Detailed information for compound 1398991

Basic information

Technical information
  • TDR Targets ID: 1398991
  • Name: 2-[(4-carboxyphenyl)methyl]-1,3-dioxoisoindol e-5-carboxylic acid
  • MW: 325.272 | Formula: C17H11NO6
  • H donors: 2 H acceptors: 6 LogP: 1.45 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccc(cc1)CN1C(=O)c2c(C1=O)cc(cc2)C(=O)O
  • InChi: 1S/C17H11NO6/c19-14-12-6-5-11(17(23)24)7-13(12)15(20)18(14)8-9-1-3-10(4-2-9)16(21)22/h1-7H,8H2,(H,21,22)(H,23,24)
  • InChiKey: JPBPTBLBYQKZFG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-carboxyphenyl)methyl]-1,3-dioxo-isoindoline-5-carboxylic acid
  • 2-[(4-carboxyphenyl)methyl]-1,3-dioxo-5-isoindolinecarboxylic acid
  • 2-(4-carboxybenzyl)-1,3-diketo-isoindoline-5-carboxylic acid
  • 2-[(4-carboxyphenyl)methyl]-1,3-dioxo-isoindole-5-carboxylic acid
  • STK156198
  • Oprea1_826656
  • IDI1_020272
  • ChemDiv3_001306

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.045
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0142 0.4404
Mycobacterium tuberculosis Putative ferredoxin reductase 0.032 0.2113 0.8946
Trypanosoma brucei trypanothione reductase 0.014 0.0867 0.2249
Loa Loa (eye worm) hypothetical protein 0.018 0.1145 0.2983
Giardia lamblia NADH oxidase lateral transfer candidate 0.0049 0.0232 0.0768
Mycobacterium tuberculosis Probable dehydrogenase 0.032 0.2113 0.8946
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0118 0.0307
Plasmodium falciparum glutathione reductase 0.0049 0.0232 0.2572
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.059
Loa Loa (eye worm) hypothetical protein 0.0065 0.0348 0.0907
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0118 0.0118
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0025 0.0072 0.0254
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0422 0.0422
Plasmodium vivax thioredoxin reductase, putative 0.014 0.0867 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0118 0.0118
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0569 0.3838 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0074 0.0407 0.106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0118 0.0307
Schistosoma mansoni regulator of G protein signaling 0.002 0.0037 0.0037
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0116 0.0217
Echinococcus granulosus dna polymerase eta 0.0023 0.0056 0.0056
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0049 0.0232 0.059
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0066 0.0159
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0013 0.0013
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0118 0.0118
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0013 0.0033
Echinococcus granulosus intermediate filament protein 0.0029 0.0095 0.0095
Brugia malayi Bromodomain containing protein 0.0082 0.0461 0.1201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0118 0.0307
Brugia malayi glutathione reductase 0.014 0.0867 0.226
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0037 0.0096
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0056 0.0147
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0236 0.1529 0.1529
Onchocerca volvulus 0.0025 0.0066 0.0197
Toxoplasma gondii exonuclease III APE 0.0025 0.0072 0.0499
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0244 0.0636
Loa Loa (eye worm) hypothetical protein 0.0236 0.1529 0.3985
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0013 0.0033
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0056 0.0132
Echinococcus multilocularis musashi 0.0029 0.0095 0.0095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.059
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0118 0.0307
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0066 0.0173
Echinococcus granulosus GPCR family 2 0.0065 0.0348 0.0348
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0018 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.004 0.004
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0466 0.0466
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0341 0.0341
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0142 0.0316
Schistosoma mansoni bromodomain containing protein 0.0069 0.0376 0.0376
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0049 0.0232 0.1101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0118 0.0307
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0264 0.0674
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0118 0.0118
Schistosoma mansoni intermediate filament proteins 0.0029 0.0095 0.0095
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0049 0.0232 0.0604
Mycobacterium tuberculosis Probable oxidoreductase 0.0356 0.2361 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0036 0.0036
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0056 0.0147
Echinococcus multilocularis transcription factor Dp 1 0.0329 0.2177 0.2177
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0307
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Brugia malayi nuclear hormone receptor 0.0032 0.0118 0.0307
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0056 0.0132
Leishmania major DNA polymerase eta, putative 0.0023 0.0056 0.0132
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0118 0.0307
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0002 0.0005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0752 0.0752
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0569 0.3838 0.3838
Echinococcus granulosus histone lysine methyltransferase setb 0.0082 0.0464 0.0464
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0025 0.0072 0.0066
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0118 0.0118
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0118 0.0118
Trypanosoma cruzi trypanothione reductase, putative 0.014 0.0867 0.2249
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.0232 1
Brugia malayi hypothetical protein 0.0034 0.0133 0.0347
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.0466 0.1288
