Detailed information for compound 1398600

Basic information

Technical information
  • TDR Targets ID: 1398600
  • Name: [2-[(2-chlorophenyl)methylamino]-2-oxoethyl] 2-(4-methoxyphenyl)acetate
  • MW: 347.793 | Formula: C18H18ClNO4
  • H donors: 1 H acceptors: 2 LogP: 3.15 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CC(=O)OCC(=O)NCc1ccccc1Cl
  • InChi: 1S/C18H18ClNO4/c1-23-15-8-6-13(7-9-15)10-18(22)24-12-17(21)20-11-14-4-2-3-5-16(14)19/h2-9H,10-12H2,1H3,(H,20,21)
  • InChiKey: RDNWGRFVYNFMAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-[(2-chlorophenyl)methylamino]-2-oxo-ethyl] 2-(4-methoxyphenyl)acetate
  • 2-(4-methoxyphenyl)acetic acid [2-[(2-chlorophenyl)methylamino]-2-oxoethyl] ester
  • 2-(4-methoxyphenyl)acetic acid [2-[(2-chlorobenzyl)amino]-2-keto-ethyl] ester
  • [2-[(2-chlorophenyl)methylamino]-2-oxo-ethyl] 2-(4-methoxyphenyl)ethanoate
  • T5272387
  • MLS001003492
  • SMR000347413
  • ZINC06230355

