Detailed information for compound 1399023

Basic information

Technical information
  • TDR Targets ID: 1399023
  • Name: 8-chloro-1-phenyl-1,3,4,5-tetrahydro-3-benzaz epine-2-thione
  • MW: 287.807 | Formula: C16H14ClNS
  • H donors: 0 H acceptors: 0 LogP: 4.16 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)C(C(=NCC2)S)c1ccccc1
  • InChi: 1S/C16H14ClNS/c17-13-7-6-11-8-9-18-16(19)15(14(11)10-13)12-4-2-1-3-5-12/h1-7,10,15H,8-9H2,(H,18,19)
  • InChiKey: OJXDNSYFROETQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-chloro-1-phenyl-1,3,4,5-tetrahydro-2H-3-benzazepine-2-thione
  • MLS000549184
  • AE-641/11701015
  • Oprea1_801841
  • SMR000113890

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0242 0.3591
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0242 0.3591
Loa Loa (eye worm) TAR-binding protein 0.0465 0.451 0.451
Leishmania major cysteine peptidase A (CPA) 0.002 0.0048 0.0709
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0042 0.0261 0.0274
Onchocerca volvulus Cathepsin F homolog 0.002 0.0048 0.0286
Onchocerca volvulus Cathepsin L homolog 0.002 0.0048 0.0286
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0042 0.0261 0.0274
Loa Loa (eye worm) cysteine protease 0.002 0.0048 0.0048
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0517 0.7678
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0042 0.062
Trypanosoma brucei PAB1-binding protein , putative 0.0083 0.0673 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0129 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.3591
Schistosoma mansoni tar DNA-binding protein 0.0465 0.451 0.4727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Brugia malayi MH1 domain containing protein 0.0051 0.0358 0.0358
Trypanosoma cruzi PAB1-binding protein , putative 0.0083 0.0673 1
Brugia malayi MH2 domain containing protein 0.0051 0.0358 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0048 0.1824
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0042 0.0261 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Schistosoma mansoni hypothetical protein 0.0321 0.3058 0.3206
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0042 0.062
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0042 0.0261 0.0261
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0048 0.005
Schistosoma mansoni hypothetical protein 0.0696 0.6818 0.7147
Onchocerca volvulus Cathepsin L homolog 0.002 0.0048 0.0286
Leishmania major hypothetical protein, conserved 0.0083 0.0673 1
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0042 0.0261 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0042 0.0261 0.0261
Schistosoma mansoni hypothetical protein 0.0321 0.3058 0.3206
Loa Loa (eye worm) transcription factor SMAD2 0.0751 0.737 0.737
Loa Loa (eye worm) hypothetical protein 0.0042 0.0261 0.0261
Leishmania major DNA polymerase eta, putative 0.004 0.0243 0.3613
Brugia malayi latrophilin 2 splice variant baaae 0.0693 0.6787 0.6787
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0967 0.954 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.3591
Schistosoma mansoni ap endonuclease 0.002 0.0042 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0119 0.1762
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0042 0.0261 0.0274
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0042 0.1727
Onchocerca volvulus 0.0042 0.0261 0.1567
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.3591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.1824
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.0074 0.0078
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0242 0.0253
Onchocerca volvulus 0.0042 0.0261 0.1567
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0042 0.0261 0.0274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.1824
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0452 0.6718
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.0074 0.0078
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0051 0.0358 0.0375
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0042 0.0261 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Schistosoma mansoni Smad4 0.0023 0.0074 0.0078
Loa Loa (eye worm) hypothetical protein 0.0321 0.3058 0.3058
Schistosoma mansoni smad 0.0023 0.0074 0.0078
Loa Loa (eye worm) hypothetical protein 0.0182 0.1669 0.1669
Schistosoma mansoni GTP-binding protein alpha subunit 0.0042 0.0261 0.0274
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0042 0.0261 0.0274
Onchocerca volvulus 0.002 0.0048 0.0286
Loa Loa (eye worm) ctsf protein 0.002 0.0048 0.0048
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0074 0.0074
Brugia malayi Latrophilin receptor protein 2 0.0321 0.3058 0.3058
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0242 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0042 0.0261 0.0274
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0709
Echinococcus multilocularis geminin 0.0696 0.6818 0.7147
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0042 0.062
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.055 0.8179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0321 0.3058 0.3058
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.3591
Brugia malayi hypothetical protein 0.0042 0.0261 0.0261
Leishmania major DNA polymerase kappa, putative 0.004 0.0242 0.3591
Plasmodium falciparum ataxin-2 like protein, putative 0.0083 0.0673 1
Trypanosoma brucei unspecified product 0.0027 0.0119 0.1762
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0967 0.954 1
Schistosoma mansoni smad1 5 8 and 0.0051 0.0358 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.3591
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0321 0.3058 0.3206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.1824
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.1824
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0048 0.1824
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0042 0.0261 0.0274
Echinococcus granulosus tar DNA binding protein 0.0465 0.451 0.4727
Brugia malayi Smad1 0.0051 0.0358 0.0358
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0042 0.0261 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.3591
Brugia malayi MH2 domain containing protein 0.0751 0.737 0.737
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0074 0.0074
Entamoeba histolytica cysteine protease, putative 0.002 0.0048 0.1824
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0042 0.0261 0.0274
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0048 0.1824
Schistosoma mansoni hypothetical protein 0.0037 0.0216 0.0227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.1824
