TDR Targets

Basic information

Technical information

TDR Targets ID: 1397109
Name: N-[(2,3-dimethoxyphenyl)methyl]-2-[2-(1-methy lindol-3-yl)-5-oxo-6,7-dihydropyrazolo[5,1-b] pyrimidin-4-yl]acetamide
MW: 473.524 | Formula: C26H27N5O4
H donors: 1 H acceptors: 3 LogP: 2.09 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(cccc1OC)CNC(=O)CN1C(=O)CCn2c1cc(n2)c1cn(c2c1cccc2)C
InChi: 1S/C26H27N5O4/c1-29-15-19(18-8-4-5-9-21(18)29)20-13-24-30(25(33)11-12-31(24)28-20)16-23(32)27-14-17-7-6-10-22(34-2)26(17)35-3/h4-10,13,15H,11-12,14,16H2,1-3H3,(H,27,32)
InChiKey: KECDJIVOTBXMNO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[(2,3-dimethoxyphenyl)methyl]-2-[2-(1-methyl-3-indolyl)-5-oxo-6,7-dihydropyrazolo[5,1-b]pyrimidin-4-yl]acetamide
N-(2,3-dimethoxybenzyl)-2-[5-keto-2-(1-methylindol-3-yl)-6,7-dihydropyrazolo[5,1-b]pyrimidin-4-yl]acetamide
N-[(2,3-dimethoxyphenyl)methyl]-2-[2-(1-methylindol-3-yl)-5-oxo-6,7-dihydropyrazolo[5,1-b]pyrimidin-4-yl]ethanamide
G581-0246
NCGC00132178-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Schistosoma mansoni	Thioredoxin glutathione reductase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania mexicana	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma congolense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium parvum	thioredoxin reductase 1	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania infantum	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania major	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei gambiense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	Glutathione reductase, related	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania braziliensis	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus multilocularis	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma cruzi	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania donovani	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Toxoplasma gondii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	Thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	MGC84926 protein, related	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium hominis	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Babesia bovis	thiodoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium knowlesi	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	518 aa	22.0 %
Neospora caninum	hypothetical protein	Thioredoxin glutathione reductase	598 aa	485 aa	30.5 %
Toxoplasma gondii	NADPH-glutathione reductase	Thioredoxin glutathione reductase	598 aa	555 aa	33.5 %
Neospora caninum	Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related	Thioredoxin glutathione reductase	598 aa	512 aa	28.3 %
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	Thioredoxin glutathione reductase	598 aa	513 aa	25.0 %
Plasmodium berghei	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	538 aa	25.3 %
Plasmodium yoelii	dihydrolipoamide dehydrogenase	Thioredoxin glutathione reductase	598 aa	537 aa	24.2 %
Onchocerca volvulus		Thioredoxin glutathione reductase	598 aa	533 aa	50.8 %
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	521 aa	21.5 %
Neospora caninum	glutathione reductase, putative	Thioredoxin glutathione reductase	598 aa	532 aa	34.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.1553	0.4038
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.1553	0.4038
Entamoeba histolytica	cysteine proteinase 1, putative	0.0196	0.0952	0.4054
Echinococcus multilocularis	cathepsin L	0.0196	0.0952	0.0949
Echinococcus multilocularis	cysteine protease	0.0336	0.184	0.1836
Brugia malayi	fibroinase precursor	0.0101	0.0347	0.0347
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0101	0.0347	0.1888
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0096	0.0316	0.0316
Brugia malayi	Papain family cysteine protease containing protein	0.0101	0.0347	0.0347
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0572	0.3333	0.3333
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0101	0.0347	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0347	0.0347
Loa Loa (eye worm)	ctsf protein	0.0336	0.184	0.184
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.1553	0.4038
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0196	0.0952	0.0657
Plasmodium falciparum	serine repeat antigen 4	0.0101	0.0347	0.1888
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1235	0.1235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0101	0.0347	0.0032
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0101	0.0347	0.0032
Echinococcus granulosus	cathepsin l1	0.0336	0.184	0.1836
