Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.5113 | 0.5113 |
Brugia malayi | MH2 domain containing protein | 0.0007 | 0.0306 | 0.0306 |
Echinococcus multilocularis | Smad4 | 0.0007 | 0.0306 | 0.0442 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0007 | 0.0306 | 0.0442 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2849 | 0.2849 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.6919 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.6919 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.6919 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.6919 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.6919 | 1 |
Echinococcus granulosus | smad | 0.0007 | 0.0306 | 0.0442 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2849 | 0.4118 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.1339 | 0.1339 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2849 | 0.4118 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2849 | 0.2849 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.6919 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.1166 | 0.1686 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2849 | 0.4118 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0007 | 0.0306 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2789 | 0.2789 |
Brugia malayi | Smad1 | 0.0007 | 0.0306 | 0.0306 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.5113 | 0.739 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2849 | 0.4118 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.5113 | 0.739 |
Schistosoma mansoni | smad | 0.0007 | 0.0306 | 0.0442 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.6919 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2849 | 0.4118 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.6919 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1107 | 0.1107 |
Echinococcus granulosus | Smad4 | 0.0007 | 0.0306 | 0.0442 |
Schistosoma mansoni | Smad4 | 0.0007 | 0.0306 | 0.0442 |
Schistosoma mansoni | lamin | 0.0033 | 0.2849 | 0.4118 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.5113 | 0.739 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.5113 | 0.5113 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.5113 | 0.739 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2849 | 0.2849 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1339 | 0.1339 |
Schistosoma mansoni | smad1 5 8 and | 0.0007 | 0.0306 | 0.0442 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.6919 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0007 | 0.0306 | 0.0442 |
Echinococcus multilocularis | smad | 0.0007 | 0.0306 | 0.0442 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0007 | 0.0306 | 0.0442 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.6919 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0007 | 0.0306 | 0.0306 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.1166 | 0.1686 |
Brugia malayi | MH1 domain containing protein | 0.0007 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2849 | 0.2849 |
Brugia malayi | MH2 domain containing protein | 0.0007 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1107 | 0.1107 |
Schistosoma mansoni | lamin | 0.0033 | 0.2849 | 0.4118 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.5113 | 0.739 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2849 | 0.4118 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.5113 | 0.739 |
Schistosoma mansoni | smad1 5 8 and | 0.0007 | 0.0306 | 0.0442 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0007 | 0.0306 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1166 | 0.1166 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2849 | 0.2849 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0007 | 0.0306 | 0.0306 |
Onchocerca volvulus | 0.0033 | 0.2849 | 1 | |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0007 | 0.0306 | 0.0442 |
Onchocerca volvulus | 0.0033 | 0.2849 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.5113 | 0.739 |
Loa Loa (eye worm) | Smad1 | 0.0007 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0007 | 0.0306 | 0.0306 |
Echinococcus granulosus | lamin | 0.0033 | 0.2849 | 0.4118 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7943 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.9362 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.