Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.082 | 0.0801 |
Schistosoma mansoni | lamin | 0.0033 | 0.082 | 0.0801 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0074 | 0.2745 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0023 | 0.0361 | 0.0341 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.082 | 0.0801 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0109 | 0.0088 |
Echinococcus multilocularis | lamin | 0.0033 | 0.082 | 0.0801 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0028 | 0.0007 |
Echinococcus granulosus | lamin | 0.0033 | 0.082 | 0.0801 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.082 | 0.082 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.082 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.082 | 0.082 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.082 | 0.082 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0023 | 0.0361 | 0.0341 |
Echinococcus multilocularis | musashi | 0.0033 | 0.082 | 0.0801 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0023 | 0.0361 | 0.0341 |
Onchocerca volvulus | 0.0033 | 0.082 | 0.5 | |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0028 | 0.0007 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.082 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0361 | 0.0361 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0023 | 0.0361 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.25 | 0.25 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.7768 | 0.7764 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0079 | 0.2988 | 0.2973 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0074 | 0.2745 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.082 | 0.0801 |
Onchocerca volvulus | 0.0033 | 0.082 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0792 | 0.0792 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0016 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0021 | 0.0021 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0079 | 0.2988 | 0.2973 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0016 | 0.0021 | 0.0021 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0023 | 0.0361 | 0.0341 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0079 | 0.2988 | 0.2973 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.082 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.7768 | 0.7768 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.082 | 0.0801 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0023 | 0.0361 | 0.0341 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0109 | 0.0109 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.7768 | 0.7764 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.7768 | 0.7768 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0028 | 0.0028 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0086 | 0.3328 | 0.3314 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0086 | 0.3328 | 0.3314 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.7768 | 0.7764 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.7768 | 0.7764 |
Echinococcus granulosus | voltage gated potassium channel | 0.0023 | 0.0361 | 0.0341 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0079 | 0.2988 | 0.2988 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 19.9526 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.