Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6206 | 0.2281 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0173 | 0.5085 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.6596 | 0.3074 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6206 | 0.2281 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0211 | 0.6448 | 0.6434 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6206 | 0.2281 |
Trichomonas vaginalis | set domain proteins, putative | 0.0241 | 0.7482 | 0.4877 |
Brugia malayi | Pre-SET motif family protein | 0.0211 | 0.6448 | 0.6434 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0173 | 0.5085 | 1 |
Giardia lamblia | Phosphoglycerate kinase | 0.0173 | 0.5085 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.6596 | 0.3074 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0173 | 0.5085 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6206 | 0.2281 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0173 | 0.5085 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0205 | 0.6206 | 0.8285 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0173 | 0.5085 | 1 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0173 | 0.5085 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6206 | 0.2281 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0173 | 0.5085 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6206 | 0.2281 |
Onchocerca volvulus | 0.0241 | 0.7482 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.5085 | 0.5065 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0173 | 0.5085 | 1 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0173 | 0.5085 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0039 | 0.0078 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0173 | 0.5085 | 0.5 |
Brugia malayi | Phosphoglycerate kinase | 0.0063 | 0.1212 | 0.1177 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0173 | 0.5085 | 0.5 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0173 | 0.5085 | 1 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0173 | 0.5085 | 0.5 |
Treponema pallidum | phosphoglycerate kinase | 0.0173 | 0.5085 | 0.5 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0173 | 0.5085 | 1 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0173 | 0.5085 | 1 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0173 | 0.5085 | 1 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0173 | 0.5085 | 0.5 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0173 | 0.5085 | 1 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0173 | 0.5085 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6206 | 0.2281 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0173 | 0.5085 | 0.5 |
Brugia malayi | Phosphoglycerate kinase | 0.0173 | 0.5085 | 0.5065 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.