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0466 0.0466
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0056 0.0189
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0118 0.0349
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0012 0.0012
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0118 0.0118
Trichomonas vaginalis mercuric reductase, putative 0.0049 0.0232 0.0585
Echinococcus granulosus lamin dm0 0.0029 0.0095 0.0095
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0096
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0118 0.0349
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0033
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0095 0.0552 0.1439
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.059
Mycobacterium ulcerans glutaminase 0.0292 0.1919 1
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0232 0.059
Schistosoma mansoni zinc finger protein 0.0016 0.0006 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0025 0.0072 0.0072
Toxoplasma gondii melibiase subfamily protein 0.0124 0.0752 0.6196
Entamoeba histolytica hypothetical protein 0.0076 0.0422 0.1013
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0118 0.0118
Schistosoma mansoni regulator of G protein signaling 0.002 0.0037 0.0037
Leishmania major hypothetical protein, conserved 0.0053 0.0264 0.0674
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0247 0.1606 0.4185
Brugia malayi Pre-SET motif family protein 0.0064 0.0341 0.0888
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2341 0.6907
Echinococcus multilocularis zinc finger protein 0.0024 0.006 0.006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.077 0.077
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0118 0.0307
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0348 0.0348
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0348 0.0907
Trypanosoma brucei unspecified product 0.0016 0.0006 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2341 0.6907
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0118 0.0307
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.035 0.035
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0056 0.0059
Brugia malayi Bromodomain containing protein 0.004 0.0172 0.0448
Echinococcus granulosus small conductance calcium activated potassium 0.0236 0.1529 0.1529
Loa Loa (eye worm) hypothetical protein 0.0048 0.0227 0.0591
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0037 0.0096
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0012 0.0016
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0095 0.0556 0.1436
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0569 0.3838 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0341 0.2754
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0364 0.0364
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.032 0.2113 0.8946
Schistosoma mansoni regulator of G protein signaling 0.002 0.0037 0.0037
Brugia malayi ecdysteroid receptor 0.0032 0.0118 0.0307
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0018 0.0016 0.0016
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0081 0.0081
Brugia malayi hypothetical protein 0.0053 0.0264 0.0688
Schistosoma mansoni calcium-activated potassium channel 0.0236 0.1529 0.1529
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0118 0.0307
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0118 0.0307
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0016 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0033
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0142 0.109
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0037 0.0096
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0018 0.0018
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.0142 0.0371
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0832 0.5662 0.5662
Loa Loa (eye worm) RGS-3 protein 0.002 0.0037 0.0096
Onchocerca volvulus 0.0029 0.0095 0.0281
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0037 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0013 0.0033
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0037 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0066 0.0159
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2341 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0142 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Schistosoma mansoni glutaminase 0.0292 0.1919 0.1919
Echinococcus granulosus dna polymerase kappa 0.0023 0.0056 0.0056
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0364 0.0948
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0237
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0049 0.0232 0.2572
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0056 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0345 0.1695
Schistosoma mansoni hypothetical protein 0.0065 0.0348 0.0348
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0422 0.0422
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0037 0.0096
Trichomonas vaginalis ap endonuclease, putative 0.0025 0.0072 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0118 0.0307
Leishmania major trypanothione reductase 0.014 0.0867 0.2249
Brugia malayi PXA domain containing protein 0.002 0.0037 0.0096
Echinococcus granulosus zinc finger protein 0.0024 0.006 0.006
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0049 0.0232 0.0937
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.004 0.0105
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0049 0.0232 0.1101
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.032 0.2113 0.8921
Brugia malayi Melibiase family protein 0.0082 0.0466 0.1215
Brugia malayi intermediate filament protein 0.0029 0.0095 0.0246
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2341 0.6907
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0307
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.004 0.0105
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.1606 0.1606