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0142	0.0611	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0572	0.3333	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0347	0.0347
Entamoeba histolytica	cysteine proteinase 2	0.0196	0.0952	0.4054
Giardia lamblia	Fructose-bisphosphate aldolase	0.0291	0.1553	0.4038
Echinococcus granulosus	cysteine protease	0.0196	0.0952	0.0949
Brugia malayi	Papain family cysteine protease containing protein	0.0336	0.184	0.184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Trypanosoma cruzi	cruzipain precursor, putative	0.0096	0.0316	0.0316
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0101	0.0347	0.1888
Mycobacterium tuberculosis	Probable reductase	0.0104	0.037	0.6063
Plasmodium vivax	vivapain-3	0.0196	0.0952	0.5177
Brugia malayi	Papain family cysteine protease containing protein	0.0101	0.0347	0.0347
Brugia malayi	Cathepsin L-like precursor	0.0241	0.1235	0.1235
Schistosoma mansoni	cathepsin F (C01 family)	0.0241	0.1235	0.0949
Toxoplasma gondii	cathepsin B	0.0572	0.3333	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0101	0.0347	0.0347
Leishmania major	cathepsin L-like protease	0.0336	0.184	0.552
Leishmania major	cathepsin L-like protease	0.0336	0.184	0.552
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0142	0.0611	1
Echinococcus multilocularis	cysteine protease	0.0336	0.184	0.1836
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0291	0.1553	0.8077
Brugia malayi	Cathepsin L-like precursor	0.0336	0.184	0.184
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0572	0.3333	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Onchocerca volvulus		0.0241	0.1235	0.5946
Onchocerca volvulus		0.0336	0.184	1
Leishmania major	cathepsin L-like protease	0.0431	0.2436	0.7311
Plasmodium falciparum	serine repeat antigen 9	0.0101	0.0347	0.1888
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Trypanosoma cruzi	cysteine proteinase, putative	0.0196	0.0952	0.0952
Plasmodium falciparum	serine repeat antigen 2	0.0101	0.0347	0.1888
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0101	0.0347	0.0032
Toxoplasma gondii	cathepsin CPC2	0.0101	0.0347	0.1042
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0101	0.0347	0.0032
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0101	0.0347	0.0032
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0101	0.0347	0.1888
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0196	0.0952	0.2857
Brugia malayi	Cathepsin L-like precursor	0.0336	0.184	0.184
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.1553	0.4038
Leishmania major	cathepsin L-like protease	0.0336	0.184	0.552
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0572	0.3333	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0142	0.0611	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0431	0.2436	0.2436
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0336	0.184	0.4999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0241	0.1235	0.2972
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0196	0.0952	0.0657
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0336	0.184	0.4999
Loa Loa (eye worm)	cathepsin B	0.0572	0.3333	0.3333
Plasmodium falciparum	serine repeat antigen 5	0.0101	0.0347	0.1888
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0101	0.0347	0.1888
Brugia malayi	Papain family cysteine protease containing protein	0.0196	0.0952	0.0952
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.037	0.6063
Entamoeba histolytica	cysteine proteinase, putative	0.0336	0.184	1
Onchocerca volvulus	Cathepsin L homolog	0.0336	0.184	1
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0101	0.0347	0.0347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0196	0.0952	0.2857
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0572	0.3333	0.3115
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0347	0.0347
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0336	0.184	0.4999
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Onchocerca volvulus		0.0336	0.184	1
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Plasmodium vivax	vivapain-2	0.0336	0.184	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0336	0.184	0.1836
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1235	0.1235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Brugia malayi	Cathepsin L-like precursor	0.0336	0.184	0.184
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1235	0.1235
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0101	0.0347	0.0347
Entamoeba histolytica	cysteine proteinase, putative	0.0196	0.0952	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0347	0.0347
Onchocerca volvulus	Cathepsin F homolog	0.0336	0.184	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0101	0.0347	0.0347
