Detailed information for compound 1398509

Basic information

Technical information
  • TDR Targets ID: 1398509
  • Name: 2,3-dimethyl-N-[(5-methylfuran-2-yl)methyl]-1 -[(3-methylphenyl)methyl]indole-5-carboxamide
  • MW: 386.486 | Formula: C25H26N2O2
  • H donors: 1 H acceptors: 1 LogP: 5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)Cn1c(C)c(c2c1ccc(c2)C(=O)NCc1ccc(o1)C)C
  • InChi: 1S/C25H26N2O2/c1-16-6-5-7-20(12-16)15-27-19(4)18(3)23-13-21(9-11-24(23)27)25(28)26-14-22-10-8-17(2)29-22/h5-13H,14-15H2,1-4H3,(H,26,28)
  • InChiKey: KOYIGAWWNLOQKY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2,3-dimethyl-N-[(5-methyl-2-furyl)methyl]-1-[(3-methylphenyl)methyl]indole-5-carboxamide
  • 2,3-dimethyl-N-[(5-methyl-2-furyl)methyl]-1-[(3-methylphenyl)methyl]-5-indolecarboxamide
  • 2,3-dimethyl-1-(3-methylbenzyl)-N-[(5-methyl-2-furyl)methyl]indole-5-carboxamide
  • NCGC00129034-01
  • G119-2364

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Histone deacetylase 1 0.0339 0.7777 0.7911
Leishmania major histone deacetylase, putative 0.0423 0.983 1
Echinococcus multilocularis peregrin 0.0035 0.0393 0.0393
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0594 0.073
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1411 0.141
Entamoeba histolytica histone deacetylase, putative 0.0339 0.7777 1
Brugia malayi histone deacetylase 1 (HD1) 0.0339 0.7777 0.7911
Trypanosoma cruzi histone deacetylase, putative 0.0423 0.983 1
Trypanosoma brucei histone deacetylase, putative 0.0423 0.983 1
Brugia malayi Histone deacetylase family protein 0.0423 0.983 1
Schistosoma mansoni hypothetical protein 0.0035 0.0393 0.0393
Brugia malayi hypothetical protein 0.0182 0.3976 0.4044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0594 0.0605
Brugia malayi Cathepsin L-like precursor 0.002 0.0029 0.0029
Onchocerca volvulus 0.0043 0.0594 0.1415
Loa Loa (eye worm) hypothetical protein 0.0239 0.534 0.5432
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0339 0.7777 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0594 0.0577
Schistosoma mansoni histone deacetylase 4 5 0.0423 0.983 0.983
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Brugia malayi Cathepsin L-like precursor 0.002 0.0029 0.0029
Echinococcus granulosus histone deacetylase 1 0.0339 0.7777 0.7777
Mycobacterium ulcerans hypothetical protein 0.0043 0.0594 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0594 0.0605
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0339 0.7777 1
Plasmodium falciparum phd finger protein, putative 0.0035 0.0393 0.0372
Trypanosoma brucei histone deacetylase 4 0.0423 0.983 1
Loa Loa (eye worm) histone deacetylase 0.0423 0.983 1
Schistosoma mansoni histone deacetylase 1 2 3 0.0185 0.4027 0.4027
Trypanosoma cruzi histone deacetylase 1, putative 0.0339 0.7777 0.7905
Toxoplasma gondii histone deacetylase HDAC2 0.0339 0.7777 0.7905
Echinococcus granulosus histone deacetylase 6 0.0423 0.983 0.983
Onchocerca volvulus Histone deacetylase 10 homolog 0.0185 0.4027 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0029 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1305 0.1328
Brugia malayi MH2 domain containing protein 0.0144 0.3044 0.3096
Mycobacterium ulcerans lipase LipD 0.0043 0.0594 0.5
Echinococcus multilocularis histone deacetylase 6 0.0423 0.983 0.983
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0594 0.0577
Brugia malayi beta-lactamase 0.0043 0.0594 0.0605
Brugia malayi Cathepsin L-like precursor 0.002 0.0029 0.0029
Brugia malayi Histone deacetylase family protein 0.0423 0.983 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1411 0.141
Trichomonas vaginalis histone deacetylase, putative 0.0339 0.7777 1
Trypanosoma cruzi histone deacetylase, putative 0.0423 0.983 1
Trypanosoma cruzi histone deacetylase, putative 0.0423 0.983 1
Trichomonas vaginalis histone deacetylase, putative 0.0339 0.7777 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.4315 0.4389
Trypanosoma cruzi histone deacetylase, putative 0.0185 0.4027 0.4079
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2342 0.2342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Loa Loa (eye worm) hypothetical protein 0.0246 0.551 0.5605
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0339 0.7777 1
Leishmania major cathepsin L-like protease 0.0077 0.1411 0.141
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0029 0.0029