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0013 0.0013
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0037 0.0037
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0056 0.0059
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0356 0.2361 1
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0048 0.0126
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0173
Schistosoma mansoni regulator of G protein signaling 0.002 0.0037 0.0037
Brugia malayi nuclear receptor RXR 0.0017 0.0013 0.0033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0025 0.0072 0.0186
Brugia malayi RNA binding protein 0.0068 0.0364 0.0948
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0096
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.0076 0.0422 0.1013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0232 0.059
Schistosoma mansoni lamin 0.0029 0.0095 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0006 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0345 0.0345
Brugia malayi hypothetical protein 0.0247 0.1606 0.4185
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0033
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0118 0.0118
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0096
Loa Loa (eye worm) RNA binding protein 0.0068 0.0364 0.0948
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0142 0.0142
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0118 0.0307
Echinococcus multilocularis small conductance calcium activated potassium 0.0236 0.1529 0.1529
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0025 0.0072 0.0172
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0569 0.3838 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0049 0.0232 0.2572
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0066 0.0229
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0037 0.0037
Schistosoma mansoni axis inhibition protein axin 0.002 0.0037 0.0037
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0348 0.0907
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0118 0.0307
Loa Loa (eye worm) hypothetical protein 0.0207 0.1328 0.346
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0056 0.0132
Treponema pallidum NADH oxidase 0.0049 0.0232 0.0707
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0056 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0345 0.1695
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0118 0.0307
Loa Loa (eye worm) hypothetical protein 0.0053 0.0264 0.0688
Schistosoma mansoni inositol monophosphatase 0.0036 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.006
Echinococcus granulosus axis inhibition protein axin 0.002 0.0037 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.0095 0.0556 0.1365
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0066 0.0173
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0012 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0056 0.0147
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0056 0.0056
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0025 0.0072 0.0091
Echinococcus multilocularis expressed protein 0.0399 0.2659 0.2659
Echinococcus multilocularis cpg binding protein 0.0064 0.0337 0.0337
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0232 0.059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0016 0.0018
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0095 0.0246
Echinococcus granulosus expressed protein 0.0399 0.2659 0.2659
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0082 0.0464 0.121
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.004 0.004
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0056 0.0176
Brugia malayi hypothetical protein 0.0017 0.0013 0.0033
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0116 0.0444
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0025 0.0072 0.0172
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0118 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0464 0.0464
Schistosoma mansoni cpg binding protein 0.0064 0.0337 0.0337
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0049 0.0232 0.059
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0066 0.0078
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0173
Onchocerca volvulus 0.0064 0.0341 0.1011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2341 0.6907
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0013 0.0013
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0422 0.0422
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0232 0.059
Loa Loa (eye worm) thioredoxin reductase 0.014 0.0867 0.226
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0142 0.0142
Schistosoma mansoni zinc finger protein 0.0024 0.006 0.006
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.0142 0.0371
Brugia malayi steroid hormone receptor 0.0032 0.0118 0.0307
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2341 0.6061
Brugia malayi nuclear receptor NHR-88 0.0032 0.0118 0.0307
Brugia malayi Protein kinase domain containing protein 0.0095 0.0556 0.1448
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0095 0.0556 0.1436
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2341 0.6907
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0095 0.0556 0.1436
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2341 0.6907
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0752 0.0752
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.059
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0118 0.0349
Echinococcus multilocularis muscleblind protein 0.018 0.1145 0.1145
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0142 0.0356
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Echinococcus granulosus traf and tnf receptor associated protein 0.02 0.1278 0.1278
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0345 0.0345
Echinococcus multilocularis lamin dm0 0.0029 0.0095 0.0095
Entamoeba histolytica protein kinase domain containing protein 0.0095 0.0556 0.1365