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0401 0.1041 0.4544
Brugia malayi Calcitonin receptor-like protein seb-1 0.119 0.336 0.3338
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0299 0.074 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0163 0.0342 1
Brugia malayi glutaminase DH11.1 0.0264 0.0639 0.0608
Brugia malayi MH2 domain containing protein 0.098 0.2745 0.2721
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0299 0.074 0.3184
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0342 0.526
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0299 0.074 0.699
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0299 0.074 1
Loa Loa (eye worm) TAR-binding protein 0.0401 0.1041 0.0989
Brugia malayi RNA recognition motif domain containing protein 0.0401 0.1041 0.1012
Brugia malayi Isocitrate dehydrogenase 0.0299 0.074 0.0709
Echinococcus granulosus mothers against decapentaplegic 5 0.0067 0.0058 0.0438
Schistosoma mansoni tar DNA-binding protein 0.0401 0.1041 0.4544
Loa Loa (eye worm) transcription factor SMAD2 0.098 0.2745 0.2703
Onchocerca volvulus 0.0236 0.0555 0.0524
Schistosoma mansoni hypothetical protein 0.0376 0.0968 0.4214
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0756 0.2085 1
Brugia malayi TAR-binding protein 0.0401 0.1041 0.1012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0342 0.526
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0376 0.1547
Schistosoma mansoni hypothetical protein 0.0376 0.0968 0.4214
Loa Loa (eye worm) isocitrate dehydrogenase 0.0299 0.074 0.0686
Brugia malayi hypothetical protein 0.0135 0.0257 0.0225
Schistosoma mansoni smad1 5 8 and 0.0067 0.0058 0.0113
Loa Loa (eye worm) hypothetical protein 0.0286 0.0701 0.0647
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0342 0.526
Toxoplasma gondii LsmAD domain-containing protein 0.0135 0.0257 0.3364
Loa Loa (eye worm) RNA binding protein 0.0401 0.1041 0.0989
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0299 0.074 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0299 0.074 0.7066
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0376 0.0345
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0299 0.074 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0362 0.3392
Brugia malayi MH1 domain containing protein 0.0067 0.0058 0.0025
Echinococcus multilocularis isocitrate dehydrogenase 0.0299 0.074 0.699
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0376 0.0968 0.9289
Schistosoma mansoni smad1 5 8 and 0.0067 0.0058 0.0113
Echinococcus granulosus GPCR family 2 0.0376 0.0968 0.9289
Loa Loa (eye worm) MH2 domain-containing protein 0.098 0.2745 0.2703
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0401 0.1041 0.0989
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0756 0.2085 1
Schistosoma mansoni hypothetical protein 0.0376 0.0968 0.4214
Echinococcus granulosus snurportin 1 0.0372 0.0954 0.9155
Schistosoma mansoni smad 0.0067 0.0058 0.0113
Echinococcus multilocularis tar DNA binding protein 0.0401 0.1041 1
Loa Loa (eye worm) acetyltransferase 0.0175 0.0376 0.032
Brugia malayi RNA binding protein 0.0401 0.1041 0.1012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0376 0.0968 0.0916
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0299 0.074 1
Trichomonas vaginalis glutaminase, putative 0.0264 0.0639 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0342 0.526
Echinococcus multilocularis mothers against decapentaplegic 5 0.0067 0.0058 0.0188
Toxoplasma gondii isocitrate dehydrogenase 0.0299 0.074 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0701 0.6606
Loa Loa (eye worm) glutaminase 2 0.0264 0.0639 0.0585
Loa Loa (eye worm) glutaminase 0.0264 0.0639 0.0585
Loa Loa (eye worm) hypothetical protein 0.0813 0.2253 0.2208
Loa Loa (eye worm) hypothetical protein 0.119 0.336 0.3321
Echinococcus granulosus tar DNA binding protein 0.0401 0.1041 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0163 0.0342 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0067 0.0058 0.0438
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0954 0.0902
Echinococcus granulosus Smad4 0.0067 0.0058 0.0438
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0756 0.2085 1
Schistosoma mansoni tar DNA-binding protein 0.0401 0.1041 0.4544
Echinococcus multilocularis Smad4 0.0067 0.0058 0.0188
Brugia malayi latrophilin 2 splice variant baaae 0.0813 0.2253 0.2228
Loa Loa (eye worm) pigment dispersing factor receptor c 0.119 0.336 0.3321
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0299 0.074 0.699
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0376 0.0968 0.9289
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0342 0.526
Plasmodium falciparum ataxin-2 like protein, putative 0.0135 0.0257 0.3477
Treponema pallidum fructose-bisphosphate aldolase 0.0163 0.0342 0.5
Loa Loa (eye worm) pax transcription factor protein 2 0.0236 0.0555 0.05
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0701 0.6692
Mycobacterium ulcerans glutaminase 0.0264 0.0639 0.193
Schistosoma mansoni hypothetical protein 0.0372 0.0954 0.4152
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0163 0.0342 1
Plasmodium vivax ataxin-2 like protein, putative 0.0135 0.0257 0.3364
Loa Loa (eye worm) hypothetical protein 0.0135 0.0257 0.0201
Echinococcus multilocularis snurportin 1 0.0372 0.0954 0.9133
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0376 0.0968 0.9271
Brugia malayi hypothetical protein 0.0286 0.0701 0.0671
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0299 0.074 1
Brugia malayi isocitrate dehydrogenase 0.0299 0.074 0.0709
Schistosoma mansoni glutaminase 0.0264 0.0639 0.2731
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0342 0.526
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0067 0.0058 0.0188
Schistosoma mansoni hypothetical protein 0.0813 0.2253 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.006 0.0039 0.0255
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0376 0.0968 0.0939
Brugia malayi MH2 domain containing protein 0.0067 0.0058 0.0025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0299 0.074 0.699
Echinococcus granulosus smad 0.0067 0.0058 0.0438
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0299 0.074 0.2491
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0342 0.526
Brugia malayi Smad1 0.0067 0.0058 0.0025
Schistosoma mansoni smad1 5 8 and 0.0067 0.0058 0.0113
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0067 0.0058 0.0113
Schistosoma mansoni hypothetical protein 0.0376 0.0968 0.4214
Loa Loa (eye worm) hypothetical protein 0.0376 0.0968 0.0916
Brugia malayi hypothetical protein 0.0087 0.0117 0.0085
Brugia malayi Pax transcription factor protein 2 0.0236 0.0555 0.0524
Schistosoma mansoni tar DNA-binding protein 0.0401 0.1041 0.4544
Plasmodium falciparum ataxin-2 like protein, putative 0.0135 0.0257 0.3477
Brugia malayi MH1 domain containing protein 0.0067 0.0058 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.119 0.336 0.3338
Schistosoma mansoni hypothetical protein 0.006 0.0039 0.0028
Brugia malayi RNA, U transporter 1 0.0099 0.0152 0.012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0342 0.526
Toxoplasma gondii isocitrate dehydrogenase 0.0299 0.074 1
Schistosoma mansoni tar DNA-binding protein 0.0401 0.1041 0.4544
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0299 0.074 1
Brugia malayi Latrophilin receptor protein 2 0.0376 0.0968 0.0939
Schistosoma mansoni Smad4 0.0067 0.0058 0.0113
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0299 0.074 0.699
Echinococcus multilocularis GPCR, family 2 0.0376 0.0968 0.9271
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0376 0.3363
Brugia malayi MH2 domain containing protein 0.0067 0.0058 0.0025
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0147 0.0293 0.4479
Echinococcus multilocularis smad 0.0067 0.0058 0.0188
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0376 0.0968 0.9271

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0126 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2936 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.8199 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.