Detailed information for compound 1397088

Basic information

Technical information
  • TDR Targets ID: 1397088
  • Name: 6-hydroxy-7-methyl-4-[[4-[(E)-3-phenylprop-2- enyl]piperazin-1-yl]methyl]chromen-2-one
  • MW: 390.475 | Formula: C24H26N2O3
  • H donors: 1 H acceptors: 2 LogP: 3.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(CN2CCN(CC2)C/C=C/c2ccccc2)c2c(o1)cc(c(c2)O)C
  • InChi: 1S/C24H26N2O3/c1-18-14-23-21(16-22(18)27)20(15-24(28)29-23)17-26-12-10-25(11-13-26)9-5-8-19-6-3-2-4-7-19/h2-8,14-16,27H,9-13,17H2,1H3/b8-5+
  • InChiKey: NHRRIBVIKCYWCH-VMPITWQZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-hydroxy-7-methyl-4-[[4-(3-phenylprop-2-enyl)piperazin-1-yl]methyl]chromen-2-one
  • 6-hydroxy-7-methyl-4-[[4-(3-phenylprop-2-enyl)-1-piperazinyl]methyl]-2-chromenone
  • 6-hydroxy-7-methyl-4-[[4-[(E)-3-phenylprop-2-enyl]-1-piperazinyl]methyl]-2-chromenone
  • 6-hydroxy-7-methyl-4-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]coumarin
  • 6-hydroxy-7-methyl-4-[[4-(3-phenylprop-2-enyl)piperazin-1-yl]methyl]coumarin
  • MLS000083762
  • SMR000048266

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Brugia malayi Cathepsin L-like precursor 0.019 0.1605 0.16
Brugia malayi cathepsin Z-like cysteine proteinase 0.0059 0.0277 0.0271
Brugia malayi Cathepsin L-like precursor 0.019 0.1605 0.16
Loa Loa (eye worm) hypothetical protein 0.0053 0.0214 0.0214
Plasmodium vivax vivapain-1 0.0112 0.0815 0.4322
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0397 0.0391
Brugia malayi jmjC domain containing protein 0.0071 0.0397 0.0391
Onchocerca volvulus 0.019 0.1605 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.019 0.1605 0.16
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0059 0.0277 0.0468
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0112 0.0815 0.081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1605 0.468
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0059 0.0277 0.0451
Giardia lamblia Cysteine protease 0.0059 0.0277 0.0468
Entamoeba histolytica cysteine protease, putative 0.0059 0.0277 0.1001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0397 0.0391
Giardia lamblia Cathepsin L precursor 0.0059 0.0277 0.0468
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0059 0.0277 0.0468
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0059 0.0277 0.0451
Entamoeba histolytica cysteine proteinase 1, putative 0.0112 0.0815 0.4649
Echinococcus multilocularis cathepsin L 0.0112 0.0815 0.081
Giardia lamblia Cathepsin L precursor 0.0059 0.0277 0.0468
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Entamoeba histolytica cysteine proteinase, putative 0.019 0.1605 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0059 0.0277 0.0468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0277 0.0468
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0196 0.0068
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0059 0.0277 0.1001
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0129 0.0123
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.1605 0.1496
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1605 0.468
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0196 0.0068
Echinococcus granulosus cysteine protease 0.0112 0.0815 0.081
Brugia malayi jmjC domain containing protein 0.0071 0.0397 0.0391
Schistosoma mansoni cathepsin F (C01 family) 0.019 0.1605 0.16
Onchocerca volvulus Cathepsin L homolog 0.019 0.1605 1
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.3381 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0277 0.0468
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0397 0.0391
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0815 0.081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0815 0.2176
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0397 0.0391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0277 0.0468
Entamoeba histolytica cysteine protease, putative 0.0059 0.0277 0.1001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1605 0.468
Giardia lamblia Cathepsin B precursor 0.0355 0.3284 1
Schistosoma mansoni lipoxygenase 0.01 0.0687 0.0681
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0277 0.0468
Loa Loa (eye worm) hypothetical protein 0.018 0.1508 0.1508
Plasmodium vivax unspecified product 0.0059 0.0277 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0277 0.0468
Brugia malayi cathepsin F-like cysteine proteinase 0.0059 0.0277 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1605 0.468
Plasmodium falciparum cysteine proteinase falcipain 2a 0.019 0.1605 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0059 0.0277 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Brugia malayi cathepsin L precursor 0.0059 0.0277 0.0271
Echinococcus multilocularis cathepsin L 0.0059 0.0277 0.0271
Echinococcus granulosus cathepsin L 0.0112 0.0815 0.081
Echinococcus multilocularis cathepsin l cysteine peptidase 0.019 0.1605 0.16
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0815 0.2111