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0345 0.0345
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0364 0.0364
Echinococcus multilocularis GPCR, family 2 0.0065 0.0348 0.0348
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0025 0.0072 0.0172
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0023 0.0131
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0569 0.3838 0.3838
Brugia malayi isocitrate dehydrogenase 0.0017 0.0012 0.0031
Echinococcus multilocularis traf and tnf receptor associated protein 0.02 0.1278 0.1278
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0118 0.0118
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0081 0.0081
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0056 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0118 0.0307
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0345 0.2785
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0142 0.0628
Schistosoma mansoni cpg binding protein 0.0064 0.0337 0.0337
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0056 0.0176
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.0752 0.0752
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0025 0.0072 0.0697
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0142 0.0356
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.0874 0.2278
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0095 0.0556 0.1448
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0264 0.0674
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0012 0.0012
Toxoplasma gondii thioredoxin reductase 0.014 0.0867 0.7162
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0012 0.0016
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0264 0.211
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.1606 0.1606
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0348 0.0348
Entamoeba histolytica hypothetical protein 0.0095 0.0556 0.1365
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0096
Brugia malayi Muscleblind-like protein 0.018 0.1145 0.2983
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0142 0.0356
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0037 0.0096
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0056 0.0056
Echinococcus multilocularis dnaJ subfamily B 0.0832 0.5662 0.5662
Loa Loa (eye worm) hypothetical protein 0.0141 0.0874 0.2278
Schistosoma mansoni cpg binding protein 0.0058 0.03 0.03
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0056 0.0051
Schistosoma mansoni lamin 0.0029 0.0095 0.0095
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0056 0.0132
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0006 0.0002
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0037 0.0037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0025 0.0072 0.0172
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0025 0.0072 0.0072
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0025 0.0072 0.0697
Brugia malayi Pre-SET motif family protein 0.0441 0.2951 0.769
Echinococcus multilocularis lamin 0.0029 0.0095 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0118 0.0307
Echinococcus granulosus muscleblind protein 0.018 0.1145 0.1145
Trichomonas vaginalis glutaminase, putative 0.0292 0.1919 0.5644
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.02 0.1278 0.3329
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0095 0.0246
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0016
Brugia malayi exodeoxyribonuclease III family protein 0.0025 0.0072 0.0186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.059
Loa Loa (eye worm) histone methyltransferase 0.002 0.0036 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0066 0.0229
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0012 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0118 0.0118
Toxoplasma gondii Alpha-galactosidase 0.0018 0.0016 0.0036
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0118 0.0118
Schistosoma mansoni ap endonuclease 0.0025 0.0072 0.0072
Brugia malayi hypothetical protein 0.0017 0.0013 0.0033
Schistosoma mansoni axis inhibition protein axin 0.002 0.0037 0.0037
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0189 0.1207 1
Trichomonas vaginalis ap endonuclease, putative 0.0025 0.0072 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0118 0.0307
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0356 0.2361 1
Echinococcus granulosus dual specificity 0.0095 0.0556 0.0556
Echinococcus granulosus axis inhibition protein axin 0.002 0.0037 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0341 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0118 0.0307
Trypanosoma brucei unspecified product 0.0023 0.0056 0.0132
Schistosoma mansoni coup transcription factor 0.0032 0.0118 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0118 0.0118
Brugia malayi hypothetical protein 0.002 0.0037 0.0096
Schistosoma mansoni hypothetical protein 0.0181 0.115 0.115
Echinococcus granulosus thioredoxin glutathione reductase 0.0141 0.0871 0.0871
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0037 0.0037
Onchocerca volvulus 0.0029 0.0095 0.0281
Trichomonas vaginalis glutathione reductase, putative 0.0049 0.0232 0.0585
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0012 0.0012
Brugia malayi CXXC zinc finger family protein 0.0058 0.03 0.0781
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0023 0.0131
Schistosoma mansoni calcium-activated potassium channel 0.0224 0.145 0.145
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0037 0.0037
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0341 0.0341
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0695 0.5721
Brugia malayi hypothetical protein 0.0076 0.0422 0.1099
Onchocerca volvulus 0.0032 0.0118 0.0349
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0037 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0049 0.0232 0.1842
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0012 0.0031
