Detailed information for compound 1398980

Basic information

Technical information
  • TDR Targets ID: 1398980
  • Name: 6-chloro-N-(2-methylphenyl)-2-(5-methylthioph en-2-yl)imidazo[3,2-a]pyridin-3-amine
  • MW: 353.868 | Formula: C19H16ClN3S
  • H donors: 1 H acceptors: 1 LogP: 6.41 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(s1)c1nc2n(c1Nc1ccccc1C)cc(cc2)Cl
  • InChi: 1S/C19H16ClN3S/c1-12-5-3-4-6-15(12)21-19-18(16-9-7-13(2)24-16)22-17-10-8-14(20)11-23(17)19/h3-11,21H,1-2H3
  • InChiKey: KMDWXDQUHJXZIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-N-(2-methylphenyl)-2-(5-methyl-2-thienyl)imidazo[3,2-a]pyridin-3-amine
  • 6-chloro-N-(2-methylphenyl)-2-(5-methyl-2-thienyl)-3-imidazo[3,2-a]pyridinamine
  • C273-0259
  • NCGC00106814-01
  • STK228318
  • [6-chloro-2-(5-methyl-2-thienyl)imidazo[3,2-a]pyridin-3-yl]-(2-methylphenyl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0338 0.3662 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0369 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0079 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.024 0.556
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0245 0.5757
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0207 0.444
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0207 0.444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0369 0.0129
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0036 0.0099
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0369 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.024 0.556
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2025 0.1824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0079 0.0018
Loa Loa (eye worm) hypothetical protein 0.006 0.0432 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0245 0.0015
Schistosoma mansoni alpha glucosidase 0.0044 0.0245 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0245 0.5757
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0432 0.0194
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0245 0.5757
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0338 0.3662 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0369 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0207 0.444
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0245 0.5757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.024 0.556
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0338 0.3662 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0369 0.0376
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0369 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0111 0.1138
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2025 0.1826
Echinococcus granulosus tumor protein p63 0.0408 0.4481 0.4344
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0369 0.0129
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0245 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.2387
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0245 0.5757
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2025 0.1826
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0369 0.1007
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0369 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0277 0.6827
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0207 0.444
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0245 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0111 0.1138
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0245 0.0003
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0245 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0369 1
Echinococcus multilocularis tumor protein p63 0.0408 0.4481 0.4344
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0245 0.5757
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0338 0.3662 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.024 0.556
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0207 0.444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0079 0.0018
Trypanosoma brucei glucosidase, putative 0.0044 0.0245 0.067
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0245 0.5757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0079 0.0018
Schistosoma mansoni alpha-glucosidase 0.0169 0.1707 0.15
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0161 0.2856
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0369 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0115 0.1267
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0369 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.024 0.556
Giardia lamblia GTOR 0.0054 0.0369 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0369 0.0129
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.024 0.0656
Schistosoma mansoni alpha-glucosidase 0.0169 0.1707 0.15
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0245 0.5757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0115 0.1267
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0338 0.3662 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0207 0.444
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0207 0.444
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0245 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0369 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0369 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0338 0.3662 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0369 0.1007
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2025 0.1826
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0245 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0115 0.1267
Onchocerca volvulus 0.0114 0.1061 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0245 0.0003
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2025 0.1826
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0245 0.5757
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0245 0.0003

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (binding) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.4927 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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