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0059 0.0277 0.0468
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.019 0.1605 0.468
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0129 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1605 0.468
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0137 0.1067 0.095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Mycobacterium ulcerans hypothetical protein 0.0192 0.1627 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1605 0.468
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0059 0.0277 0.0468
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1429 0.3998
Onchocerca volvulus 0.019 0.1605 1
Trypanosoma cruzi cysteine protease, putative 0.0112 0.0815 0.0695
Entamoeba histolytica cysteine protease, putative 0.0059 0.0277 0.1001
Brugia malayi Cathepsin L-like precursor 0.019 0.1605 0.16
Brugia malayi cathepsin L-like precursor 0.0137 0.1067 0.1061
Leishmania major cathepsin L-like protease 0.019 0.1605 0.4541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0355 0.3284 0.328
Echinococcus multilocularis cathepsin L cysteine protease 0.019 0.1605 0.16
Giardia lamblia Cysteine protease 0.0059 0.0277 0.0468
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1627 0.5
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0059 0.0277 0.0277
Toxoplasma gondii preprocathepsin c precursor, putative 0.0059 0.0277 0.0013
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0059 0.0277 0.0271
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0397 0.0391
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0815 0.081
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.0277 0.0271
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0059 0.0277 0.0271
Echinococcus multilocularis cysteine protease 0.019 0.1605 0.16
Loa Loa (eye worm) hypothetical protein 0.0053 0.0214 0.0214
Leishmania major cathepsin L-like protease 0.019 0.1605 0.4541
Loa Loa (eye worm) hypothetical protein 0.0053 0.0214 0.0214
Onchocerca volvulus Cathepsin L homolog 0.0059 0.0277 0.1692
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0059 0.0277 0.0451
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0059 0.0277 0.0271
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0355 0.3284 0.3196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Loa Loa (eye worm) hypothetical protein 0.019 0.1605 0.1605
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0277 0.0271
Onchocerca volvulus 0.019 0.1605 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0006 0.0006
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.3381 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Echinococcus granulosus muscleblind protein 0.018 0.1508 0.1503
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0059 0.0277 0.0451
Brugia malayi Cathepsin L-like precursor 0.019 0.1605 0.16
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.1067 0.2973
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0196 0.0068
Giardia lamblia Cathepsin B precursor 0.0059 0.0277 0.0468
Toxoplasma gondii cathepsin CPC1 0.0059 0.0277 0.0013
Entamoeba histolytica cysteine protease, putative 0.0059 0.0277 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0815 0.2176
Brugia malayi cathepsin F-like cysteine proteinase 0.0053 0.0214 0.0208
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0214 0.0214
Brugia malayi Muscleblind-like protein 0.018 0.1508 0.1503
Trypanosoma cruzi cruzipain precursor, putative 0.0053 0.0214 0.0086
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0129 0.0123
Loa Loa (eye worm) hypothetical protein 0.0137 0.1067 0.1067
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1122 0.1117
Onchocerca volvulus Cathepsin L homolog 0.019 0.1605 1
Onchocerca volvulus 0.019 0.1605 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0059 0.0277 0.0468
Giardia lamblia Cathepsin B precursor 0.0355 0.3284 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.019 0.1605 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.019 0.1605 0.16
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Giardia lamblia Encystation-specific protease 0.0059 0.0277 0.0468
Brugia malayi Cathepsin L-like precursor 0.0137 0.1067 0.1061
Loa Loa (eye worm) hypothetical protein 0.0059 0.0277 0.0277
Schistosoma mansoni cathepsin B (C01 family) 0.0059 0.0277 0.0271
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0059 0.0277 0.0468
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0059 0.0277 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0059 0.0277 0.0468
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0059 0.0277 0.0451
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.031 0.0184
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0059 0.0277 0.0468
Brugia malayi cathepsin L-like cysteine proteinase 0.0059 0.0277 0.0271
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0129 0.0123