Mycobacterium tuberculosis Probable reductase 0.032 0.2113 0.8946
Schistosoma mansoni hypothetical protein 0.0065 0.0348 0.0348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0118 0.0118
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0118 0.0118
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0037 0.0037
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0118 0.0118
Echinococcus granulosus transcription factor Dp 1 0.0329 0.2177 0.2177
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0023 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0307
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0081 0.0081
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0118 0.0118
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0118 0.0118
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0049 0.0232 0.2572
Brugia malayi hypothetical protein 0.0161 0.1014 0.2642
Mycobacterium ulcerans hypothetical protein 0.0025 0.0066 0.0229
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0049 0.0232 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0307
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0016 0.0018
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0118 0.0118
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0037 0.0037
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0049 0.0232 0.0232
Toxoplasma gondii NADPH-glutathione reductase 0.0049 0.0232 0.1842
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Entamoeba histolytica hypothetical protein 0.0076 0.0422 0.1013
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0037 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.2951 0.769
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0569 0.3838 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0316 0.0316
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0118 0.0118
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0056 0.0189
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0037 0.0037
Loa Loa (eye worm) glutathione reductase 0.014 0.0867 0.226
Trypanosoma brucei unspecified product 0.0016 0.0006 0.0002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0066 0.0078
Brugia malayi TAR-binding protein 0.0068 0.0364 0.0948
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0232 0.059
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0197 0.1258 0.3277
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0016 0.0018
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.032 0.2113 0.8946
Trichomonas vaginalis set domain proteins, putative 0.0502 0.3372 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.035 0.035
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0066 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0066 0.0232
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0264 0.2947
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.0232 1
Schistosoma mansoni hypothetical protein 0.0141 0.0874 0.0874
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0118 0.0118
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0049 0.0232 0.1101
Loa Loa (eye worm) hypothetical protein 0.0161 0.1014 0.2642
Plasmodium falciparum glutathione reductase 0.014 0.0867 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0049 0.0232 0.059
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0095 0.0246
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.032 0.2113 0.8946
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.1328 0.346
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0036 0.0036
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0056 0.0056
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0049 0.0232 0.2572
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0307
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0095 0.0552 0.1439
Onchocerca volvulus 0.0015 0.0002 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0066 0.0229
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0307
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0142 0.0277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0118 0.0307
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.1328 0.346
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.006
Brugia malayi PHD-finger family protein 0.0029 0.0098 0.0256
Loa Loa (eye worm) hypothetical protein 0.018 0.1145 0.2983
Entamoeba histolytica hypothetical protein 0.0076 0.0422 0.1013
Onchocerca volvulus 0.0161 0.1014 0.3007
Echinococcus granulosus cpg binding protein 0.0064 0.0337 0.0337
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0118 0.0118
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.014 0.0867 0.3642
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0037 0.0037
Brugia malayi hypothetical protein 0.002 0.0037 0.0096
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0066 0.0232
Onchocerca volvulus 0.005 0.0244 0.0723
Onchocerca volvulus 0.0058 0.03 0.0889
Brugia malayi glutaminase DH11.1 0.0292 0.1919 0.5001
Schistosoma mansoni hypothetical protein 0.0076 0.0422 0.0422
Echinococcus granulosus tar DNA binding protein 0.0068 0.0364 0.0364
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0142 0.0356
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0155 0.0155
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0569 0.3838 0.3838
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.006 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0264 0.0674
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0066 0.0173
Echinococcus multilocularis thioredoxin glutathione reductase 0.0141 0.0871 0.0871
Leishmania major DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0142 0.0316
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.004 0.004
Echinococcus granulosus lamin 0.0029 0.0095 0.0095
Onchocerca volvulus 0.0502 0.3372 1
Brugia malayi Thioredoxin reductase 0.014 0.0867 0.226
Schistosoma mansoni DNA polymerase eta 0.0023 0.0056 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0264 0.2947