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0101	0.0347	0.1888
Schistosoma mansoni	cathepsin F (C01 family)	0.0336	0.184	0.1573
Plasmodium vivax	vivapain-1	0.0196	0.0952	0.5177
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0101	0.0347	0.1888
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.037	0.6063
Brugia malayi	cathepsin L precursor	0.0101	0.0347	0.0347
Schistosoma mansoni	cathepsin S (C01 family)	0.0101	0.0347	0.0032
Leishmania major	cysteine peptidase A (CPA)	0.0336	0.184	0.552
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.1553	0.4038
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0291	0.1553	0.8077
Echinococcus granulosus	cathepsin L	0.0196	0.0952	0.0949
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0101	0.0347	0.1888
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0316	0.0316
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0196	0.0952	0.0952
Entamoeba histolytica	cysteine proteinase, putative	0.0196	0.0952	0.4054
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.1553	0.4038
Leishmania major	cathepsin L-like protease	0.0336	0.184	0.552
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0336	0.184	0.4999
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0316	0.0316
Trypanosoma cruzi	cysteine peptidase, putative	0.0096	0.0316	0.0316
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Entamoeba histolytica	cysteine proteinase, putative	0.0241	0.1235	0.5946
Echinococcus granulosus	cathepsin L cysteine protease	0.0196	0.0952	0.0949
Loa Loa (eye worm)	fibroinase	0.0336	0.184	0.184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0241	0.1235	0.2972
Toxoplasma gondii	cathepsin CPL	0.0336	0.184	0.552
Entamoeba histolytica	cysteine proteinase, putative	0.0336	0.184	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0336	0.184	0.4999
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0336	0.184	0.4999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0196	0.0952	0.2027
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.037	0.6063
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0336	0.184	0.4999
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0101	0.0347	0.0347
Plasmodium vivax	unspecified product	0.0096	0.0316	0.1718
Onchocerca volvulus		0.0336	0.184	1
Leishmania major	cathepsin L-like protease	0.0336	0.184	0.552
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0336	0.184	0.4999
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0336	0.184	0.1836
Onchocerca volvulus		0.0336	0.184	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.1553	0.4038
Echinococcus granulosus	cathepsin l1	0.0241	0.1235	0.1231
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0101	0.0347	0.1888
Trypanosoma cruzi	major cysteine proteinase, putative	0.0101	0.0347	0.0347
Brugia malayi	Cathepsin L-like precursor	0.0096	0.0316	0.0316
Plasmodium falciparum	serine repeat antigen 8	0.0101	0.0347	0.1888
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.0444	0.7267
Plasmodium vivax	unspecified product	0.0101	0.0347	0.1888
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0336	0.184	0.4999
Entamoeba histolytica	cysteine proteinase, putative	0.0196	0.0952	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0196	0.0952	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0336	0.184	0.1836
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0101	0.0347	0.1888
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0316	0.0316
Brugia malayi	cathepsin F-like cysteine proteinase	0.0101	0.0347	0.0347
Brugia malayi	cathepsin L-like precursor	0.0241	0.1235	0.1235
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0808	0.4821	0.4819
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0347	0.0347
Brugia malayi	Cathepsin L-like precursor	0.0241	0.1235	0.1235
Echinococcus multilocularis	cathepsin L	0.0101	0.0347	0.0344
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0101	0.0347	0.0347
Trypanosoma cruzi	cysteine protease, putative	0.0196	0.0952	0.0952
Trypanosoma cruzi	cysteine peptidase, putative	0.0431	0.2436	0.2436
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0101	0.0347	0.1042
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0101	0.0347	0.1888
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0336	0.184	0.184
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Plasmodium falciparum	serine repeat antigen 7	0.0101	0.0347	0.1888
Plasmodium vivax	vivapain-2	0.0336	0.184	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0196	0.0952	0.2027
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.1553	0.4038
Plasmodium falciparum	serine repeat antigen 1	0.0101	0.0347	0.1888
