0.0103
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0039	0.0103	0.0103
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0039	0.0103	0.5
Leishmania major	hypothetical protein, conserved	0.0039	0.0103	0.1953
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0059	0.0687	0.0687
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0039	0.0103	0.4548
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0227	0.0227
Toxoplasma gondii	ABC1 family protein	0.0043	0.0227	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0227	0.0315
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0039	0.0103	0.1953
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0059	0.0687	0.082
Trypanosoma cruzi	cAMP binding protein, putative	0.0039	0.0103	0.1953
Leishmania major	hypothetical protein, conserved	0.0039	0.0103	0.1953
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0103	0.1953
Schistosoma mansoni	voltage-gated potassium channel	0.0325	0.8612	0.8612
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0086	0.1501	0.1925
Echinococcus granulosus	hyperpolarization activated cyclic	0.0059	0.0687	0.0687
Leishmania major	cytochrome p450-like protein	0.0054	0.0529	1
Leishmania major	hypothetical protein, conserved	0.0039	0.0103	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0103	0.0103
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0039	0.0103	0.1953
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0103	0.0143
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0039	0.0103	0.0103
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0103	0.1953
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0103	0.1953
Leishmania major	protein kinase A regulatory subunit, putative	0.0039	0.0103	0.1953
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0039	0.0103	0.0103
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0103	0.0143
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0059	0.0687	0.082
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0059	0.0687	0.0687
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0039	0.0103	0.0103
Treponema pallidum	cyclic nucleotide binding protein	0.0039	0.0103	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0086	0.1501	0.1501

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0828 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	6.5131 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1516059

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1397056