Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | snurportin 1 | No references | |
Homo sapiens | karyopherin (importin) beta 1 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.0346 | 0.9251 | 0.9251 |
Brugia malayi | RNA, U transporter 1 | 0.0099 | 0.1906 | 0.206 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0132 | 0.2899 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0346 | 0.9251 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0346 | 0.9251 | 0.9251 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0346 | 0.9251 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0346 | 0.9251 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0346 | 0.9251 | 0.9251 |
Brugia malayi | dihydrofolate reductase family protein | 0.0346 | 0.9251 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0346 | 0.9251 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0132 | 0.2899 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0132 | 0.2899 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0132 | 0.2899 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0132 | 0.2899 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0346 | 0.9251 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0346 | 0.9251 | 0.9251 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0132 | 0.2899 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 195 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.