Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.2772 | 0.2772 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.6509 | 0.5 |
Brugia malayi | Inositol-1 | 0.0045 | 0.6509 | 0.6407 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.6509 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.5556 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 0.6509 | 0.6509 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0.6509 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.2772 | 0.5 | |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.6509 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.6509 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.5556 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2674 | 0.2674 |
Echinococcus granulosus | lamin | 0.0026 | 0.2772 | 0.2772 |
Echinococcus multilocularis | lamin | 0.0026 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2772 | 0.2772 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.2772 | 0.2561 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.6509 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.2772 | 0.2561 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.6509 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0.6509 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.2772 | 0.2772 |
Onchocerca volvulus | 0.0026 | 0.2772 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 0.6509 | 0.6509 |
Echinococcus multilocularis | musashi | 0.0026 | 0.2772 | 0.2772 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.6509 | 0.517 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.2772 | 0.2772 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.2772 | 0.2772 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 0.6509 | 0.6509 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.6509 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0.6509 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.6509 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.6509 | 0.517 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0285 | 0.0285 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.