Schistosoma mansoni Smad4 0.0023 0.0074 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0465 0.451 0.4727
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0042 0.5
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0242 0.0242
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0048 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0242 0.3591
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0042 0.1595
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0042 0.0261 0.0261
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0967 0.954 1
Loa Loa (eye worm) Smad1 0.0051 0.0358 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Loa Loa (eye worm) G protein alpha subunit 3 0.0042 0.0261 0.0261
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0042 0.0261 0.0274
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0242 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Onchocerca volvulus 0.002 0.0048 0.0286
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0042 0.0044
Echinococcus multilocularis GPCR, family 2 0.0321 0.3058 0.3206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.088 0.867 0.9088
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0617 0.9175
Echinococcus granulosus smad 0.0051 0.0358 0.0375
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0321 0.3058 0.3206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0048 0.1824
Brugia malayi MH2 domain containing protein 0.0023 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0083 0.0673 0.0673
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0242 0.9239
Plasmodium vivax ataxin-2 like protein, putative 0.0083 0.0673 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0042 0.0261 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0617 0.9175
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0042 0.0042
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0042 0.0261 1
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0709
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0048 0.005
Echinococcus granulosus dna polymerase eta 0.0067 0.0517 0.0541
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0042 0.0261 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0051 0.0358 0.0375
Loa Loa (eye worm) nuclear factor I 0.0028 0.0129 0.0129
Brugia malayi G-protein alpha subunit 0.0042 0.0261 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0119 0.1762
Echinococcus multilocularis Smad4 0.0051 0.0358 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0048 0.0709
Onchocerca volvulus 0.0042 0.0261 0.1567
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0042 0.0261 0.0274
Schistosoma mansoni smad 0.0051 0.0358 0.0375
Brugia malayi MH2 domain containing protein 0.0051 0.0358 0.0358
Schistosoma mansoni Smad4 0.0051 0.0358 0.0375
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Toxoplasma gondii cathepsin CPL 0.002 0.0048 0.0709
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0042 0.062
Echinococcus granulosus geminin 0.0696 0.6818 0.7147
Loa Loa (eye worm) fibroinase 0.002 0.0048 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0242 0.3591
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0042 0.0261 0.0261
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0243 0.3613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0967 0.954 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0023 0.0074 0.0445
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0242 0.0253
Toxoplasma gondii LsmAD domain-containing protein 0.0083 0.0673 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0074 0.0074
Brugia malayi RNA recognition motif domain containing protein 0.0465 0.451 0.451
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0042 0.0261 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0243 0.3613
Loa Loa (eye worm) hypothetical protein 0.0042 0.0261 0.0261
Loa Loa (eye worm) MH2 domain-containing protein 0.0751 0.737 0.737
Schistosoma mansoni tar DNA-binding protein 0.0465 0.451 0.4727
Schistosoma mansoni smad1 5 8 and 0.0051 0.0358 0.0375
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0042 0.0261 0.0261
Leishmania major cathepsin L-like protease 0.0077 0.0617 0.9175
Giardia lamblia DINP protein human, muc B family 0.004 0.0242 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.3591
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0967 0.954 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0042 0.0261 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Echinococcus granulosus dna polymerase kappa 0.004 0.0242 0.0253
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0042 0.0261 0.0261
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0042 0.0042
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0242 0.0253
Echinococcus multilocularis dna polymerase kappa 0.004 0.0242 0.0253
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0042 0.0261 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0042 0.062
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0517 0.0517
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0617 0.9175
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0048 0.005
Leishmania major DNA polymerase eta, putative 0.0067 0.0517 0.7678
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0048 0.005
Brugia malayi TAR-binding protein 0.0465 0.451 0.451
Entamoeba histolytica G protein alpha subunit, putative 0.0042 0.0261 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0042 0.0261 0.0274
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0042 0.0261 1
Loa Loa (eye worm) RNA binding protein 0.0465 0.451 0.451
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0321 0.3058 0.3206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Echinococcus multilocularis mothers against decapentaplegic 5 0.0051 0.0358 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0119 0.1762
Loa Loa (eye worm) hypothetical protein 0.0067 0.0517 0.0517
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0709
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0042 0.0261 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Plasmodium vivax vivapain-2 0.002 0.0048 0.0709
Leishmania major cathepsin L-like protease 0.0077 0.0617 0.9175
Loa Loa (eye worm) MH2 domain-containing protein 0.0051 0.0358 0.0358
Echinococcus multilocularis cysteine protease 0.002 0.0048 0.005
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0048 0.005
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0242 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0042 0.0261 0.0274
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0242 0.3591
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0321 0.3058 0.3206
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0042 0.062