Entamoeba histolytica cysteine proteinase, putative 0.019 0.1605 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0277 0.0468
Giardia lamblia Cathepsin L-like protease 0.0059 0.0277 0.0468
Loa Loa (eye worm) cysteine protease 0.019 0.1605 0.1605
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Entamoeba histolytica hypothetical protein 0.0059 0.0277 0.1001
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0815 0.4649
Plasmodium vivax vivapain-2 0.019 0.1605 1
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.1605 0.1496
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0277 0.0277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Loa Loa (eye worm) hypothetical protein 0.0059 0.0277 0.0277
Plasmodium vivax serine-repeat antigen (SERA) 0.0059 0.0277 0.0451
Plasmodium vivax vivapain-3 0.0112 0.0815 0.4322
Trypanosoma cruzi cysteine proteinase, putative 0.0112 0.0815 0.0695
Entamoeba histolytica cysteine proteinase, putative 0.0137 0.1067 0.6352
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.019 0.1605 0.1605
Loa Loa (eye worm) cathepsin B 0.0355 0.3284 0.3284
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.019 0.1605 0.468
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0129 0.0123
Giardia lamblia Cathepsin B precursor 0.0059 0.0277 0.0468
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0277 0.0277
Plasmodium vivax serine-repeat antigen (SERA) 0.0059 0.0277 0.0451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0277 0.0468
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Entamoeba histolytica cysteine protease, putative 0.019 0.1605 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0355 0.3284 0.9702
Toxoplasma gondii cathepsin CPC2 0.0059 0.0277 0.0013
Toxoplasma gondii cathepsin CPL 0.019 0.1605 0.4426
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0006 0.0006
Onchocerca volvulus 0.0059 0.0277 0.1692
Loa Loa (eye worm) hypothetical protein 0.018 0.1508 0.1508
Giardia lamblia Cathepsin B precursor 0.0059 0.0277 0.0468
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0815 0.2111
Brugia malayi Cathepsin L-like precursor 0.0137 0.1067 0.1061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Loa Loa (eye worm) hypothetical protein 0.0059 0.0277 0.0277
Schistosoma mansoni cathepsin F (C01 family) 0.019 0.1605 0.16
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1605 0.468
Onchocerca volvulus 0.019 0.1605 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0059 0.0277 0.0271
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0059 0.0277 0.0451
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0059 0.0277 0.0451
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0196 0.0207
Loa Loa (eye worm) fibroinase 0.019 0.1605 0.1605
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3381 0.3294
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1122 0.1117
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0815 0.4649
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0397 0.0391
Plasmodium falciparum cysteine proteinase falcipain 3 0.019 0.1605 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Giardia lamblia Cathepsin B precursor 0.0355 0.3284 1
Plasmodium vivax vivapain-2 0.019 0.1605 1
Echinococcus multilocularis cysteine protease 0.019 0.1605 0.16
Brugia malayi Cathepsin L-like cysteine proteinase 0.0137 0.1067 0.1061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Onchocerca volvulus Cathepsin F homolog 0.019 0.1605 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0112 0.0815 0.0695
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0277 0.0271
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0214 0.0086
Giardia lamblia Cathepsin L precursor 0.0059 0.0277 0.0468
Loa Loa (eye worm) hypothetical protein 0.0045 0.0129 0.0129
Schistosoma mansoni cathepsin F (C01 family) 0.0137 0.1067 0.1061
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0059 0.0277 0.0451
Giardia lamblia Hypothetical protein 0.0059 0.0277 0.0468
Brugia malayi Papain family cysteine protease containing protein 0.019 0.1605 0.16
Giardia lamblia Cathepsin L-like protease 0.0059 0.0277 0.0468
Giardia lamblia Cathepsin L precursor 0.0059 0.0277 0.0468
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1605 0.468
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0277 0.0468
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0129 0.0123
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3381 0.3294
Schistosoma mansoni lipoxygenase 0.0142 0.1122 0.1117
Toxoplasma gondii cathepsin B 0.0355 0.3284 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.1067 0.2973
Schistosoma mansoni cathepsin S (C01 family) 0.0059 0.0277 0.0271
Trypanosoma cruzi cruzipain precursor, putative 0.019 0.1605 0.1496
Giardia lamblia Cathepsin L precursor 0.0059 0.0277 0.0468
Brugia malayi Cathepsin L-like precursor 0.0053 0.0214 0.0208
Giardia lamblia Cysteine protease 0.0059 0.0277 0.0468
Onchocerca volvulus 0.019 0.1605 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1429 0.3998