Loa Loa (eye worm) ctsf protein 0.002 0.0029 0.0029
Onchocerca volvulus 0.0043 0.0594 0.1415
Loa Loa (eye worm) histone deacetylase 11 0.0381 0.8805 0.8957
Onchocerca volvulus 0.0043 0.0594 0.1415
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0594 0.073
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0594 0.5
Echinococcus granulosus histone deacetylase 7 0.0423 0.983 0.983
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Echinococcus granulosus histone deacetylase 3 0.0339 0.7777 0.7777
Loa Loa (eye worm) hypothetical protein 0.006 0.1001 0.1018
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0393 0.0393
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0393 0.0372
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1765 0.1765
Trypanosoma brucei histone deacetylase 1 0.0339 0.7777 0.7777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Loa Loa (eye worm) hypothetical protein 0.0035 0.0393 0.04
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0573 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Echinococcus granulosus histone deacetylase 8 0.0185 0.4027 0.4027
Toxoplasma gondii ABC1 family protein 0.0043 0.0594 0.0577
Brugia malayi jmjC domain containing protein 0.0043 0.0573 0.0583
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2342 0.2342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0594 0.073
Brugia malayi Bromodomain containing protein 0.0035 0.0393 0.04
Leishmania major histone deacetylase, putative 0.0339 0.7777 0.7905
Loa Loa (eye worm) hypothetical protein 0.0339 0.7777 0.7911
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0182 0.3976 0.4044
Brugia malayi beta-lactamase family protein 0.0043 0.0594 0.0605
Loa Loa (eye worm) hypothetical protein 0.0043 0.0594 0.0605
Schistosoma mansoni histone deacetylase 0.0339 0.7777 0.7777
Trichomonas vaginalis histone deacetylase, putative 0.0339 0.7777 1
Leishmania major cathepsin L-like protease 0.0077 0.1411 0.141
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Schistosoma mansoni histone deacetylase 4 5 0.0423 0.983 0.983
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0594 0.073
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0029 0.0029
Trichomonas vaginalis histone deacetylase, putative 0.0339 0.7777 1
Loa Loa (eye worm) histone deacetylase 3 0.0339 0.7777 0.7911
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0029 0.0029
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0594 0.5
Echinococcus granulosus histone deacetylase 6 0.0423 0.983 0.983
Loa Loa (eye worm) hypothetical protein 0.0185 0.4027 0.4096
Brugia malayi jmjC domain containing protein 0.0115 0.2342 0.2382
Echinococcus multilocularis histone deacetylase 6 0.0423 0.983 0.983
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0029 0.0029
Echinococcus multilocularis histone deacetylase 0.0423 0.983 0.983
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0573 0.0573
Echinococcus granulosus histone deacetylase 0.0423 0.983 0.983
Toxoplasma gondii histone deacetylase HDAC4 0.0381 0.8805 0.8954
Echinococcus granulosus cathepsin l1 0.002 0.0029 0.0029
Toxoplasma gondii histone deacetylase HDAC5 0.0185 0.4027 0.4079
Schistosoma mansoni hypothetical protein 0.0041 0.0538 0.0538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0029 0.0029
Loa Loa (eye worm) cysteine protease 0.002 0.0029 0.0029
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0538 0.0547
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0594 0.0577
Schistosoma mansoni histone deacetylase 0.0339 0.7777 0.7777
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1001 0.1018
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1411 0.141
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1411 0.141
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0393 0.0393
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3044 0.3096
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3044 0.3096
Leishmania major histone deacetylase, putative 0.0339 0.7777 0.7905
Brugia malayi histone deacetylase 3 (HD3) 0.0339 0.7777 0.7911
Loa Loa (eye worm) beta-lactamase 0.0043 0.0594 0.0605
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0043 0.0594 0.0605
Loa Loa (eye worm) hypothetical protein 0.0043 0.0594 0.0605
Leishmania major hypothetical protein, conserved 0.0043 0.0594 0.0577
Plasmodium vivax histone deacetylase, putative 0.0381 0.8805 0.8954
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1001 0.1018