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0049 0.0232 0.0232
Loa Loa (eye worm) glutaminase 2 0.0292 0.1919 0.5001
Echinococcus multilocularis dual specificity 0.0095 0.0556 0.0556
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.03 0.0781
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0118 0.0307
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2341 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0025 0.0072 0.0255
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0013 0.0013
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0264 0.2947
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.006
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0037 0.0096
Echinococcus granulosus geminin 0.0181 0.115 0.115
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.109 0.446
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0118 0.0118
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0118 0.0714 0.1861
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0023 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2341 0.6907
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0348 0.0348
Schistosoma mansoni hypothetical protein 0.005 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0043 0.019 0.0494
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0345 0.1416
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0044 0.0115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0066 0.0229
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2341 0.6061
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0049 0.0232 0.059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0082 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0246
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0066 0.0159
Schistosoma mansoni hypothetical protein 0.0181 0.115 0.115
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0752 0.0752
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0056 0.0147
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.059
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0118 0.0118
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0095 0.0556 0.1436
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.0752 0.0752
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2341 0.6907
Schistosoma mansoni hypothetical protein 0.0024 0.006 0.006
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0056 0.0056
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0118 0.0307
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0118 0.0307
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.059
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0018 0.0018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0847 0.5764 0.5764
Loa Loa (eye worm) hypothetical protein 0.0106 0.063 0.1642
Plasmodium vivax SET domain protein, putative 0.0064 0.0341 0.3845
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0066 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0033
Plasmodium falciparum thioredoxin reductase 0.0049 0.0232 0.2572
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0307
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0065 0.0348 0.0348
Brugia malayi Inositol-1 0.0036 0.0142 0.037
Loa Loa (eye worm) hypothetical protein 0.0082 0.0466 0.1215
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0118 0.0307
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0049 0.0232 0.0232
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0569 0.3838 1
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0348 0.0907
Echinococcus multilocularis geminin 0.0181 0.115 0.115
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0569 0.3838 1
Schistosoma mansoni hypothetical protein 0.0065 0.0348 0.0348
Loa Loa (eye worm) glutaminase 0.0292 0.1919 0.5001
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0356 0.2361 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0364 0.0364
Brugia malayi PXA domain containing protein 0.002 0.0037 0.0096
Schistosoma mansoni hypothetical protein 0.0022 0.0044 0.0044
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0364 0.0948
Echinococcus multilocularis muscleblind protein 1 0.018 0.1145 0.1145
Echinococcus multilocularis dna polymerase eta 0.0023 0.0056 0.0056
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0569 0.3838 1
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0364 0.0948
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0132
Plasmodium vivax glutathione reductase, putative 0.014 0.0867 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.006 0.006
Entamoeba histolytica protein kinase, putative 0.0095 0.0556 0.1365
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0142 0.0316
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.109 0.5625
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.1328 0.346
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.109 0.4588
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.006
Schistosoma mansoni survival motor neuron protein 0.005 0.0244 0.0244
Schistosoma mansoni ap endonuclease 0.0025 0.0072 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0006 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0066 0.0229
Plasmodium falciparum thioredoxin reductase 0.014 0.0867 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.004 0.004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0345 0.1695
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.004 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0118 0.0307
Echinococcus granulosus dnaJ subfamily B 0.0832 0.5662 0.5662
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0345 0.0884
Loa Loa (eye worm) inositol-1 0.0036 0.0142 0.037
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0345 0.0345
Schistosoma mansoni regulator of G protein signaling 0.002 0.0037 0.0037
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0066 0.0229

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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