Onchocerca volvulus 0.002 0.0048 0.0286
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.0074 0.0078
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0242 1
Schistosoma mansoni tar DNA-binding protein 0.0465 0.451 0.4727
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0042 0.1595
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0242 0.3591
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0048 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.3591
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0042 0.0261 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0967 0.954 1
Echinococcus multilocularis cysteine protease 0.002 0.0048 0.005
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0693 0.6787 0.6787
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.1824
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0048 0.0048
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0242 0.3591
Echinococcus multilocularis smad 0.0051 0.0358 0.0375
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0048 0.0709
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0042 0.0261 0.0274
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0042 0.0261 0.0261
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0042 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.1824
Brugia malayi MH1 domain containing protein 0.0028 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Plasmodium vivax vivapain-2 0.002 0.0048 0.0709
Brugia malayi MH1 domain containing protein 0.0051 0.0358 0.0358
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0042 0.0261 0.0274
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0042 0.0261 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0465 0.451 0.4727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Schistosoma mansoni hypothetical protein 0.0693 0.6787 0.7114
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0242 0.0242
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0042 0.0261 0.0274
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0037 0.0216 0.0227
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0042 0.5
Schistosoma mansoni smad1 5 8 and 0.0051 0.0358 0.0375
Loa Loa (eye worm) hypothetical protein 0.0042 0.0261 0.0261
Echinococcus granulosus cathepsin l1 0.002 0.0048 0.005
Schistosoma mansoni hypothetical protein 0.0696 0.6818 0.7147
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0051 0.0358 0.0375
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0242 0.9239
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0042 0.0261 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.3591
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0042 0.0261 0.0274
Brugia malayi N-terminal motif family protein 0.0182 0.1669 0.1669
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.1824
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0042 0.0261 0.0261
Onchocerca volvulus 0.002 0.0048 0.0286
Trypanosoma cruzi PAB1-binding protein , putative 0.0083 0.0673 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0967 0.954 0.954
Echinococcus multilocularis tar DNA binding protein 0.0465 0.451 0.4727
Brugia malayi hypothetical protein 0.0083 0.0673 0.0673
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0037 0.0216 0.0227
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0242 0.0253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0967 0.954 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Schistosoma mansoni DNA polymerase eta 0.0067 0.0517 0.0541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0042 0.0261 0.0261
Trypanosoma brucei unspecified product 0.0027 0.0119 0.1762
Plasmodium falciparum ataxin-2 like protein, putative 0.0083 0.0673 1
Echinococcus granulosus expressed protein 0.0042 0.0261 0.0274
Echinococcus granulosus GPCR family 2 0.0321 0.3058 0.3206
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0048 0.0709
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0242 0.3591
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0042 0.0261 0.0261
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0048 0.005
Brugia malayi RNA binding protein 0.0465 0.451 0.451
Onchocerca volvulus 0.002 0.0048 0.0286
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0048 0.0709
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0465 0.451 0.451
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0042 0.0261 0.0274
Toxoplasma gondii exonuclease III APE 0.002 0.0042 0.062
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.1669 1
Schistosoma mansoni ap endonuclease 0.002 0.0042 0.0044
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0967 0.954 0.954
Brugia malayi MH1 domain containing protein 0.0028 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Brugia malayi hypothetical protein 0.0053 0.0379 0.0379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.1824
Trypanosoma brucei DNA polymerase eta, putative 0.0067 0.0517 0.7678
Onchocerca volvulus 0.002 0.0048 0.0286
Onchocerca volvulus 0.002 0.0048 0.0286
Loa Loa (eye worm) MH1 domain-containing protein 0.0051 0.0358 0.0358
Leishmania major cathepsin L-like protease 0.0077 0.0617 0.9175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0321 0.3058 0.3058
Echinococcus multilocularis expressed protein 0.0042 0.0261 0.0274
Echinococcus granulosus Smad4 0.0051 0.0358 0.0375
Echinococcus multilocularis dna polymerase eta 0.0067 0.0517 0.0541
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0709
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.3591
Schistosoma mansoni hypothetical protein 0.0321 0.3058 0.3206
Loa Loa (eye worm) hypothetical protein 0.0042 0.0261 0.0261
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0709
Echinococcus granulosus mothers against decapentaplegic 5 0.0051 0.0358 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.1824
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.0074 0.0078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0321 0.3058 0.3206
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0048 0.005
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0042 0.0261 0.0261
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0042 0.1595
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0617 0.9175
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0242 0.9239
Trypanosoma brucei unspecified product 0.004 0.0242 0.3591
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0042 0.0261 0.0261
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0617 0.9175

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5104 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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