Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | 0.0084 | 0.085 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0102 | 0.1392 | 0.1545 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0527 | 0.0527 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0069 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.7597 | 0.8428 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0084 | 0.085 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0084 | 0.085 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0407 | 0.0451 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0069 | 0.0407 | 0.0407 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0084 | 0.085 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0069 | 0.0407 | 0.0407 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0069 | 0.0407 | 0.0451 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0527 | 0.62 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0351 | 0.9014 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0069 | 0.0407 | 0.0407 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0328 | 0.8308 | 1 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0069 | 0.0407 | 0.0451 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0102 | 0.1392 | 0.1545 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0069 | 0.0407 | 0.0451 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0351 | 0.9014 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0102 | 0.1392 | 0.1392 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0069 | 0.0407 | 0.0451 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0102 | 0.1392 | 0.1545 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0527 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0177 | 0.3702 | 0.4107 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0069 | 0.0407 | 0.0451 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0527 | 0.62 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1392 | 0.1545 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0084 | 0.085 | 0.0943 |
Brugia malayi | Cytochrome P450 family protein | 0.0084 | 0.085 | 0.0943 |
Leishmania major | cytochrome p450-like protein | 0.0084 | 0.085 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0069 | 0.0407 | 0.0451 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0527 | 0.62 |
Echinococcus granulosus | voltage gated potassium channel | 0.0102 | 0.1392 | 0.1545 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0069 | 0.0407 | 0.0451 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0527 | 0.0585 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0084 | 0.085 | 0.0943 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0527 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0328 | 0.8308 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0069 | 0.0407 | 0.0451 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0527 | 0.0527 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0069 | 0.0407 | 0.0407 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0102 | 0.1392 | 0.1545 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0527 | 0.62 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0102 | 0.1392 | 0.1392 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0069 | 0.0407 | 0.0451 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0069 | 0.0407 | 0.0451 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0084 | 0.085 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0069 | 0.0407 | 0.0451 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0351 | 0.9014 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0177 | 0.3702 | 0.4107 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0069 | 0.0407 | 0.0451 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0527 | 0.0585 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0069 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0084 | 0.085 | 0.0943 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0069 | 0.0407 | 0.0451 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0351 | 0.9014 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0069 | 0.0407 | 0.0451 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.