Detailed information for compound 1399116

Basic information

Technical information
  • TDR Targets ID: 1399116
  • Name: 4-[5-[(4-methylphenyl)sulfanylmethyl]-1,2,4-o xadiazol-3-yl]pyridine
  • MW: 283.348 | Formula: C15H13N3OS
  • H donors: 0 H acceptors: 3 LogP: 3.14 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)SCc1onc(n1)c1ccncc1
  • InChi: 1S/C15H13N3OS/c1-11-2-4-13(5-3-11)20-10-14-17-15(18-19-14)12-6-8-16-9-7-12/h2-9H,10H2,1H3
  • InChiKey: RBXIYNQUDBEIKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[5-[[(4-methylphenyl)thio]methyl]-1,2,4-oxadiazol-3-yl]pyridine
  • 4-(5-{[(4-methylphenyl)thio]methyl}-1,2,4-oxadiazol-3-yl)pyridine
  • MLS000065343
  • ZINC02866799
  • STK323411
  • MLS-0039523.P003
  • SDCCGMLS-0039523.P002
  • SMR000079051

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0115 0.2898 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2844 1
Brugia malayi RNA binding protein 0.0076 0.1202 0.3707
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2844 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0203 0.0298
Loa Loa (eye worm) hypothetical protein 0.006 0.0497 0.1112
Echinococcus granulosus tar DNA binding protein 0.0076 0.1202 0.1767
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0203 0.0298
Echinococcus multilocularis neuropeptide s receptor 0.0054 0.0203 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0054 0.0203 0.0298
Echinococcus multilocularis G-protein coupled receptor, putative 0.0054 0.0203 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1202 0.1514
Echinococcus granulosus neuropeptide FF receptor 2 0.0054 0.0203 0.0298
Echinococcus granulosus somatostatin receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1036 0.3153
Giardia lamblia Kinase, PLK 0.0114 0.2844 0.5
Echinococcus granulosus g protein coupled receptor 0.0054 0.0203 0.0298
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Echinococcus multilocularis neuropeptide FF receptor 2 0.0054 0.0203 0.0298
Echinococcus granulosus neuropeptide receptor 0.0054 0.0203 0.0298
Schistosoma mansoni hypothetical protein 0.0205 0.6803 1
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2844 0.4002
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2844 0.5
Echinococcus granulosus neuropeptide s receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1202 0.3783
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2844 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2844 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2898 0.4261
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis allatostatin A receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis serotonin receptor 0.0054 0.0203 0.0298
Echinococcus granulosus orexin receptor type 2 0.0054 0.0203 0.0298
Echinococcus granulosus dro:myosuppressin receptor 0.0054 0.0203 0.0298
Echinococcus granulosus serotonin receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1202 0.1767
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1202 0.1514
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0203 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1202 0.1514
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2844 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0203 0.0298
Echinococcus granulosus neuropeptide receptor 0.0054 0.0203 0.0298
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0203 0.0298
Echinococcus granulosus G protein coupled receptor 139 0.0054 0.0203 0.0298
Echinococcus granulosus hypothetical protein 0.0054 0.0203 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Schistosoma mansoni hypothetical protein 0.0205 0.6803 1
Echinococcus granulosus g protein coupled receptor 0.0054 0.0203 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2844 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1202 0.3783
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Echinococcus granulosus fmrfamide receptor 0.0054 0.0203 0.0298
Echinococcus granulosus g-protein coupled receptor 0.0054 0.0203 0.0298
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1863 0.2515
Echinococcus granulosus neuropeptide receptor A26 0.0054 0.0203 0.0298
Brugia malayi TAR-binding protein 0.0076 0.1202 0.3707
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0203 0.0298
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0203 0.0298
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0054 0.0203 0.0298
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0203 0.0298
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0054 0.0203 0.0298
Echinococcus multilocularis g-protein coupled receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis serotonin receptor 0.0054 0.0203 0.0298
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2844 0.5
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2844 0.5
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0203 0.0298
Echinococcus granulosus alpha 1A adrenergic receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0054 0.0203 0.0298
Trypanosoma brucei polo-like protein kinase 0.0114 0.2844 0.5
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0054 0.0203 0.0298
Echinococcus granulosus 7TM GPCR rhodopsin 0.0054 0.0203 0.0298
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2844 0.4181
Loa Loa (eye worm) RNA binding protein 0.0076 0.1202 0.3783
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0054 0.0203 0.0298
Echinococcus multilocularis neuropeptide receptor A26 0.0054 0.0203 0.0298
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0054 0.0203 0.0298
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2844 0.4181
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0054 0.0203 0.0298
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2844 0.9799
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2898 0.4261
Echinococcus granulosus geminin 0.0205 0.6803 1
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0203 0.0298
Echinococcus granulosus tachykinin peptides receptor 99D 0.0054 0.0203 0.0298
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0203 0.0298
Echinococcus multilocularis somatostatin receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis orexin receptor type 2 0.0054 0.0203 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2844 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2844 1
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0203 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Echinococcus granulosus 7tm_1 domain containing protein 0.0054 0.0203 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0203 0.0298
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0203 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1202 0.1514
Echinococcus granulosus allatostatin A receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis G protein coupled receptor 139 0.0054 0.0203 0.0298
Echinococcus granulosus peptide allatostatin:somatostatin 0.0054 0.0203 0.0298
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1202 0.3707
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0203 0.0298
Echinococcus granulosus sex peptide receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis sex peptide receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0203 0.0298
Echinococcus granulosus g protein coupled receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis dro:myosuppressin receptor 0.0054 0.0203 0.0298
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0203 0.0298
Schistosoma mansoni kinase 0.0058 0.0392 0.0287
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0203 0.0298
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2844 1
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0203 0.0298
Echinococcus multilocularis geminin 0.0205 0.6803 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0054 0.0203 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0203 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2844 1
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0203 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1202 0.1514
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0203 0.0298

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 2.9935 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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