Trichomonas vaginalis histone deacetylase, putative 0.0339 0.7777 1
Trypanosoma brucei histone deacetylase 3 0.0423 0.983 1
Echinococcus multilocularis histone deacetylase 1 0.0339 0.7777 0.7777
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0594 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0538 0.0547
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0029 0.0029
Plasmodium vivax histone deacetylase 2, putative 0.0423 0.983 1
Plasmodium falciparum histone deacetylase, putative 0.0423 0.983 1
Toxoplasma gondii histone deacetylase HDAC3 0.0339 0.7777 0.7905
Onchocerca volvulus 0.0182 0.3976 0.9873
Trypanosoma cruzi histone deacetylase 1, putative 0.0339 0.7777 0.7905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Leishmania major histone deacetylase, putative 0.0423 0.983 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0594 0.5
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0393 0.0393
Echinococcus multilocularis histone deacetylase 8 0.0185 0.4027 0.4027
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0393 0.0372
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0594 0.0594
Brugia malayi PHD-finger family protein 0.0035 0.0393 0.04
Trypanosoma cruzi histone deacetylase, putative 0.0185 0.4027 0.4079
Loa Loa (eye worm) histone deacetylase 1 0.0339 0.7777 0.7911
Echinococcus multilocularis cysteine protease 0.002 0.0029 0.0029
Brugia malayi Cathepsin L-like precursor 0.002 0.0029 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0393 0.0372
Plasmodium vivax histone deacetylase, putative 0.0423 0.983 1
Onchocerca volvulus Alhambra homolog 0.0035 0.0393 0.0912
Brugia malayi Cathepsin L-like precursor 0.002 0.0029 0.0029
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0729 0.0729
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0393 0.04
Plasmodium vivax histone deacetylase 1, putative 0.0339 0.7777 0.7905
Leishmania major cathepsin L-like protease 0.0077 0.1411 0.141
Trypanosoma brucei histone deacetylase 2 0.0185 0.4027 0.3716
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0029 0.0029
Plasmodium falciparum histone deacetylase 2 0.0423 0.983 1
Echinococcus multilocularis cysteine protease 0.002 0.0029 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1411 0.0884
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0573 0.0573
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0594 0.0594
Brugia malayi beta-lactamase family protein 0.0043 0.0594 0.0605
Schistosoma mansoni histone deacetylase hda2 0.0185 0.4027 0.4027
Plasmodium falciparum histone deacetylase 1 0.0339 0.7777 0.7905
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.6294 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1001 0.1018
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0594 0.073
Echinococcus granulosus peregrin 0.0035 0.0393 0.0393
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0729 0.0729
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0029 0.0029
Trichomonas vaginalis histone deacetylase, putative 0.0339 0.7777 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0029 0.0029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0594 0.0594
Mycobacterium leprae Probable lipase LipE 0.0043 0.0594 0.5
Brugia malayi histone deacetylase 11 0.0381 0.8805 0.8957
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.101 0.1001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0594 0.0605
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0029 0.0029
Echinococcus multilocularis histone deacetylase 7 0.0423 0.983 0.983
Loa Loa (eye worm) hypothetical protein 0.0043 0.0594 0.0605
Toxoplasma gondii histone deacetylase HDAC1 0.0423 0.983 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0594 0.0605
Echinococcus multilocularis histone deacetylase 3 0.0339 0.7777 0.7777
Loa Loa (eye worm) histone deacetylase 7A 0.0423 0.983 1
Trichomonas vaginalis esterase, putative 0.0043 0.0594 0.073
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0573 0.0573
Loa Loa (eye worm) fibroinase 0.002 0.0029 0.0029
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1248 0.1244
Giardia lamblia Histone deacetylase 0.0339 0.7777 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1005 0.1022
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0594 0.0594

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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