Loa Loa (eye worm) papain family cysteine protease containing protein 0.019 0.1605 0.1605
Leishmania major cathepsin L-like protease 0.019 0.1605 0.4541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0277 0.0468
Leishmania major cathepsin L-like protease 0.019 0.1605 0.4541
Leishmania major cathepsin L-like protease 0.019 0.1605 0.4541
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0277 0.0468
Loa Loa (eye worm) hypothetical protein 0.0059 0.0277 0.0277
Plasmodium vivax unspecified product 0.0112 0.0815 0.4322
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.0277 0.0271
Plasmodium falciparum cysteine proteinase falcipain 1 0.0112 0.0815 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.0277 0.0271
Giardia lamblia Cysteine protease 0.0059 0.0277 0.0468
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0397 0.0391
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0815 0.4649
Entamoeba histolytica cysteine protease, putative 0.0059 0.0277 0.1001
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.1605 0.1496
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0112 0.0815 0.081
Echinococcus granulosus cathepsin L 0.0059 0.0277 0.0271
Onchocerca volvulus 0.0137 0.1067 0.6632
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0129 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0059 0.0277 0.0468
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0397 0.0397
Brugia malayi fibroinase precursor 0.0059 0.0277 0.0271
Echinococcus multilocularis cathepsin l cysteine peptidase 0.019 0.1605 0.16
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0355 0.3284 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0277 0.0468
Giardia lamblia Cathepsin B precursor 0.0059 0.0277 0.0468
Leishmania major cathepsin L-like protease 0.019 0.1605 0.4541
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0129 0.0123
Brugia malayi Cathepsin L-like precursor 0.019 0.1605 0.16
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.1605 0.1496
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1429 0.1317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0059 0.0277 0.0271
Entamoeba histolytica cysteine protease, putative 0.0059 0.0277 0.1001
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0277 0.015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1605 0.468
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0059 0.0277 0.0468
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.0277 0.0271
Trypanosoma cruzi cysteine proteinase, putative 0.0112 0.0815 0.0695
Schistosoma mansoni cathepsin s 0.0053 0.0214 0.0208
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0277 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0059 0.0277 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0277 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0059 0.0277 0.0468
Leishmania major cathepsin L-like protease 0.019 0.1605 0.4541
Leishmania major cysteine peptidase A (CPA) 0.019 0.1605 0.4541
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0059 0.0277 0.0451
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0129 0.0123
Echinococcus multilocularis muscleblind protein 1 0.018 0.1508 0.1503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1605 0.4541
Echinococcus multilocularis cathepsin L cysteine protease 0.019 0.1605 0.16
Leishmania major cathepsin L-like protease 0.019 0.1605 0.4541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1605 0.468
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0112 0.0815 0.081
Loa Loa (eye worm) hypothetical protein 0.0137 0.1067 0.1067
Entamoeba histolytica cysteine protease, putative 0.0112 0.0815 0.4649
Loa Loa (eye worm) hypothetical protein 0.0059 0.0277 0.0277
Echinococcus multilocularis muscleblind protein 0.018 0.1508 0.1503
Loa Loa (eye worm) ctsf protein 0.019 0.1605 0.1605
Giardia lamblia Hypothetical protein 0.0059 0.0277 0.0468
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0053 0.0214 0.0208
Giardia lamblia Cathepsin B precursor 0.0059 0.0277 0.0468
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0355 0.3284 0.9702
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.0277 0.0271
Entamoeba histolytica cysteine proteinase 2 0.0112 0.0815 0.4649
Schistosoma mansoni cathepsin C 0.0059 0.0277 0.0271
Onchocerca volvulus 0.019 0.1605 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.1067 0.1067
Trypanosoma cruzi cysteine peptidase, putative 0.0112 0.0815 0.0695
Giardia lamblia Cathepsin L precursor 0.0059 0.0277 0.0468
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0815 0.4649
Echinococcus granulosus cathepsin L cysteine protease 0.0112 0.0815 0.081
Brugia malayi Cathepsin L-like precursor 0.019 0.1605 0.16
Echinococcus granulosus cathepsin l1 0.019 0.1605 0.16
Loa Loa (eye worm) hypothetical protein 0.0059 0.0277 0.0277
Echinococcus granulosus cathepsin l1 0.0137 0.1067 0.1061

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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