Trypanosoma cruzi	cysteine peptidase, putative	0.0431	0.2436	0.2436
Plasmodium vivax	serine-repeat antigen (SERA)	0.0101	0.0347	0.1888
Echinococcus multilocularis	cathepsin L cysteine protease	0.0336	0.184	0.1836
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0101	0.0347	0.0032
Leishmania major	cathepsin L-like protease	0.0431	0.2436	0.7311
Trypanosoma cruzi	cysteine peptidase, putative	0.0336	0.184	0.184
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.0444	0.3059
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0196	0.0952	0.5177
Plasmodium vivax	serine-repeat antigen (SERA)	0.0101	0.0347	0.1888
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0347	0.0347
Echinococcus multilocularis	cathepsin L cysteine protease	0.0336	0.184	0.1836
Toxoplasma gondii	cathepsin CPC1	0.0101	0.0347	0.1042
Trypanosoma cruzi	cysteine peptidase, putative	0.0196	0.0952	0.0952
Loa Loa (eye worm)	cysteine protease	0.0336	0.184	0.184
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.037	0.6063
Loa Loa (eye worm)	hypothetical protein	0.0336	0.184	0.184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Trypanosoma cruzi	major cysteine proteinase, putative	0.0195	0.0944	0.0944
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Giardia lamblia	Cathepsin B precursor	0.0572	0.3333	1
Plasmodium falciparum	serine repeat antigen 3	0.0101	0.0347	0.1888
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0101	0.0347	0.1888
Onchocerca volvulus		0.0336	0.184	1
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0336	0.184	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0336	0.184	0.1836
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0101	0.0347	0.1888
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.037	0.6063
Brugia malayi	Cathepsin L-like precursor	0.0336	0.184	0.184
Onchocerca volvulus		0.0336	0.184	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0336	0.184	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.0444	0.7267
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0101	0.0347	0.1888
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0336	0.184	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Trypanosoma cruzi	cysteine peptidase, putative	0.0431	0.2436	0.2436
Brugia malayi	Cathepsin L-like precursor	0.0336	0.184	0.184
Leishmania major	cathepsin L-like protease	0.0431	0.2436	0.7311
Trypanosoma cruzi	cysteine proteinase, putative	0.0196	0.0952	0.0952
Entamoeba histolytica	cysteine protease, putative	0.0336	0.184	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0291	0.1553	0.5
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0101	0.0347	0.0032
Brugia malayi	cathepsin L-like cysteine proteinase	0.0101	0.0347	0.0347
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0096	0.0316	0.0316
Plasmodium vivax	unspecified product	0.0196	0.0952	0.5177
Giardia lamblia	Cathepsin B precursor	0.0572	0.3333	1
Schistosoma mansoni	cathepsin C	0.0101	0.0347	0.0032
Brugia malayi	cathepsin F-like cysteine proteinase	0.0096	0.0316	0.0316
Brugia malayi	Papain family cysteine protease containing protein	0.0196	0.0952	0.0952
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0241	0.1235	0.1235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Plasmodium falciparum	serine repeat antigen 6	0.0101	0.0347	0.1888
Schistosoma mansoni	cathepsin F (C01 family)	0.0336	0.184	0.1573
Entamoeba histolytica	cysteine protease, putative	0.0196	0.0952	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0336	0.184	0.184
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0336	0.184	0.4999
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.2436	0.7311
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0101	0.0347	0.0032
Echinococcus granulosus	cathepsin L	0.0101	0.0347	0.0344
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.0444	0.7267
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0336	0.184	0.184
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0196	0.0952	0.0657
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.184	0.4999
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0335	0.1831	0.1831
Onchocerca volvulus		0.0336	0.184	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0101	0.0347	0.0032
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0336	0.184	0.4999
Brugia malayi	Papain family cysteine protease containing protein	0.0101	0.0347	0.0347
Giardia lamblia	Cathepsin B precursor	0.0572	0.3333	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0336	0.184	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	100 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1516310

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1397109